المؤلفون: Fridkis-Hareli M; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Storek M; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Or E; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Altman R; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Katti S; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Sun F; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Peng T; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Hunter J; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Johnson K; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Wang Y; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Lundberg AS; Alexion Pharmaceuticals, 100 College street New Haven CT, 06510, USA., Mehta G; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA., Banda NK; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA. Electronic address: Nirmal.Banda@UCDenver.edu., Michael Holers V; Division of Rheumatology, School of Medicine, University of Colorado Anschutz Medical Campus, Denver, CO, USA.

المصدر: Molecular immunology [Mol Immunol] 2019 Jan; Vol. 105, pp. 150-164. Date of Electronic Publication: 2018 Dec 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Pergamon Press Country of Publication: England NLM ID: 7905289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9142 (Electronic) Linking ISSN: 01615890 NLM ISO Abbreviation: Mol Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Immunization, Passive*, Arthritis, Experimental/*therapy , Complement C3 Convertase, Alternative Pathway/*immunology , Receptors, Complement/*immunology , Receptors, Complement 3d/*immunology , Recombinant Fusion Proteins/*immunology, Animals ; Arthritis, Experimental/genetics ; Arthritis, Experimental/immunology ; Arthritis, Experimental/pathology ; Complement C3 Convertase, Alternative Pathway/genetics ; Humans ; Male ; Mice ; Rabbits ; Receptors, Complement/genetics ; Recombinant Fusion Proteins/genetics ; Sheep

المؤلفون: Pedersen H; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Jensen RK; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark., Hansen AG; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Petersen SV; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Thiel S; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Laursen NS; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Andersen GR; Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark.

المصدر: Frontiers in immunology [Front Immunol] 2022 Jul 22; Vol. 13, pp. 872536. Date of Electronic Publication: 2022 Jul 22 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Complement C3* , Complement C3b*/metabolism, Animals ; Complement Activation ; Complement C3 Convertase, Alternative Pathway ; Complement C3-C5 Convertases/metabolism ; Fibrinogen/metabolism ; Humans ; Rats

المؤلفون: Michels MAHM; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., van de Kar NCAJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., van Kraaij SAW; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands., Sarlea SA; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands., Gracchi V; Department of Pediatric Nephrology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands., Engels FAPT; Department of Pediatric Nephrology, Maastricht University Medical Center+, Maastricht, Netherlands., Dorresteijn EM; Department of Pediatric Nephrology, Sophia Children's Hospital, Erasmus Medical Center, Rotterdam, Netherlands., van der Deure J; Department of Pediatrics, Deventer Hospital, Deventer, Netherlands., Duineveld C; Department of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., Wetzels JFM; Department of Nephrology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands., van den Heuvel LPWJ; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Pediatrics/Pediatric Nephrology, University Hospitals Leuven, Leuven, Belgium.; Department of Development and Regeneration, University Hospitals Leuven, Leuven, Belgium., Volokhina EB; Department of Pediatric Nephrology, Radboud Institute for Molecular Life Sciences, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Nijmegen, Netherlands.

المصدر: Frontiers in immunology [Front Immunol] 2021 Aug 11; Vol. 12, pp. 715704. Date of Electronic Publication: 2021 Aug 11 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antigen-Antibody Complex/*immunology , Complement C3/*immunology , Complement Pathway, Classical/*immunology , Glomerulonephritis, Membranoproliferative/*etiology , Glomerulonephritis, Membranoproliferative/*metabolism, Adolescent ; Animals ; Autoantibodies/immunology ; Biomarkers ; Child ; Complement Activation ; Complement C3/metabolism ; Complement C3 Convertase, Alternative Pathway/immunology ; Complement C3 Nephritic Factor/immunology ; Complement System Proteins/immunology ; Disease Susceptibility ; Enzyme Activation ; Female ; Follow-Up Studies ; Genetic Predisposition to Disease ; Glomerulonephritis, Membranoproliferative/diagnosis ; Humans ; Male

المؤلفون: Bettoni S; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo., Bresin E; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo., Remuzzi G; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo, the Azienda Ospedaliera Papa Giovanni XXIII, Unit of Nephrology and Dialysis, 24127 Bergamo, and the Department of Biomedical and Clinical Sciences, University of Milan, 20157 Milan, Italy., Noris M; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo, marina.noris@marionegri.it., Donadelli R; From the IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Clinical Research Center for Rare Diseases Aldo e Cele Daccò, 24020 Ranica, Bergamo.

