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المؤلفون: Westmacott KL; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK., Crew AP; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK., Doran O; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK., Hart JP; Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the West England, Frenchay Campus, Coldharbour Lane, Bristol, BS16 1QY, UK. Electronic address: john.hart@uwe.ac.uk.

المصدر: Biosensors & bioelectronics [Biosens Bioelectron] 2020 Feb 15; Vol. 150, pp. 111837. Date of Electronic Publication: 2019 Nov 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE

مواضيع طبية MeSH: Biosensing Techniques*, Androsterone/*isolation & purification , Meat/*analysis , Skatole/*isolation & purification, Adipose Tissue/chemistry ; Androsterone/chemistry ; Animals ; Humans ; Male ; Skatole/chemistry ; Swine

المؤلفون: Salami J; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, 06511, CT, USA., Alabi S; Department of Pharmacology, Yale School of Medicine, New Haven, 06510, CT, USA., Willard RR; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Vitale NJ; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Wang J; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Dong H; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Jin M; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., McDonnell DP; Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, 27710, NC, USA., Crew AP; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Neklesa TK; Arvinas, LLC, 5 Science Park, New Haven, 06511, CT, USA., Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, 06511, CT, USA. craig.crews@yale.edu.; Department of Pharmacology, Yale School of Medicine, New Haven, 06510, CT, USA. craig.crews@yale.edu.; Department of Chemistry, Yale University, New Haven, 06511, CT, USA. craig.crews@yale.edu.

المصدر: Communications biology [Commun Biol] 2018 Aug 02; Vol. 1, pp. 100. Date of Electronic Publication: 2018 Aug 02 (Print Publication: 2018).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group UK Country of Publication: England NLM ID: 101719179 Publication Model: eCollection Cited Medium: Internet ISSN: 2399-3642 (Electronic) Linking ISSN: 23993642 NLM ISO Abbreviation: Commun Biol Subsets: PubMed not MEDLINE

المؤلفون: Sun B; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Fiskus W; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Qian Y; Arvinas LLC, New Haven, CT, USA., Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Raina K; Arvinas LLC, New Haven, CT, USA., Coleman KG; Arvinas LLC, New Haven, CT, USA., Crew AP; Arvinas LLC, New Haven, CT, USA., Shen A; Arvinas LLC, New Haven, CT, USA., Saenz DT; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mill CP; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Nowak AJ; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Jain N; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Zhang L; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wang M; Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khoury JD; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Crews CM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, USA.; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Pharmacology, Yale University, New Haven, CT, USA., Bhalla KN; Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

المصدر: Leukemia [Leukemia] 2018 Feb; Vol. 32 (2), pp. 343-352. Date of Electronic Publication: 2017 Jun 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

مواضيع طبية MeSH: Lymphoma, Mantle-Cell*/drug therapy , Lymphoma, Mantle-Cell*/metabolism , Proteins*/metabolism, Animals ; Humans ; Mice ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Azepines/pharmacology ; Cell Line, Tumor ; NF-kappa B/metabolism ; Nuclear Proteins/metabolism ; Proteolysis ; Signal Transduction/drug effects ; Thalidomide/analogs & derivatives ; Thalidomide/pharmacology ; Transcription Factors/metabolism

المؤلفون: Crew AP; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Raina K; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Dong H; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Qian Y; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Wang J; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Vigil D; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Serebrenik YV, Hamman BD; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Morgan A; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Ferraro C; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Siu K; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Neklesa TK; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Winkler JD; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Coleman KG; Arvinas LLC , 5 Science Park, New Haven, Connecticut 06511, United States., Crews CM

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Jan 25; Vol. 61 (2), pp. 583-598. Date of Electronic Publication: 2017 Jul 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Protein Serine-Threonine Kinases/*metabolism , Proteolysis/*drug effects , Von Hippel-Lindau Tumor Suppressor Protein/*metabolism, Cell Line ; Cell Proliferation/drug effects ; Chemistry Techniques, Synthetic ; Fluorescence Polarization ; Genes, ras ; Humans ; I-kappa B Kinase/genetics ; I-kappa B Kinase/metabolism ; Molecular Structure ; Mutation ; Protein Serine-Threonine Kinases/genetics ; RNA Interference ; Structure-Activity Relationship ; Von Hippel-Lindau Tumor Suppressor Protein/chemistry ; Von Hippel-Lindau Tumor Suppressor Protein/genetics

