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المؤلفون: Naeem MM; Institute of Medical Science., Maheshan R; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Costford SR; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Wahedi A; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada., Trajkovski M; National Institute of Chemistry, Slovenian NMR Center, Ljubljana, Slovenia., Plavec J; National Institute of Chemistry, Slovenian NMR Center, Ljubljana, Slovenia., Yatsunyk LA; Department of Chemistry and Biochemistry, Swarthmore College, Swarthmore PA, USA., Ciesielski GL; Department of Chemistry, Auburn University at Montgomery, Montgomery, AL, USA., Kaufman BA; Center for Metabolism and Mitochondrial Medicine, Division of Cardiology, Vascular Medicine Institute, Department of Medicine, University of Pittsburgh Medical School, Pittsburgh, PA, USA., Sondheimer N; Institute of Medical Science.; Departments of Paediatrics and Molecular Genetics, The University of Toronto, Toronto, ON, Canada.; Program in Genetics and Genome Biology, The Hospital for Sick Children, Toronto, ON, Canada.

المصدر: Human molecular genetics [Hum Mol Genet] 2019 Oct 01; Vol. 28 (19), pp. 3163-3174.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Berberine Alkaloids/*pharmacology , DNA, Mitochondrial/*genetics , Leigh Disease/*genetics, Berberine/chemistry ; Berberine Alkaloids/chemistry ; Cells, Cultured ; DNA Polymerase gamma/metabolism ; DNA, Mitochondrial/chemistry ; DNA, Mitochondrial/drug effects ; Fibroblasts/cytology ; Fibroblasts/drug effects ; G-Quadruplexes/drug effects ; Genetic Variation ; Humans ; Leigh Disease/metabolism

المؤلفون: Brouwers B; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States., Stephens NA; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States., Costford SR; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Hopf ME; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Ayala JE; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Yi F; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States., Xie H; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States., Li JL; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Gardell SJ; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Sparks LM; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States.; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States., Smith SR; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, FL, United States.; Sanford Burnham Prebys Medical Discovery Institute, Orlando, FL, United States.

المصدر: Frontiers in physiology [Front Physiol] 2018 Jun 11; Vol. 9, pp. 704. Date of Electronic Publication: 2018 Jun 11 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101549006 Publication Model: eCollection Cited Medium: Print ISSN: 1664-042X (Print) Linking ISSN: 1664042X NLM ISO Abbreviation: Front Physiol Subsets: PubMed not MEDLINE

المؤلفون: Hogarth KA; Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada., Costford SR; Division of Genetics and Genome Biology, SickKids Research Institute, 686 Bay Street, Toronto, M5G 0A4, Canada., Yoon G; Department of Paediatrics, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada., Sondheimer N; Division of Genetics and Genome Biology, SickKids Research Institute, 686 Bay Street, Toronto, M5G 0A4, Canada.; Department of Paediatrics, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, Canada., Maynes JT; Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada. jason.maynes@sickkids.ca.; Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, M5S 1A8, Canada. jason.maynes@sickkids.ca.

المصدر: Biochemical genetics [Biochem Genet] 2018 Apr; Vol. 56 (1-2), pp. 56-77. Date of Electronic Publication: 2017 Nov 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE

مواضيع طبية MeSH: Mutation, Missense*, GTP Phosphohydrolases/*genetics , Microtubule-Associated Proteins/*genetics , Mitochondria/*genetics , Mitochondrial Dynamics/*genetics , Mitochondrial Proteins/*genetics , Nervous System Diseases/*genetics , Oxidative Stress/*genetics, Amino Acid Substitution ; Dynamins ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; GTP Phosphohydrolases/metabolism ; Homozygote ; Humans ; Male ; Microtubule-Associated Proteins/metabolism ; Mitochondria/metabolism ; Mitochondria/pathology ; Mitochondrial Proteins/metabolism ; Nervous System Diseases/metabolism ; Nervous System Diseases/pathology ; Reactive Oxygen Species/metabolism

المؤلفون: Costford SR; University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario,Canada., Tattoli I; University of Toronto, Toronto, Ontario, Canada., Duan FT; University of Toronto, Toronto, Ontario, Canada., Volchuk A; University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario,Canada., Klip A; University of Toronto, Toronto, Ontario, Canada.; The Hospital for Sick Children, Toronto, Ontario,Canada., Philpott DJ; University of Toronto, Toronto, Ontario, Canada., Woo M; University of Toronto, Toronto, Ontario, Canada.; Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada., Girardin SE; University of Toronto, Toronto, Ontario, Canada.

