المؤلفون: Cohen, SIA, Arosio, P, Presto, J, Kurudenkandy, FR, Biverstal, H, Dolfe, L, Dunning, C, Yang, XT, Frohm, B, Vendruscolo, M, Johansson, J, Dobson, CM, Fisahn, A, Knowles, TPJ, Linse, S

المصدر: Nature structural & molecular biology. 22(3):207-213

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:130873608

المؤلفون: Perni, M, Flagmeier, P, Limbocker, R, Cascella, R, Aprile, Fa, Galvagnion, C, Heller, Gt, Meisl, G, Chen, Sw, Kumita, Jr, Challa, Pk, Kirkegaard, Jb, Cohen, Sia, Mannini, B, Barbut, D, Nollen, Eaa, Cecchi, C, Cremades, N, Knowles, Tpj, Chiti, F, Zasloff, M, Vendruscolo, M, Dobson, Cm

مصطلحات موضوعية: α‑Synuclein aggregation, Trodusquemine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od_______310::643934268520e9e7d9e32fb2a8239319
http://hdl.handle.net/2158/1132660

المؤلفون: Michaels TCT; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, United Kingdom., Dear AJ; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA., Cohen SIA; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, United Kingdom., Vendruscolo M; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom., Knowles TPJ; Yusuf Hamied Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom.

المصدر: The Journal of chemical physics [J Chem Phys] 2022 Apr 28; Vol. 156 (16), pp. 164904.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Institute of Physics Country of Publication: United States NLM ID: 0375360 Publication Model: Print Cited Medium: Internet ISSN: 1089-7690 (Electronic) Linking ISSN: 00219606 NLM ISO Abbreviation: J Chem Phys Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid*/metabolism , Neurodegenerative Diseases*, Amyloidogenic Proteins ; Humans ; Kinetics

المؤلفون: Rodriguez Camargo DC; Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE-221 00 Lund, Sweden.; Wren Therapeutics Limited, Clarendon House, Clarendon Road, Cambridge CB2 8FH, United Kingdom., Sileikis E; Wren Therapeutics Limited, Clarendon House, Clarendon Road, Cambridge CB2 8FH, United Kingdom., Chia S; Wren Therapeutics Limited, Clarendon House, Clarendon Road, Cambridge CB2 8FH, United Kingdom., Axell E; Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE-221 00 Lund, Sweden., Bernfur K; Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE-221 00 Lund, Sweden., Cataldi RL; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom., Cohen SIA; Wren Therapeutics Limited, Clarendon House, Clarendon Road, Cambridge CB2 8FH, United Kingdom., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom., Habchi J; Wren Therapeutics Limited, Clarendon House, Clarendon Road, Cambridge CB2 8FH, United Kingdom., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom.; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge CB3 0HE, United Kingdom., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, CB2 1EW Cambridge, United Kingdom., Linse S; Department of Biochemistry and Structural Biology, Chemical Centre, Lund University, SE-221 00 Lund, Sweden.

المصدر: ACS chemical neuroscience [ACS Chem Neurosci] 2021 Dec 01; Vol. 12 (23), pp. 4406-4415. Date of Electronic Publication: 2021 Nov 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease* , tau Proteins*/metabolism, Cell Proliferation ; Humans ; Kinetics ; Neurofibrillary Tangles/metabolism ; Protein Aggregates

المؤلفون: Meisl G; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Kurt T; Department of Pathology, UC San Diego, San Diego, CA, USA., Condado-Morales I; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Bett C; Department of Pathology, UC San Diego, San Diego, CA, USA., Sorce S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Nuvolone M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland.; Amyloidosis Research and Treatment Center, Foundation IRCCS Policlinico San Matteo, Department of Molecular Medicine, University of Pavia, Pavia, Italy., Michaels TCT; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, USA., Heinzer D; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Avar M; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Cohen SIA; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK.; Wren Therapeutics, Cambridge, UK., Hornemann S; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Aguzzi A; Institute of Neuropathology, University of Zurich, Zurich, Switzerland., Dobson CM; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK., Sigurdson CJ; Department of Pathology, UC San Diego, San Diego, CA, USA. csigurdson@ucsd.edu., Knowles TPJ; Centre for Misfolding Diseases, Yusuf Hamied Department of Chemistry, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.; Cavendish Laboratory, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2021 Apr; Vol. 28 (4), pp. 365-372. Date of Electronic Publication: 2021 Mar 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*genetics , Parkinson Disease/*genetics , Prions/*genetics , Protein Aggregation, Pathological/*genetics, Alzheimer Disease/pathology ; Amyloid/genetics ; Animals ; Humans ; Mice ; Models, Theoretical ; Parkinson Disease/pathology

المؤلفون: Perni M; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., van der Goot A; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Limbocker R; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom.; Department of Chemistry and Life Science, United States Military Academy, West Point, NY, United States., van Ham TJ; Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, Netherlands., Aprile FA; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Xu CK; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Flagmeier P; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Thijssen K; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Sormanni P; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Fusco G; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Chen SW; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Challa PK; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Kirkegaard JB; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, United Kingdom., Laine RF; MRC Laboratory for Molecular Cell Biology (LMCB) University College London, London, United Kingdom., Ma KY; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom.; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Müller MBD; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom.; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Sinnige T; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Kumita JR; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Cohen SIA; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Seinstra R; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Kaminski Schierle GS; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom., Kaminski CF; Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom., Barbut D; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, United States., De Simone A; Department of Life Sciences, Imperial College London, London, United Kingdom., Knowles TPJ; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Zasloff M; MedStar-Georgetown Transplant Institute, Georgetown University School of Medicine, Washington, DC, United States., Nollen EAA; University Medical Centre Groningen, European Research Institute for the Biology of Aging, University of Groningen, Groningen, Netherlands., Vendruscolo M; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom., Dobson CM; Department of Chemistry, Centre for Misfolding Diseases, University of Cambridge, Cambridge, United Kingdom.

