المؤلفون: Wang J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: jwang301@its.jnj.com., Nakafuku KM; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States. Electronic address: knakafuk@its.jnj.com., Ziff J; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gelin CF; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Gholami H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Thompson AA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Karpowich NK; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Limon L; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Coate HR; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Damm-Ganamet KL; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shih AY; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Grant JC; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Côte M; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Mak PA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Pascual HA; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Rives ML; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Edwards JP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venable JD; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Venkatesan H; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shi Z; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Allen SJ; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Sharma S; Janssen Research & Development L.L.C., 1400 McKean Rd., Spring House, PA 19477, United States., Kung PP; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States., Shireman BT; Janssen Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA, 92121, United States.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129492. Date of Electronic Publication: 2023 Sep 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: NK Cell Lectin-Like Receptor Subfamily K*/metabolism , Carrier Proteins*/metabolism, Humans ; Histocompatibility Antigens Class I/metabolism ; Protein Binding ; Killer Cells, Natural/metabolism ; Ligands

المؤلفون: Thompson AA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Harbut MB; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Kung PP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Karpowich NK; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Branson JD; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Grant JC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Hagan D; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Pascual HA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Bai G; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Zavareh RB; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Coate HR; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Collins BC; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Côte M; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gelin CF; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Damm-Ganamet KL; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gholami H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Huff AR; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Limon L; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Lumb KJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Mak PA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Nakafuku KM; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Price EV; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shih AY; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Tootoonchi M; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Vellore NA; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wang J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Wei N; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Ziff J; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Berger SB; Discovery Immunology, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Edwards JP; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Gardet A; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Sun S; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Towne JE; Discovery Immunology, Janssen Research & Development, San Diego, CA 92121., Venable JD; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Shi Z; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Venkatesan H; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Rives ML; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Sharma S; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002., Shireman BT; Therapeutics Discovery, Janssen Research & Development, San Diego, CA 92121., Allen SJ; Therapeutics Discovery, Janssen Research & Development, Lower Gwynedd Township, PA 19002.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 02; Vol. 120 (18), pp. e2216342120. Date of Electronic Publication: 2023 Apr 25.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Killer Cells, Natural* , NK Cell Lectin-Like Receptor Subfamily K*, Ligands ; CD8-Positive T-Lymphocytes ; Protein Binding

المؤلفون: Mulvihill MJ; (OSI) Oncology, OSI Pharmaceuticals, Inc., 41 Pinelawn Road, Melville, NY 11747, USA. mmulvihill@osip.com, Ji QS, Coate HR, Cooke A, Dong H, Feng L, Foreman K, Rosenfeld-Franklin M, Honda A, Mak G, Mulvihill KM, Nigro AI, O'Connor M, Pirrit C, Steinig AG, Siu K, Stolz KM, Sun Y, Tavares PA, Yao Y, Gibson NW

المصدر: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2008 Feb 01; Vol. 16 (3), pp. 1359-75. Date of Electronic Publication: 2007 Oct 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Imidazoles/*chemical synthesis , Imidazoles/*pharmacology , Protein Kinase Inhibitors/*chemical synthesis , Protein Kinase Inhibitors/*pharmacology , Pyrazines/*chemical synthesis , Pyrazines/*pharmacology , Quinolines/*chemistry , Receptor, IGF Type 1/*antagonists & inhibitors, Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Blood Glucose/metabolism ; Cell Line ; Dogs ; Female ; Humans ; Imidazoles/chemistry ; Insulin/blood ; Ligands ; Mice ; Molecular Structure ; Protein Kinase Inhibitors/chemistry ; Pyrazines/chemistry ; Rats ; Receptor, IGF Type 1/genetics ; Receptor, IGF Type 1/metabolism ; Xenograft Model Antitumor Assays