المؤلفون: Zuo H; Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China., Wu A; Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China., Wang M; Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China., Hong L; Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China., Wang H; Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou Normal University, Hangzhou, 311121, China. wanghu19860315@163.com.

المصدر: Nature communications [Nat Commun] 2024 Jul 08; Vol. 15 (1), pp. 5706. Date of Electronic Publication: 2024 Jul 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mechanistic Target of Rapamycin Complex 1*/metabolism , Signal Transduction* , RNA, Transfer*/metabolism , RNA, Transfer*/genetics , Hematopoietic Stem Cells*/metabolism , Hematopoietic Stem Cells*/cytology , Tuberous Sclerosis Complex 1 Protein*/metabolism , Tuberous Sclerosis Complex 1 Protein*/genetics , Cell Proliferation*, Animals ; Mice ; Cell Self Renewal/genetics ; Mice, Knockout ; Methyltransferases/metabolism ; Methyltransferases/genetics ; Mice, Inbred C57BL ; Methylation

المؤلفون: Kitai H; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Choi PH; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yang YC; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Boyer JA; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Whaley A; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Pancholi P; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Thant C; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Reiter J; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Chen K; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Markov V; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Taniguchi H; Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Yamaguchi R; Division of Cancer Systems Biology, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan., Ebi H; Division of Molecular Therapeutics, Aichi Cancer Center Research Institute, Nagoya, Aichi, 464-8681, Japan., Evans J; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Jiang J; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Lee B; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Wildes D; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., de Stanchina E; Antitumor Assessment Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Smith JAM; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA., Singh M; Department of Biology, Revolution Medicines Inc., Redwood City, CA, USA. msingh@revmed.com., Rosen N; Program in Molecular Pharmacology and Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rosenn@mskcc.org.

المصدر: Nature communications [Nat Commun] 2024 Jul 19; Vol. 15 (1), pp. 6076. Date of Electronic Publication: 2024 Jul 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Proto-Oncogene Proteins p21(ras)*/genetics , Proto-Oncogene Proteins p21(ras)*/metabolism , Carcinoma, Non-Small-Cell Lung*/drug therapy , Carcinoma, Non-Small-Cell Lung*/metabolism , Carcinoma, Non-Small-Cell Lung*/pathology , Carcinoma, Non-Small-Cell Lung*/genetics , Lung Neoplasms*/drug therapy , Lung Neoplasms*/metabolism , Lung Neoplasms*/pathology , Lung Neoplasms*/genetics , Drug Synergism*, Humans ; Animals ; Cell Line, Tumor ; Mice ; TOR Serine-Threonine Kinases/metabolism ; TOR Serine-Threonine Kinases/antagonists & inhibitors ; Protein Kinase Inhibitors/pharmacology ; Xenograft Model Antitumor Assays ; Signal Transduction/drug effects ; Cyclin D1/metabolism ; Cyclin D1/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Myeloid Cell Leukemia Sequence 1 Protein/genetics ; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors ; Female ; Bcl-2-Like Protein 11/metabolism ; Bcl-2-Like Protein 11/genetics

المؤلفون: De la Cruz-López KG; Programa de Doctorado en Ciencias Biomédicas, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Mexico City, Mexico.; Laboratorio de Virus y Cáncer, Unidad de Investigación Biomédica en Cáncer. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México & Instituto Nacional de Cancerología., Av. San Fernando No. 22 Colonia Sección XVI, Tlalpan, Mexico City, 14080, Mexico., Alvarado-Ortiz E; Departamento de Bioquímica, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico., Valencia-González HA; Laboratorio de Células Troncales y Desarrollo Terapéutico Antineoplásico, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Secretaría de Salud, Mexico City, Mexico., Beltrán-Anaya FO; Laboratorio de Diagnóstico e Investigación en Salud, Facultad de Ciencias Químico-Biológicas, Universidad Autónoma de Guerrero, Chilpancingo de los Bravo, Gro, Mexico., Zamora-Fuentes JM; Laboratorio de Oncología Teórica, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.; Centro de Ciencias de La Complejidad, Universidad Nacional Autónoma de México, Mexico City, Mexico., Hidalgo-Miranda A; Laboratorio de Genómica de Cáncer, Instituto Nacional de Medicina Genómica, Mexico City, Mexico., Ortiz-Sánchez E; Laboratorio de Células Troncales y Desarrollo Terapéutico Antineoplásico, Subdirección de Investigación Básica, Instituto Nacional de Cancerología, Secretaría de Salud, Mexico City, Mexico., Espinal-Enríquez J; Laboratorio de Oncología Teórica, Instituto Nacional de Medicina Genómica, Mexico City, Mexico.; Centro de Ciencias de La Complejidad, Universidad Nacional Autónoma de México, Mexico City, Mexico., García-Carrancá A; Laboratorio de Virus y Cáncer, Unidad de Investigación Biomédica en Cáncer. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México & Instituto Nacional de Cancerología., Av. San Fernando No. 22 Colonia Sección XVI, Tlalpan, Mexico City, 14080, Mexico. carranca@iibiomedicas.unam.mx.

