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1Compartmentalized Actions of the Plasminogen Activator Inhibitors, PAI-1 and Nsp, in Ischemic Stroke
المؤلفون: Daniel Torrente, Enming Joseph Su, Linda Fredriksson, Mark Warnock, David Bushart, Kris M. Mann, Cory D. Emal, Daniel A. Lawrence
المصدر: Translational stroke research. 13(5)
مصطلحات موضوعية: Mice, Blood-Brain Barrier, General Neuroscience, Tissue Plasminogen Activator, Neuropeptides, Plasminogen Activator Inhibitor 1, Animals, Neurology (clinical), Cardiology and Cardiovascular Medicine, Hemorrhagic Disorders, Serpins, Cerebral Hemorrhage, Ischemic Stroke
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2
المؤلفون: Daniel A. Lawrence, Ashley A. Reinke, Naga Sandhya Guntaka, Jose A. Diaz, Cory D. Emal, Maxim E. Shaydakov, Shih Hon Li, Mark Warnock, Enming J. Su
المصدر: Journal of Biological Chemistry. 294:1464-1477
مصطلحات موضوعية: 0301 basic medicine, Serine protease, 030102 biochemistry & molecular biology, biology, Drug discovery, Chemistry, Cell Biology, Pharmacology, Serpin, Biochemistry, Small molecule, 03 medical and health sciences, 030104 developmental biology, In vivo, biology.protein, Vitronectin, Molecular Biology, Plasminogen activator, Ex vivo
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::0cc89e4808199cbb43a481e21a40e234
https://doi.org/10.1074/jbc.ra118.004885 -
3
المؤلفون: William R. Roush, Michael Mareš, Pavla Fajtová, Jiří Brynda, Martin Lepšík, Cory D. Emal, Pavlína Řezáčová, Adam R. Renslo, Adéla Jílková, Jindřich Fanfrlík, Martin Horn, Helena Mertlíková-Kaiserová, Conor R. Caffrey, Petra Rubešová
المصدر: ACS Infectious Diseases
مصطلحات موضوعية: 0301 basic medicine, Peptidomimetic, cathepsin B, 030106 microbiology, Druggability, Schistosomiasis, Cathepsin B, Article, drug target, 03 medical and health sciences, medicine, Moiety, Animals, Humans, Sulfones, vinyl sulfone inhibitor, Schistosoma, biology, Chemistry, Rational design, Schistosoma mansoni, biology.organism_classification, medicine.disease, 030104 developmental biology, Infectious Diseases, Biochemistry, parasite, cysteine peptidase
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4
المؤلفون: Daniel A. Lawrence, Manisha Vadali, Hekmat B Khoukaz, Ahmed A. Abdelhamid, Yan Ji, Drew J. Braet, Cory D. Emal, William P. Fay
المصدر: Arterioscler Thromb Vasc Biol
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Cellular senescence, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Fibrinolysis, Plasminogen Activator Inhibitor 1, medicine, Animals, Obesity, Cellular Senescence, Metabolic Syndrome, Mice, Knockout, Indoleacetic Acids, business.industry, Macrophages, medicine.disease, Atherosclerosis, Plaque, Atherosclerotic, Disease Models, Animal, 030104 developmental biology, Targeted drug delivery, chemistry, Receptors, LDL, Murine model, Diet, Western, Plasminogen activator inhibitor-1, Cancer research, Metabolic syndrome, Cardiology and Cardiovascular Medicine, business, Plasminogen activator
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f07da8646849f86282c2626e76e285b
https://europepmc.org/articles/PMC7255962/ -
5
المؤلفون: Cory D. Emal, Daniel A. Lawrence, Shih Hon Li, Mary Migliorini, Dudley K. Strickland, Anqi Zhou
المصدر: J Biol Chem
