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1
المصدر: Front Cell Dev Biol.
URL الوصول: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::d12db7ff0cc277070fded33a2ed13d65
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المؤلفون: Forster, M, Chaikuad, A, Bauer, SM, Holstein, J, Robers, MB, Corona, CR, Gehringer, M, Pfaffenrot, E, Ghoreschi, K, Knapp, S, Laufer, SA
المصدر: Cell Chemical Biology, 23 (11)
Cell Chemical Biologyمصطلحات موضوعية: Binding Sites, T-Lymphocytes, chemical probe, Janus Kinase 3, Brief Communication, kinome selectivity, Molecular Docking Simulation, covalent reversible inhibitor, Drug Discovery, Janus kinases, Humans, JAK3, Protein Kinase Inhibitors, Signal Transduction
وصف الملف: application/application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7ee3c3020c7581505aea9d568fe0541
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3دورية أكاديمية
المؤلفون: Němec V; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Remeš M; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Beňovský P; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Böck MC; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Šranková E; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Wong JF; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Williams E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Tse LH; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Gomolková R; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Fafílek B; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Kahounová Z; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Víchová R; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Vacek O; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Berger BT; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Corona CR; Promega Corporation, Madison, Wisconsin 53716, United States., Vasta JD; Promega Corporation, Madison, Wisconsin 53716, United States., Robers MB; Promega Corporation, Madison, Wisconsin 53716, United States., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Souček K; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Paruch K; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.
المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12632-12659. Date of Electronic Publication: 2024 Jul 18.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Activin Receptors, Type II*/metabolism , Activin Receptors, Type II*/antagonists & inhibitors, Animals ; Humans ; Mice ; Activin Receptors, Type I/antagonists & inhibitors ; Activin Receptors, Type I/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Signal Transduction/drug effects ; Drug Discovery ; Molecular Probes/chemistry ; Bone Morphogenetic Proteins/metabolism ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrazoles/chemical synthesis
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4دورية أكاديمية
المؤلفون: Teske KA; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Su W; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Corona CR; Promega Biosciences Incorporated, 277 Granada Drive, San Luis Obispo, CA 93401, USA., Wen J; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Deng J; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Ping Y; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Zhang Z; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Zhang Q; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Wilkinson J; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Beck MT; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Nealey KR; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Cong M; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Meisenheimer PL; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Kuai L; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China. Electronic address: letian_kuai@wuxiapptec.com., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA. Electronic address: matt.robers@promega.com.
المصدر: Cell chemical biology [Cell Chem Biol] 2023 Aug 17; Vol. 30 (8), pp. 987-998.e24. Date of Electronic Publication: 2023 Jul 24.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE
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5دورية أكاديمية
المؤلفون: Murray NH; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Asquith CRM; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Fang Z; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., East MP; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ptak N; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Smith RW; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Zimprich CA; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Robers MB; Promega Corporation, Madison, WI, USA., Johnson GL; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bingman CA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Pagliarini DJ; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. pagliarini@wustl.edu.; Morgridge Institute for Research, Madison, WI, USA. pagliarini@wustl.edu.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.
المصدر: Nature chemical biology [Nat Chem Biol] 2023 Feb; Vol. 19 (2), pp. 230-238. Date of Electronic Publication: 2022 Oct 27.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
مواضيع طبية MeSH: Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae Proteins*/metabolism, Humans ; Ubiquinone/pharmacology ; Ubiquinone/chemistry
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6دورية أكاديمية
المؤلفون: Vasta JD; Promega Corporation, Madison, WI, USA., Peacock DM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Zheng Q; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Walker JA; Promega Corporation, Madison, WI, USA., Zhang Z; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Zimprich CA; Promega Corporation, Madison, WI, USA., Thomas MR; Promega Corporation, Madison, WI, USA., Beck MT; Promega Corporation, Madison, WI, USA., Binkowski BF; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Robers MB; Promega Corporation, Madison, WI, USA. Matt.Robers@promega.com., Shokat KM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.