المصدر: BMC cancer [BMC Cancer] 2024 Jul 18; Vol. 24 (1), pp. 853. Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Metformin*/pharmacology , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Uterine Cervical Neoplasms*/drug therapy , Uterine Cervical Neoplasms*/metabolism , Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/genetics , Xenograft Model Antitumor Assays*, Humans ; Female ; Animals ; Mice ; HeLa Cells ; Gene Expression Regulation, Neoplastic/drug effects ; Mice, SCID ; Mice, Inbred NOD ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Signal Transduction/drug effects ; Sirolimus/pharmacology

المؤلفون: Zahraeifard S; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Xiao Z; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., So JY; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Ahad A; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Montoya S; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Park WY; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Sornapudi T; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Andohkow T; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Read A; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Kedei N; Collaborative Protein Technology Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Koparde V; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.; Advanced Biomedical Computational Sciences, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21701, USA., Yang H; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Lee M; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Wong N; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA.; Advanced Biomedical Computational Sciences, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, 21701, USA., Cam M; Collaborative Bioinformatics Resource, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Wang K; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Ruppin E; Cancer Data Science Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Luo J; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Hollander C; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA., Yang L; Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA. yangl3@mail.nih.gov.

المصدر: Nature communications [Nat Commun] 2024 Jul 12; Vol. 15 (1), pp. 5873. Date of Electronic Publication: 2024 Jul 12.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Microenvironment*/immunology , Lymphocyte Activation Gene 3 Protein* , Triple Negative Breast Neoplasms*/immunology , Triple Negative Breast Neoplasms*/pathology , Triple Negative Breast Neoplasms*/genetics , Immune Checkpoint Inhibitors*/pharmacology , Immune Checkpoint Inhibitors*/therapeutic use , Tuberous Sclerosis Complex 1 Protein*/genetics , Tuberous Sclerosis Complex 1 Protein*/metabolism , B7-H1 Antigen*/metabolism , B7-H1 Antigen*/genetics, Animals ; Mice ; Female ; Humans ; Neurofibromin 1/genetics ; Neurofibromin 1/metabolism ; Cell Line, Tumor ; CD8-Positive T-Lymphocytes/immunology ; Inflammation/immunology ; CD4-Positive T-Lymphocytes/immunology ; Gene Expression Regulation, Neoplastic ; CRISPR-Cas Systems

المؤلفون: Ciapponi M; Laboratory of Chromatin Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany., Karlukova E; Laboratory of Chromatin Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany., Schkölziger S; Laboratory of Chromatin Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany., Benda C; Department of Structural Cell Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany. benda@biochem.mpg.de., Müller J; Laboratory of Chromatin Biology, Max-Planck Institute of Biochemistry, Martinsried, Germany. muellerj@biochem.mpg.de.