المؤلفون: Burslem GM; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Smith BE; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Lai AC; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Jaime-Figueroa S; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., McQuaid DC; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Bondeson DP; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Toure M; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Dong H; Arvinas, LLC, 5 Science Park, New Haven, CT, USA., Qian Y; Arvinas, LLC, 5 Science Park, New Haven, CT, USA., Wang J; Arvinas, LLC, 5 Science Park, New Haven, CT, USA., Crew AP; Arvinas, LLC, 5 Science Park, New Haven, CT, USA., Hines J; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA., Crews CM; Department of Molecular, Cellular, and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, USA; Departments of Chemistry and Pharmacology, Yale University, New Haven, CT, USA. Electronic address: craig.crews@yale.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2018 Jan 18; Vol. 25 (1), pp. 67-77.e3. Date of Electronic Publication: 2017 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Proteolysis* , Receptor Protein-Tyrosine Kinases*/antagonists & inhibitors , Receptor Protein-Tyrosine Kinases*/metabolism , Ubiquitin-Protein Ligases*/antagonists & inhibitors , Ubiquitin-Protein Ligases*/metabolism, Humans ; Ligands

المؤلفون: Saenz DT; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Fiskus W; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Qian Y; Arvinas LLC, New Haven, CT, USA., Manshouri T; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Rajapakshe K; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Raina K; Arvinas LLC, New Haven, CT, USA., Coleman KG; Arvinas LLC, New Haven, CT, USA., Crew AP; Arvinas LLC, New Haven, CT, USA., Shen A; Arvinas LLC, New Haven, CT, USA., Mill CP; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Sun B; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Qiu P; Department of Biomedical Engineering, Georgia Tech and Emory University, Atlanta, GA, USA., Kadia TM; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Pemmaraju N; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., DiNardo C; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Kim MS; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Nowak AJ; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Coarfa C; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA., Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.; Department of Chemistry, Yale University, New Haven, CT, USA.; Department of Pharmacology, Yale University, New Haven, CT, USA., Verstovsek S; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA., Bhalla KN; Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

المصدر: Leukemia [Leukemia] 2017 Sep; Vol. 31 (9), pp. 1951-1961. Date of Electronic Publication: 2017 Feb 02.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

مواضيع طبية MeSH: Azepines*/pharmacology , Azepines*/therapeutic use , Leukemia, Myeloid, Acute*/drug therapy , Leukemia, Myeloid, Acute*/pathology , Myeloproliferative Disorders*/pathology , Nuclear Proteins*/metabolism , Thalidomide*/analogs & derivatives , Thalidomide*/pharmacology , Thalidomide*/therapeutic use , Transcription Factors*/metabolism, Animals ; Humans ; Mice ; Antigens, CD34 ; Apoptosis/drug effects ; Cell Cycle Proteins ; Cell Line, Tumor ; Leukemia ; Nitriles ; Proteolysis ; Pyrazoles/pharmacology ; Pyrimidines ; Tumor Burden/drug effects ; Ubiquitin-Protein Ligases/metabolism

المؤلفون: Raina K; Arvinas, LLC, New Haven, CT 06511;, Lu J; Arvinas, LLC, New Haven, CT 06511;, Qian Y; Arvinas, LLC, New Haven, CT 06511;, Altieri M; Arvinas, LLC, New Haven, CT 06511;, Gordon D; Arvinas, LLC, New Haven, CT 06511;, Rossi AM; Arvinas, LLC, New Haven, CT 06511;, Wang J; Arvinas, LLC, New Haven, CT 06511;, Chen X; Arvinas, LLC, New Haven, CT 06511;, Dong H; Arvinas, LLC, New Haven, CT 06511;, Siu K; Arvinas, LLC, New Haven, CT 06511;, Winkler JD; Arvinas, LLC, New Haven, CT 06511;, Crew AP; Arvinas, LLC, New Haven, CT 06511;, Crews CM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520; Department of Chemistry, Yale University, New Haven, CT 06520; Department of Pharmacology, Yale University, New Haven, CT 06520., Coleman KG; Arvinas, LLC, New Haven, CT 06511; kevin.coleman@arvinas.com.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jun 28; Vol. 113 (26), pp. 7124-9. Date of Electronic Publication: 2016 Jun 06.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*administration & dosage , Nuclear Proteins/*metabolism , Prostatic Neoplasms, Castration-Resistant/*drug therapy , Prostatic Neoplasms, Castration-Resistant/*metabolism , Protein Serine-Threonine Kinases/*metabolism , RNA-Binding Proteins/*metabolism , Transcription Factors/*metabolism, Animals ; Cell Cycle Proteins ; Cell Line, Tumor ; Humans ; Male ; Mice ; Nuclear Proteins/genetics ; Prostatic Neoplasms, Castration-Resistant/genetics ; Protein Serine-Threonine Kinases/genetics ; Proteolysis ; RNA-Binding Proteins/genetics ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Signal Transduction/drug effects ; Transcription Factors/genetics