المصدر: Journal of the Endocrine Society [J Endocr Soc] 2018 Feb 21; Vol. 2 (4), pp. 336-347. Date of Electronic Publication: 2018 Feb 21 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Endocrine Society Country of Publication: United States NLM ID: 101697997 Publication Model: eCollection Cited Medium: Internet ISSN: 2472-1972 (Electronic) Linking ISSN: 24721972 NLM ISO Abbreviation: J Endocr Soc Subsets: PubMed not MEDLINE

المؤلفون: Costford SR; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Brouwers B; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Hopf ME; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Sparks LM; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Dispagna M; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Gomes AP; Harvard Medical School, Boston, MA, USA., Cornnell HH; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Petucci C; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Phelan P; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Xie H; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Yi F; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA., Walter GA; University of Florida, Gainesville, FL, USA., Osborne TF; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Sinclair DA; Harvard Medical School, Boston, MA, USA., Mynatt RL; Pennington Biomedical Research Center, Baton Rouge, LA, USA., Ayala JE; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Gardell SJ; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA., Smith SR; Sanford-Burnham-Prebys Medical Discovery Institute, Orlando, FL, USA; Pennington Biomedical Research Center, Baton Rouge, LA, USA; Translational Research Institute for Metabolism and Diabetes, Orlando, FL, USA. Electronic address: Steven.R.Smith.MD@flhosp.org.

المصدر: Molecular metabolism [Mol Metab] 2018 Jan; Vol. 7, pp. 1-11. Date of Electronic Publication: 2017 Nov 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Oxygen Consumption* , Physical Conditioning, Animal*, Cytokines/*metabolism , Muscle, Skeletal/*metabolism , Nicotinamide Phosphoribosyltransferase/*metabolism, Animals ; Cytokines/genetics ; Diet, High-Fat ; Mice ; Mice, Inbred C57BL ; Mitochondria/metabolism ; Muscle, Skeletal/physiology ; NAD/metabolism ; Nicotinamide Phosphoribosyltransferase/genetics

المؤلفون: Chan KL; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Tam TH; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Boroumand P; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Prescott D; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Costford SR; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Escalante NK; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Fine N; Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada., Tu Y; Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Robertson SJ; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Prabaharan D; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Liu Z; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Bilan PJ; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Salter MW; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Neurosciences and Mental Health Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada., Glogauer M; Matrix Dynamics Group, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5S 3E2, Canada., Girardin SE; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Philpott DJ; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Klip A; Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 0A4, Canada; Department of Physiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address: amira@sickkids.ca.

المصدر: Cell reports [Cell Rep] 2017 Mar 07; Vol. 18 (10), pp. 2415-2426.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Hematopoiesis*/drug effects , Insulin Resistance*, Inflammation/*metabolism , Inflammation/*pathology , Nod1 Signaling Adaptor Protein/*metabolism, Adipose Tissue/pathology ; Animals ; Cell Movement/drug effects ; Cell Polarity/drug effects ; Chemokine CXCL1/metabolism ; Chemotactic Factors/pharmacology ; Diet, High-Fat ; Disease Models, Animal ; Gene Deletion ; Glucose/metabolism ; Inflammation/complications ; Macrophages/drug effects ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Mice, Knockout ; Neutrophil Infiltration/drug effects ; Obesity/blood ; Obesity/complications ; Obesity/pathology

