-
1
المؤلفون: Robin A. Fairhurst, Pascal Furet, Patricia Imbach-Weese, Frédéric Stauffer, Heinrich Rueeger, Clive McCarthy, Sebastien Ripoche, Susanne Oswald, Bertrand Arnaud, Aline Jary, Michel Maira, Christian Schnell, Daniel A. Guthy, Markus Wartmann, Michael Kiffe, Sandrine Desrayaud, Francesca Blasco, Toni Widmer, Frank Seiler, Sascha Gutmann, Mark Knapp, Giorgio Caravatti
المصدر: Journal of Medicinal Chemistry. 65:8345-8379
مصطلحات موضوعية: Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Drug Discovery, Aminopyridines, Molecular Medicine, Antineoplastic Agents, Organic Chemicals, Protein Kinase Inhibitors, Phosphoinositide-3 Kinase Inhibitors
-
2
المؤلفون: Francesco Hofmann, William R. Sellers, Clive McCarthy, Markus Wartmann, Peter Drueckes, Dorothea Haasen, Jutta Blank, Michael D. Jones, John E. Monahan, David A. Ruddy, Emily Buck, Joseph Schoepfer, Sabrina Wagner, Brent A. Appleton, Pascal Furet, Elisa Degenkolbe, Ralph Tiedt
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3613711d07dd229641d5f5262ca31848
https://doi.org/10.1158/0008-5472.22388450.v1 -
3
المؤلفون: Henry Danahay, Holly Charlton, Juan R. Sabater, Clive Mccarthy, Sarah Lilley, Brian Button, Roy Fox, Martin Gosling, Stephen Paul Collingwood
المصدر: American Journal of Respiratory and Critical Care Medicine
مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Cystic Fibrosis, Mucociliary clearance, mucus hydration, Cystic Fibrosis Transmembrane Conductance Regulator, Pharmacology, Critical Care and Intensive Care Medicine, Aminophenols, Cystic fibrosis, ANO1, 03 medical and health sciences, 0302 clinical medicine, Medicine, Humans, Secretion, 030212 general & internal medicine, Calcium signaling, biology, business.industry, calcium-activated chloride channel, anoctamin-1, mucus clearance, Original Articles, Potentiator, respiratory system, medicine.disease, Mucus, Cystic fibrosis transmembrane conductance regulator, 030228 respiratory system, biology.protein, business
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0e0290f5994a6672f70006cf2022760
-
4
المؤلفون: Nicola Arnold, Julie Christie, Sandra Haberthuer, Roger J. Taylor, Alastair Denholm, Mark Keenan, Julia Hatto, Mark Mercer, Lyndon Nigel Brown, Clive Mccarthy, Neil John Press, Helen Oakman, Andrew R. Tuffnell, Morris Tweed, Alexandre Trifilieff, Robert Cheung, Joseph D. Fullerton, Thomas H. Keller, David Beer, Helene Sahri, Pamela Tranter
المصدر: Journal of Medicinal Chemistry. 58:6747-6752
مصطلحات موضوعية: Drug, Cyclohexanecarboxylic Acids, Vomiting, Nausea, media_common.quotation_subject, Pulmonary disease, Pharmacology, Pulmonary Disease, Chronic Obstructive, Structure-Activity Relationship, Pharmacokinetics, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Dosing, Naphthyridines, PDE4 Inhibitors, media_common, COPD, Dose-Response Relationship, Drug, Chemistry, medicine.disease, Rats, Solubility, Thermodynamics, Molecular Medicine, Phosphodiesterase 4 Inhibitors, medicine.symptom
-
5
المؤلفون: Jonathan White, Steven J. Charlton, Peter Finan, Marta Assuncao, Elisabeth Rosethorne, Roy Pettipher, Soraya Pores, Karolina Gherbi, Viral Patel, Ben Moulton, K. Sengmany, Clive Mccarthy
المصدر: Cancer Immunology Research. 8:A94-A94
مصطلحات موضوعية: Cancer Research, Tumor microenvironment, Chemistry, Modulation, Immunology, Cancer research, Identification (biology)
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b6bad3f509406e1263c907d6f855ab1b
https://doi.org/10.1158/2326-6074.tumimm18-a94 -
6
المؤلفون: John R. Fozard, Martin Gosling, David Farr, Lynne Jordan, David A. Sykes, Darryl Brynley Jones, David Beattie, Joe Fullerton, Lyndon Nigel Brown, Julia Hatto, Rachel Profit, Mark Mercer, Diana Janus, Christine Lewis, Helen Oakman, Robin Alec Fairhurst, Friedrich Schuerch, Michelle Bradley, Nicola Arnold, Roger J. Taylor, Janet Maas, Steven J. Charlton, Andrew Brearley, Andrew R. Tuffnell, Alexandre Trifilieff, Clive Mccarthy, Neil John Press
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:4341-4347
