المؤلفون: Bennett C; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Lawrence M; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Guerrero JA; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Stritt S; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., Waller AK; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Yan Y; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Mifsud RW; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Ballester-Beltrán J; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Baig A; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., Mueller A; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Mayer L; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Warland J; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Penkett CJ; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Akbari P; Medical Research Council/British Heart Foundation Cardiovascular Epidemiology Unit, Strangeways Research Laboratory, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.; Department of Human Genetics, Wellcome Trust Sanger Institute, Cambridge, United Kingdom., Moreau T; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom., Evans AL; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Mookerjee S; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Hoffman GJ; Faculty of Health and Medical Sciences, Medical School, University of Western Australia, Crawley, WA, Australia., Saeb-Parsy K; Department of Surgery, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, United Kingdom., Adams DJ; Wellcome Trust Sanger Institute, Cambridge, United Kingdom; and., Couzens AL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Bender M; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., Erber WN; Faculty of Health and Medical Sciences, Medical School, University of Western Australia, Crawley, WA, Australia., Nieswandt B; Institute of Experimental Biomedicine, University Hospital, University of Würzburg, Würzburg, Germany., Read RJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom., Ghevaert C; Department of Haematology, Cambridge Blood Centre, National Health Service Blood and Transplant, University of Cambridge, Cambridge, United Kingdom.; Jeffrey Cheah Biomedical Centre, Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom.

المصدر: Blood [Blood] 2022 Apr 07; Vol. 139 (14), pp. 2227-2239.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 7603509 Publication Model: Print Cited Medium: Internet ISSN: 1528-0020 (Electronic) Linking ISSN: 00064971 NLM ISO Abbreviation: Blood Subsets: MEDLINE

مواضيع طبية MeSH: Blood Platelets*/metabolism , Thrombocythemia, Essential*/drug therapy, Humans ; Megakaryocytes/metabolism ; Microtubules ; Platelet Count ; Receptors, Cytokine ; Thrombopoiesis/genetics

المؤلفون: Szewczyk MM; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Ishikawa Y; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Organ S; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Sakai N; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Couzens AL; Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, 600 University Ave, Room 992, Toronto, ON, M5G 1X5, Canada., Eram M; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Dilworth D; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Fukushi H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Harding R; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Dela Seña CC; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Sugo T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Hayashi K; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., McLeod D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Zepeda C; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Sánchez-Osuna M; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Bonneil E; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Takagi S; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Tyers M; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Richard S; Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Takizawa M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Gingras AC; Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, 600 University Ave, Room 992, Toronto, ON, M5G 1X5, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada., Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Nara H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. nara@pharm.or.jp., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada. d.barsyte@utoronto.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. d.barsyte@utoronto.ca.; Nature Research Center, Vilnius, Akademijos 2, Lithuania. d.barsyte@utoronto.ca.

المصدر: Nature communications [Nat Commun] 2020 May 26; Vol. 11 (1), pp. 2683. Date of Electronic Publication: 2020 May 26.

نوع المنشور: Journal Article; Published Erratum

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Szewczyk MM; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Ishikawa Y; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Organ S; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Sakai N; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Li F; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Halabelian L; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Ackloo S; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Couzens AL; Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, 600 University Ave, Room 992, Toronto, ON, M5G 1X5, Canada., Eram M; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Dilworth D; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Fukushi H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Harding R; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Dela Seña CC; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Sugo T; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Hayashi K; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., McLeod D; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Zepeda C; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Aman A; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada., Sánchez-Osuna M; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Bonneil E; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Takagi S; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Al-Awar R; Drug Discovery Program, Ontario Institute for Cancer Research, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Tyers M; Institute for Research in Immunology and Cancer (IRIC) University of Montreal, 2950 Chemin de Polytechnique, Montreal, QC, H3T 1J4, Canada., Richard S; Terry Fox Molecular Oncology Group and Bloomfield Center for Research on Aging, Lady Davis Institute for Medical Research and Departments of Oncology and Medicine, McGill University, Montreal, QC, H3T 1E2, Canada., Takizawa M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan., Gingras AC; Network Biology Collaborative Centre at the Lunenfeld-Tanenbaum Research Institute, 600 University Ave, Room 992, Toronto, ON, M5G 1X5, Canada., Arrowsmith CH; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Princess Margaret Cancer Centre and Department of Medical Biophysics, University of Toronto, Toronto, ON, M5G 2M9, Canada., Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada., Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada., Nara H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, 251-8555, Japan. nara@pharm.or.jp., Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, ON, M5G 1L7, Canada. d.barsyte@utoronto.ca.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, M5S 1A8, Canada. d.barsyte@utoronto.ca.; Nature Research Center, Vilnius, Akademijos 2, Lithuania. d.barsyte@utoronto.ca.

