المؤلفون: Brian Y. Lee, Elizabeth K. J. Hogg, Christopher R. Below, Alexander Kononov, Adrian Blanco-Gomez, Felix Heider, Jingshu Xu, Colin Hutton, Xiaohong Zhang, Tamara Scheidt, Kenneth Beattie, Angela Lamarca, Mairéad McNamara, Juan W. Valle, Claus Jørgensen

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)

مصطلحات موضوعية: Science

وصف الملف: electronic resource

Relation: https://doaj.org/toc/2041-1723

URL الوصول: https://doaj.org/article/3b444973af7e4c88bad9060cb4eb9f37

المؤلفون: Laura Novellasdemunt, Anna Kucharska, Anna Baulies, Colin Hutton, Georgios Vlachogiannis, Dimitra Repana, Andrew Rowan, A. Suárez-Bonnet, Francesca Ciccarelli, Nicola Valeri, Vivian S.W. Li

المصدر: Stem Cell Reports. 18:570-584

مصطلحات موضوعية: Genetics, Cell Biology, Biochemistry, Developmental Biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8511911da284f4fb83f4cd809c06a9bc
https://doi.org/10.1016/j.stemcr.2022.12.013

المؤلفون: Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a3c40264b8e2f69612f9eb8e7c603
https://doi.org/10.1158/2159-8290.22539473

المؤلفون: Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::8984675ccc2ee02aad006ca4186bf241
https://doi.org/10.1158/2159-8290.c.6549104.v1

المؤلفون: Santiago Zelenay, Daniela S. Thommen, Ton N. Schumacher, Claus Jørgensen, Shih-Chieh Chiang, Eimear Flanagan, Christian P. Bromley, Antonia Banyard, Adrian Blanco-Gomez, Colin Hutton, Charlotte R. Bell, Eduardo Bonavita, Lisanne M. Roelofsen, Agrin Moeini, Victoria S. Pelly

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b85f9b253cc646efd59ce772aa109
https://doi.org/10.1158/2159-8290.22539494.v1

المؤلفون: Colin Hutton, Xiaohong Zhang, Antonia Banyard, Alexander Kononov, Felix Heider, Adrian Blanco-Gomez, Saadia Karim, Viola Paulus-Hock, Dale Watt, Nina Steele, Samantha Kemp, Rene-Filip Jackstadt, Filipa Lopes, Matteo Menotti, Luke Chisholm, Angela Lamarca, Juan Valle, Owen J. Sansom, Caroline Springer, Angeliki Malliri, Richard Marais, Marina Pasca di Magliano, Santiago Zelenay, Jennifer P. Morton, Claus Jørgensen

مصطلحات موضوعية: Fibroblast, pancreatic cancer, tumor microenvironment, stroma, CD105, Endoglin

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1165979ffc6e94f1b4f54f1af691f522

المؤلفون: Christopher Below, Joanna Kelly, Alexander Brown, Jonathan D. Humphries, Colin Hutton, Jingshu Xu, Brian Y. Lee, Celia Cintas, Xiaohong Zhang, Victor Hernandez-Gordillo, Janet Askari, Jessica Burns, Linda Stockdale, Matthew A. Goldsworthy, Joe Geraghty, Lucy Foster, Derek A. O'Reilly, Barbara Schedding, Nigel Hodson, Duncan Smith, Catherine Lally, Garry Ashton, David Knight, Aleksandr Mironov, Antonia Banyard, Johannes A Eble, Jennifer P. Morton, Martin J. Humphries, Linda G. Griffith, Claus Jørgensen

مصطلحات موضوعية: Pancreatic Cancer, Organoids, Synthetic Matrix, ECM

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e48cf8fbdc8e9d8e315d99e3fd60199

المؤلفون: Christian P. Bromley, Adrian Blanco-Gomez, Eduardo Bonavita, Antonia Banyard, Santiago Zelenay, Victoria S. Pelly, Shih-Chieh Chiang, Eimear Flanagan, Ton N. Schumacher, Agrin Moeini, Colin Hutton, Charlotte R. Bell, Lisanne M. Roelofsen, Claus Jørgensen, Daniela S. Thommen