المصدر: Nature structural & molecular biology [Nat Struct Mol Biol] 2024 Jul; Vol. 31 (7), pp. 1023-1027. Date of Electronic Publication: 2024 Mar 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Histones*/metabolism , Histones*/chemistry , Ubiquitination* , Nucleosomes*/metabolism , Nucleosomes*/chemistry , Polycomb Repressive Complex 1*/metabolism , Polycomb Repressive Complex 1*/chemistry , Repressor Proteins*/metabolism , Repressor Proteins*/chemistry, Humans ; Protein Binding ; Models, Molecular ; Intracellular Signaling Peptides and Proteins/metabolism ; Intracellular Signaling Peptides and Proteins/chemistry ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitin-Protein Ligases/chemistry ; Cell Cycle Proteins

المؤلفون: Hu J; School of Life Sciences, Lanzhou University, Lanzhou, China; Key Laboratory Biotherapy and Regenerative Medicine of Gansu Province, Lanzhou, China., Xu H; The Fourth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Ma X; School of Life Sciences, Lanzhou University, Lanzhou, China., Bai M; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Zhou Y; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Miao R; School of Life Sciences, Lanzhou University, Lanzhou, China., Wang F; The Fourth Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China., Li X; The First School of Clinical Medicine, Lanzhou University, Lanzhou, China; Department of General Surgery, The First Hospital of Lanzhou University, Lanzhou, China. Electronic address: lix@lzu.edu.cn., Cheng B; School of Life Sciences, Lanzhou University, Lanzhou, China; Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, Lanzhou University, Lanzhou, China. Electronic address: bocheng@lzu.edu.cn.

المصدر: The American journal of pathology [Am J Pathol] 2024 Jul; Vol. 194 (7), pp. 1388-1404. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/metabolism , Cholangiocarcinoma*/genetics , Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/metabolism , Bile Duct Neoplasms*/genetics , Polycomb Repressive Complex 1*/metabolism , Polycomb Repressive Complex 1*/genetics, Humans ; Cell Movement ; Neoplasm Metastasis ; Animals ; Gene Expression Regulation, Neoplastic ; Mice ; Cell Line, Tumor ; Male ; STAT3 Transcription Factor/metabolism

المؤلفون: Zou J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Wu B; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Tao Y; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Liu Z; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Zhao H; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Wang P; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China., Liang Y; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Wenzhou, China; Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China., Qu J; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Wenzhou, China. Electronic address: jia.qu@eye.ac.cn., Zhang S; The Eye Hospital, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, China; National Clinical Research Center for Ocular Diseases, Wenzhou, China; Glaucoma Research Institute, Wenzhou Medical University, Wenzhou, China. Electronic address: shaodan_zhang@eye.ac.cn.

المصدر: Experimental eye research [Exp Eye Res] 2024 Jul; Vol. 244, pp. 109927. Date of Electronic Publication: 2024 May 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: England NLM ID: 0370707 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0007 (Electronic) Linking ISSN: 00144835 NLM ISO Abbreviation: Exp Eye Res Subsets: MEDLINE

مواضيع طبية MeSH: Transforming Growth Factor beta1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/antagonists & inhibitors , Fibroblasts*/metabolism , Fibroblasts*/drug effects , Fibroblasts*/pathology , Sirolimus*/pharmacology , Fibrosis*/metabolism , Tenon Capsule*/metabolism , Tenon Capsule*/drug effects , Adaptor Proteins, Signal Transducing*/metabolism , Adaptor Proteins, Signal Transducing*/genetics, Animals ; Humans ; Rats ; Cells, Cultured ; Cell Movement/drug effects ; Disease Models, Animal ; Blotting, Western ; Rats, Sprague-Dawley ; Cell Cycle Proteins/metabolism ; Signal Transduction ; Real-Time Polymerase Chain Reaction ; Male ; Glaucoma/metabolism ; Glaucoma/drug therapy ; Glaucoma/pathology ; Immunosuppressive Agents/pharmacology

المؤلفون: Das F; VA Research, South Texas Veterans Health Care System, San Antonio, TX, USA; Department of Medicine, TX, USA., Ghosh-Choudhury N; Department of Pathology, UT Health, San Antonio, TX, USA., Kasinath BS; Department of Medicine, TX, USA., Sharma K; VA Research, South Texas Veterans Health Care System, San Antonio, TX, USA; Department of Medicine, TX, USA., Choudhury GG; VA Research, South Texas Veterans Health Care System, San Antonio, TX, USA; Department of Medicine, TX, USA; Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX, USA. Electronic address: choudhuryg@uthscsa.edu.

