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1دورية أكاديمية
المؤلفون: Michael Lampa, Heike Arlt, Timothy He, Beatriz Ospina, Jason Reeves, Bailin Zhang, Joshua Murtie, Gejing Deng, Claude Barberis, Dietmar Hoffmann, Hong Cheng, Jack Pollard, Christopher Winter, Victoria Richon, Carlos Garcia-Escheverria, Francisco Adrian, Dmitri Wiederschain, Lakshmi Srinivasan
المصدر: PLoS ONE, Vol 12, Iss 9, p e0185092 (2017)
وصف الملف: electronic resource
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2
المؤلفون: Ingrid Mechin, Chris Arendt, Mikhail Levit, Claude Barberis, Sandra Moreno-Mazza, Tahir Majid, Neil Moorcroft, Joseph D. Batchelor
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4730-4734
مصطلحات موضوعية: 0301 basic medicine, Indoles, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, PIM1, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Humans, Protein Kinase Inhibitors, Molecular Biology, Cell Proliferation, Binding Sites, Chemistry, Kinase, Organic Chemistry, Combinatorial chemistry, Protein Structure, Tertiary, 030104 developmental biology, 030220 oncology & carcinogenesis, Initial phase, Molecular Medicine, Drug Screening Assays, Antitumor, Transferase inhibitor
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3Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III
المؤلفون: Andrew Hebert, Paul Erdman, Maniar Sachin, Anlai Wang, Alexandre Gross, Elina Tserlin, Claude Barberis, Vinod F. Patel, Jiang John Z, Mark Czekaj, Mikhail Levit, James Pribish, Frank Sun, Matthieu Barrague, Luke Fire, Shih-Min A. Huang
المصدر: Bioorganicmedicinal chemistry letters. 29(3)
مصطلحات موضوعية: Indoles, Clinical Biochemistry, hERG, Compound 17, Pharmaceutical Science, Antineoplastic Agents, 01 natural sciences, Biochemistry, Part iii, Mice, Structure-Activity Relationship, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Neoplasms, Experimental, Combinatorial chemistry, 0104 chemical sciences, Rats, 010404 medicinal & biomolecular chemistry, Pim kinases, biology.protein, Molecular Medicine, Tumor growth inhibition, Drug Screening Assays, Antitumor
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4
المؤلفون: Sachin Maniar, Anlai Wang, James Pribish, Shih-Min A. Huang, Andrew Hebert, Mikhail Levit, Jinyu Liu, Claude Barberis, Luke Fire, Elina Tserlin, Paul Erdman, Vinod F. Patel, Mark Czekaj, Joseph D. Batchelor, Frank Sun
المصدر: Bioorganic & Medicinal Chemistry Letters. 30:127625
مصطلحات موضوعية: Indoles, Pyrrolidines, Clinical Biochemistry, hERG, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Mice, Piperidines, Proto-Oncogene Proteins c-pim-1, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, Tumor growth, Protein Kinase Inhibitors, Molecular Biology, PK/PD models, Aza Compounds, biology, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, Stereoisomerism, medicine.disease, Xenograft Model Antitumor Assays, Rats, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Permeability (electromagnetism), biology.protein, Cancer research, Molecular Medicine, Tumor growth inhibition, Protein Binding
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5
المؤلفون: Fangxian Sun, Laurent Schio, Carlos Garcia-Echeverria, Dietmar Hoffmann, Shih Min A Huang, Christoph Lengauer, Bailin Zhang, Vinod F. Patel, Francisco Adrian, Michel Tabart, Hong Cheng, Weidong Zhang, Anlai Wang, Qiang Gao, Zhuyan Guo, Jingxin Zhang, Claude Barberis, Stefan Gross, Josh Murtie, Jennifer Rocnik, Mikhail Levit, Dmitri Wiederschain, Marion Dorsch
المصدر: Blood. 124:1777-1789
مصطلحات موضوعية: Male, Myeloid, Immunology, Antineoplastic Agents, HL-60 Cells, Biology, Biochemistry, Proto-Oncogene Proteins c-myc, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, STAT5 Transcription Factor, medicine, Humans, IL-2 receptor, Oncogene, Gene Expression Regulation, Leukemic, Interleukin-2 Receptor alpha Subunit, Cancer, Myeloid leukemia, Cell Biology, Hematology, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Proteolysis, Cancer cell, Cancer research, Female, Blast Crisis, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86fd20272c355acdbc0ebc55c54bddc6
https://doi.org/10.1182/blood-2014-01-551234 -
6
المؤلفون: James Pribish, Claude Barberis, Liduo Shen, Mark Czekaj, Neil Moorcroft, Mikhail Levit, Elina Tserlin, Anlai Wang, Andrew Hebert, Sandra Moreno-Mazza, Matthieu Barrague, Tahir Majid, Joseph D. Batchelor, Paul Erdman, Alexandre Gross
المصدر: Bioorganicmedicinal chemistry letters. 27(20)
