المؤلفون: Li F; Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China.; Department of Pathology, The First People's Hospital of Tancheng, Linyi, Shandong Province, China., Chen D; Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China., Chen J; Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China., Nie L; Department of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu Province, China.

المصدر: International journal of surgical pathology [Int J Surg Pathol] 2024 Sep; Vol. 32 (6), pp. 1177-1181. Date of Electronic Publication: 2023 Nov 23.

نوع المنشور: Journal Article; Case Reports; Review

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9314927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-2465 (Electronic) Linking ISSN: 10668969 NLM ISO Abbreviation: Int J Surg Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/diagnosis , Adenocarcinoma, Clear Cell*/surgery , Adenocarcinoma, Clear Cell*/metabolism , Colonic Neoplasms*/pathology , Colonic Neoplasms*/diagnosis, Humans ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/metabolism ; Male ; Female ; Aged ; Middle Aged

المؤلفون: Nagase S; Department of Human Pathology, Juntendo University Faculty of Medicine, Tokyo, Japan., Saeki H; Department of Human Pathology, Juntendo University Faculty of Medicine, Tokyo, Japan., Ura A; Department of Human Pathology, Juntendo University Faculty of Medicine, Tokyo, Japan., Terao Y; Department of Obstetrics and Gynecology, Juntendo University Faculty of Medicine, Tokyo, Japan., Matsumoto T; Department of Diagnostic Pathology, Juntendo Nerima Hospital Faculty of Medicine, Tokyo, Japan., Yao T; Department of Human Pathology, Juntendo University Faculty of Medicine, Tokyo, Japan.

المصدر: International journal of surgical pathology [Int J Surg Pathol] 2024 Sep; Vol. 32 (6), pp. 1140-1148. Date of Electronic Publication: 2023 Nov 22.

نوع المنشور: Journal Article; Case Reports

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9314927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-2465 (Electronic) Linking ISSN: 10668969 NLM ISO Abbreviation: Int J Surg Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Endometrioid*/pathology , Carcinoma, Endometrioid*/diagnosis , Carcinoma, Endometrioid*/genetics , Endometriosis*/pathology , Endometriosis*/complications , Endometriosis*/diagnosis , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/diagnosis , Adenocarcinoma, Clear Cell*/genetics , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/diagnosis, Humans ; Female ; Middle Aged ; Biomarkers, Tumor/analysis ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism ; Adenocarcinoma/pathology ; Adenocarcinoma/diagnosis ; Adenocarcinoma/genetics

المؤلفون: Nishijima A; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Oda K; Division of Integrative Genomics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. katsutoshi-tky@umin.ac.jp., Hasegawa K; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan., Koso T; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Asada K; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Ikeda Y; Department of Obstetrics and Gynecology, Nihon University, Tokyo, Japan., Taguchi A; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Maeda D; Department of Molecular and Cellular Pathology, Kanazawa University, Ishikawa, Japan., Nagae G; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Tsuji S; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Tatsuno K; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan., Uehara Y; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Kurosaki A; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan., Sato S; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan., Tanikawa M; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Sone K; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Mori M; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Ikemura M; Department of Pathology, The University of Tokyo, Tokyo, Japan., Fujiwara K; Department of Gynecologic Oncology, Saitama Medical University International Medical Center, Saitama, Japan., Ushiku T; Department of Pathology, The University of Tokyo, Tokyo, Japan., Osuga Y; Department of Obstetrics and Gynecology, The University of Tokyo, Tokyo, Japan., Aburatani H; Genome Science Division, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan. haburata-tky@umin.ac.jp.

المصدر: Scientific reports [Sci Rep] 2024 Aug 13; Vol. 14 (1), pp. 18797. Date of Electronic Publication: 2024 Aug 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Mutation* , Adenocarcinoma, Clear Cell*/genetics , Adenocarcinoma, Clear Cell*/pathology , DNA Methylation*, Humans ; Female ; Genomics/methods ; Class I Phosphatidylinositol 3-Kinases/genetics ; Epigenomics/methods ; Exome Sequencing ; Middle Aged

المؤلفون: Shi H; Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Folma Road, Jin'an District, Fuzhou, 350014, Fujian, China., Zheng L; Department of Abdominal Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China., Jiang X; Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Folma Road, Jin'an District, Fuzhou, 350014, Fujian, China., Chen H; Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, No. 420 Folma Road, Jin'an District, Fuzhou, 350014, Fujian, China. ChenhongJuu@163.com.