المصدر: The Journal of biological chemistry [J Biol Chem] 2016 Apr 08; Vol. 291 (15), pp. 8214-30. Date of Electronic Publication: 2016 Feb 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Complement C3 Convertase, Alternative Pathway/*immunology , Complement C3-C5 Convertases/*immunology , Complement Factor H/*immunology, Complement C3/immunology ; Complement C3 Convertase, Alternative Pathway/analysis ; Complement C3-C5 Convertases/analysis ; Complement C3b/immunology ; Complement Factor B/immunology ; Complement Factor H/analysis ; Enzyme-Linked Immunosorbent Assay ; Humans ; Manganese/analysis ; Manganese/immunology ; Properdin/immunology

المؤلفون: Mannes M; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany., Dopler A; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany., Zolk O; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany., Lang SJ; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany., Halbgebauer R; Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, Germany., Höchsmann B; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany.; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, University Hospital of Ulm and German Red Cross Blood Service Baden-Württemberg-Hessen, Ulm, Germany; and., Skerra A; Lehrstuhl für Biologische Chemie, Technische Universität München, Freising, Germany., Braun CK; Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, Germany., Huber-Lang M; Institute of Clinical and Experimental Trauma Immunology, University Hospital of Ulm, Ulm, Germany., Schrezenmeier H; Institute of Transfusion Medicine, University of Ulm, Ulm, Germany.; Institute of Clinical Transfusion Medicine and Immunogenetics Ulm, University Hospital of Ulm and German Red Cross Blood Service Baden-Württemberg-Hessen, Ulm, Germany; and., Schmidt CQ; Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany.

المصدر: Blood [Blood] 2021 Jan 28; Vol. 137 (4), pp. 443-455.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Models, Immunological*, Complement C3/*antagonists & inhibitors , Complement C3 Convertase, Alternative Pathway/*physiology , Complement C4b/*physiology , Complement C5/*antagonists & inhibitors , Complement Inactivating Agents/*pharmacology , Complement Pathway, Classical/*drug effects, Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Cell Membrane/immunology ; Complement C5/chemistry ; Complement Inactivating Agents/therapeutic use ; Complement Membrane Attack Complex/physiology ; Drug Resistance ; Human Umbilical Vein Endothelial Cells ; Humans ; Models, Molecular ; Peptides, Cyclic/pharmacology ; Peptides, Cyclic/therapeutic use ; Protein Conformation

المؤلفون: Józsi M; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary. mihaly.jozsi@gmx.net., Uzonyi B; Department of Immunology, ELTE Eötvös Loránd University, Budapest, Hungary.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2227, pp. 141-145.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Autoantibodies/*analysis , Complement Factor B/*immunology, Autoantibodies/blood ; Complement C3 Convertase, Alternative Pathway/immunology ; Complement C3 Nephritic Factor/immunology ; Complement C3-C5 Convertases/immunology ; Enzyme-Linked Immunosorbent Assay/methods ; Glomerulonephritis/blood ; Glomerulonephritis/diagnosis ; Glomerulonephritis/immunology ; Humans

المؤلفون: Foley JH; Centre for Blood Research, Life Sciences Institute, University of British Columbia, Vancouver, BC, Canada; Division of Hematology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Peterson EA, Lei V, Wan LW, Krisinger MJ, Conway EM

المصدر: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2015 Apr; Vol. 13 (4), pp. 610-8. Date of Electronic Publication: 2015 Feb 04.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE

مواضيع طبية MeSH: Complement Activation*/drug effects , Complement C3 Convertase, Alternative Pathway*/drug effects , Fibrinolysis*/drug effects , Immunity, Innate*/drug effects , Phagocytosis*/drug effects, Complement C3b/*metabolism , Fibrinolysin/*metabolism , Macrophages/*enzymology, Animals ; Cell Line ; Complement C3b/immunology ; Fibrinolysin/immunology ; Fibrinolysin/pharmacology ; Humans ; Inflammation Mediators/immunology ; Inflammation Mediators/metabolism ; Interleukin-12/immunology ; Interleukin-12/metabolism ; Macrophages/immunology ; Peptide Fragments/immunology ; Peptide Fragments/metabolism ; Proteolysis ; Rabbits ; Signal Transduction ; Time Factors

المؤلفون: Paixão-Cavalcante D; Institute of Infection & Immunity, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom;, Torreira E, Lindorfer MA, Rodriguez de Cordoba S, Morgan BP, Taylor RP, Llorca O, Harris CL

المصدر: Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2014 May 15; Vol. 192 (10), pp. 4844-51. Date of Electronic Publication: 2014 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association of Immunologists Country of Publication: United States NLM ID: 2985117R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1550-6606 (Electronic) Linking ISSN: 00221767 NLM ISO Abbreviation: J Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal, Humanized/*immunology , Complement C3 Convertase, Alternative Pathway/*immunology , Complement C3-C5 Convertases/*immunology , Complement Factor B/*immunology , Complement Pathway, Alternative/*immunology , Kidney Diseases/*immunology, Antibodies, Monoclonal, Humanized/therapeutic use ; Complement C3 Convertase, Alternative Pathway/antagonists & inhibitors ; Complement Pathway, Alternative/drug effects ; Humans ; Kidney Diseases/drug therapy ; Kidney Diseases/pathology

المؤلفون: Michels MAHM; Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands., Volokhina EB; Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands.; Department of Laboratory Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands., van de Kar NCAJ; Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands., van den Heuvel LPWJ; Radboud Institute for Molecular Life Sciences, Department of Pediatric Nephrology, Amalia Children's Hospital, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands. bert.vandenheuvel@radboudumc.nl.; Department of Laboratory Medicine, Radboud University Medical Center, Geert Grooteplein Zuid 10, PO Box 9101, 6525 GA, Nijmegen, The Netherlands. bert.vandenheuvel@radboudumc.nl.; Department of Pediatrics/Pediatric Nephrology and Department of Development & Regeneration, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. bert.vandenheuvel@radboudumc.nl.

المصدر: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2019 Aug; Vol. 34 (8), pp. 1349-1367. Date of Electronic Publication: 2018 Aug 23.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

مواضيع طبية MeSH: Complement Pathway, Alternative*, Atypical Hemolytic Uremic Syndrome/*immunology , Glomerulonephritis, Membranoproliferative/*immunology , Nephritis, Interstitial/*immunology , Properdin/*metabolism, Atypical Hemolytic Uremic Syndrome/drug therapy ; Complement C3/immunology ; Complement C3/metabolism ; Complement C3 Convertase, Alternative Pathway/metabolism ; Glomerulonephritis, Membranoproliferative/drug therapy ; Humans ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Nephritis, Interstitial/complications ; Nephritis, Interstitial/drug therapy ; Nephritis, Interstitial/urine ; Properdin/antagonists & inhibitors ; Protein Stability/drug effects ; Proteinuria/immunology

المؤلفون: Ricklin D; Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia 19104, USA. ricklin@upenn.edu

المصدر: Immunobiology [Immunobiology] 2012 Nov; Vol. 217 (11), pp. 1057-66.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8002742 Publication Model: Print Cited Medium: Internet ISSN: 1878-3279 (Electronic) Linking ISSN: 01712985 NLM ISO Abbreviation: Immunobiology Subsets: MEDLINE

مواضيع طبية MeSH: Complement Pathway, Alternative*, Complement C3 Convertase, Alternative Pathway/*metabolism, Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/immunology ; Complement C3/immunology ; Complement C3/metabolism ; Complement C3 Convertase, Alternative Pathway/antagonists & inhibitors ; Drug Discovery ; Humans ; Immune Evasion ; Infections/drug therapy ; Infections/immunology ; Inflammation/drug therapy ; Inflammation/immunology ; Molecular Targeted Therapy