المؤلفون: Simpson DS; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Anderton H; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Yousef J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Vaibhav V; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Cobbold SA; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Bandala-Sanchez E; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia.; Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia., Dagley LF; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia.; Olivia Newton-John Cancer and Wellness Centre, Austin Health, Melbourne, VIC 3084, Australia.; School of Cancer Medicine, La Trobe University, Heidelberg, VIC 3084, Australia., Silke J; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Vince JE; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, Parkville, Melbourne, VIC 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, Melbourne, VIC 3050, Australia.

المصدر: PNAS nexus [PNAS Nexus] 2023 Dec 18; Vol. 3 (1), pp. pgad438. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press on behalf of the National Academy of Sciences Country of Publication: England NLM ID: 9918367777906676 Publication Model: eCollection Cited Medium: Internet ISSN: 2752-6542 (Electronic) Linking ISSN: 27526542 NLM ISO Abbreviation: PNAS Nexus Subsets: PubMed not MEDLINE

المؤلفون: Chen H; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Nguyen NH; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Magtoto CM; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Cobbold SA; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Bidgood GM; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Meza Guzman LG; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Richardson LW; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Corbin J; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Au AE; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Lechtenberg BC; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Sutherland KD; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Grohmann C; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Nicholson SE; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia., Sleebs BE; The Walter and Eliza Hall Institute of Medical Research, Parkville, 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, 3010, Australia. Electronic address: sleebs@wehi.edu.au.

المصدر: Redox biology [Redox Biol] 2023 Feb; Vol. 59, pp. 102552. Date of Electronic Publication: 2022 Nov 26.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Antioxidants*/pharmacology , Antioxidants*/metabolism , NF-E2-Related Factor 2*/metabolism, Humans ; Reactive Oxygen Species/metabolism ; Kelch-Like ECH-Associated Protein 1/metabolism ; HEK293 Cells ; Oxidative Stress

المؤلفون: Frank D; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Garnish SE; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Sandow JJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Weir A; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Liu L; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Clayer E; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.; Zentrum für Allergie und Umwelt München (ZAUM), Zentrum München, 80333 Munich, Bayern, Germany., Meza L; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Rashidi M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Cobbold SA; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Scutts SR; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Doerflinger M; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Anderton H; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Lawlor KE; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia., Lalaoui N; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Kueh AJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Eng VV; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia., Ambrose RL; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia., Herold MJ; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Samson AL; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Feltham R; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Murphy JM; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia., Ebert G; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.; Institute of Virology, Technical University of Munich/Helmholtz Zentrum München, 80802 Munich, Bayern, Germany., Pearson JS; Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.; Department of Molecular and Translational Science, Monash University, Clayton, VIC 3168, Australia.; Department of Microbiology, Monash University, Clayton, VIC 3168, Australia., Vince JE; The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, VIC 3052, Australia.; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia.

المصدر: IScience [iScience] 2022 Jun 17; Vol. 25 (7), pp. 104632. Date of Electronic Publication: 2022 Jun 17 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101724038 Publication Model: eCollection Cited Medium: Internet ISSN: 2589-0042 (Electronic) Linking ISSN: 25890042 NLM ISO Abbreviation: iScience Subsets: PubMed not MEDLINE

المؤلفون: Grohmann C; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Magtoto CM; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Walker JR; Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA., Chua NK; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Gabrielyan A; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Hall M; Promega Biosciences LLC, 277 Granada Drive, San Luis Obispo, CA, 93401, USA., Cobbold SA; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia., Mieruszynski S; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Brzozowski M; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Simpson DS; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Dong H; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Dorizzi B; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Jacobsen AV; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Morrish E; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Silke N; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Murphy JM; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Heath JK; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Testa A; Amphista Therapeutics Ltd, Bo'Ness Road Newhouse, Glasgow, ML1 5UH, UK., Maniaci C; Chemistry School of Natural and Environmental Sciences, Bedson Building, Newcastle University Edwards Walk, Newcastle, NE1 8QB, UK., Ciulli A; Division of Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, UK., Lessene G; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia.; Department of Pharmacology and Therapeutics, University of Melbourne, Parkville, VIC, 3052, Australia., Silke J; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia., Feltham R; The Walter and Eliza Hall Institute for Medical Research, 1G Royal Parade, Parkville, Melbourne, VIC, 3052, Australia. feltham.r@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3052, Australia. feltham.r@wehi.edu.au.

