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المؤلفون: Kyle E. Landgraf, Clifford Quan, Charles Eigenbrot, Henry R. Maun, Jeffrey Tom, Micah Steffek, Lydia Santell, Robert A. Lazarus, Christine Yu
المصدر: Nature Chemical Biology. 10:567-573
مصطلحات موضوعية: Models, Molecular, Proteases, Cell Survival, Molecular Sequence Data, Allosteric regulation, CHO Cells, Protein Engineering, Serine, Cricetulus, Allosteric Regulation, Cell Movement, Peptide Library, Catalytic Domain, Proto-Oncogene Proteins, Zymogen, medicine, Animals, Humans, Amino Acid Sequence, Protein Precursors, Molecular Biology, Serine protease, biology, Hepatocyte Growth Factor, Activator (genetics), Molecular Mimicry, Cell Biology, Proto-Oncogene Proteins c-met, Protein Structure, Tertiary, Cell biology, Gene Expression Regulation, Biochemistry, biology.protein, Signal transduction, Peptides, Allosteric Site, Protein C, Protein Binding, Signal Transduction, medicine.drug
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المؤلفون: Clifford Quan, Paul Moran, Daniel Kirchhofer, Wei Li, Paola Di Lello, Charles Eigenbrot, Andrew S. Peterson, Steven Shia, Jeffrey Tom, Monica Kong-Beltran, Yingnan Zhang, Lijuan Zhou, Nicholas J. Skelton
المصدر: Journal of Biological Chemistry. 289:942-955
مصطلحات موضوعية: Models, Molecular, Magnetic Resonance Spectroscopy, Peptide, CHO Cells, Plasma protein binding, Crystallography, X-Ray, Binding, Competitive, Biochemistry, Protein Structure, Secondary, Cricetulus, Peptide Library, Cricetinae, Animals, Humans, Amino Acid Sequence, Enzyme Inhibitors, Binding site, Molecular Biology, chemistry.chemical_classification, Binding Sites, Dose-Response Relationship, Drug, Chemistry, PCSK9, Serine Endopeptidases, Hep G2 Cells, Cell Biology, Proprotein convertase, Protein Structure, Tertiary, Receptors, LDL, Protein Structure and Folding, LDL receptor, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertases, Proprotein Convertase 9, Oligopeptides, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf82b7a53e92e51dbeda44fe967b2e3
https://doi.org/10.1074/jbc.m113.514067 -
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المؤلفون: Clifford Quan, Brian J. Smith, Peter E. Czabotar, Kerry Zobel, Kurt Deshayes, Anna V. Fedorova, David C.S. Huang, Toru Okamoto, Hong Yang, Wayne J. Fairbrother
المصدر: ACS Chemical Biology. 8:297-302
مصطلحات موضوعية: chemistry.chemical_classification, Cell, Peptide, Biological activity, General Medicine, Biology, Biochemistry, medicine.anatomical_structure, Protein structure, chemistry, Apoptosis, Intramolecular force, Helix, Biophysics, medicine, Molecular Medicine, Stapled peptide
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المؤلفون: Rami N. Hannoush, Karen Stanger, Lijuan Zhou, Christine Tam, Yingnan Zhang, Irina N. Krylova, Clifford Quan, Micah Steffek, Christine Pozniak, Joseph W. Lewcock, J. Michael Elliott, Yvonne Franke, Jeremy Murray, Jeff Y.K. Tom
المصدر: Nature Chemical Biology. 8:655-660
مصطلحات موضوعية: biology, Drug discovery, NLRP1, Chemistry, Caspase 2, Allosteric regulation, Cell Biology, Plasma protein binding, Biochemistry, Zymogen, biology.protein, Caspase 10, Molecular Biology, Caspase
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المؤلفون: Robert J. Newman, Mercedesz Balazs, Kebing Yu, Jinfeng Liu, Keisuke Horikawa, Wendy Sandoval, Wyne P. Lee, Kim Newton, Flavius Martin, Michael J. Townsend, Nandhini Ramamoorthi, Lorna Kategaya, Jeffrey Tom, Erin C. Dueber, Wayne J. Fairbrother, Christopher C. Goodnow, Allyn J. Schoeffler, Saritha Kusam, Anuradha Zindal, Vishva M. Dixit, Clifford Quan, Ganesh Kolumam, Elizabeth Helgason, Juan Zhang, Debra L. Dugger, Jason DeVoss, Cynthia Lam, Surinder Jeet, Søren Warming, Patrick Caplazi, Dhaya Seshasayee, Susmith Mukund, Ingrid E. Wertz, Nataliya Popovych
المصدر: Nature. 528(7582)
مصطلحات موضوعية: Male, Ubiquitin binding, Deubiquitinating enzyme, Mice, Ubiquitin, immune system diseases, hemic and lymphatic diseases, Animals, Phosphorylation, Polyubiquitin, Tumor Necrosis Factor alpha-Induced Protein 3, Inflammation, Multidisciplinary, biology, Cell Death, Kinase, Tumor Necrosis Factor-alpha, Lysine, Intracellular Signaling Peptides and Proteins, Ubiquitination, Cell biology, Mice, Inbred C57BL, Cysteine Endopeptidases, Biochemistry, Mutation, biology.protein, Tumor necrosis factor alpha, Female, Signal transduction, Protein Kinases, Protein Binding, Signal Transduction
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المؤلفون: Kyle E. Landgraf, Lydia Santell, Karen Billeci, Robert A. Lazarus, Clifford Quan, Daniel Kirchhofer, Henry R. Maun, Judy Young