مصطلحات موضوعية: 0301 basic medicine, Lysine, Serpin, Biochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Plasminogen Activator Inhibitor 1, Humans, Site-directed mutagenesis, Molecular Biology, chemistry.chemical_classification, Binding Sites, 030102 biochemistry & molecular biology, Cell Biology, LRP1, 030104 developmental biology, Enzyme, chemistry, Amino Acid Substitution, Plasminogen activator inhibitor-1, LDL receptor, Biophysics, Plasminogen activator, Low Density Lipoprotein Receptor-Related Protein-1, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef4984bdf38a2681404b6e259a466e5
https://europepmc.org/articles/PMC6952620/ -
6
المؤلفون: Ashley A, Reinke, Shih-Hon, Li, Mark, Warnock, Maxim E, Shaydakov, Naga Sandhya, Guntaka, Enming J, Su, Jose A, Diaz, Cory D, Emal, Daniel A, Lawrence
المصدر: The Journal of biological chemistry. 294(5)
مصطلحات موضوعية: Small Molecule Libraries, Mice, Serine Proteinase Inhibitors, Genes, Reporter, Plasminogen Activator Inhibitor 1, Enzymology, Animals, Humans, Calorimetry, Fluorescence, Serpins, High-Throughput Screening Assays, Rats
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::12fcd025f91beb104d063b0177e1e05c
https://pubmed.ncbi.nlm.nih.gov/30510136 -
7
المؤلفون: Enming J. Su, Paul R. North, Shih Hon Li, Jacqueline M. Cale, Karen L. Sanders, Daniel A. Lawrence, Cory D. Emal, Mark Warnock, Maria M. Puscau
المصدر: Journal of Biological Chemistry. 285:7892-7902
مصطلحات موضوعية: medicine.medical_treatment, Mice, Transgenic, Serpin, Biochemistry, Mice, chemistry.chemical_compound, Phenols, In vivo, Plasminogen Activator Inhibitor 1, Serpin E2, medicine, Animals, Humans, Protease Inhibitors, Vitronectin, Molecular Biology, Serpins, Flavonoids, Protease, biology, Polyphenols, Cell Biology, Surface Plasmon Resonance, Recombinant Proteins, Protease inhibitor (biology), Mice, Inbred C57BL, Mechanism of action, chemistry, Drug Design, Plasminogen activator inhibitor-1, Protein Structure and Folding, biology.protein, Electrophoresis, Polyacrylamide Gel, medicine.symptom, Plasminogen activator, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ded305ee8ea485b0fa42884303c2459c
https://doi.org/10.1074/jbc.m109.067967 -
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المؤلفون: Cory D. Emal, Shih Hon Li, Nadine C. El-Ayache, Daniel A. Lawrence, Mark Warnock
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:966-970
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Serpin, Biochemistry, Chemical synthesis, Article, chemistry.chemical_compound, Plasminogen Activator Inhibitor 1, Drug Discovery, Plasminogen Inactivators, Humans, Molecular Biology, Sulfonyl, chemistry.chemical_classification, Sulfonamides, biology, Aryl, Organic Chemistry, chemistry, Enzyme inhibitor, Plasminogen activator inhibitor-1, biology.protein, Molecular Medicine, Plasminogen activator
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9
المؤلفون: Shih Hon Li, James C. Whisstock, Ashley A. Reinke, Cory D. Emal, Karen L. Sanders, Jeanne A. Stuckey, Daniel A. Lawrence
المصدر: Proceedings of the National Academy of Sciences. 110
مصطلحات موضوعية: Proteases, animal structures, Allosteric regulation, Serpin, Crystallography, X-Ray, Protein Structure, Secondary, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Plasminogen Activator Inhibitor 1, Humans, Vitronectin, Binding site, Multidisciplinary, biology, Small molecule, Protein Structure, Tertiary, carbohydrates (lipids), PNAS Plus, Biochemistry, chemistry, Plasminogen activator inhibitor-1, embryonic structures, biology.protein, Plasminogen activator, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041d8b8175c05bd16ee62cccff0b8da2
https://doi.org/10.1073/pnas.1216499110