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المؤلفون: Elisabetta Armani, Andrea Rizzi, Nicolò Iotti, Francesca Saccani, Maria Rosaria Di Lascia, Laura Tigli, Alice Pappani, Gessica Marchini, Annalisa Murgo, Anna Maria Capelli, Maurizio Delcanale, Paola Puccini, Gino Villetti, Maurizio Civelli, Claudia Beato, Marta Giuliani, Claudia Mundi, Francesca Murarolli, Mafalda Pagano, Luca F. Raveglia, Rosaria Remelli, Gabriele Amari
المصدر: Journal of Medicinal Chemistry. 66:5622-5656
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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المصدر: Journal of Computer-Aided Molecular Design. 35:1195-1206
مصطلحات موضوعية: Virtual screening, Binding Sites, business.industry, Computer science, Process (engineering), Molecular Conformation, Proteins, Ligands, Supercomputer, computer.software_genre, Automation, Computer Science Applications, Molecular Docking Simulation, Workflow, Docking (molecular), Test set, Drug Discovery, Data mining, Physical and Theoretical Chemistry, business, Protocol (object-oriented programming), computer, Algorithms, Protein Binding
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المؤلفون: Peng Gao, Paolo Vincetti, Fabio Maria Sabbatini, Holly J. Carlisle, Luisa Mengatto, Stéphane De Lombaert, Anna Sava, Kerry Zobel, Xinying Liu, Claudia Beato, Jessica M. Bright, Alyssa M. A. Toda, Elena Serra, Federica Budassi, Marco Migliore, Laura Caberlotto, Cristiana Griffante, Silvia Bernardi, Mingliang Zhang, Albert W. Garofalo, Daniele Andreotti
المصدر: Journal of Medicinal Chemistry. 63:14821-14839
مصطلحات موضوعية: Indazoles, Tetrazoles, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, 01 natural sciences, Small Molecule Libraries, Mice, Structure-Activity Relationship, 03 medical and health sciences, Drug Discovery, Animals, Humans, Kinase activity, Protein Kinase Inhibitors, Gene, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, Highly selective, LRRK2, High-Throughput Screening Assays, nervous system diseases, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, HEK293 Cells, Pyrimidines, Mutation, Cancer research, Molecular Medicine
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المؤلفون: Riccardo Romoli, Marcel T. den Hartog, Zdenek Spacil, Francesca Fallarino, Marilena Pariano, Antonella De Luca, Xin Liu, Anne Beauvais, Tsokyi Choera, Claudia Galosi, Teresa Zelante, Paul E. Verweij, Louis Boon, Mario Calvitti, Paolo Puccetti, Adilia Warris, Luigina Romani, Francesca Boscaro, Marco Pieroni, Giuseppe Pieraccini, Giuseppe Paolicelli, Vasilis Oikonomou, Monica Borghi, Gabriele Costantino, Claudia Beato, Nancy P. Keller, Eloise Ballard, Jean-Paul Latgé, Carmine Vacca, Marco Gargaro, Alicia Yoke Wei Wong
المصدر: Cell Reports, 34
Cell Reports, 34, 4
Cell Reportsمصطلحات موضوعية: 0301 basic medicine, Cell signaling, lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4], Catabolite repression, Nicotinamide adenine dinucleotide, Article, General Biochemistry, Genetics and Molecular Biology, IDO, Aspergillus fumigatus, Mice, 03 medical and health sciences, chemistry.chemical_compound, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Animals, Humans, aspergillosis, tryptophan, Indoleamine 2,3-dioxygenase, biology, AhR, Tryptophan, indoles, NAD, Aryl hydrocarbon receptor, biology.organism_classification, 3. Good health, Cell biology, Metabolic pathway, 030104 developmental biology, chemistry, inflammation, IL-33, biology.protein, 030217 neurology & neurosurgery
وصف الملف: application/pdf
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المؤلفون: Marco Pieroni, Federica Vacondio, Michal Zolkiewski, Gabriele Costantino, Elisa Azzali, Nicoletta Basilico, Silvia Parapini, Giannamaria Annunziato, Claudia Beato, Agostino Bruno
المصدر: Journal of Medicinal Chemistry. 60:1959-1970
مصطلحات موضوعية: 0301 basic medicine, Combination therapy, Phenotypic screening, Drug Evaluation, Preclinical, Thiophenes, Pharmacology, Biology, 01 natural sciences, Antimalarials, Structure-Activity Relationship, 03 medical and health sciences, parasitic diseases, Drug Discovery, medicine, Humans, Structure–activity relationship, Antimalarial Agent, Artemisinin, Biological evaluation, 010405 organic chemistry, Drug discovery, medicine.disease, Amides, 0104 chemical sciences, 030104 developmental biology, Molecular Medicine, Malaria, medicine.drug
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المؤلفون: Giannamaria Annunziato, Manuela Villa, Claudia Beato, Gabriele Costantino, Marco Pieroni, Elisa Azzali, Mario Varasi, Paolo Trifiro, Paola Vianello, Paola Dessanti, Ciro Mercurio, Giuseppe Meroni
المصدر: European Journal of Medicinal Chemistry. 92:377-386
مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Stereochemistry, Structure-Activity Relationship, Drug Discovery, Histone methylation, medicine, Humans, Epigenetics, Histone Demethylases, Pharmacology, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Tranylcypromine, KDM1A, General Medicine, Recombinant Proteins, Histone, Biochemistry, Acetylation, DNA methylation, biology.protein, Demethylase, medicine.drug
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المؤلفون: Claudia Beato, Gabriele Costantino, Carlo Cavazzoni, Andrea R. Beccari
المصدر: Journal of Chemical Information and Modeling. 53:1518-1527
مصطلحات موضوعية: business.industry, Computer science, General Chemical Engineering, Suite, General Chemistry, Library and Information Sciences, Ligands, computer.software_genre, Data science, Molecular Docking Simulation, Workflow, Computer Science Applications, Software, Docking (molecular), Drug Design, Biological property, Data mining, Pharmacophore, business, computer
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المؤلفون: Thelma A. Pertinhez, Roberto Benoni, Andrea Mozzarelli, Randy Wouters, Barbara Campanini, Giannamaria Annunziato, Claudia Beato, Stefano Bettati, Marco Pieroni, Gabriele Costantino
المصدر: Journal of medicinal chemistry 59 (2016): 2567–2578. doi:10.1021/acs.jmedchem.5b01775
info:cnr-pdr/source/autori:Pieroni M, Annunziato G, Beato C, Wouters R, Benoni R, Campanini B, Pertinhez TA, Bettati S, Mozzarelli A, Costantino G/titolo:Rational Design, Synthesis, and Preliminary Structure-Activity Relationships of alpha-Substituted-2-Phenylcyclopropane Carboxylic Acids as Inhibitors of Salmonella typhimurium O-Acetylserine Sulfhydrylase/doi:10.1021%2Facs.jmedchem.5b01775/rivista:Journal of medicinal chemistry/anno:2016/pagina_da:2567/pagina_a:2578/intervallo_pagine:2567–2578/volume:59مصطلحات موضوعية: 0301 basic medicine, Cyclopropanes, Models, Molecular, Salmonella typhimurium, Magnetic Resonance Spectroscopy, Stereochemistry, Carboxylic Acids, Swarming motility, Microbial Sensitivity Tests, Cysteine synthase, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Biosynthesis, alpha-aminoacrylate intermediate, ligand-receptor complexes, cysteine synthase complex, transfer difference nmr, anion-binding site, serine acetyltransferase, mycobacterium-tuberculosis, escherichia-coli, gene-expression, 3-dimensional structure, Drug Discovery, Drug Resistance, Bacterial, Structure–activity relationship, Pyridoxal phosphate, chemistry.chemical_classification, Cysteine Synthase, biology, Chemistry, Rational design, Anti-Bacterial Agents, Isoenzymes, 030104 developmental biology, Enzyme, Biochemistry, Pyridoxal Phosphate, biology.protein, Molecular Medicine, Cysteine, Protein Binding
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المؤلفون: Chiara Pecchini, Chiara Cocconcelli, Andrea Mozzarelli, Gabriele Costantino, Barbara Campanini, Claudia Beato, Marco Pieroni, Marialaura Marchetti
المصدر: Journal of enzyme inhibition and medicinal chemistry
31 (2016): 645–652. doi:10.3109/14756366.2015.1057720
info:cnr-pdr/source/autori:Beato C, Pecchini C, Cocconcelli C, Campanini B, Marchetti ML, Pieroni M, Mozzarelli A, Costantino G/titolo:Cyclopropane derivatives as potential human serine racemase inhibitors: unveiling novel insights into a difficult target/doi:10.3109%2F14756366.2015.1057720/rivista:Journal of enzyme inhibition and medicinal chemistry (Print)/anno:2016/pagina_da:645/pagina_a:652/intervallo_pagine:645–652/volume:31مصطلحات موضوعية: Cyclopropanes, 0301 basic medicine, Stereochemistry, Racemases and Epimerases, Malonic acid, Inhibitory postsynaptic potential, Cyclopropane, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Humans, Enzyme Inhibitors, Inhibition, Binding affinities, Pharmacology, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, General Medicine, Molecular Docking Simulation, Serine recemase, 030104 developmental biology, Dicarboxylic acid, chemistry, Biochemistry, Serine racemase, Molecular docking, Glycine, Conformational ensemble, NMDA receptor
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf2077a646f095d4b3aa2fb0a0d310f
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المؤلفون: Claudia Beato, Margarita A. Tararina, Gabriele Costantino, Gian Paolo Vallerini, Xiao-Dan Wang, Robert Schwarcz, Laura Amori
المصدر: Journal of medicinal chemistry. 56(23)
مصطلحات موضوعية: Pathogenesis, Cyclic N-Oxides, chemistry.chemical_compound, Drug Stability, In vivo, Drug Discovery, Animals, Humans, 3-Hydroxyanthranilate 3,4-Dioxygenase, Enzyme Inhibitors, chemistry.chemical_classification, Chemistry, Nicotinic Acids, Brain, Neurodegenerative Diseases, Quinolinic Acid, Mammalian brain, Rat brain, In vitro, Rats, Disease Models, Animal, Tryptophan Metabolite, Enzyme, Biochemistry, Molecular Medicine, Quinolinic acid
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