المؤلفون: Sam R J Hoare

المصدر: SLAS Discovery. 26:835-850

مصطلحات موضوعية: 0301 basic medicine, Kinetics, Computational biology, In Vitro Techniques, Ligands, Biochemistry, Analytical Chemistry, 03 medical and health sciences, 0302 clinical medicine, Drug Discovery, Humans, Potency, Bioassay, Receptor, Pharmacology, Chemistry, Drug discovery, Computational Biology, Ligand (biochemistry), In vitro, 030104 developmental biology, Molecular Medicine, Classical pharmacology, 030217 neurology & neurosurgery, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d22325d8931350092be022f8e29261a
https://doi.org/10.1177/24725552211019653

المؤلفون: Zanders, Edward D.^Aff1_4

المساهمون: Zanders, Edward D.^AffID1

المصدر: The Science and Business of Drug Discovery : Demystifying the Jargon. :57-90

Degree: Ph.D.

المؤلفون: Paul R. Riley, Sophia Malandraki-Miller

المصدر: Drug Discovery Today. 26:887-901

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Scrutiny, Computer science, Drug discovery, business.industry, Machine Learning, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Development, Drug development, Artificial Intelligence, 030220 oncology & carcinogenesis, Research community, Drug Discovery, Humans, Classical pharmacology, Molecular Targeted Therapy, Artificial intelligence, Phenomics, business, Productivity, Pharmaceutical industry

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e14dbcb503456eef442ff279b8f08701
https://doi.org/10.1016/j.drudis.2021.01.013

المؤلفون: Rebecca E. Hughes, John C. Dawson, Neil O. Carragher, Richard J. R. Elliott

المصدر: Hughes, B, Elliott, R, Dawson, J C & Carragher, N O 2021, ' High content phenotypic and pathway profiling to advance drug discovery in diseases of unmet need ', Cell Chemical Biology . https://doi.org/10.1016/j.chembiol.2021.02.015

مصطلحات موضوعية: Pharmacology, 010405 organic chemistry, Drug discovery, Clinical Biochemistry, Computational biology, Biology, Highly selective, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, Unmet needs, Phenotype, Pharmaceutical Preparations, Network pharmacology, Drug Discovery, medicine, Humans, Molecular Medicine, Profiling (information science), Disease, Classical pharmacology, Molecular Biology, High content imaging, Glioblastoma

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27e56b1a4730709aaf2f24876f58cf5f
https://doi.org/10.1016/j.chembiol.2021.02.015

المؤلفون: J. Willem M. Nissink, Jonathan B. Baell, Francis S. Willard, Ina Rothenaigner, Jonathan Z. Sexton, Douglas S. Auld, Jayme L. Dahlin, John Strelow, Michael A. Walters, Bruce K. Hua, Steve Haney, Lori Ferrins, Jarrod Walsh, Bridget K. Wagner, Jonathan A. Lee, Kamyar Hadian

المصدر: Cell Chem. Bio. 28, 356-370 (2021)
Cell Chem Biol

مصطلحات موضوعية: High-throughput screening, Phenotypic screening, Clinical Biochemistry, Chemical biology, Computational biology, Biology, 01 natural sciences, Biochemistry, Article, Assay interference, Artifacts, Chemical Biology, Drug Discovery, High-content Screening, High-throughput Screening, Interference, Nuisance Compounds, Phenotypic Drug Discovery, Phenotypic Screening, Artificial Intelligence, Humans, Molecular Biology, Pharmacology, Biological Products, 010405 organic chemistry, Drug discovery, Cheminformatics, 0104 chemical sciences, Pharmaceutical Preparations, High-content screening, Molecular Medicine, Classical pharmacology, Nuisance

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f70a37970ff95ac15de8c8aee188c39
https://doi.org/10.1016/j.chembiol.2021.01.021

المؤلفون: Samreen K. Syed, David Gene Barrett, Francis S. Willard, Karen Leigh Cox, Dirk Tomandl, Alexander M. Efanov, Luyan Song

المصدر: ASSAY and Drug Development Technologies. 19:27-37

مصطلحات موضوعية: medicine.medical_treatment, Phenotypic screening, Drug Evaluation, Preclinical, Sulfonylurea Receptors, Insulin-Secreting Cells, Insulin Secretion, Drug Discovery, medicine, Diazoxide, Humans, Potassium Channels, Inwardly Rectifying, Cells, Cultured, Drug discovery, Chemistry, Secretagogues, Insulin, Optical Imaging, Potassium channel, High-Throughput Screening Assays, Potassium channel activity, Phenotype, Sulfonylurea Compounds, Biochemistry, Molecular Medicine, Classical pharmacology, Beta cell, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b9ab4bd48304b142f94dca349233cb
https://doi.org/10.1089/adt.2020.1011

المؤلفون: Georg C. Terstappen, Angela J. Russell, Isabel V.L. Wilkinson

المصدر: Drug Discovery Today. 25:1998-2005

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Mechanism (biology), Computer science, Target engagement, Computational biology, 03 medical and health sciences, Identification (information), 030104 developmental biology, 0302 clinical medicine, Drug development, 030220 oncology & carcinogenesis, Direct binding, Drug Discovery, Classical pharmacology, Functional studies, Deconvolution

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761c620b4dc4d41918444224b0ccfffd
https://doi.org/10.1016/j.drudis.2020.09.016

المؤلفون: Adam Zweifach, Haim Bar

المصدر: SLAS Discovery. 25:1000-1008

مصطلحات موضوعية: 0303 health sciences, Computer science, Computational biology, Cell based assays, 01 natural sciences, Biochemistry, 0104 chemical sciences, Analytical Chemistry, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Metric (mathematics), Molecular Medicine, Classical pharmacology, 030304 developmental biology, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b2711942e15d4b2c50130080b6055f8d
https://doi.org/10.1177/2472555220942764

المؤلفون: Ina Rothenaigner, Kenji Schorpp, Sean Lin, Kamyar Hadian

المصدر: Drug Discov. Today 25, 1348-1361 (2020)

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Computer science, Drug discovery, Phenotypic screening, Computational biology, behavioral disciplines and activities, High-Throughput Screening Assays, Machine Learning, 03 medical and health sciences, Identification (information), Phenotype, 030104 developmental biology, 0302 clinical medicine, Workflow, 030220 oncology & carcinogenesis, High-content screening, mental disorders, Drug Discovery, Humans, Image acquisition, Classical pharmacology, Image based

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6382e64659a6af66268178596a4ae95
https://doi.org/10.1016/j.drudis.2020.06.001

المؤلفون: Elisabeth Bäck, Jörgen Östling, Mei Ding, Christopher McCrae, Christian Tyrchan, Steffen Schubert

المصدر: SLAS Discovery. 25:634-645

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Rhinovirus, Phenotypic screening, Druggability, Bronchi, Biology, Virus Replication, medicine.disease_cause, 030226 pharmacology & pharmacy, Biochemistry, Analytical Chemistry, Small Molecule Libraries, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, CRISPR, Gene Regulatory Networks, Molecular Targeted Therapy, RNA, Small Interfering, Intramolecular Transferases, Gene, Epithelial Cells, 030104 developmental biology, Viral replication, Virus Diseases, Cancer research, Molecular Medicine, Classical pharmacology, CRISPR-Cas Systems, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b4f8369a5524d8f0b23da8d2f65f89
https://doi.org/10.1177/2472555220909726