المؤلفون: Soohoo AM; 1Department of Chemical Engineering, Stanford University, Stanford, California, USA; email: khosla@stanford.edu.; 3Sarafan ChEM-H, Stanford University, Stanford, California, USA., Cogan DP; 2Department of Chemistry, Stanford University, Stanford, California, USA.; 4Current affiliation: Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California, USA., Brodsky KL; 2Department of Chemistry, Stanford University, Stanford, California, USA., Khosla C; 1Department of Chemical Engineering, Stanford University, Stanford, California, USA; email: khosla@stanford.edu.; 2Department of Chemistry, Stanford University, Stanford, California, USA.; 3Sarafan ChEM-H, Stanford University, Stanford, California, USA.

المصدر: Annual review of biochemistry [Annu Rev Biochem] 2024 Apr 25. Date of Electronic Publication: 2024 Apr 25.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Annual Reviews Country of Publication: United States NLM ID: 2985150R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-4509 (Electronic) Linking ISSN: 00664154 NLM ISO Abbreviation: Annu Rev Biochem Subsets: MEDLINE

المؤلفون: Guzman KM; Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States., Cogan DP; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Brodsky KL; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Soohoo AM; Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States., Li X; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Sevillano N; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States., Mathews II; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States., Nguyen KP; Department of Chemistry, Stanford University, Stanford, California 94305, United States., Craik CS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States., Khosla C; Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States.; Department of Chemistry, Stanford University, Stanford, California 94305, United States.; Sarafan ChEM-H, Stanford University, Stanford, California 94305, United States.

المصدر: Biochemistry [Biochemistry] 2023 Jun 06; Vol. 62 (11), pp. 1589-1593. Date of Electronic Publication: 2023 May 15.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Polyketide Synthases*/chemistry , Erythromycin*, Acyltransferases/chemistry ; Antibodies

المؤلفون: Goodyer WR; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Pediatrics, Stanford University, Stanford, California, USA., Beyersdorf BM; Department of Cardiovascular Surgery, Institute Insure (Institute for Translational Cardiac Surgery), German Heart Center Munich, Technische Universität München, Munich, Germany., Duan L; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA., van den Berg NS; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California, USA., Mantri S; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA., Galdos FX; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA., Puluca N; Department of Cardiovascular Surgery, Institute Insure (Institute for Translational Cardiac Surgery), German Heart Center Munich, Technische Universität München, Munich, Germany., Buikema JW; Department of Cardiology, Utrecht Regenerative Medicine Center, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Department of Cardiology, Amsterdam University Medical Center, Location VUmc, Amsterdam, Netherlands., Lee S; Department of Pharmacy, Bioconvergence Program, Sungkyunkwan University, Suwon, South Korea., Salmi D; Department of Pathology and., Robinson ER; Department of Radiology, Stanford University, Stanford, California, USA., Rogalla S; Division of Gastroenterology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA., Cogan DP; Departments of Chemistry and Chemical Engineering and Sarafan ChEM-H Institute, Stanford University, Stanford, California, USA., Khosla C; Departments of Chemistry and Chemical Engineering and Sarafan ChEM-H Institute, Stanford University, Stanford, California, USA., Rosenthal EL; Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Wu SM; Cardiovascular Institute, Stanford University School of Medicine, Stanford, California, USA.; Department of Pediatrics, Stanford University, Stanford, California, USA.; Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.

المصدر: The Journal of clinical investigation [J Clin Invest] 2022 Oct 17; Vol. 132 (20). Date of Electronic Publication: 2022 Oct 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: Electronic Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

مواضيع طبية MeSH: Heart Conduction System*/metabolism , Molecular Targeted Therapy*, Animals ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Heart/physiology ; Humans ; Mice ; Myocardium

المؤلفون: Cogan DP; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Bhushan A; Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland., Reyes R; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Zhu L; School of Chemical Sciences NMR Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Piel J; Institute of Microbiology, Eidgenössische Technische Hochschule Zurich, CH-8093 Zurich, Switzerland., Nair SK; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana IL 61801.; Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2022 Mar 29; Vol. 119 (13), pp. e2116578119. Date of Electronic Publication: 2022 Mar 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Amides* , Cytotoxins*, Methylation ; Peptides/chemistry ; Protein Processing, Post-Translational

المؤلفون: Cogan DP; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., Zhang K; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; MOE Key Laboratory for Cellular Dynamics, Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China., Li X; Department of Chemistry, Stanford University, Stanford, CA 94305, USA., Li S; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; MOE Key Laboratory for Cellular Dynamics, Hefei National Laboratory for Physical Sciences at the Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China., Pintilie GD; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA., Roh SH; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; Department of Biological Sciences, Institute of Molecular Biology & Genetics, Seoul National University, Seoul 151-742, Korea., Craik CS; Department of Pharmaceutical Chemistry, University of California-San Francisco, San Francisco, CA 94158, USA., Chiu W; Department of Bioengineering, Stanford University, Stanford, CA 94305, USA.; Division of CryoEM and Bioimaging, Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, CA 94025, USA., Khosla C; Department of Chemistry, Stanford University, Stanford, CA 94305, USA.; Department of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.; Stanford ChEM-H, Stanford, CA 94305, USA.