المصدر: Experimental cell research [Exp Cell Res] 2024 Jul 01; Vol. 440 (1), pp. 114116. Date of Electronic Publication: 2024 Jun 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Academic Press Country of Publication: United States NLM ID: 0373226 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2422 (Electronic) Linking ISSN: 00144827 NLM ISO Abbreviation: Exp Cell Res Subsets: MEDLINE

مواضيع طبية MeSH: Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology , Diabetic Nephropathies*/genetics , Glucose*/metabolism , Glucose*/pharmacology , Kidney Tubules, Proximal*/metabolism , Kidney Tubules, Proximal*/pathology , Kidney Tubules, Proximal*/drug effects , Mechanistic Target of Rapamycin Complex 1*/metabolism , Mechanistic Target of Rapamycin Complex 1*/genetics , PTEN Phosphohydrolase*/metabolism , PTEN Phosphohydrolase*/genetics, Animals ; Humans ; Male ; Mice ; Down-Regulation/drug effects ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-akt/metabolism ; Proto-Oncogene Proteins c-akt/genetics ; Signal Transduction

المؤلفون: Song Y; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Lian S; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Fan H; Department of General Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, China., Ma C; Department of Hepatobiliary Surgery, Jining First People's Hospital, Jining, Shandong, 272002, China., Zheng L; Department of General Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, China., Huang F; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Huang S; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Tang Y; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Shi A; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Shu L; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Zhao L; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Xu Y; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China., Guo S; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: guosen4321@163.com., Liu Z; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China; Department of General Surgery, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, China. Electronic address: 202162090025@email.sdu.edu.cn., Zhang Z; Department of General Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China. Electronic address: zzlzzl1900@163.com.

المصدر: Cancer letters [Cancer Lett] 2024 Jun 28; Vol. 592, pp. 216921. Date of Electronic Publication: 2024 May 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ireland Country of Publication: Ireland NLM ID: 7600053 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-7980 (Electronic) Linking ISSN: 03043835 NLM ISO Abbreviation: Cancer Lett Subsets: MEDLINE

مواضيع طبية MeSH: Bile Duct Neoplasms*/pathology , Bile Duct Neoplasms*/genetics , Bile Duct Neoplasms*/metabolism , Cell Proliferation* , Cholangiocarcinoma*/pathology , Cholangiocarcinoma*/genetics , Cholangiocarcinoma*/metabolism , Disease Progression* , Forkhead Transcription Factors*/metabolism , Forkhead Transcription Factors*/genetics , Gene Expression Regulation, Neoplastic* , Histones*/metabolism , Polycomb Repressive Complex 1*/metabolism , Polycomb Repressive Complex 1*/genetics , Ubiquitination*, Animals ; Female ; Humans ; Mice ; Cell Line, Tumor ; Epithelial-Mesenchymal Transition ; Mice, Nude ; Prognosis ; Mice, Inbred BALB C

المؤلفون: Li Q; Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Jinan, 250000, Shandong, China., Fu T; Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Jinan, 250000, Shandong, China., Wei N; Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Jinan, 250000, Shandong, China., Wang Q; Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Jinan, 250000, Shandong, China., Zhang X; Department of Ophthalmology, The Second People's Hospital of Jinan, No. 148, Jingyi Road, Jinan, 250000, Shandong, China. zhang100657@163.com.

المصدر: Scientific reports [Sci Rep] 2024 Jun 24; Vol. 14 (1), pp. 14544. Date of Electronic Publication: 2024 Jun 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Retinoblastoma*/pathology , Retinoblastoma*/metabolism , Retinoblastoma*/genetics , Polycomb Repressive Complex 1*/metabolism , Polycomb Repressive Complex 1*/genetics , Cell Proliferation* , Apoptosis*/genetics , Cell Movement*/genetics , Neoplasm Invasiveness* , Mice, Nude* , Phosphatidylethanolamine Binding Protein*/metabolism , Phosphatidylethanolamine Binding Protein*/genetics, Humans ; Animals ; Cell Line, Tumor ; Mice ; Gene Expression Regulation, Neoplastic ; Retinal Neoplasms/pathology ; Retinal Neoplasms/metabolism ; Retinal Neoplasms/genetics