المؤلفون: E. Falcó, Reyes Ferreiro-Monteagudo, T. Cano, Manuel Benavides, E. Polo, Enrique Aranda, Enrique Grande, Emma Dotor, G. Durán-Ogalla, Alfredo Carrato, Margarita Reboredo, Antonieta Salud, B. Massuti, Mercedes Rodríguez-Garrote, Jose María Vieitez, Aitana Calvo, Laura Layos, P. García Alfonso, Javier Gallego

المساهمون: [Carrato,A] Medical Oncology Department, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERONC, Alcala University, Madrid, Spain. [Benavides,M, Durán-Ogalla,G] Hospital Regional Universitario Virgen de la Victoria, Málaga, Spain. [Massutí,B] Hospital General Universitario de Alicante, Alicante, Spain. [Ferreiro-Monteagudo,R, Rodriguez-Garrote,M, Grande,E] Medical Oncology Department, Hospital Universitario Ramón y Cajal, IRYCIS, CIBERONC, Alcala University, Madrid, Spain. [García Alfonso,P, Calvo,A] Hospital Gregorio Marañón, Madrid, Spain. [Falcó,E] Hospital Son Llatzer, Mallorca, Spain. [Reboredo,M] Complejo Hospitalario Universitario A Coruña, La Coruña, Spain. [Cano,T, Aranda,E] Hospital Universitario Reina Sofia, IMIBIC, University of Córdoba, CIBERONC, Instituto de Salud Carlos III, Córdoba, Spain. [Gallego,J] Hospital General Universitario de Elche, Alicante, Spain. [Viéitez,JM] Hospital Universitario Central de Asturias, Oviedo, Spain. [Layos,L] Hospital Germans Trias i Pujol, ICO, Badalona, Spain. [Salud,A] Hospital de Lleida Arnau de Vilanova, Lérida, Spain. [Polo,E] Hospital Miguel Servet, Zaragoza, Spain. [Dotor,E] Corporació Sanitària Parc Taulí, Barcelona, Spain., Financial support for this research was provided by Bayer Hispania, which has no role in the design of the study, collection, analysis, and interpretation of data, and in writing the manuscript.

المصدر: BMC Cancer
r-ISABIAL. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica y Sanitaria de Alicante
instname
r-FISABIO. Repositorio Institucional de Producción Científica
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
r-FISABIO: Repositorio Institucional de Producción Científica
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
BMC Cancer, Vol 19, Iss 1, Pp 1-9 (2019)
Zaguán. Repositorio Digital de la Universidad de Zaragoza

مصطلحات موضوعية: 0301 basic medicine, Male, Colorrectal cancer, Cancer Research, Persons::Persons::Age Groups::Adult::Aged::Frail Elderly [Medical Subject Headings], astenia, Colorectal cancer, Hypophosphatemia, Pyridines, health care facilities, manpower, and services, humanos, Administration, Oral, Pilot Projects, estudios de seguimiento, Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines [Medical Subject Headings], Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], chemistry.chemical_compound, 0302 clinical medicine, Stable Disease, Elderly, Neoplasias colorrectales, Surgical oncology, Medicine, Neoplasm Metastasis, metástasis neoplásica, mediana edad, Persons::Persons::Age Groups::Adult::Aged [Medical Subject Headings], Regorafenib, Aged, 80 and over, anciano, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration, Oral [Medical Subject Headings], resultado del tratamiento, proyectos piloto, First-line, Middle Aged, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, hipofosfatemia, Progression-Free Survival, Diarrhea, Treatment Outcome, Oncology, 030220 oncology & carcinogenesis, Hypertension, Female, medicine.symptom, Colorectal Neoplasms, Diseases::Pathological Conditions, Signs and Symptoms::Signs and Symptoms::Asthenia [Medical Subject Headings], Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Phosphorus Metabolism Disorders::Hypophosphatemia [Medical Subject Headings], Research Article, Colorectal cancer, Elderly, First-line, Frail patients, Monotherapy, Regorafenib, Frail patients, medicine.medical_specialty, neoplasias colorrectales, Frail Elderly, Anciano, piridinas, Check Tags::Male [Medical Subject Headings], lcsh:RC254-282, Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension [Medical Subject Headings], 03 medical and health sciences, Internal medicine, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies [Medical Subject Headings], Diseases::Neoplasms::Neoplastic Processes::Neoplasm Metastasis [Medical Subject Headings], Genetics, Humans, Adverse effect, neoplasms, Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome [Medical Subject Headings], Aged, Geographical Locations::Geographic Locations::Europe::Spain [Medical Subject Headings], Dose-Response Relationship, Drug, business.industry, Phenomena and Processes::Physiological Phenomena::Pharmacological Phenomena::Dose-Response Relationship, Drug [Medical Subject Headings], Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Evaluation Studies as Topic::Pilot Projects [Medical Subject Headings], Phenylurea Compounds, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms [Medical Subject Headings], Persons::Persons::Age Groups::Adult::Middle Aged [Medical Subject Headings], medicine.disease, Monotherapy, Confidence interval, digestive system diseases, 030104 developmental biology, Check Tags::Female [Medical Subject Headings], chemistry, Persons::Persons::Age Groups::Adult::Aged::Aged, 80 and over [Medical Subject Headings], Spain, Asthenia, Chemicals and Drugs::Organic Chemicals::Hydrocarbons::Hydrocarbons, Cyclic::Hydrocarbons, Aromatic::Benzene Derivatives::Phenylurea Compounds [Medical Subject Headings], hipertensión, business, compuestos de fenilurea, human activities, Follow-Up Studies