المصدر: Nature communications [Nat Commun] 2020 May 14; Vol. 11 (1), pp. 2396. Date of Electronic Publication: 2020 May 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Stress, Physiological*, Arginine/*metabolism , HSP70 Heat-Shock Proteins/*metabolism , Protein-Arginine N-Methyltransferases/*metabolism, Animals ; Gene Knockdown Techniques ; HCT116 Cells ; Humans ; Methylation/drug effects ; Protein Processing, Post-Translational/drug effects ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/genetics ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Sf9 Cells

المؤلفون: Gill MK; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada., Christova T; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada., Zhang YY; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Gregorieff A; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Department of Pathology, McGill University and Research Institute of the McGill University Health Center, Montreal, H4A 3J1, QC, Canada., Zhang L; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada.; Department of Biomedical Sciences, College of Veterinary Medicine and Life Sciences, City University of Hong Kong, 999077, Hong Kong, China.; City University of Hong Kong Shenzhen Research Institute, Shenzhen, Guangdong, 518057, China., Narimatsu M; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Song S; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada., Xiong S; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Couzens AL; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Tong J; Program in Cell Biology, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Krieger JR; SPARC BioCentre, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Moran MF; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Program in Cell Biology, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada.; SPARC BioCentre, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada., Zlotta AR; Department of Surgery, Division of Urology, University of Toronto, Mount Sinai Hospital and University Health Network, Toronto, M5G 1X5, ON, Canada., van der Kwast TH; Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON, M5G 2C4, Canada., Gingras AC; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Sicheri F; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Wrana JL; Department of Molecular Genetics, University of Toronto, Toronto, ON, M5S 1A8, Canada.; Centre for Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, M5G 1X5, Canada., Attisano L; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. liliana.attisano@utoronto.ca.; Donnelly Centre, University of Toronto, Toronto, ON, M5S 3E1, Canada. liliana.attisano@utoronto.ca.

المصدر: Nature communications [Nat Commun] 2018 Aug 29; Vol. 9 (1), pp. 3510. Date of Electronic Publication: 2018 Aug 29.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Carcinogenesis/*metabolism , Phosphoproteins/*metabolism , Transcription Factors/*metabolism, Acyltransferases ; Adaptor Proteins, Signal Transducing/genetics ; Carcinogenesis/genetics ; Cell Line, Tumor ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Female ; HEK293 Cells ; Humans ; Immunoblotting ; Immunoprecipitation ; Microscopy, Fluorescence ; Phosphoproteins/genetics ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Real-Time Polymerase Chain Reaction ; Signal Transduction/genetics ; Signal Transduction/physiology ; Transcription Factor AP-1/genetics ; Transcription Factor AP-1/metabolism ; Transcription Factors/genetics ; Tumor Suppressor Proteins/genetics ; Tumor Suppressor Proteins/metabolism ; YAP-Signaling Proteins

المؤلفون: Xiong S; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada., Lorenzen K; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Couzens AL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Templeton CM; Divisions of Structural Biology and Cancer Biology, The Institute of Cancer Research (ICR), London SW7 3RP, UK., Rajendran D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Mao DYL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Juang YC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Chiovitti D; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Kurinov I; Cornell University, Department of Chemistry and Chemical Biology, NE-CAT, Advanced Photon Source, Bldg. 436E, 9700 S. Cass Avenue, Argonne, IL 60439, USA., Guettler S; Divisions of Structural Biology and Cancer Biology, The Institute of Cancer Research (ICR), London SW7 3RP, UK. Electronic address: sebastian.guettler@icr.ac.uk., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: gingras@lunenfeld.ca., Sicheri F; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: sicheri@lunenfeld.ca.

المصدر: Structure (London, England : 1993) [Structure] 2018 Aug 07; Vol. 26 (8), pp. 1101-1115.e6. Date of Electronic Publication: 2018 Jul 05.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*chemistry , Epithelial Cells/*enzymology , Hepatocyte Growth Factor/*chemistry , Microtubule-Associated Proteins/*chemistry , Protein Serine-Threonine Kinases/*chemistry , Proto-Oncogene Proteins/*chemistry, Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Amino Acid Sequence ; Binding Sites ; Cell Cycle Proteins ; Cell Line, Tumor ; Cloning, Molecular ; Crystallography, X-Ray ; Epithelial Cells/cytology ; Escherichia coli/genetics ; Escherichia coli/metabolism ; Gene Expression ; Gene Expression Regulation ; Genetic Vectors/chemistry ; Genetic Vectors/metabolism ; HEK293 Cells ; Hepatocyte Growth Factor/genetics ; Hepatocyte Growth Factor/metabolism ; Humans ; Kinetics ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Models, Molecular ; Mutation ; Protein Binding ; Protein Conformation, alpha-Helical ; Protein Conformation, beta-Strand ; Protein Interaction Domains and Motifs ; Protein Serine-Threonine Kinases/genetics ; Protein Serine-Threonine Kinases/metabolism ; Proto-Oncogene Proteins/genetics ; Proto-Oncogene Proteins/metabolism ; Recombinant Proteins/chemistry ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Sequence Alignment ; Sequence Homology, Amino Acid ; Serine-Threonine Kinase 3 ; Signal Transduction ; Substrate Specificity