المصدر: Nature communications [Nat Commun] 2022 Apr 19; Vol. 13 (1), pp. 2073. Date of Electronic Publication: 2022 Apr 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Benchmarking* , Tacrolimus Binding Protein 1A*/genetics, Luciferases ; Proteolysis

المؤلفون: Gan ZY; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Callegari S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Cobbold SA; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Cotton TR; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Mlodzianoski MJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Schubert AF; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Geoghegan ND; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Rogers KL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Leis A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Dewson G; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Glukhova A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Drug Discovery Biology, Monash Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Komander D; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. dk@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia. dk@wehi.edu.au.

المصدر: Nature [Nature] 2022 Mar; Vol. 603 (7903), pp. E33.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Cotton TR; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia., Cobbold SA; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia., Bernardini JP; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia., Richardson LW; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia., Wang XS; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia., Lechtenberg BC; Ubiquitin Signalling Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, The University of Melbourne, Parkville, VIC 3010, Australia. Electronic address: lechtenberg.b@wehi.edu.au.

المصدر: Molecular cell [Mol Cell] 2022 Feb 03; Vol. 82 (3), pp. 598-615.e8. Date of Electronic Publication: 2022 Jan 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Protein Processing, Post-Translational*, Cerebellar Ataxia/*enzymology , Gonadotropin-Releasing Hormone/*deficiency , Hypogonadism/*enzymology , Ubiquitin-Protein Ligases/*metabolism, Allosteric Regulation ; Binding Sites ; Catalysis ; Cerebellar Ataxia/genetics ; Crystallography, X-Ray ; Genetic Predisposition to Disease ; Gonadotropin-Releasing Hormone/genetics ; HEK293 Cells ; Humans ; Hypogonadism/genetics ; Loss of Function Mutation ; Lysine ; Models, Molecular ; Phenotype ; Phosphorylation ; Protein Binding ; Protein Conformation ; Structure-Activity Relationship ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination

SCR Disease Name: Cerebellar Ataxia and Hypogonadotropic Hypogonadism

المؤلفون: Gan ZY; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Callegari S; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Cobbold SA; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Cotton TR; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Mlodzianoski MJ; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Schubert AF; Medical Research Council Laboratory of Molecular Biology, Cambridge, UK., Geoghegan ND; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Rogers KL; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Leis A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Dewson G; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia., Glukhova A; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia.; Drug Discovery Biology, Monash Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.; Department of Biochemistry and Pharmacology, University of Melbourne, Melbourne, Victoria, Australia., Komander D; Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia. dk@wehi.edu.au.; Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia. dk@wehi.edu.au.

المصدر: Nature [Nature] 2022 Feb; Vol. 602 (7896), pp. 328-335. Date of Electronic Publication: 2021 Dec 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Insect Proteins*/metabolism , Pediculus* , Protein Kinases*/metabolism, Animals ; Cryoelectron Microscopy ; Mitochondria ; Mitophagy ; Phosphorylation ; Protein Conformation ; Ubiquitin/metabolism

المؤلفون: Cobbold SA; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., V Tutor M; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., Frasse P; Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA., McHugh E; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., Karnthaler M; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., Creek DJ; Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Vic., Australia., Odom John A; The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA., Tilley L; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., Ralph SA; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia., McConville MJ; Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, University of Melbourne, Parkville, Vic., Australia.