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb1bd4ac74bdbea35c9c3c9efe9921b8
https://hdl.handle.net/10668/14069

المؤلفون: Prieto-Domínguez, Nestor, Ordóñez, Raquel, Fernández, Anna, García-Palomo, Andres, Muntané, Jordi, González-Gallego, Javier, Mauriz, José L

المساهمون: [Prieto-Domínguez,N, Ordóñez,R, Fernández,A, Muntané,J, González-Gallego,J, Mauriz,JL] Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd)León, Spain. [Prieto-Domínguez,N, Mauriz,JL] Institute of Biomedicine (IBIOMED), University of LeónLeón, Spain. [García-Palomo,A] Service of Clinical Oncology, Complejo Asistencial Universitario de León (Hospital of León) León, Spain. [Muntané,J] Department of General Surgery'Virgen del Rocío'-'Virgen Macarena' University Hospital/IBiS/CSIC/Universidad de Sevilla, Spain., CIBERehd is funded by Instituto de la Salud Carlos III, Spain. NP and RO are granted by the Program 'Formación del Profesorado Universitario' (Becas FPU, references FPU13/04173 and FPU12/01433, respectively) from Ministerio de Educación, Cultura y Deporte (Spain).

مصطلحات موضوعية: Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia [Medical Subject Headings], Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Biochemical Processes::Phosphorylation [Medical Subject Headings], Hepatocellular carcinoma, Dug resistance, Anatomy::Cells::Myeloid Cells [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Urea::Phenylurea Compounds [Medical Subject Headings], Supervivencia celular, Neoplasias hepáticas, Compuestos de fenilurea, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Hepatocellular [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Histologic Type::Lymphoma::Lymphoma, Non-Hodgkin::Lymphoma, B-Cell [Medical Subject Headings], Anatomy::Cells::Cellular Structures::Intracellular Space::Cytoplasm::Cytoplasmic Structures::Organelles [Medical Subject Headings], Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival [Medical Subject Headings], Autophagy, Organisms::Eukaryota::Animals [Medical Subject Headings], Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Autophagy [Medical Subject Headings], neoplasms, Diseases::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings], Proteínas quinasas activadas por AMP, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::AMP-Activated Protein Kinases [Medical Subject Headings], Sorafenib, Cancer therapeutic, Chemicals and Drugs::Organic Chemicals::Lactones::Macrolides::Sirolimus [Medical Subject Headings], Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAs [Medical Subject Headings], Células mieloides, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Transferases::Phosphotransferases::Phosphotransferases (Alcohol Group Acceptor)::Protein Kinases::Protein-Serine-Threonine Kinases::TOR Serine-Threonine Kinases [Medical Subject Headings], Carcinoma hepatocelular, Chemicals and Drugs::Heterocyclic Compounds::Acids, Heterocyclic::Nicotinic Acids::Niacinamide [Medical Subject Headings]

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______2636::09ef598c635f04e9996848418fdc6a82
https://hdl.handle.net/10668/2535

المؤلفون: G. Suárez-Artacho, J. Serrano-Díaz-Canedo, Sheila Pereira, G. Blanco-Fernández, C.A. Padilla, L.M. Marín-Gómez, Raúl González, L. Barrera-Pulido, D. Pacheco, Miguel Ángel Gómez-Bravo, M.A. Torres-Nieto, A. Nogales-Muñoz, Elena Navarro-Villarán, F.J. Padillo, J.M. Álamo-Martínez, A. Gila-Bohórquez, C. Bernal-Bellido, José Antonio Bárcena, A. Sarrias-Giménez, L.B. Soriano-De Castro, A. Rodríguez-Hernández, A. Serrablo-Requejo, Jordi Muntané