المؤلفون: Knight JF; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Sung VYC; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada., Kuzmin E; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada., Couzens AL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., de Verteuil DA; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Ratcliffe CDH; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada., Coelho PP; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada., Johnson RM; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Samavarchi-Tehrani P; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada., Gruosso T; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Oncology, McGill University, Montreal, QC H2W 1S6, Canada., Smith HW; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Lee W; Department of Biomedical Engineering, McGill University, Montreal, QC H3A 2B4, Canada., Saleh SM; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Zuo D; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Zhao H; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada., Guiot MC; Montreal Neurological Institute, Department of Pathology, McGill University, Montreal, QC H3A 2B4, Canada., Davis RR; Department of Pathology and Laboratory Medicine, University of California at Davis School of Medicine, Sacramento, CA 95817, USA., Gregg JP; Department of Pathology and Laboratory Medicine, University of California at Davis School of Medicine, Sacramento, CA 95817, USA., Moraes C; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biomedical Engineering, McGill University, Montreal, QC H3A 2B4, Canada; Department of Chemical Engineering, McGill University, Montreal, QC H3A 0C5, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Park M; Goodman Cancer Research Centre, McGill University, Montreal, QC H3G 0B1, Canada; Department of Biochemistry, McGill University, Montreal, QC H2W 1S6, Canada; Department of Oncology, McGill University, Montreal, QC H2W 1S6, Canada. Electronic address: morag.park@mcgill.ca.

المصدر: Cell reports [Cell Rep] 2018 Mar 20; Vol. 22 (12), pp. 3191-3205.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Tumor Suppressor*, Anemia, Macrocytic/*genetics , Intracellular Signaling Peptides and Proteins/*genetics , Mammary Neoplasms, Experimental/*genetics , Phosphoproteins/*genetics , Triple Negative Breast Neoplasms/*genetics, Animals ; Chromosome Deletion ; Chromosomes, Human, Pair 5/genetics ; Disease Models, Animal ; Female ; Humans ; Intracellular Signaling Peptides and Proteins/metabolism ; Mammary Neoplasms, Experimental/metabolism ; Mammary Neoplasms, Experimental/pathology ; Mice ; Neoplasm Metastasis ; Phosphoproteins/metabolism ; Triple Negative Breast Neoplasms/metabolism ; Triple Negative Breast Neoplasms/pathology

SCR Disease Name: Chromosome 5q Deletion Syndrome

المؤلفون: Sandí MJ; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada., Marshall CB; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada., Balan M; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Coyaud É; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada., Zhou M; Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA., Monson DM; Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA., Ishiyama N; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada., Chandrakumar AA; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., La Rose J; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada., Couzens AL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario M5G 1X5, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada., Raught B; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Xu W; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.; Department of Biostatistics, Princess Margaret Cancer Centre, Toronto, Ontario, Canada., Ikura M; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada.; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada., Morrison DK; Center for Cancer Research, National Cancer Institute at Frederick, P.O. Box B, Frederick, MD 21702, USA., Rottapel R; Princess Margaret Cancer Centre, University Health Network, 101 College Street, Princess Margaret Cancer Research Tower, Toronto, Ontario M5G 1L7, Canada. rottapel@uhnresearch.ca.; Department of Medical Biophysics, University of Toronto, 1 King's College Circle, Toronto, Ontario M5S 1A8, Canada.; Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.; Division of Rheumatology, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario M5B 1W8, Canada.

