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1دورية أكاديمية
المؤلفون: Eleonora Lekova, Wioleta M. Zelek, David Gower, Claus Spitzfaden, Isabelle H. Osuch, Elen John-Morris, Lasse Stach, Darren Gormley, Andrew Sanderson, Angela Bridges, Elizabeth R. Wear, Sebastien Petit-Frere, Michael N. Burden, Richard Priest, Trevor Wattam, Semra J. Kitchen, Maria Feeney, Susannah Davis, B. Paul Morgan, Eva-Maria Nichols
المصدر: Frontiers in Immunology, Vol 13 (2022)
مصطلحات موضوعية: myasthenia gravis, autoantibodies, terminal pathway, MAC assembly, complement C7, myasthenia gravis patient stratification, Immunologic diseases. Allergy, RC581-607
وصف الملف: electronic resource
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المؤلفون: Michael M. Hann, Claus Spitzfaden, Claudine Mayer, Alexandra Aubry, Alka Agrawal, Mélanie Roué, Stéphanie Petrella, Benjamin D. Bax
المصدر: Biochemical Journal. 456:263-273
مصطلحات موضوعية: Models, Molecular, Stereochemistry, ATPase, GTPase, Crystallography, X-Ray, Biochemistry, DNA gyrase, Protein Structure, Secondary, chemistry.chemical_compound, Adenosine Triphosphate, Protein structure, Bacterial Proteins, ATP hydrolysis, Catalytic Domain, Molecular Biology, Adenosine Triphosphatases, biology, Hydrolysis, Topoisomerase, Hydrogen Bonding, Mycobacterium tuberculosis, Cell Biology, DNA Topoisomerases, Type II, chemistry, DNA Gyrase, Structural Homology, Protein, Biocatalysis, biology.protein, ATP synthase alpha/beta subunits, DNA, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f43c26c77cb631a175bbde22ead99b0
https://doi.org/10.1042/bj20130538 -
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المؤلفون: Colin J. Suckling, Claus Spitzfaden, Andrew N. Hobbs, Craig Jamieson, Peter Francis, Robert J. Young, Ian Churcher, Sophie M. Bertrand, Ryan P. Bingham, Sarah E. Smith, Donald O. Somers, Nicolas Ancellin, Nerina Dodic, Paul S. Carter, Chun-wa Chung, Charlène Fournier, Jennifer A. Borthwick, Stephen D. Pickett
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Cellular activity, Magnetic Resonance Spectroscopy, Branched chain aminotransferase, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Fragment (logic), Drug Discovery, Adipocytes, Molecule, Humans, QD, Transaminases, 010405 organic chemistry, Chemistry, Ligand (biochemistry), Peptide Fragments, 0104 chemical sciences, High-Throughput Screening Assays, Mitochondria, 030104 developmental biology, Biochemistry, Molecular Medicine, Protein Binding
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019a009ff86efad911c0ace056f53ba5
https://strathprints.strath.ac.uk/55944/1/Borthwick_etal_JMC_2016_structurally_diverse_mitochondrial_branched_chain_aminotransferase_BCATm_leads_with_varying_binding_modes_identified_by_fragment_screening.pdf -
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المؤلفون: Michael N. Gwynn, Jianzhong Huang, Martin Hibbs, Claus Spitzfaden, Jason Pizzollo, Haifeng Cui, Velupillai Srikannathasan, Robert Tanner, Karen A. Ingraham, Robert A. Stavenger, Pan F. Chan, Minghua Gu, Carol Shen, Paul Homes, Andrew J. Theobald, Andrew P. Fosberry, Anthony Shillings, Michael M. Hann, Benjamin D. Bax
المصدر: Nature Communications
مصطلحات موضوعية: DNA, Bacterial, Models, Molecular, Staphylococcus aureus, Moxifloxacin, General Physics and Astronomy, Antineoplastic Agents, Cleavage (embryo), 01 natural sciences, DNA gyrase, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, chemistry.chemical_compound, Drug Resistance, Bacterial, medicine, Topoisomerase II Inhibitors, Etoposide, 030304 developmental biology, 0303 health sciences, Multidisciplinary, Molecular Structure, biology, 010405 organic chemistry, Topoisomerase, General Chemistry, Anti-Bacterial Agents, 0104 chemical sciences, 3. Good health, chemistry, Biochemistry, DNA Gyrase, biology.protein, Topoisomerase-II Inhibitor, Antibacterial activity, DNA, Fluoroquinolones, medicine.drug
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المؤلفون: Ian Churcher, Sarah E. Smith, Ryan P. Bingham, Clare I. Hobbs, Donald O. Somers, Eric Boursier, Chun Wa Chung, Charlène Fournier, Yoshiaki Washio, Peter Francis, Claus Spitzfaden, Iain H. Reid, Stephen D. Pickett, Sophie M. Bertrand, Graham L. Simpson, Andrew N. Hobbs, Klára Valkó, Laura A. Gummer, Robert J. Young, Nicolas Ancellin, Craig Jamieson, Colin J. Suckling, Anne Bénédicte Boullay, Lisa A. Sloan, Kenny Herry, Paul S. Carter, Nerina Dodic, Paul Homes, Edwige Nicodeme, Jennifer A. Borthwick, Benjamin Beaufils, Marie Helene Fouchet