المصدر: Nature chemical biology [Nat Chem Biol] 2022 Jun; Vol. 18 (6), pp. 596-604. Date of Electronic Publication: 2022 Mar 21.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
مواضيع طبية MeSH: Multiple Myeloma* , Proto-Oncogene Proteins p21(ras)*/genetics, Humans ; Ligands ; Mutation
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7دورية أكاديمية
المؤلفون: Wittlinger F; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Heppner DE; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., To C; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Günther M; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Shin BH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Rana JK; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Berger LM; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Berger BT; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Bauer N; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Corona CR; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Knapp S; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States.; Belfer Center for Applied Cancer Science, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Laufer SA; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany.
المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Jan 27; Vol. 65 (2), pp. 1370-1383. Date of Electronic Publication: 2021 Oct 20.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
مواضيع طبية MeSH: Drug Design* , Mutation*, Carcinoma, Non-Small-Cell Lung/*drug therapy , Drug Resistance, Neoplasm/*drug effects , Imidazoles/*chemistry , Protein Kinase Inhibitors/*pharmacology, Acrylamides/pharmacology ; Allosteric Site ; Aniline Compounds/pharmacology ; Antineoplastic Agents/pharmacology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology
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8دورية أكاديمية
المؤلفون: Vasta JD; Promega Corporation, Fitchburg, WI, USA. jim.vasta@promega.com., Corona CR; Promega Corporation, Fitchburg, WI, USA., Robers MB; Promega Corporation, Fitchburg, WI, USA.
المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2365, pp. 265-282.
نوع المنشور: Journal Article
بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE
مواضيع طبية MeSH: Cell Membrane Permeability* , Ubiquitin-Protein Ligases*/metabolism, Permeability ; Proteolysis
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9دورية أكاديمية
المؤلفون: Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Corona CR; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Wilkinson J; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Zimprich CA; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Ingold MR; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Pickett JE; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Pugh KM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Schwinn MK; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Hwang BB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Zegzouti H; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Huber KVM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Cong M; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Meisenheimer PL; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. tim.willson@unc.edu., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA. matt.robers@promega.com.
المصدر: Nature communications [Nat Commun] 2020 Jun 02; Vol. 11 (1), pp. 2743. Date of Electronic Publication: 2020 Jun 02.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
مواضيع طبية MeSH: Cell Cycle Checkpoints/*drug effects , Cyclin-Dependent Kinase Inhibitor Proteins/*pharmacology , Cyclin-Dependent Kinases/*antagonists & inhibitors, CDC2 Protein Kinase ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Cyclin-Dependent Kinase 9 ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Phosphorylation ; Structure-Activity Relationship
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10دورية أكاديمية
المؤلفون: Ferguson FM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liu Y; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Leggett AL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Kuljanin M; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., He S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sulahian R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li L; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Poulin EJ; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Huang L; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Koren J; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Dieguez-Martinez N; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Espinosa S; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Zeng Z; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Ohi R; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA., Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea and KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea., Kim ND; NDBio Therapeutics Inc, Incheon, Republic of Korea., Harshbarger W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; GSK Vaccines, Rockville, MD, USA., Lizcano JM; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Robers MB; Promega Corporation, Madison, WI, USA., Muthaswamy S; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Departments of Medicine and Pathology, Harvard Medical School, Boston, MA, USA., Lin CY; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Haigis KM; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA, USA., Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Westover KD; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.
المصدر: Nature chemical biology [Nat Chem Biol] 2020 Jun; Vol. 16 (6), pp. 635-643. Date of Electronic Publication: 2020 Apr 06.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE
مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal/*drug therapy , Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors , Pancreatic Neoplasms/*drug therapy , Protein Kinase Inhibitors/*chemistry , Protein Serine-Threonine Kinases/*antagonists & inhibitors, Animals ; Cell Line, Tumor ; Cell Movement ; Doublecortin Protein ; Doublecortin-Like Kinases ; Drug Screening Assays, Antitumor ; Gene Expression Regulation ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacokinetics ; Proteomics ; Rats ; Structure-Activity Relationship ; Zebrafish ; Pancreatic Neoplasms