مصطلحات موضوعية: Agonist, medicine.drug_class, Guinea Pigs, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Bronchodilator, Administration, Inhalation, Drug Discovery, medicine, Animals, Benzothiazoles, Adrenergic beta-2 Receptor Agonists, Molecular Biology, Short duration, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Organic Chemistry, β2 adrenoceptor agonist, Long acting, Lipophilicity, Rapid onset, Molecular Medicine, Indacaterol, Receptors, Adrenergic, beta-2, medicine.drug
-
7
المؤلفون: Viral Patel, Jonathan White, Soraya S. Porres, Ben Moulton, Roy Pettipher, Peter Finan, Clive Mccarthy, Steven J. Charlton, Elizabeth M. Rosethorne, Karolina Gherbi
المصدر: Cancer Research. 79:5014-5014
مصطلحات موضوعية: Cancer Research, Chemistry, T cell, Adenosinergic, Pharmacology, Adenosine, Adenosine receptor, medicine.anatomical_structure, Oncology, medicine, Cytotoxic T cell, Receptor, IC50, CD8, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::eff7fdde7c97578edb206b575538cffe
https://doi.org/10.1158/1538-7445.am2019-5014 -
8
المؤلفون: Michel Niklaus, Stefan Stutz, Sébastien Jeay, Robin Alec Fairhurst, Andreas Boos, Vito Guagnano, Frédéric Stauffer, Andrea Vaupel, Clive Mccarthy, Pascal Furet, Wenshuo Lu, Thomas H. Marsilje, Pierre-Yves Michellys, Songchun Jiang, Christian Schnell, Bei Chen
المصدر: Bioorganicmedicinal chemistry letters. 26(8)
مصطلحات موضوعية: 0301 basic medicine, Linsitinib, Clinical Biochemistry, Substituent, Pharmaceutical Science, chemistry.chemical_element, Mice, Nude, Ether, Antineoplastic Agents, Biochemistry, Medicinal chemistry, Receptor, IGF Type 1, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, Moiety, Animals, Humans, Pyrroles, Molecular Biology, Protein Kinase Inhibitors, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Imidazoles, Neoplasms, Experimental, Combinatorial chemistry, Xenograft Model Antitumor Assays, 030104 developmental biology, Pyrimidines, chemistry, 030220 oncology & carcinogenesis, Cyclic ether, Pyrazines, Fluorine, NIH 3T3 Cells, Molecular Medicine, Selectivity
-
9
المؤلفون: Trevor John Howe, Paul Nicklin, Michelle Bradley, Angela Glen, Cecile Mocquet, Andrew Dunstan, Urs Baettig, Gurdip Bhalay, Juliet Leighton-Davies, Charles Owen, Elizabeth M. Rosethorne, Clive Mccarthy, Zarin Brown, Peter Gedeck, Mohammed Akhlaq, Alice Li, Thomas H. Keller, Birgit Albrecht, David Beer, Steven J. Charlton
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:6249-6252
مصطلحات موضوعية: Chemokine, Molecular model, medicine.drug_class, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Biochemistry, Chemical synthesis, Cell Line, Small Molecule Libraries, Chemokine receptor, Cricetulus, Cricetinae, Drug Discovery, medicine, Animals, Molecular Biology, biology, Chemistry, Organic Chemistry, Biological activity, biology.organism_classification, Drug Design, biology.protein, Molecular Medicine, Chemokines, Pharmacophore
-
10
المؤلفون: Jutta Blank, David A. Ruddy, Elisa Degenkolbe, Dorothea Haasen, Pascal Furet, Joseph Schoepfer, Ralph Tiedt, Brent A. Appleton, Sabrina Wagner, Francesco Hofmann, Michael D. Jones, John Monahan, Markus Wartmann, Clive Mccarthy, Peter Drueckes, William R. Sellers, Emily Buck
المصدر: Cancer Research. 71:5255-5264
مصطلحات موضوعية: Models, Molecular, Cancer Research, Protein Conformation, DNA Mutational Analysis, Mutation, Missense, Aminopyridines, Antineoplastic Agents, Drug resistance, Biology, Crystallography, X-Ray, medicine.disease_cause, Receptor tyrosine kinase, Mice, Cell Line, Tumor, Neoplasms, medicine, Animals, Humans, Point Mutation, Missense mutation, Receptors, Growth Factor, Protein Kinase Inhibitors, Cell Line, Transformed, Mutation, Mutation Spectra, Point mutation, Imatinib, DNA, Neoplasm, Proto-Oncogene Proteins c-met, Bridged Bicyclo Compounds, Heterocyclic, Molecular biology, Protein Structure, Tertiary, Enzyme Activation, Amino Acid Substitution, Oncology, Protein kinase domain, Drug Resistance, Neoplasm, Mutagenesis, Quinolines, biology.protein, Pyrazoles, Tyrosine, Protein Binding, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b39c282911cb88e005d88a37176fd51
https://doi.org/10.1158/0008-5472.can-10-4433