المؤلفون: Schwalm MP, Berger LM, Meuter MN, Vasta JD, Corona CR, Röhm S, Berger BT, Farges F, Beinert SM, Preuss F, Morasch V, Rogov VV, Mathea S, Saxena K, Robers MB, Müller S, Knapp S.

المصدر: Front Cell Dev Biol.

URL الوصول: https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::d12db7ff0cc277070fded33a2ed13d65

المؤلفون: Forster, M, Chaikuad, A, Bauer, SM, Holstein, J, Robers, MB, Corona, CR, Gehringer, M, Pfaffenrot, E, Ghoreschi, K, Knapp, S, Laufer, SA

المصدر: Cell Chemical Biology, 23 (11)
Cell Chemical Biology

مصطلحات موضوعية: Binding Sites, T-Lymphocytes, chemical probe, Janus Kinase 3, Brief Communication, kinome selectivity, Molecular Docking Simulation, covalent reversible inhibitor, Drug Discovery, Janus kinases, Humans, JAK3, Protein Kinase Inhibitors, Signal Transduction

وصف الملف: application/application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f7ee3c3020c7581505aea9d568fe0541

المؤلفون: Němec V; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany.; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Remeš M; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Beňovský P; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Böck MC; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Šranková E; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic., Wong JF; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Cros J; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Williams E; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Tse LH; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Smil D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Ensan D; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Isaac MB; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, 661 University Avenue, Toronto, Ontario M5G 0A3, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Gomolková R; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic., Ursachi VC; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Fafílek B; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Kahounová Z; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Víchová R; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Vacek O; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Berger BT; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States., Corona CR; Promega Corporation, Madison, Wisconsin 53716, United States., Vasta JD; Promega Corporation, Madison, Wisconsin 53716, United States., Robers MB; Promega Corporation, Madison, Wisconsin 53716, United States., Krejci P; Department of Biology, Faculty of Medicine, Masaryk University, 625 00 Brno, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic., Souček K; International Clinical Research Center, St. Anne's University Hospital, 602 00 Brno, Czech Republic.; Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno Czech Republic., Bullock AN; Centre for Medicines Discovery, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7FZ, U.K., Knapp S; Institute for Pharmaceutical Chemistry, Structural Genomics Consortium, Johann Wolfgang Goethe-University, Max-von-Laue-Strasse 9, Frankfurt am Main, 60438, Germany., Paruch K; Department of Chemistry, Masaryk University, Brno 625 00, Czech Republic.; Institute of Animal Physiology and Genetics of the Czech Academy of Sciences, 602 00 Brno, Czech Republic.

المصدر: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 12632-12659. Date of Electronic Publication: 2024 Jul 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Activin Receptors, Type II*/metabolism , Activin Receptors, Type II*/antagonists & inhibitors, Animals ; Humans ; Mice ; Activin Receptors, Type I/antagonists & inhibitors ; Activin Receptors, Type I/metabolism ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/chemistry ; Structure-Activity Relationship ; Signal Transduction/drug effects ; Drug Discovery ; Molecular Probes/chemistry ; Bone Morphogenetic Proteins/metabolism ; Pyrazoles/chemistry ; Pyrazoles/pharmacology ; Pyrazoles/chemical synthesis

المؤلفون: Teske KA; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Su W; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Corona CR; Promega Biosciences Incorporated, 277 Granada Drive, San Luis Obispo, CA 93401, USA., Wen J; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Deng J; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Ping Y; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Zhang Z; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Zhang Q; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China., Wilkinson J; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Beck MT; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Nealey KR; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Cong M; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Meisenheimer PL; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA., Kuai L; WuXi AppTec Headquarters, 288 Fute Shong Road Waigaopqiao Free Trade Zone, Pudong District, Shanghai 200131, China. Electronic address: letian_kuai@wuxiapptec.com., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, WI 53711, USA. Electronic address: matt.robers@promega.com.

