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المؤلفون: Shang J; Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Coe KJ; Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine, Janssen R&D, San Diego, California 92121, United States., Lim HK; Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Chen L; Global Discovery Chemistry, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Khatri BB; Global Discovery Chemistry, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Salter R; Global Discovery Chemistry, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Mitra K; Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States., Iyer R; Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine, Janssen R&D, Spring House, Pennsylvania 19002, United States.

المصدر: Chemical research in toxicology [Chem Res Toxicol] 2024 Apr 15; Vol. 37 (4), pp. 540-544. Date of Electronic Publication: 2024 Mar 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocytes*/metabolism, Humans ; Coculture Techniques ; Cells, Cultured ; Body Burden ; Risk Assessment

المؤلفون: Leu JH; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Miao X; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Shalayda K; Janssen Research & Development, LLC, Raritan, New Jersey, USA., Coe KJ; Janssen Research & Development, LLC, San Diego, California, USA., Kahnt A; Janssen Research & Development, Beerse, Belgium., Wu B; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Schnarr M; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Franks C; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Devlin J; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Yang TY; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA., Palmer JA; Janssen Research & Development, LLC, San Diego, California, USA., Zhang M; Janssen Research & Development, LLC, San Diego, California, USA., Zhou H; Janssen Research & Development, LLC, Spring House, Pennsylvania, USA.; Present affiliation: Kira Pharmaceuticals, Cambridge, Massachusetts, USA., Van Damme W; Clinical Pharmacology Unit, Janssen Research & Development, Merksem, Belgium., Smets S; Clinical Pharmacology Unit, Janssen Research & Development, Merksem, Belgium., Aguilar Z; Janssen Research & Development, LLC, San Diego, California, USA., Chaplan SR; Janssen Research & Development, LLC, San Diego, California, USA.

المصدر: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2023 Jun; Vol. 12 (6), pp. 611-624. Date of Electronic Publication: 2023 May 01.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

مواضيع طبية MeSH: Agammaglobulinaemia Tyrosine Kinase* , Tyrosine Kinase Inhibitors*/pharmacokinetics , Tyrosine Kinase Inhibitors*/pharmacology, Female ; Humans ; Male ; Area Under Curve ; Dose-Response Relationship, Drug ; Double-Blind Method ; Half-Life

المؤلفون: Gelin CF; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Stenne B; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coate H; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Hiscox A; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Soyode-Johnson A; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wall JL; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Lord B; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Schoellerman J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wang K; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Alcázar J; Janssen Research & Development, Janssen-Cilag, S.A., Jarama 75A, 45007 Toledo, Spain., Chrovian CC; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Dvorak CA; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Carruthers NI; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Koudriakova T; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Balana B; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Letavic MA; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2023 Feb 23; Vol. 66 (4), pp. 2877-2892. Date of Electronic Publication: 2023 Feb 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Brain*/metabolism , Pyrimidines* , Receptors, N-Methyl-D-Aspartate*/metabolism, Animals ; Rats ; Structure-Activity Relationship

المؤلفون: Tichenor MS; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wiener JJM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rao NL; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Bacani GM; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wei J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Pooley Deckhut C; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Barbay JK; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Kreutter KD; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Chang L; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Clancy KW; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Murrey HE; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wang W; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Ahn K; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Huber M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rex E; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wu J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rui H; Janssen Research & Development, 4560 Jinke Road, Pudong New Area, Shanghai 201319, P. R. China., Sepassi K; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Gaudiano M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bekkers M; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Cornelissen I; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Packman K; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Seierstad M; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Xiouras C; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Bembenek SD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Alexander R; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Milligan C; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Balasubramanian S; Janssen Research & Development, LLC, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Lebsack AD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Venable JD; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Philippar U; Janssen Research & Development, Turnhoutseweg 30, B-2340 Beerse, Belgium., Edwards JP; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Hirst G; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Nov 10; Vol. 65 (21), pp. 14326-14336. Date of Electronic Publication: 2022 Oct 31.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Rheumatoid*/drug therapy , Autoimmune Diseases*/drug therapy , Lupus Erythematosus, Systemic*/drug therapy, Humans ; Agammaglobulinaemia Tyrosine Kinase ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Coe KJ; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.) kcoe2@its.jnj.com., Feinstein M; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Higgins JW; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Leung P; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Scott BP; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Skaptason J; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Tam Y; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Volak LP; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Kinong J; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Bittner A; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., McAllister H; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Lim NM; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Hack M; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.)., Koudriakova T; Janssen Research & Development, L.L.C., San Diego, California (K.J.C., M.F., P.L., B.P.S., L.P.V., H.M., N.M.L., M.H., T.K.); Janssen Research & Development, L.L.C., San Francisco, California (Y.T.), Neurocrine Biosciences, Inc, San Diego, California (J.S.); Pfizer, San Diego, California (J.K.); Turnstone Biologics, La Jolla, California (A.B.); and Trestle Biotherapeutics, San Diego, California (J.W.H.).