المصدر: Science signaling [Sci Signal] 2017 Oct 31; Vol. 10 (503). Date of Electronic Publication: 2017 Oct 31.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Actin Cytoskeleton/*metabolism , Cell Polarity/*physiology , Microtubules/*metabolism , Protein Serine-Threonine Kinases/*metabolism , Rho Guanine Nucleotide Exchange Factors/*metabolism, AMP-Activated Protein Kinase Kinases ; Animals ; COS Cells ; Chlorocebus aethiops ; Dyneins/genetics ; Dyneins/metabolism ; Focal Adhesions/metabolism ; HEK293 Cells ; Humans ; Phosphorylation ; Protein Phosphatase 2/genetics ; Protein Phosphatase 2/metabolism ; Protein Serine-Threonine Kinases/genetics ; Rho Guanine Nucleotide Exchange Factors/genetics ; Serine/metabolism ; Stress Fibers/metabolism ; rhoA GTP-Binding Protein/genetics ; rhoA GTP-Binding Protein/metabolism

المؤلفون: Couzens AL; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Xiong S; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5.; §Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8., Knight JDR; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Mao DY; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Guettler S; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5.; ¶New address: The Institute of Cancer Research, Divisions of Structural Biology and Cancer Biology, London, UK, SW7 3RP., Picaud S; ‖Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, U.K., Kurinov I; *NE-CAT APS, Building 436E, Argonne National Lab, 9700 S. Cass Avenue, Argonne, Illinois 60439., Filippakopoulos P; ‖Structural Genomics Consortium, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, U.K.; ‡‡Ludwig Institute for Cancer Research, University of Oxford, Oxford OX3 7DQ, U.K., Sicheri F; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5, sicheri@lunenfeld.ca gingras@lunenfeld.ca.; §Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.; §§Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8., Gingras AC; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5, sicheri@lunenfeld.ca gingras@lunenfeld.ca.; §§Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

المصدر: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2017 Jun; Vol. 16 (6), pp. 1098-1110. Date of Electronic Publication: 2017 Apr 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Protein Serine-Threonine Kinases/*metabolism, Adaptor Proteins, Signal Transducing/chemistry ; HeLa Cells ; Humans ; Intracellular Signaling Peptides and Proteins ; Phosphopeptides/metabolism ; Phosphorylation ; Protein Binding ; Protein Serine-Threonine Kinases/chemistry ; Protein Serine-Threonine Kinases/genetics ; Recombinant Proteins/metabolism ; Serine-Threonine Kinase 3 ; Signal Transduction

المؤلفون: Xiong S; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5.; §Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8., Couzens AL; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Kean MJ; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Mao DY; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5., Guettler S; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5.; ¶The Institute of Cancer Research, Divisions of Structural Biology and Cancer Biology, London, UK, SW7 3RP., Kurinov I; ‖NE-CAT APS, Building 436E, Argonne National Lab, 9700 S. Cass Avenue, Argonne, Illinois 60439., Gingras AC; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5; gingras@lunenfeld.ca sicheri@lunenfeld.ca.; *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8., Sicheri F; From the ‡Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada, M5G 1X5; gingras@lunenfeld.ca sicheri@lunenfeld.ca.; §Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.; *Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada, M5S 1A8.

المصدر: Molecular & cellular proteomics : MCP [Mol Cell Proteomics] 2017 Jun; Vol. 16 (6), pp. 1111-1125. Date of Electronic Publication: 2017 Apr 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 101125647 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1535-9484 (Electronic) Linking ISSN: 15359476 NLM ISO Abbreviation: Mol Cell Proteomics Subsets: MEDLINE

مواضيع طبية MeSH: Adaptor Proteins, Signal Transducing/*metabolism , Protein Serine-Threonine Kinases/*metabolism, Adaptor Proteins, Signal Transducing/genetics ; Intracellular Signaling Peptides and Proteins ; Phosphoprotein Phosphatases/metabolism ; Phosphorylation ; Protein Serine-Threonine Kinases/genetics ; Proteomics ; Rho Guanine Nucleotide Exchange Factors/metabolism ; Serine-Threonine Kinase 3

المؤلفون: St-Denis N; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Gupta GD; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Lin ZY; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Gonzalez-Badillo B; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Veri AO; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Knight JDR; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Rajendran D; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Couzens AL; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Currie KW; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada., Tkach JM; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Cheung SWT; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada., Pelletier L; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: pelletier@lunenfeld.ca., Gingras AC; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, ON M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: gingras@lunenfeld.ca.

المصدر: Cell reports [Cell Rep] 2016 Nov 22; Vol. 17 (9), pp. 2488-2501.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Mitosis* , Protein Interaction Maps*, Phosphoric Monoester Hydrolases/*metabolism, Biological Evolution ; Centrioles/metabolism ; Dual-Specificity Phosphatases/metabolism ; HeLa Cells ; Humans ; Phenotype ; Protein Binding ; Protein Serine-Threonine Kinases/metabolism ; Protein Subunits/metabolism ; Receptor-Like Protein Tyrosine Phosphatases, Class 2/metabolism ; Reproducibility of Results