المصدر: Cell chemical biology [Cell Chem Biol] 2023 Aug 17; Vol. 30 (8), pp. 987-998.e24. Date of Electronic Publication: 2023 Jul 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Research*, Ligands

المؤلفون: Murray NH; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.; Morgridge Institute for Research, Madison, WI, USA.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., Asquith CRM; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Structural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland., Fang Z; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA., East MP; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Ptak N; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Smith RW; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Zimprich CA; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Robers MB; Promega Corporation, Madison, WI, USA., Johnson GL; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bingman CA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA., Pagliarini DJ; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA. pagliarini@wustl.edu.; Morgridge Institute for Research, Madison, WI, USA. pagliarini@wustl.edu.; Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.; Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.; Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. pagliarini@wustl.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2023 Feb; Vol. 19 (2), pp. 230-238. Date of Electronic Publication: 2022 Oct 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Saccharomyces cerevisiae*/metabolism , Saccharomyces cerevisiae Proteins*/metabolism, Humans ; Ubiquinone/pharmacology ; Ubiquinone/chemistry

المؤلفون: Vasta JD; Promega Corporation, Madison, WI, USA., Peacock DM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Zheng Q; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Walker JA; Promega Corporation, Madison, WI, USA., Zhang Z; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA., Zimprich CA; Promega Corporation, Madison, WI, USA., Thomas MR; Promega Corporation, Madison, WI, USA., Beck MT; Promega Corporation, Madison, WI, USA., Binkowski BF; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Robers MB; Promega Corporation, Madison, WI, USA. Matt.Robers@promega.com., Shokat KM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA. Kevan.Shokat@ucsf.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2022 Jun; Vol. 18 (6), pp. 596-604. Date of Electronic Publication: 2022 Mar 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Multiple Myeloma* , Proto-Oncogene Proteins p21(ras)*/genetics, Humans ; Ligands ; Mutation

المؤلفون: Wittlinger F; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Heppner DE; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., To C; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Günther M; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany., Shin BH; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Rana JK; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Schmoker AM; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Beyett TS; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Berger LM; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Berger BT; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Bauer N; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Corona CR; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Fitchburg, Wisconsin 53711, United States., Knapp S; Structural Genomics Consortium, Institute for Pharmaceutical Chemistry, Johann Wolfgang Goethe University, Max-von-Laue-Straße 9, 60438 Frankfurt am Main, Germany.; Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe University, Max-von-Laue-Straße 15, 60438 Frankfurt am Main, Germany., Jänne PA; Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Department of Medical Oncology, Department of Medicine, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States.; Belfer Center for Applied Cancer Science, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Eck MJ; Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Longwood Center, 360 Longwood Avenue, Boston, Massachusetts 02215, United States., Laufer SA; Institute of Pharmaceutical Sciences, Eberhard Karls Universität Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.; Cluster of Excellence iFIT (EXC 2180) 'Image-Guided and Functionally Instructed Tumor Therapies', Eberhard Karls Universität Tübingen, 72076 Tübingen, Germany.; Tübingen Center for Academic Drug Discovery & Development (TüCAD2), 72076 Tübingen, Germany.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 Jan 27; Vol. 65 (2), pp. 1370-1383. Date of Electronic Publication: 2021 Oct 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Design* , Mutation*, Carcinoma, Non-Small-Cell Lung/*drug therapy , Drug Resistance, Neoplasm/*drug effects , Imidazoles/*chemistry , Protein Kinase Inhibitors/*pharmacology, Acrylamides/pharmacology ; Allosteric Site ; Aniline Compounds/pharmacology ; Antineoplastic Agents/pharmacology ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology

المؤلفون: Vasta JD; Promega Corporation, Fitchburg, WI, USA. jim.vasta@promega.com., Corona CR; Promega Corporation, Fitchburg, WI, USA., Robers MB; Promega Corporation, Fitchburg, WI, USA.

المصدر: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2021; Vol. 2365, pp. 265-282.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Humana Press Country of Publication: United States NLM ID: 9214969 Publication Model: Print Cited Medium: Internet ISSN: 1940-6029 (Electronic) Linking ISSN: 10643745 NLM ISO Abbreviation: Methods Mol Biol Subsets: MEDLINE

مواضيع طبية MeSH: Cell Membrane Permeability* , Ubiquitin-Protein Ligases*/metabolism, Permeability ; Proteolysis

المؤلفون: Wells CI; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Vasta JD; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Corona CR; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Wilkinson J; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Zimprich CA; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Ingold MR; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Pickett JE; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Drewry DH; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA., Pugh KM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Schwinn MK; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Hwang BB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Zegzouti H; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Huber KVM; Target Discovery Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Cong M; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Meisenheimer PL; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA., Willson TM; Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. tim.willson@unc.edu., Robers MB; Promega Corporation, 2800 Woods Hollow Road, Madison, WI, 53711, USA. matt.robers@promega.com.

المصدر: Nature communications [Nat Commun] 2020 Jun 02; Vol. 11 (1), pp. 2743. Date of Electronic Publication: 2020 Jun 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle Checkpoints/*drug effects , Cyclin-Dependent Kinase Inhibitor Proteins/*pharmacology , Cyclin-Dependent Kinases/*antagonists & inhibitors, CDC2 Protein Kinase ; Cyclin-Dependent Kinase 2 ; Cyclin-Dependent Kinase 4 ; Cyclin-Dependent Kinase 6 ; Cyclin-Dependent Kinase 9 ; Enzyme Inhibitors/pharmacology ; HEK293 Cells ; Humans ; Phosphorylation ; Structure-Activity Relationship

المؤلفون: Ferguson FM; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Liu Y; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Leggett AL; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Kuljanin M; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yang A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., He S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wang J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sulahian R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Li L; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Poulin EJ; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Huang L; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Koren J; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Dieguez-Martinez N; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Espinosa S; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Zeng Z; Promega Corporation, Madison, WI, USA., Corona CR; Promega Corporation, Madison, WI, USA., Vasta JD; Promega Corporation, Madison, WI, USA., Ohi R; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, MI, USA., Sim T; Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul, Republic of Korea and KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea., Kim ND; NDBio Therapeutics Inc, Incheon, Republic of Korea., Harshbarger W; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; GSK Vaccines, Rockville, MD, USA., Lizcano JM; Departament de Bioquímica i Biologia Molecular & Institut de Neurociencies, Facultat de Medicina. Universitat Autonoma de Barcelona, Bellaterra, Spain., Robers MB; Promega Corporation, Madison, WI, USA., Muthaswamy S; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Departments of Medicine and Pathology, Harvard Medical School, Boston, MA, USA., Lin CY; Department of Molecular and Human Genetics, Therapeutic Innovation Center Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX, USA., Look AT; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Division of Pediatric Hematology/Oncology, Boston Children's Hospital, Boston, MA, USA., Haigis KM; Cancer Research Institute and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.; Harvard Digestive Disease Center, Harvard Medical School, Boston, MA, USA., Mancias JD; Division of Radiation and Genome Stability, Department of Radiation Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Westover KD; Departments of Biochemistry and Radiation Oncology, the University of Texas Southwestern Medical Center, Dallas, TX, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. nathanael_gray@dfci.harvard.edu.

المصدر: Nature chemical biology [Nat Chem Biol] 2020 Jun; Vol. 16 (6), pp. 635-643. Date of Electronic Publication: 2020 Apr 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal/*drug therapy , Intracellular Signaling Peptides and Proteins/*antagonists & inhibitors , Pancreatic Neoplasms/*drug therapy , Protein Kinase Inhibitors/*chemistry , Protein Serine-Threonine Kinases/*antagonists & inhibitors, Animals ; Cell Line, Tumor ; Cell Movement ; Doublecortin Protein ; Doublecortin-Like Kinases ; Drug Screening Assays, Antitumor ; Gene Expression Regulation ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Male ; Mice ; Molecular Docking Simulation ; Molecular Structure ; Protein Kinase Inhibitors/pharmacokinetics ; Proteomics ; Rats ; Structure-Activity Relationship ; Zebrafish ; Pancreatic Neoplasms