المصدر: Molecular systems biology [Mol Syst Biol] 2021 Apr; Vol. 17 (4), pp. e10023.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: EMBO Press Country of Publication: England NLM ID: 101235389 Publication Model: Print Cited Medium: Internet ISSN: 1744-4292 (Electronic) Linking ISSN: 17444292 NLM ISO Abbreviation: Mol Syst Biol Subsets: MEDLINE

مواضيع طبية MeSH: Isotope Labeling* , Metabolic Networks and Pathways* , Metabolomics*, Parasites/*metabolism , Plasmodium falciparum/*metabolism, Animals ; Electron Transport ; Erythrocytes/parasitology ; Glycine Hydroxymethyltransferase/metabolism ; Hemoglobins/metabolism ; Humans ; Metabolic Flux Analysis ; Metabolome ; Mitochondria/metabolism ; Parasites/growth & development ; Phosphoprotein Phosphatases/metabolism ; Plasmodium falciparum/growth & development ; Protozoan Proteins/metabolism ; Serine/metabolism ; Terpenes/metabolism ; Trophozoites/metabolism

المؤلفون: Fisher GM; Griffith Institute for Drug Discovery, Griffith University, Queensland, Australia., Cobbold SA; University of Melbourne, Victoria, Australia., Jezewski A; Washington School of Medicine, St. Louis, Missouri, USA., Carpenter EF; Wellcome Sanger Institute, Cambridge, United Kingdom., Arnold M; Griffith Institute for Drug Discovery, Griffith University, Queensland, Australia., Cowell AN; University of California, San Diego, San Diego, California, USA., Tjhin ET; The Australian National University, Canberra, Australia., Saliba KJ; The Australian National University, Canberra, Australia., Skinner-Adams TS; Griffith Institute for Drug Discovery, Griffith University, Queensland, Australia., Lee MCS; Wellcome Sanger Institute, Cambridge, United Kingdom., Odom John A; Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA., Winzeler EA; University of California, San Diego, San Diego, California, USA., McConville MJ; University of Melbourne, Victoria, Australia., Poulsen SA; Griffith Institute for Drug Discovery, Griffith University, Queensland, Australia., Andrews KT; Griffith Institute for Drug Discovery, Griffith University, Queensland, Australia k.andrews@griffith.edu.au.

المصدر: MBio [mBio] 2020 Dec 08; Vol. 11 (6). Date of Electronic Publication: 2020 Dec 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Glycosides/*pharmacology , Phosphofructokinases/*metabolism , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*enzymology, Alleles ; Antimalarials/chemistry ; Dose-Response Relationship, Drug ; Drug Resistance ; Erythrocytes/metabolism ; Erythrocytes/parasitology ; Glycolysis ; Glycosides/chemistry ; Metabolomics/methods ; Models, Molecular ; Molecular Structure ; Parasitic Sensitivity Tests ; Phosphofructokinases/genetics ; Plasmodium falciparum/genetics ; Polymorphism, Single Nucleotide ; Protein Conformation ; Structure-Activity Relationship

المؤلفون: Shafik SH; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., Cobbold SA; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, 3052, Australia., Barkat K; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., Richards SN; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., Lancaster NS; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., Llinás M; Department of Biochemistry and Molecular Biology, Department of Chemistry, and Huck Center for Malaria Research, The Pennsylvania State University, University Park, PA, 16802, USA., Hogg SJ; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., Summers RL; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia., McConville MJ; Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Melbourne, VIC, 3052, Australia., Martin RE; Research School of Biology, The Australian National University, Canberra, ACT, 2601, Australia. rowena.martin@anu.edu.au.

المصدر: Nature communications [Nat Commun] 2020 Aug 06; Vol. 11 (1), pp. 3922. Date of Electronic Publication: 2020 Aug 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Antimalarials/*pharmacology , Chloroquine/*pharmacology , Membrane Transport Proteins/*metabolism , Plasmodium falciparum/*drug effects , Plasmodium falciparum/*metabolism , Protozoan Proteins/*metabolism, Animals ; Biological Transport, Active ; Drug Resistance/genetics ; Female ; Host-Parasite Interactions/genetics ; Host-Parasite Interactions/physiology ; Humans ; Malaria, Falciparum/drug therapy ; Malaria, Falciparum/metabolism ; Malaria, Falciparum/parasitology ; Membrane Transport Proteins/genetics ; Models, Biological ; Mutant Proteins/genetics ; Mutant Proteins/metabolism ; Oligopeptides/metabolism ; Oocytes/metabolism ; Plasmodium falciparum/genetics ; Protein Transport ; Protozoan Proteins/genetics ; Xenopus laevis