المصدر: Molecular genetics and genomics : MGG [Mol Genet Genomics] 2024 Aug 06; Vol. 299 (1), pp. 77. Date of Electronic Publication: 2024 Aug 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 101093320 Publication Model: Electronic Cited Medium: Internet ISSN: 1617-4623 (Electronic) Linking ISSN: 16174623 NLM ISO Abbreviation: Mol Genet Genomics Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma, Clear Cell*/genetics , Adenocarcinoma, Clear Cell*/drug therapy , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/metabolism , Autophagy*/genetics , Autophagy*/drug effects , Drug Resistance, Neoplasm* , Gene Expression Regulation, Neoplastic*/drug effects , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/pathology, Female ; Humans ; Calcium/metabolism ; Calcium Signaling/genetics ; Calcium Signaling/drug effects ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/genetics ; Calcium-Calmodulin-Dependent Protein Kinase Type 2/metabolism ; Cell Line, Tumor ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/genetics

المؤلفون: Huang T; Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China., Lu F; Emergency Department, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong Province, China.

المصدر: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics [Int J Gynaecol Obstet] 2024 Aug; Vol. 166 (2), pp. 707-717. Date of Electronic Publication: 2024 Mar 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0210174 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3479 (Electronic) Linking ISSN: 00207292 NLM ISO Abbreviation: Int J Gynaecol Obstet Subsets: MEDLINE

مواضيع طبية MeSH: Nomograms* , SEER Program* , Uterine Neoplasms*/mortality , Uterine Neoplasms*/therapy , Uterine Neoplasms*/pathology , Neoplasm Staging* , Adenocarcinoma, Clear Cell*/mortality , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/therapy, Humans ; Female ; Middle Aged ; Aged ; Adult ; Prognosis ; Risk Factors ; Survival Rate ; United States/epidemiology ; Retrospective Studies

المؤلفون: Wu CH; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Fu HC; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan., Ou YC; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.; Department of Obstetrics and Gynecology, Chia-Yi Chang Gung Memorial Hospital, Chiayi 613, Taiwan., Chuang IC; Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 883, Taiwan., Lan J; Department of Anatomic Pathology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 883, Taiwan., Yang MY; Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Department of Otolaryngology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 883, Taiwan., Lin H; Department of Obstetrics and Gynecology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2024 Jul 20; Vol. 25 (14). Date of Electronic Publication: 2024 Jul 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Ovarian Neoplasms*/metabolism , Ovarian Neoplasms*/drug therapy , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Receptors, Progesterone*/metabolism , Receptors, Progesterone*/genetics , Adenocarcinoma, Clear Cell*/metabolism , Adenocarcinoma, Clear Cell*/drug therapy , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/genetics , Drug Resistance, Neoplasm*/genetics , Cisplatin*/pharmacology , Cisplatin*/therapeutic use, Humans ; Female ; Middle Aged ; Cell Line, Tumor ; Aged ; Adult ; Retrospective Studies ; Cell Movement/drug effects ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Platinum/pharmacology ; Platinum/therapeutic use ; Gene Expression Regulation, Neoplastic/drug effects

المؤلفون: Tsunematsu R; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan.; Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan., Murai A; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Mizue Y; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Kubo T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Mariya T; Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan., Morita R; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Murata K; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Kanaseki T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Tsukahara T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan., Hirohashi Y; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan hirohash@sapmed.ac.jp., Saito T; Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan., Torigoe T; Department of Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan torigoe@sapmed.ac.jp.

المصدر: Cancer genomics & proteomics [Cancer Genomics Proteomics] 2024 Jul-Aug; Vol. 21 (4), pp. 414-420.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: International Institute of Anticancer Research Country of Publication: Greece NLM ID: 101188791 Publication Model: Print Cited Medium: Internet ISSN: 1790-6245 (Electronic) Linking ISSN: 11096535 NLM ISO Abbreviation: Cancer Genomics Proteomics Subsets: MEDLINE

مواضيع طبية MeSH: Ovarian Neoplasms*/immunology , Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Ovarian Neoplasms*/metabolism , Transcription Factors*/genetics , Transcription Factors*/metabolism , DNA-Binding Proteins*/genetics , DNA-Binding Proteins*/metabolism , Adenocarcinoma, Clear Cell*/pathology , Adenocarcinoma, Clear Cell*/genetics , Adenocarcinoma, Clear Cell*/immunology , Adenocarcinoma, Clear Cell*/metabolism , T-Lymphocytes, Cytotoxic*/immunology, Humans ; Female ; Cell Line, Tumor ; Antigens, Neoplasm/genetics ; Antigens, Neoplasm/metabolism ; Antigens, Neoplasm/immunology ; HLA-A2 Antigen/genetics ; HLA-A2 Antigen/immunology ; HLA-A2 Antigen/metabolism ; Membrane Proteins

المؤلفون: Pascual MG; Anschutz Medical Campus, University of Colorado School of Medicine, Aurora, Colorado, USA., Bruckner AL; Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado, USA., Torres-Zegarra C; Department of Dermatology, University of Colorado School of Medicine, Aurora, Colorado, USA.

