نتائج البحث - "Corkill, DJ"

المؤلفون: Ouberai MM; Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge, United Kingdom., Gomes Dos Santos AL; Advanced Drug Delivery, Pharmaceutical Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Kinna S; Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge, United Kingdom., Hornigold DC; Cardiovascular, Renal and Metabolic Diseases, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Baker D; Cardiovascular, Renal and Metabolic Diseases, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Naylor J; Cardiovascular, Renal and Metabolic Diseases, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Liang L; Cardiovascular, Renal and Metabolic Diseases, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom., Corkill DJ; Bioscience In Vivo, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals, R&D, AstraZeneca, Cambridge, United Kingdom., Welland ME; Nanoscience Centre, Department of Engineering, University of Cambridge, Cambridge, United Kingdom.

المصدر: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jul 24; Vol. 14, pp. 1217021. Date of Electronic Publication: 2023 Jul 24 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE

مواضيع طبية MeSH: Glucagon*/metabolism , Glucagon-Like Peptide 1*/pharmacology, Eating/physiology ; Oxyntomodulin/chemistry ; Oxyntomodulin/pharmacology ; Peptide Hydrolases ; Peptides/pharmacology ; Receptors, Glucagon/metabolism ; Animals

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Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction.

المؤلفون: England E; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Rees DG; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Scott IC; Translational Science and Experimental Medicine, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Carmen S; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chan DTY; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Chaillan Huntington CE; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Houslay KF; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Erngren T; Drug Metabolism and Pharmacokinetics, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Penney M; Early Oncology DMPK, Oncology R&D, AstraZeneca, Cambridge, UK., Majithiya JB; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Rapley L; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Sims DA; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Gaithersburg, MD, USA., Hollins C; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Hinchy EC; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Strain MD; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Kemp BP; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Corkill DJ; Bioscience In Vivo, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., May RD; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Vousden KA; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Butler RJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Mustelin T; Division of Rheumatology, Department of Medicine, University of Washington, Seattle, WA, USA., Vaughan TJ; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Lowe DC; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Colley C; Biologics Engineering, R&D, AstraZeneca, Cambridge, UK., Cohen ES; Bioscience Asthma and Skin Immunity, Research and Early Development, Respiratory & Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK. suzanne.cohen@astrazeneca.com.

المصدر: Scientific reports [Sci Rep] 2023 Jun 17; Vol. 13 (1), pp. 9825. Date of Electronic Publication: 2023 Jun 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Interleukin-1 Receptor-Like 1 Protein*/metabolism , Inflammation*/metabolism, Mice ; Humans ; Animals ; Interleukin-33/metabolism ; Cytokines/metabolism ; ErbB Receptors/metabolism ; Signal Transduction

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Chronic pharmacological antagonism of the GM-CSF receptor in mice does not replicate the pulmonary alveolar proteinosis phenotype but does alter lung surfactant turnover.

المؤلفون: Corkill DJ; Research and Early Development, Respiratory & Immunology (R&I), AstraZeneca, Cambridge, U.K., Hunt AN; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Hinrichs MJ; Biologics Safety Assessment, AstraZeneca, Gaithersburg, MD, U.S.A., White N; Bioanalytical Sciences, AstraZeneca, Cambridge, U.K., Rebelatto M; Biologics Safety Assessment, AstraZeneca, Gaithersburg, MD, U.S.A., Roskos L; Biologics Safety Assessment, AstraZeneca, Gaithersburg, MD, U.S.A., Nys J; Research and Early Development, Respiratory & Immunology (R&I), AstraZeneca, Cambridge, U.K., Scott A; Biologics Safety Assessment, AstraZeneca, Cambridge, U.K., Robinson MJ; Research and Early Development, Respiratory & Immunology (R&I), AstraZeneca, Cambridge, U.K., Ryan P; Biologics Safety Assessment, AstraZeneca, Gaithersburg, MD, U.S.A., Postle AD; Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton SO16 6YD, U.K., Sleeman MA; Research and Early Development, Respiratory & Immunology (R&I), AstraZeneca, Cambridge, U.K.

المصدر: Clinical science (London, England : 1979) [Clin Sci (Lond)] 2021 Nov 26; Vol. 135 (22), pp. 2559-2573.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Portland Press on behalf of the Medical Research Society and the Biochemical Society Country of Publication: England NLM ID: 7905731 Publication Model: Print Cited Medium: Internet ISSN: 1470-8736 (Electronic) Linking ISSN: 01435221 NLM ISO Abbreviation: Clin Sci (Lond) Subsets: MEDLINE

مواضيع طبية MeSH: Arthritis, Rheumatoid/*metabolism , COVID-19/*therapy , Pulmonary Alveolar Proteinosis/*immunology , Pulmonary Surfactants/*metabolism , Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*antagonists & inhibitors , Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*metabolism, Animals ; Antibodies, Monoclonal, Humanized/pharmacology ; Arthritis, Rheumatoid/therapy ; Autoantibodies/chemistry ; Bronchoalveolar Lavage Fluid ; COVID-19/immunology ; Choline/analogs & derivatives ; Female ; Granulocyte-Macrophage Colony-Stimulating Factor/chemistry ; Inflammation ; Interleukin-6/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Phenotype ; Pulmonary Alveolar Proteinosis/genetics ; SARS-CoV-2/immunology ; Surface-Active Agents

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دورية أكاديمية

Neutrophil GM-CSF receptor dynamics in acute lung injury.

المؤلفون: De Alessandris S; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Ferguson GJ; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Dodd AJ; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Juss JK; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Devaprasad A; Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Centre, Utrecht, Netherlands., Piper S; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Wyatt O; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Killick H; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Corkill DJ; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Cohen ES; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Pandit A; Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Centre, Utrecht, Netherlands., Radstake TRDJ; Department of Rheumatology and Clinical Immunology and Laboratory of Translational Immunology, University Medical Centre, Utrecht, Netherlands., Simmonds R; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Condliffe AM; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Sleeman MA; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Cowburn AS; Department of Medicine, University of Cambridge, Cambridge, United Kingdom., Finch DK; Respiratory, Inflammation and Autoimmunity, MedImmune Ltd., Cambridge, United Kingdom., Chilvers ER; Department of Medicine, University of Cambridge, Cambridge, United Kingdom.

المصدر: Journal of leukocyte biology [J Leukoc Biol] 2019 Jun; Vol. 105 (6), pp. 1183-1194. Date of Electronic Publication: 2019 Apr 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 8405628 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-3673 (Electronic) Linking ISSN: 07415400 NLM ISO Abbreviation: J Leukoc Biol Subsets: MEDLINE

مواضيع طبية MeSH: Acute Lung Injury/*immunology , Gene Expression Regulation/*immunology , Neutrophils/*immunology , Pulmonary Alveoli/*immunology , Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/*immunology, Acute Lung Injury/chemically induced ; Acute Lung Injury/genetics ; Acute Lung Injury/pathology ; Adult ; Animals ; Cell Line, Tumor ; Cytokine Receptor Common beta Subunit/genetics ; Cytokine Receptor Common beta Subunit/immunology ; Disease Models, Animal ; Female ; Humans ; Lipopolysaccharides/toxicity ; Male ; Mice ; Mice, Inbred BALB C ; Mice, Transgenic ; Neutrophils/pathology ; Pulmonary Alveoli/pathology ; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/genetics ; Time Factors

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