المصدر: Science (New York, N.Y.) [Science] 2021 Nov 05; Vol. 374 (6568), pp. 729-734. Date of Electronic Publication: 2021 Nov 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

مواضيع طبية MeSH: Polyketide Synthases/*chemistry, Biocatalysis ; Catalytic Domain ; Cryoelectron Microscopy ; Models, Molecular ; Polyketide Synthases/metabolism ; Protein Conformation ; Protein Domains ; Saccharopolyspora/enzymology

المؤلفون: Cogan DP, Ly J, Nair SK

المصدر: ACS chemical biology [ACS Chem Biol] 2020 Oct 16; Vol. 15 (10), pp. 2783-2791. Date of Electronic Publication: 2020 Oct 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Actinobacteria/*enzymology , Carbon-Carbon Ligases/*metabolism , Polyketides/*metabolism, Actinobacteria/metabolism ; Carbon-Carbon Ligases/chemistry ; Carbon-Carbon Ligases/genetics ; Cerulenin/chemistry ; Computational Biology ; Cyclization ; Models, Chemical ; Molecular Docking Simulation ; Mutagenesis, Site-Directed ; Mutation ; Organic Chemicals/chemistry ; Organic Chemicals/metabolism ; Polyketides/chemistry

SCR Organism: Saccharothrix syringae

المؤلفون: Cogan DP, Li X, Sevillano N; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States., Mathews II; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States., Matsui T; Stanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Stanford University, Menlo Park, California 94025, United States., Craik CS; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California 94158, United States., Khosla C; Chemical Engineering, Stanford University, Stanford, California 94305, United States.; Stanford ChEM-H, Stanford University, Stanford, California 94305, United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2020 Sep 02; Vol. 142 (35), pp. 14933-14939. Date of Electronic Publication: 2020 Aug 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Aldo-Keto Reductases/*metabolism , Antibodies, Monoclonal/*metabolism , Molecular Probes/*metabolism , Polyketide Synthases/*metabolism, Aldo-Keto Reductases/chemistry ; Antibodies, Monoclonal/chemistry ; Humans ; Lactones/chemistry ; Lactones/metabolism ; Molecular Conformation ; Molecular Probes/chemistry ; Oxidation-Reduction ; Polyketide Synthases/chemistry

المؤلفون: Bothwell IR; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Cogan DP; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Kim T; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Reinhardt CJ; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801., van der Donk WA; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801; vddonk@illinois.edu snair@illinois.edu.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, IL 61801., Nair SK; Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801; vddonk@illinois.edu snair@illinois.edu.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801.; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2019 Aug 27; Vol. 116 (35), pp. 17245-17250. Date of Electronic Publication: 2019 Aug 13.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Glutamic Acid/*chemistry , Hydro-Lyases/*chemistry , RNA, Transfer, Amino Acyl/*chemistry, Alanine/analogs & derivatives ; Alanine/chemistry ; Alanine/genetics ; Crystallography, X-Ray ; Glutamic Acid/genetics ; Hydro-Lyases/genetics ; Nisin/chemistry ; Protein Domains ; RNA, Transfer, Amino Acyl/genetics ; Recombinant Proteins

المؤلفون: An L; Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Cogan DP; Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA., Navo CD; Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, La Rioja, Spain., Jiménez-Osés G; Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, La Rioja, Spain., Nair SK; Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA. s-nair@life.uiuc.edu.; Center for Biophysics and Computational Biology, University of Illinois at Urbana-Champaign, Champaign, IL, USA. s-nair@life.uiuc.edu., van der Donk WA; Department of Chemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA. vddonk@illinois.edu.; Department of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, USA. vddonk@illinois.edu.; Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, USA. vddonk@illinois.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2018 Oct; Vol. 14 (10), pp. 928-933. Date of Electronic Publication: 2018 Sep 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Bacteriocins/*chemistry , Lysinoalanine/*chemistry , Peptides/*chemistry, Alanine/analogs & derivatives ; Anti-Bacterial Agents/chemistry ; Bacillus subtilis/drug effects ; Catalysis ; Cross-Linking Reagents/chemistry ; Crystallography, X-Ray ; DNA Mutational Analysis ; Escherichia coli/enzymology ; Hydrolysis ; Molecular Dynamics Simulation ; Mutation ; Protein Multimerization ; Protein Processing, Post-Translational ; Protein Structure, Secondary ; Stereoisomerism ; Streptomyces/metabolism ; Substrate Specificity

المؤلفون: Cogan DP; From the Department of Biochemistry.; Institute for Genomic Biology, and., Baraquet C; the Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195., Harwood CS; the Department of Microbiology, University of Washington School of Medicine, Seattle, Washington 98195., Nair SK; From the Department of Biochemistry, s-nair@life.illinois.edu.; Institute for Genomic Biology, and.; Center for Biophysics and Computational Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801 and.

المصدر: The Journal of biological chemistry [J Biol Chem] 2018 Jul 27; Vol. 293 (30), pp. 11727-11735. Date of Electronic Publication: 2018 May 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Regulation, Bacterial* , Operon*, Acyl Coenzyme A/*metabolism , Bacterial Proteins/*metabolism , Repressor Proteins/*metabolism , Rhodopseudomonas/*genetics, Acyl Coenzyme A/chemistry ; Amino Acid Sequence ; Bacterial Proteins/chemistry ; Bacterial Proteins/genetics ; Base Sequence ; Cloning, Molecular ; Coumaric Acids/metabolism ; Crystallography, X-Ray ; Protein Conformation ; Repressor Proteins/chemistry ; Repressor Proteins/genetics ; Rhodopseudomonas/chemistry ; Rhodopseudomonas/metabolism ; Transcriptional Activation