المصدر: Frontiers in cell and developmental biology [Front Cell Dev Biol] 2021 Mar 22; Vol. 9, pp. 552549. Date of Electronic Publication: 2021 Mar 22 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Media S.A Country of Publication: Switzerland NLM ID: 101630250 Publication Model: eCollection Cited Medium: Print ISSN: 2296-634X (Print) Linking ISSN: 2296634X NLM ISO Abbreviation: Front Cell Dev Biol Subsets: PubMed not MEDLINE

المؤلفون: Linse S; Biochemistry and Structural Biology, Lund University, Lund, Sweden. sara.linse@biochemistry.lu.se., Scheidt T; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Bernfur K; Biochemistry and Structural Biology, Lund University, Lund, Sweden., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Dobson CM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Cohen SIA; Wren Therapeutics Ltd, Cambridge, UK., Sileikis E; Biochemistry and Structural Biology, Lund University, Lund, Sweden., Lundqvist M; Biochemistry and Structural Biology, Lund University, Lund, Sweden., Qian F; Biogen, Cambridge, MA, USA., O'Malley T; Biogen, Cambridge, MA, USA., Bussiere T; Biogen, Cambridge, MA, USA., Weinreb PH; Biogen, Cambridge, MA, USA., Xu CK; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Devenish SRA; Fluidic Analytics, Cambridge, UK., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.; Cavendish Laboratory, Department of Physics, University of Cambridge, Cambridge, UK., Hansson O; Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden.; Memory Clinic, Skåne University Hospital, Malmö, Sweden.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2020 Dec; Vol. 27 (12), pp. 1125-1133. Date of Electronic Publication: 2020 Sep 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Amyloid beta-Peptides/*antagonists & inhibitors , Antibodies, Monoclonal, Humanized/*pharmacology , Neuroprotective Agents/*pharmacology , Peptide Fragments/*antagonists & inhibitors, Alzheimer Disease/drug therapy ; Amyloid beta-Peptides/chemistry ; Antibodies, Monoclonal, Humanized/chemistry ; Humans ; Kinetics ; Models, Biological ; Models, Molecular ; Neuroprotective Agents/chemistry ; Peptide Fragments/chemistry ; Peptide Mapping/methods ; Protein Aggregates/drug effects ; Protein Conformation ; Structure-Activity Relationship

المؤلفون: Michaels TCT; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA., Šarić A; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, UK.; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Curk S; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, UK.; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.; Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia., Bernfur K; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden., Arosio P; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Dear AJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA., Cohen SIA; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Dobson CM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. mv245@cam.ac.uk., Linse S; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden. Sara.Linse@biochemistry.lu.se., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.; Cavendish Laboratory, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.

المصدر: Nature chemistry [Nat Chem] 2020 May; Vol. 12 (5), pp. 445-451. Date of Electronic Publication: 2020 Apr 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*metabolism , Amyloid beta-Peptides/*metabolism , Peptide Fragments/*metabolism, Computer Simulation ; Humans ; Kinetics ; Models, Molecular ; Peptide Fragments/chemistry ; Protein Conformation ; Protein Folding ; Protein Multimerization

المؤلفون: Michaels TCT; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA., Šarić A; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, UK.; MRC Laboratory for Molecular Cell Biology, University College London, London, UK., Curk S; Department of Physics and Astronomy, Institute for the Physics of Living Systems, University College London, London, UK.; MRC Laboratory for Molecular Cell Biology, University College London, London, UK.; Faculty of Natural Sciences and Mathematics, University of Maribor, Maribor, Slovenia., Bernfur K; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden., Arosio P; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland., Meisl G; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Dear AJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK.; Paulson School of Engineering and Applied Science, Harvard University, Cambridge, MA, USA., Cohen SIA; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Dobson CM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. mv245@cam.ac.uk., Linse S; Department of Chemistry, Division for Biochemistry and Structural Biology, Lund University, Lund, Sweden. Sara.Linse@biochemistry.lu.se., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.; Cavendish Laboratory, University of Cambridge, Cambridge, UK. tpjk2@cam.ac.uk.

المصدر: Nature chemistry [Nat Chem] 2020 May; Vol. 12 (5), pp. 497.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Scheidt T; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Łapińska U; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Kumita JR; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Whiten DR; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia., Klenerman D; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Wilson MR; School of Biological Sciences, University of Wollongong, Wollongong, New South Wales, Australia., Cohen SIA; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Linse S; Department of Biochemistry and Structural Biology, Lund University, Box 124, SE221 00 Lund, Sweden., Vendruscolo M; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Dobson CM; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Knowles TPJ; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Cavendish Laboratory, University of Cambridge, J J Thomson Avenue, Cambridge CB3 0HE, UK., Arosio P; Centre for Misfolding Diseases, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK.; Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg, 8093 Zurich, Switzerland.

المصدر: Science advances [Sci Adv] 2019 Apr 17; Vol. 5 (4), pp. eaau3112. Date of Electronic Publication: 2019 Apr 17 (Print Publication: 2019).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: eCollection Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

مواضيع طبية MeSH: Alzheimer Disease/*pathology , Amyloid beta-Peptides/*metabolism , Protein Aggregates/*physiology, Alzheimer Disease/metabolism ; Amyloid beta-Peptides/genetics ; Clusterin/metabolism ; Humans ; Kinetics ; Microfluidics ; Peptide Fragments/genetics ; Peptide Fragments/metabolism ; Protein Binding ; Recombinant Proteins/biosynthesis ; Recombinant Proteins/chemistry