المصدر: Journal of medicinal chemistry. 58(18)
مصطلحات موضوعية: Models, Molecular, Branched chain aminotransferase, Pyrimidinones, Crystallography, X-Ray, Mitochondrial Proteins, Structure-Activity Relationship, Valine, Leucine, Drug Discovery, Adipocytes, Structure–activity relationship, Transferase, Animals, Humans, Isoleucine, Transaminases, chemistry.chemical_classification, Mice, Inbred BALB C, Ligand efficiency, Chemistry, Molecular biology, Amino acid, Mice, Inbred C57BL, Biochemistry, Molecular Medicine, Pyrazoles
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المؤلفون: Claus Spitzfaden, Paul Homes, Andrew P. Fosberry, Jianzhong Huang, Martin Hibbs, Michael N. Gwynn, Anthony Shillings, Alexandre Wohlkonig, Andrew J. Theobald, Pan F. Chan, Velupillai Srikannathasan, Onkar M. P. Singh, Benjamin D. Bax
المساهمون: Department of Bio-engineering Sciences, Structural Biology Brussels
مصطلحات موضوعية: Staphylococcus aureus, Etoposide/chemistry, crystallization, Molecular Sequence Data, Moxifloxacin, Biophysics, medicine.disease_cause, Crystallography, X-Ray, Biochemistry, DNA gyrase, Heterocyclic Compounds, 4 or More Rings, law.invention, Research Communications, chemistry.chemical_compound, Structural Biology, law, Genetics, medicine, Spiro Compounds, DNA Gyrase/chemistry, Crystallization, DNA Cleavage, Etoposide, Heterocyclic Compounds, 4 or More Rings/chemistry, biology, Base Sequence, Topoisomerase, Spiro Compounds/chemistry, Staphylococcus aureus/enzymology, Condensed Matter Physics, biology.organism_classification, Fluoroquinolones/chemistry, Crystallography, chemistry, Covalent bond, DNA Gyrase, biology.protein, DNA, Bacteria, medicine.drug, Fluoroquinolones
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10eeb8df12cca74374d1610c9aeae7
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72 -
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المؤلفون: Harry John Wadsworth, Fiona Godfrey, Claus Spitzfaden, Stephen J. Wood, Kevin H. Jennings, Amanda E. Perry, Roger Edward Markwell, Jane E. Swatton, David R. Howlett
المصدر: Biochemical Journal. 340:283-289
مصطلحات موضوعية: chemistry.chemical_classification, Amyloid, Chemistry, Ligand binding assay, Biological activity, Peptide, macromolecular substances, Cell Biology, Nuclear magnetic resonance spectroscopy, Fibril, Biochemistry, chemistry.chemical_compound, Benzofuran, Beta (finance), Molecular Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c49c2883d557da0fe9d17efd76b1de2c
https://doi.org/10.1042/bj3400283 -
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المصدر: Journal of Molecular Biology. 270:763-770
مصطلحات موضوعية: Protein Folding, Proline, Sequence Homology, Amino Acid, biology, Protein Conformation, Chemistry, Recombinant Fusion Proteins, Molecular Sequence Data, Kinetics, Hydrogen-Ion Concentration, Sequence identity, Fibronectins, Fibronectin, Crystallography, Isomerism, Structural Biology, biology.protein, Homologous chromosome, Humans, Thermodynamics, Protein folding, Amino Acid Sequence, Molecular Biology
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المصدر: Journal of Biological Chemistry. 272:6159-6166
مصطلحات موضوعية: Magnetic Resonance Spectroscopy, PTK2, Biology, Biochemistry, Article, Focal adhesion, Structure-Activity Relationship, Cell Adhesion, Humans, Binding site, Cell adhesion, Molecular Biology, Binding Sites, Cell adhesion molecule, Wild type, Cell Biology, Protein-Tyrosine Kinases, Fibronectins, Protein Structure, Tertiary, Cell biology, Fibronectin, Focal Adhesion Kinase 1, Focal Adhesion Protein-Tyrosine Kinases, biology.protein, Phosphorylation, Cell Adhesion Molecules, Oligopeptides
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a76effeda15da9abddd92e4ceefed874
https://doi.org/10.1074/jbc.272.10.6159 -
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المؤلفون: Richard P. Grant, Claus Spitzfaden, Helen J. Mardon, Iain D. Campbell
المصدر: Journal of Molecular Biology. 265:565-579
مصطلحات موضوعية: Models, Molecular, Protein Folding, Magnetic Resonance Spectroscopy, Protein Conformation, Recombinant Fusion Proteins, Peptide, In Vitro Techniques, Protein–protein interaction, Structural Biology, Humans, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, C-terminus, Protein engineering, Fibronectins, Kinetics, Crystallography, chemistry, Thermodynamics, Protein folding, Oligopeptides, Linker, Two-dimensional nuclear magnetic resonance spectroscopy, Heteronuclear single quantum coherence spectroscopy