المساهمون: [Rodríguez-Hernández,A, Navarro-Villarán,E, Pereira,S, Soriano-De Castro,LB, Sarrias-Giménez,A] Institute of Biomedicine of Seville (IBiS), Hospital Universitario 'Virgen del Rocío'/CSIC/Universidad de Sevilla, Sevilla, Spain. [González,R, Barcena,JA, Padilla,CA] Departament of Biochemistry and Molecular Biology, University of Cordoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Barrera-Pulido,L, Álamo-Martínez,JM, Nogales-Muñoz,A, Gila-Bohórquez,A, Serrano-Díaz-Canedo,J, Suárez-Artacho,G, Bernal-Bellido,C, Marín-Gómez,LM, Gómez-Bravo,MA, Padillo,FJ, Muntané,J] Department of General Surgery, Hospital Universitario 'Virgen del Rocío' – 'Virgen Macarena'/Instituto de Biomedicina de Sevilla (IBiS)/CSIC/Universidad de Sevilla, Sevilla, Spain. [Serrablo-Requejo,A] Hepato-Biliary Surgery Unit, Hospital Universitario 'Miguel Servet', Zaragoza, Spain. [Blanco-Fernández,G] Hepato-Biliary-Pancreatic and Liver Transplant Service, Hospital Universitario 'Infanta Cristina', Badajoz, Spain. [Pacheco,D] Department of General Surgery and Department of Pathology, Hospital Universitario 'Rio Hortega', Valladolid, Spain.[Torres-Nieto,MA] Department of Pathology, Hospital Universitario 'Rio Hortega', Valladolid, Spain. [Álamo-Martínez,JM, Muntané,J] CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain., We thank the Instituto de Salud Carlos III (PI13/00021), Spanish Ministry of Economy and Competitiveness (BFU2012-32056), Consejería Economía, Innovación, Ciencia y Empleo, Junta de An- dalucia (BIO-0216 and CTS-6264) and Consejería de Salud (PI13/ 00025) for its financial support. We thank Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by Instituto de Salud Carlos III., Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. CTS664: Cirugía Avanzada y Trasplantes. Terapia Celular y Bioingeniería Aplicada a la Cirugía

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

مصطلحات موضوعية: Hepatoblastoma, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Complex and Mixed::Hepatoblastoma [Medical Subject Headings], Neoplasias Hepáticas, Receptor expression, Clinical Biochemistry, Apoptosis, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3 [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Urea::Phenylurea Compounds [Medical Subject Headings], Biochemistry, TNF-R1, tumor necrosis factor receptor type I, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Hepatocellular [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Initiator::Caspase 8 [Medical Subject Headings], FADD, Receptor, NOS, nitric oxide synthase, Caspase 8, Cell Death, Caspase 3, Caspasa 8, Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Nitric Oxide [Medical Subject Headings], Hep G2 Cells, CSNO, S-nitroso-l-cysteine, Sorafenib, Caspase 9, Cell biology, Gene Expression Regulation, Neoplastic, Receptors, Tumor Necrosis Factor, Type I, H2O2, hydrogen peroxide, Anatomy::Cells::Cells, Cultured::Tumor Cells, Cultured::Cell Line, Tumor::Hep G2 Cells [Medical Subject Headings], Signal transduction, Chemicals and Drugs::Heterocyclic Compounds::Acids, Heterocyclic::Nicotinic Acids::Niacinamide [Medical Subject Headings], medicine.drug, Research Paper, Signal Transduction, Niacinamide, Programmed cell death, Nitric Oxide Synthase Type III, TRAIL-R1, tumor necrosis factor-related apoptosis-inducing ligand type I, Muerte Celular, Diseases::Digestive System Diseases::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings], Antineoplastic Agents, Biology, Nitric Oxide, NO, medicine, Death-receptors, Humans, Caspasa 3, Nitric Oxide Donors, Cysteine, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Nitric Oxide Donors [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Death Domain [Medical Subject Headings], FADD, Fas-associated death domain, NO, nitric oxide, S-Nitrosothiols, Óxido Nítrico, NONOate, 1,1-diethyl-2-hydroxy-2-nitroso-hydrazine sodium, Phenylurea Compounds, Organic Chemistry, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings], digestive system diseases, S-nitrosylation, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings], Receptors, TNF-Related Apoptosis-Inducing Ligand, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amino Acid Oxidoreductases::Nitric Oxide Synthase::Nitric Oxide Synthase Type III [Medical Subject Headings], biology.protein, Cancer research, DAF-FM, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate, O2·−, superoxide anion, Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Fragmentation [Medical Subject Headings], Compuestos de Fenilurea

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b6e36ed61083a2525dbb900b9fc31
https://hdl.handle.net/10668/2005