المصدر: Cancer Discovery
Cancer Discov

مصطلحات موضوعية: medicine.drug_class, Prostaglandin E2 receptor, Anti-Inflammatory Agents, Article, Dinoprostone, Anti-inflammatory, Mice, Immune system, Cell Line, Tumor, Neoplasms, medicine, Tumor Microenvironment, Animals, Humans, Immune Checkpoint Inhibitors, Inflammation, Effector, business.industry, Immunogenicity, Cancer, Receptors, Prostaglandin E, EP2 Subtype, medicine.disease, Immune checkpoint, 3. Good health, Blockade, Disease Models, Animal, Oncology, Firefighters, Cancer research, Drug Therapy, Combination, business, Receptors, Prostaglandin E, EP4 Subtype

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68413b6beab25a8685a6e5f72ddc5552
https://pubmed.ncbi.nlm.nih.gov/34598950

المؤلفون: Dale M Watt, Luke Chisholm, Rene-Filip Jackstadt, Caroline J. Springer, Antonia Banyard, Colin Hutton, Joanna Kelly, Viola Paulus-Hock, Angeliki Malliri, Samantha Kemp, Santiago Zelenay, Richard Marais, Elizabeth K. J. Hogg, Marina Pasca di Magliano, Juan W. Valle, Filipa Lopes, Angela Lamarca, Saadia A. Karim, Xiaohong Zhang, Owen J. Sansom, Claus Jørgensen, Alexander Kononov, Felix Heider, Matteo Menotti, Jennifer P. Morton, Adrian Blanco-Gomez, Nina Steele

المصدر: Cancer Cell

مصطلحات موضوعية: mass cytometry, Cancer Research, Stromal cell, cancer-associated fibroblast lineages, pancreatic cancer, Cell Plasticity, Biology, Adaptive Immunity, Article, Mice, Single-cell analysis, Cancer-Associated Fibroblasts, Pancreatic cancer, Cell Line, Tumor, medicine, Tumor Microenvironment, Animals, Humans, CAF, Fibroblast, Tumor microenvironment, tumor-restrictive fibroblasts, Gene Expression Profiling, Mesenchymal stem cell, Endoglin, Fibroblasts, Acquired immune system, medicine.disease, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, CD105, Eng, medicine.anatomical_structure, Oncology, Case-Control Studies, Cancer research, CyTOF, Single-Cell Analysis, Pancreas, Neoplasm Transplantation, Carcinoma, Pancreatic Ductal

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0095cc461a60d09fdb1e8f741a435801
https://pubmed.ncbi.nlm.nih.gov/34520729

المؤلفون: Julie A. Tucker, Ben Acton, Ian D. Waddell, Alexandra Stowell, Nicola Hamilton, Niall M. Hamilton, Kate M. Smith, Stuart Donald Jones, James R. Hitchin, Bohdan Waszkowycz, Alison E. McGonagle, Dominic I. James, Allan M. Jordan, Daniel P. Mould, Clifford David Jones, Colin Hutton, Helen F. Small, Emma E. Fairweather, Donald J. Ogilvie, Louise A. Griffiths

المصدر: Waszkowycz, B, Smith, K, Mcgonagle, A, Jordan, A, Acton, B, Fairweather, E, Griffiths, L, Hamilton, N M, Hamilton, N, Hitchin, J R, Hutton, C, James, D I, Jones, C D, Jones, S, Mould, D, Small, H F, Stowell, A, Tucker, J, Waddell, I & Ogilvie, D J 2018, ' Cell-active Small Molecule Inhibitors of the DNA-damage Repair Enzyme Poly(ADP-ribose) Glycohydrolase (PARG): Discovery and Optimization of Orally Bioavailable Quinazolinedione Sulfonamides ', Journal of Medicinal Chemistry, vol. 61, no. 23, pp. 10767–10792 . https://doi.org/10.1021/acs.jmedchem.8b01407

مصطلحات موضوعية: 0301 basic medicine, Male, Models, Molecular, DNA Repair, Glycoside Hydrolases, DNA repair, Administration, Oral, Biological Availability, 03 medical and health sciences, Mice, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Catalytic Domain, Drug Discovery, Structure–activity relationship, Animals, Humans, Glycoside Hydrolase Inhibitors, Poly(ADP-ribose) glycohydrolase, Quinazolinones, chemistry.chemical_classification, Virtual screening, PARG, Manchester Cancer Research Centre, Chemistry, ResearchInstitutes_Networks_Beacons/mcrc, Small molecule, 030104 developmental biology, Enzyme, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, Molecular Medicine, HeLa Cells

وصف الملف: application/msword

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e713bd6a754c7026f2f63ab3b3df4e2
https://doi.org/10.1021/acs.jmedchem.8b01407