مصطلحات موضوعية: 0301 basic medicine, Indoles, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, 03 medical and health sciences, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, 0302 clinical medicine, Proto-Oncogene Proteins c-pim-1, hemic and lymphatic diseases, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, PK/PD models, ADME, Kinase, Chemistry, Organic Chemistry, Hit to lead, Combinatorial chemistry, Rats, Enzyme Activation, 030104 developmental biology, 030220 oncology & carcinogenesis, Microsomes, Liver, Molecular Medicine, Identification (biology), Half-Life
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7
المؤلفون: Hong Cheng, Heike Arlt, Dmitri Wiederschain, Claude Barberis, Victoria M. Richon, Michael Lampa, Gejing Deng, Joshua Murtie, Timothy He, Carlos Garcia-Escheverria, Jack Pollard, Francisco Adrian, Bailin Zhang, Jason Reeves, Dietmar Hoffmann, Christopher Winter, Beatriz Ospina, Lakshmi Srinivasan
المصدر: PLoS ONE, Vol 12, Iss 9, p e0185092 (2017)
PLoS ONEمصطلحات موضوعية: 0301 basic medicine, Metabolic Processes, Glutamine, lcsh:Medicine, Triple Negative Breast Neoplasms, Biochemistry, Small hairpin RNA, 0302 clinical medicine, Drug Metabolism, Breast Tumors, Medicine and Health Sciences, Amino Acids, lcsh:Science, Cellular Stress Responses, Gene knockdown, Multidisciplinary, Glutaminase, Organic Compounds, TOR Serine-Threonine Kinases, Acidic Amino Acids, Neurochemistry, Neurotransmitters, Chemistry, Oncology, Cell Processes, 030220 oncology & carcinogenesis, Physical Sciences, Female, Glutamate, Research Article, Cell Physiology, Citric Acid Cycle, Biology, 03 medical and health sciences, Cell Line, Tumor, Breast Cancer, Humans, Pharmacokinetics, PI3K/AKT/mTOR pathway, Pharmacology, Glutaminolysis, Cell growth, ATF4, Organic Chemistry, lcsh:R, Chemical Compounds, Biology and Life Sciences, Proteins, Cancers and Neoplasms, Cell Biology, Molecular biology, Cell Metabolism, Amino Acid Metabolism, 030104 developmental biology, Metabolism, Cancer research, lcsh:Q, Neuroscience
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8
المؤلفون: Shih-Min A. Huang, Anlai Wang, Rita Greco, Zhifang Li, Fangxian Sun, Claude Barberis, Michel Tabart, Vinod Patel, Laurent Schio, Raelene Hurley, Bo Chen, Hong Cheng, Christoph Lengauer, Jack Pollard, James Watters, Carlos Garcia-Echeverria, Dmitri Wiederschain, Francisco Adrian, JingXin Zhang
المصدر: Oncotarget. 5:3362-3374
مصطلحات موضوعية: Janus kinase 2, biology, Kinase, Cell growth, food and beverages, Molecular biology, Small hairpin RNA, chemistry.chemical_compound, Myeloproliferative Disorders, Oncology, chemistry, hemic and lymphatic diseases, biology.protein, Cancer research, Growth inhibition, Kinase activity, Transcription factor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5ea866e86d0a32dbdc183085b972904b
https://doi.org/10.18632/oncotarget.1951 -
9
المؤلفون: Bailin Zhang, Claude Barberis, Jason Reeves, Dietmar Hoffmann, Victoria M. Richon, Adrian Francisco, Carlos Garcia-Echeverria, Christophe Henry, Gejing Deng, Michael Lampa, Jack Pollard, Dmitri Wiederschain, Joshua Murtie, Timothy He, Christopher Winter, Heike Arlt, Lakshmi Srinivasan, Hong Cheng, Beatriz Ospina
المصدر: Cancer Research. 78:5472-5472
مصطلحات موضوعية: Cancer Research, Glutaminolysis, Glutaminase, Cell growth, Biology, medicine.disease, Glutamine, Breast cancer, Oncology, Glutamine synthetase, Cancer cell, medicine, Cancer research, PI3K/AKT/mTOR pathway
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1c479d557e3f238be7036e818b96e31f
https://doi.org/10.1158/1538-7445.am2018-5472 -
10
المؤلفون: Joanne Kamens, Kristine E. Frank, Xiaolei Zhang, Silvia Kwak, Lu Wang, Denise C. Perron, Biqin Li, Andrew Burchat, David J. Calderwood, Neil Wishart, Richard W. Dixon, Eric F. Johnson, George A. Cunha, Claude Barberis, Maria A. Argiriadi, Christopher M. Harris, Kelly D. Mullen, Xiaoyun Wu, Anna M. Ericsson, Robert V. Talanian, David W. Borhani, Tami R. Zmetra
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:334-337
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Anti-Inflammatory Agents, Administration, Oral, Pharmaceutical Science, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Rats, Sprague-Dawley, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Animals, Humans, Computer Simulation, Protein Kinase Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Bicyclic molecule, biology, Tumor Necrosis Factor-alpha, Chemistry, Organic Chemistry, Intracellular Signaling Peptides and Proteins, In vitro, Rats, Pyrimidines, Enzyme, Diaminopyrimidine, Enzyme inhibitor, Mitogen-activated protein kinase, biology.protein, Molecular Medicine, Selectivity