المصدر: Pediatric dermatology [Pediatr Dermatol] 2024 Jul-Aug; Vol. 41 (4), pp. 684-687. Date of Electronic Publication: 2024 Jan 20.

نوع المنشور: Case Reports; Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8406799 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-1470 (Electronic) Linking ISSN: 07368046 NLM ISO Abbreviation: Pediatr Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: Sarcoma, Clear Cell*/diagnosis , Sarcoma, Clear Cell*/pathology , Scalp*/pathology , Kidney Neoplasms*/pathology , Kidney Neoplasms*/diagnosis , Skin Neoplasms*/pathology , Skin Neoplasms*/diagnosis, Humans ; Male ; Child

المؤلفون: Benedetti DJ; Division of Hematology/Oncology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Renfro LA; Division of Biostatistics, University of Southern California, Los Angeles, California, USA.; Children's Oncology Group, Monrovia, California, USA., Tfirn I; Children's Oncology Group, Monrovia, California, USA., Daw NC; Division of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Kalapurakal JA; Department of Radiation Oncology, Northwestern University, Chicago, Illinois, USA., Ehrlich PF; Section of Pediatric Surgery, University of Michigan, Ann Arbor, Michigan, USA., Khanna G; Department of Radiology and Imaging Sciences, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA., Perlman E; Department of Pathology and Laboratory Medicine, Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA., Warwick A; Department of Pediatrics, F. Edward Hébert School of Medicine, Uniformed Services University, Bethesda, Maryland, USA., Gow KW; Division of Pediatric General and Thoracic Surgery, Seattle Children's Hospital, University of Washington, Seattle, Washington, USA., Paulino AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Seibel NL; Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA., Grundy P; Division of Immunology, Hematology, Oncology, Palliative Care, and Environmental Interactions, University of Alberta, Edmonton, Alberta, Canada., Fernandez CV; Division of Pediatric Hematology/Oncology, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada., Geller JI; Division of Oncology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA., Mullen EA; Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute/Boston Children's Hospital, Boston, Massachusetts, USA., Dome JS; Division of Oncology and Department of Pediatrics, Children's National Hospital and the George Washington University School of Medicine and Health Sciences, Washington, District of Columbia, USA.

المصدر: Cancer [Cancer] 2024 Jul 01; Vol. 130 (13), pp. 2361-2371. Date of Electronic Publication: 2024 Feb 23.

نوع المنشور: Clinical Study; Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 0374236 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0142 (Electronic) Linking ISSN: 0008543X NLM ISO Abbreviation: Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols*/therapeutic use , Kidney Neoplasms*/pathology , Kidney Neoplasms*/therapy , Kidney Neoplasms*/mortality , Kidney Neoplasms*/drug therapy , Sarcoma, Clear Cell*/pathology , Sarcoma, Clear Cell*/therapy , Sarcoma, Clear Cell*/mortality , Vincristine*/therapeutic use , Vincristine*/administration & dosage, Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Carboplatin/administration & dosage ; Carboplatin/therapeutic use ; Cyclophosphamide/administration & dosage ; Cyclophosphamide/therapeutic use ; Disease-Free Survival ; Doxorubicin/administration & dosage ; Doxorubicin/therapeutic use ; Etoposide/administration & dosage ; Etoposide/therapeutic use ; Neoplasm Staging ; Treatment Outcome

المؤلفون: Hoshino H; Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan., Inoue D; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan., Shinagawa A; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan., Yoshida H; Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan., Shigeto S; Department of Laboratory Medicine, Shinshu University Hospital, Matsumoto, Japan., Matsuda K; Department of Clinical Laboratory Sciences, School of Health Sciences, Shinshu University, Matsumoto, Japan., Akama TO; Department of Pharmacology, Kansai Medical University, Hirakata, Japan., Yoshida Y; Department of Obstetrics and Gynecology, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan., Kobayashi M; Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji, Fukui, 910-1193, Japan. motokoba@u-fukui.ac.jp.

المصدر: Human cell [Hum Cell] 2024 Jul; Vol. 37 (4), pp. 1184-1193. Date of Electronic Publication: 2024 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer Country of Publication: Japan NLM ID: 8912329 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1749-0774 (Electronic) Linking ISSN: 09147470 NLM ISO Abbreviation: Hum Cell Subsets: MEDLINE

مواضيع طبية MeSH: Ovarian Neoplasms*/genetics , Ovarian Neoplasms*/pathology , Class I Phosphatidylinositol 3-Kinases*/genetics , Adenocarcinoma, Clear Cell*/genetics , Adenocarcinoma, Clear Cell*/pathology, Humans ; Female ; Cell Line, Tumor ; Middle Aged ; Transcription Factors/genetics ; Transcription Factors/metabolism ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Nuclear Proteins/genetics ; Nuclear Proteins/metabolism ; Mutation/genetics ; Point Mutation/genetics ; Cell Proliferation/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinases/genetics