المؤلفون: Sparks LM; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida 32804.; Clinical and Molecular Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827., Redman LM; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808., Conley KE; Departments of Radiology.; Physiology & Biophysics, and.; Bioengineering, University of Washington Medical Center, Seattle, Washington 98195., Harper ME; Department of Biochemistry, Microbiology, and Immunology, University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada., Yi F; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida 32804., Hodges A; Bioinformatics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and., Eroshkin A; Bioinformatics Core, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and., Costford SR; Hospital for Sick Children, Toronto ON M5G 1X8, Canada., Gabriel ME; Clinical and Molecular Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827., Shook C; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida 32804., Cornnell HH; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida 32804., Ravussin E; Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808., Smith SR; Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Orlando, Florida 32804.; Clinical and Molecular Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827.

المصدر: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2017 Jan 01; Vol. 102 (1), pp. 111-121.

نوع المنشور: Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Caloric Restriction* , Energy Metabolism* , Gene Expression Profiling*, Biomarkers/*analysis , Mitochondria, Muscle/*metabolism , Muscle, Skeletal/*metabolism, Adult ; Body Composition ; Body Mass Index ; Body Weight ; Exercise/physiology ; Female ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Oxidative Stress ; Time Factors

المؤلفون: Sparks LM; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Redman LM; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Conley KE; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Harper ME; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Hodges A; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Eroshkin A; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Costford SR; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Gabriel ME; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Yi F; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Shook C; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Cornnell HH; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Ravussin E; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada., Smith SR; Translational Research Institute for Metabolism and Diabetes (L.M.S., F.Y., C.S., H.H.C., S.R.S.), Florida Hospital, Orlando, Florida 32804; Clinical and Molecular Origins of Disease (L.M.S., M.E.G., S.R.S.), Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827; Pennington Biomedical Research Center (L.M.R., E.R.), Louisiana State University System, Baton Rouge, Louisiana 70808; Departments of Radiology, Physiology and Biophysics, and Bioengineering (K.E.C.), University of Washington Medical Center, Seattle, Washington 98195; Department of Biochemistry, Microbiology, and Immunology (M.-E.H.), University of Ottawa, Ottawa, Ontario ON K1N 6N5, Canada; Bioinformatics Core (A.H., A.E.), Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California 92037; and Hospital for Sick Children (S.R.C.), Toronto, Ontario, ON M5G 1X8 Canada.

المصدر: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2016 Dec; Vol. 101 (12), pp. 4994-5003. Date of Electronic Publication: 2016 Oct 06.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Profiling* , Hormesis* , Oxidative Coupling* , Oxidative Stress* , Oxygen Consumption* , Sedentary Behavior*, Adenosine Triphosphate/*metabolism , Mitochondria, Muscle/*metabolism , Muscle, Skeletal/*metabolism, Absorptiometry, Photon ; Adult ; Female ; Humans ; Magnetic Resonance Spectroscopy ; Male ; Middle Aged

المؤلفون: Jeschke MG; Department of Surgery, Division of Plastic Surgery, University of Toronto, Canada; Department of Immunology, University of Toronto, Canada; Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, Toronto, Canada; Sunnybrook Research Institute, Toronto, Canada. Electronic address: marc.jeschke@sunnybrook.ca., Pinto R; Sunnybrook Research Institute, Toronto, Canada., Costford SR; Sunnybrook Research Institute, Toronto, Canada., Amini-Nik S; Sunnybrook Research Institute, Toronto, Canada.

المصدر: Burns : journal of the International Society for Burn Injuries [Burns] 2016 Mar; Vol. 42 (2), pp. 276-81. Date of Electronic Publication: 2016 Jan 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8913178 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1409 (Electronic) Linking ISSN: 03054179 NLM ISO Abbreviation: Burns Subsets: MEDLINE

مواضيع طبية MeSH: Burns/*mortality , Length of Stay/*statistics & numerical data , Sepsis/*epidemiology, Adult ; Age Factors ; Aged ; Body Surface Area ; Burns/pathology ; Cohort Studies ; Databases, Factual ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Prognosis ; Trauma Severity Indices