المؤلفون: Lu J; Arvinas, Inc., New Haven, CT 06511, USA., Qian Y; Arvinas, Inc., New Haven, CT 06511, USA., Altieri M; Arvinas, Inc., New Haven, CT 06511, USA., Dong H; Arvinas, Inc., New Haven, CT 06511, USA., Wang J; Arvinas, Inc., New Haven, CT 06511, USA., Raina K; Arvinas, Inc., New Haven, CT 06511, USA., Hines J; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA., Winkler JD; Arvinas, Inc., New Haven, CT 06511, USA., Crew AP; Arvinas, Inc., New Haven, CT 06511, USA., Coleman K; Arvinas, Inc., New Haven, CT 06511, USA., Crews CM; Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Department of Pharmacology, Yale University, New Haven, CT 06511, USA. Electronic address: craig.crews@yale.edu.

المصدر: Chemistry & biology [Chem Biol] 2015 Jun 18; Vol. 22 (6), pp. 755-63. Date of Electronic Publication: 2015 Jun 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 9500160 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1301 (Electronic) Linking ISSN: 10745521 NLM ISO Abbreviation: Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Azepines/*pharmacology , Nuclear Proteins/*metabolism , Peptide Hydrolases/*metabolism , Signal Transduction/*drug effects , Thalidomide/*analogs & derivatives , Transcription Factors/*metabolism, Acetanilides/toxicity ; Adaptor Proteins, Signal Transducing ; Apoptosis/drug effects ; Azepines/chemistry ; Azepines/toxicity ; Cell Cycle Proteins ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Heterocyclic Compounds, 3-Ring/toxicity ; Humans ; Nuclear Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins c-myc/metabolism ; Thalidomide/chemistry ; Thalidomide/pharmacology ; Transcription Factors/antagonists & inhibitors ; Triazoles/toxicity ; Ubiquitin-Protein Ligases

المؤلفون: Hornberger KR; OSI Pharmaceuticals LLC, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA. keith.hornberger@boehringer-ingelheim.com, Chen X, Crew AP, Kleinberg A, Ma L, Mulvihill MJ, Wang J, Wilde VL, Albertella M, Bittner M, Cooke A, Kadhim S, Kahler J, Maresca P, May E, Meyn P, Romashko D, Tokar B, Turton R

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Aug 15; Vol. 23 (16), pp. 4511-6. Date of Electronic Publication: 2013 Jun 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Enzyme Inhibitors*/chemical synthesis , Enzyme Inhibitors*/pharmacokinetics , Enzyme Inhibitors*/pharmacology , Pyridines*/chemical synthesis , Pyridines*/pharmacokinetics , Pyridines*/pharmacology, MAP Kinase Kinase Kinases/*antagonists & inhibitors, Amines/chemical synthesis ; Amines/chemistry ; Amines/pharmacology ; Animals ; Crystallography, X-Ray ; Enzyme Activation/drug effects ; Furans/chemical synthesis ; Furans/chemistry ; Furans/pharmacology ; Humans ; Inhibitory Concentration 50 ; MAP Kinase Kinase Kinases/metabolism ; Mice ; Molecular Structure ; Neoplasms/drug therapy ; Phosphotransferases/chemistry ; Phosphotransferases/metabolism ; Structure-Activity Relationship ; Xenograft Model Antitumor Assays