المصدر: Journal of Biological Chemistry. 285:40362-40372
مصطلحات موضوعية: Proteases, Cell Survival, Allosteric regulation, Mutation, Missense, Peptide, CHO Cells, Biochemistry, Receptor tyrosine kinase, Serine, Cricetulus, Allosteric Regulation, Cricetinae, Animals, Humans, Receptors, Growth Factor, Phosphorylation, Protein Precursors, Molecular Biology, Serine protease, chemistry.chemical_classification, biology, Hepatocyte Growth Factor, Cell Biology, Proto-Oncogene Proteins c-met, Amino Acid Substitution, chemistry, biology.protein, Serine Proteases, Signal transduction, Oligopeptides, Proto-Oncogene Proteins c-akt, Signal Transduction, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7795773e0d15be6eaa18b70099f4ad
https://doi.org/10.1074/jbc.m110.179721 -
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المؤلفون: Sarah G. Hymowitz, Nathaniel C. Gordon, Thuy Tran, Jeremy Johnson, Heidi J.A. Wallweber, Mary Mathieu, Robert F. Kelley, Clifford Quan, Samantha Lien, Bridget Currell, Melissa A. Starovasnik
المصدر: Journal of Molecular Biology. 396:166-177
مصطلحات موضوعية: Models, Molecular, Phage display, Molecular Sequence Data, Tumor Necrosis Factor Ligand Superfamily Member 13, Peptide, Biology, Protein Structure, Secondary, Mice, Antigen, Peptide Library, Structural Biology, Animals, Amino Acid Sequence, B-Cell Maturation Antigen, Receptor, B-cell activating factor, Molecular Biology, chemistry.chemical_classification, Alanine, Activator (genetics), Molecular biology, Transmembrane protein, Immobilized Proteins, Solubility, chemistry, Mutagenesis, Peptides, Sequence motif, Protein Binding
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المؤلفون: Daniel P. Sutherlin, Thuy Tran, Christian Wiesmann, Beni Wolf, Clifford Quan
المصدر: Mini-Reviews in Medicinal Chemistry. 8:719-727
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_treatment, Cancer therapy, Antineoplastic Agents, Biology, medicine.disease_cause, Substrate Specificity, Fibroblast activation protein, alpha, Antigens, Neoplasm, Neoplasms, Endopeptidases, Drug Discovery, Biomarkers, Tumor, medicine, Humans, neoplasms, Pharmacology, Protease, Serine Endopeptidases, Membrane Proteins, Cancer, General Medicine, medicine.disease, digestive system diseases, Biochemistry, Membrane protein, Gelatinases, Cancer research, Substrate specificity, Carcinogenesis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa183b5f7e90eb0cc3aa0299efda64d6
https://doi.org/10.2174/138955708784567449 -
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المؤلفون: Mark Mayeda, Clifford Quan, Christian Wiesmann, Dan Sutherlin, Conrad Yap Edosada, Beni Wolf, Thuy Tran
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:1438-1442
مصطلحات موضوعية: Boron Compounds, Serine Proteinase Inhibitors, Proline, Stereochemistry, Dipeptidyl Peptidase 4, Clinical Biochemistry, Pharmaceutical Science, Oligopeptidase, Inhibitory postsynaptic potential, Biochemistry, Structure-Activity Relationship, Fibroblast activation protein, alpha, Antigens, Neoplasm, Endopeptidases, Drug Discovery, Adenosine Deaminase Inhibitors, Biomarkers, Tumor, Structure–activity relationship, Molecular Biology, Glycoproteins, Dipeptidyl-Peptidase IV Inhibitors, Chemistry, Serine Endopeptidases, Organic Chemistry, Membrane Proteins, body regions, Gelatinases, Molecular Medicine, lipids (amino acids, peptides, and proteins), Prolyl Oligopeptidases, Selectivity
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المؤلفون: Clifford Quan, Nelly Tan, Jennifer Tan, Loren G. Miller, Arnold S. Bayer, Kelli Matayoshi, Grace Tagudar, Jason Cronin, Anthony Shay, Katayoun Mostafaie, Kiran Bharadwa
المصدر: Clinical Infectious Diseases. 44:483-492
مصطلحات موضوعية: Adult, Male, Microbiology (medical), Staphylococcus aureus, medicine.medical_specialty, Adolescent, Endemic Diseases, medicine.medical_treatment, Microbial Sensitivity Tests, Skin infection, medicine.disease_cause, Cohort Studies, Age Distribution, Anti-Infective Agents, Recurrence, Internal medicine, Incision and drainage, Confidence Intervals, medicine, Humans, Prospective Studies, Sex Distribution, Child, Prospective cohort study, Probability, Antibacterial agent, business.industry, Incidence, Odds ratio, Middle Aged, medicine.disease, Methicillin-resistant Staphylococcus aureus, Patient Discharge, Surgery, Community-Acquired Infections, Treatment Outcome, Infectious Diseases, Child, Preschool, Female, Methicillin Resistance, Staphylococcal Skin Infections, business, Methicillin Susceptible Staphylococcus Aureus, Follow-Up Studies
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa544b3ffef48e627c63b41048644139
https://doi.org/10.1086/511041