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2022 Aug; Vol. 50 (8), pp. 1064-1076. Date of Electronic Publication: 2022 Jun 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP1A1*/metabolism , Receptors, Aryl Hydrocarbon*/metabolism, Amines ; Animals ; Humans ; Pyrimidines/pharmacology ; Rats ; Thiazoles/pharmacology

المؤلفون: Tichenor MS; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wiener JJM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rao NL; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Pooley Deckhut C; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Barbay JK; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Kreutter KD; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Bacani GM; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wei J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Chang L; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Murrey HE; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Wang W; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Ahn K; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Huber M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rex E; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wu J; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Seierstad M; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Bembenek SD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Leonard KA; Janssen Research & Development, 1400 McKean Road, Spring House, Pennsylvania 19477-0776, United States., Lebsack AD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Venable JD; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Edwards JP; Janssen Research & Development, 3210 Merryfield Row, San Diego, California 92121-1126, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Apr 05; Vol. 12 (5), pp. 782-790. Date of Electronic Publication: 2021 Apr 05 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Chrovian CC; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Soyode-Johnson A; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Stenne B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Pippel DJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Schoellerman J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Lord B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Needham AS; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Xia C; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Sepassi K; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Schoetens F; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Scott B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Nguyen L; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Jiang X; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Koudriakova T; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Balana B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Letavic MA; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Sep 10; Vol. 63 (17), pp. 9181-9196. Date of Electronic Publication: 2020 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design*, Antipsychotic Agents/*chemical synthesis , Imidazoles/*chemistry , Pyridines/*chemistry , Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors, Allosteric Regulation ; Animals ; Antipsychotic Agents/pharmacokinetics ; Antipsychotic Agents/therapeutic use ; Brain/metabolism ; Dogs ; Drug Evaluation, Preclinical ; Half-Life ; Humans ; Imidazoles/pharmacokinetics ; Imidazoles/therapeutic use ; Male ; Mood Disorders/drug therapy ; Mood Disorders/pathology ; Nanostructures/chemistry ; Permeability/drug effects ; Pyridines/pharmacokinetics ; Pyridines/therapeutic use ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/genetics ; Receptors, N-Methyl-D-Aspartate/metabolism ; Solubility ; Structure-Activity Relationship

المؤلفون: Préville C; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Bonaventure P; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Koudriakova T; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Lord B; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Nepomuceno D; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Rizzolio M; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Mani N; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Coe KJ; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Ndifor A; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Dugovic C; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Dvorak CA; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Coate H; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Pippel DJ; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Fitzgerald A; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Allison B; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Lovenberg TW; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Carruthers NI; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States., Shireman BT; Janssen Research & Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Apr 27; Vol. 11 (10), pp. 2002-2009. Date of Electronic Publication: 2020 Apr 27 (Print Publication: 2020).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: Chrovian CC; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Soyode-Johnson A; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Wall JL; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Rech JC; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Schoellerman J; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Lord B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Coe KJ; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Carruthers NI; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Nguyen L; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Jiang X; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Koudriakova T; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Balana B; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States., Letavic MA; Janssen Research & Development, LLC, 3210 Merryfield Row, San Diego, California 92121-1126, United States.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2019 Jan 10; Vol. 10 (3), pp. 261-266. Date of Electronic Publication: 2019 Jan 10 (Print Publication: 2019).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE