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1
المؤلفون: Stefano Sainas, Marta Giorgis, Paola Circosta, Giulio Poli, Marta Alberti, Alice Passoni, Valentina Gaidano, Agnese C. Pippione, Nicoletta Vitale, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Cristina Ramondetti, Alessia Lanno, Davide M. Ferraris, Barbara Canepa, Barbara Buccinnà, Marco Piccinini, Menico Rizzi, Giuseppe Saglio, Salam Al-Karadaghi, Donatella Boschi, Riccardo Miggiano, Tiziano Tuccinardi, Marco L. Lolli
المصدر: Journal of Medicinal Chemistry. 65:12701-12724
مصطلحات موضوعية: Myeloid, Oxidoreductases Acting on CH-CH Group Donors, Leukemia, Pyridines, Dihydroorotate Dehydrogenase, Dipyridamole, Acute, Antiviral Agents, Mice, Structure-Activity Relationship, Animals, Enzyme Inhibitors, Humans, Leukemia, Myeloid, Acute, Drug Discovery, Molecular Medicine
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2
المؤلفون: Stefano, Sainas, Marta, Giorgis, Paola, Circosta, Giulio, Poli, Marta, Alberti, Alice, Passoni, Valentina, Gaidano, Agnese C, Pippione, Nicoletta, Vitale, Davide, Bonanni, Barbara, Rolando, Alessandro, Cignetti, Cristina, Ramondetti, Alessia, Lanno, Davide M, Ferraris, Barbara, Canepa, Barbara, Buccinnà, Marco, Piccinini, Menico, Rizzi, Giuseppe, Saglio, Salam, Al-Karadaghi, Donatella, Boschi, Riccardo, Miggiano, Tiziano, Tuccinardi, Marco L, Lolli
المصدر: Journal of medicinal chemistry. 65(19)
مصطلحات موضوعية: Leukemia, Myeloid, Acute, Mice, Oxidoreductases Acting on CH-CH Group Donors, Structure-Activity Relationship, Pyridines, Dihydroorotate Dehydrogenase, Animals, Humans, Dipyridamole, Enzyme Inhibitors, Antiviral Agents
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3
المؤلفون: Barbara Buccinnà, Cristina Ramondetti, Marco Piccinini
المصدر: Biochemical pharmacology. 204
مصطلحات موضوعية: AMPK, Pharmacology, Receptor, ErbB-2, Neuregulin-1, Breast cancer, GSK-621, HER3, Lapatinib, Neuregulin, Antineoplastic Agents, Breast Neoplasms, AMP-Activated Protein Kinases, Ligands, Biochemistry, Chromatin, Up-Regulation, Cell Line, Tumor, Quinazolines, Humans, Female, Proto-Oncogene Proteins c-akt, Cell Proliferation, Signal Transduction
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4
المؤلفون: Marta Giorgis, Donatella Boschi, Barbara Buccinnà, Stefano Sainas, Mariia Mishina, Davide Bonanni, Alice Passoni, Salam Al-Karadaghi, Yaqi Qiu, Cristina Ramondetti, Paola Circosta, Giuseppe Saglio, Marco Piccinini, Valentina Gaidano, Mohammad Houshmand, Alessandro Bona, Alessandro Cignetti, Enrico Giraudo, Carina Florina Cojocaru, Marco Lucio Lolli, Barbara Rolando, Renzo Bagnati, Agnese Chiara Pippione, Barbara Canepa
المصدر: Journal of Medicinal Chemistry. 64:5404-5428
مصطلحات موضوعية: Myeloid, Male, Oxidoreductases Acting on CH-CH Group Donors, Pyridines, Apoptosis, Acute, Pharmacology, 01 natural sciences, Jurkat cells, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, Myelogenous, Microsomes, hemic and lymphatic diseases, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, Enzyme Inhibitors, Cytotoxicity, Inbred BALB C, 030304 developmental biology, Dihydroorotate Dehydrogenase Inhibitor, 0303 health sciences, Binding Sites, Tumor, Leukemia, Chemistry, Biphenyl Compounds, Cell Differentiation, medicine.disease, Rats, 0104 chemical sciences, Molecular Docking Simulation, Biphenyl compound, 010404 medicinal & biomolecular chemistry, Liver, Drug Design, Dihydroorotate dehydrogenase, Pyrazoles, Molecular Medicine, Female, Sprague-Dawley, Cell Line, Tumor, Half-Life, Leukemia, Myeloid, Acute, Mice, Inbred BALB C, Microsomes, Liver, Rats, Sprague-Dawley
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5
المؤلفون: Stefano, Sainas, Marta, Giorgis, Paola, Circosta, Valentina, Gaidano, Davide, Bonanni, Agnese C, Pippione, Renzo, Bagnati, Alice, Passoni, Yaqi, Qiu, Carina Florina, Cojocaru, Barbara, Canepa, Alessandro, Bona, Barbara, Rolando, Mariia, Mishina, Cristina, Ramondetti, Barbara, Buccinnà, Marco, Piccinini, Mohammad, Houshmand, Alessandro, Cignetti, Enrico, Giraudo, Salam, Al-Karadaghi, Donatella, Boschi, Giuseppe, Saglio, Marco L, Lolli
المصدر: Journal of Medicinal Chemistry
مصطلحات موضوعية: Male, Oxidoreductases Acting on CH-CH Group Donors, Pyridines, Dihydroorotate Dehydrogenase, Apoptosis, Article, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, hemic and lymphatic diseases, Cell Line, Tumor, Animals, Humans, Enzyme Inhibitors, Mice, Inbred BALB C, Binding Sites, Biphenyl Compounds, Cell Differentiation, Rats, Molecular Docking Simulation, Leukemia, Myeloid, Acute, Drug Design, Microsomes, Liver, Pyrazoles, Female, Half-Life
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6
المؤلفون: Parveen Goyal, Salam Al-Karadaghi, Rodolpho C. Braga, Carolina Horta Andrade, Marco Lucio Lolli, Stefano Sainas, Cristina Ramondetti, Ann Christin Moritzer, Stefano Mensa, Rosmarie Friemann, Elisa Lupino, Marco Piccinini, Agnese Chiara Pippione, Marta Giorgis, Mikael Andersson, Donatella Boschi, Barbara Buccinnà
المصدر: European Journal of Medicinal Chemistry. 129:287-302
مصطلحات موضوعية: Models, Molecular, Azoles, 0301 basic medicine, Autoimmune diseases, Dihydroorotate Dehydrogenase, Pyrazole, 01 natural sciences, Jurkat Cells, chemistry.chemical_compound, X-Ray Diffraction, Models, Amide, Drug Discovery, Moiety, Enzyme Inhibitors, Cells, Cultured, Dihydroorotate Dehydrogenase Inhibitor, Bioisosterism, chemistry.chemical_classification, Cultured, Molecular Structure, General Medicine, Brequinar, Leflunomide, Oxidoreductases Acting on CH-CH Group Donors, Cell Survival, Stereochemistry, Cells, Triazole, Hydroxylation, Structure-Activity Relationship, 03 medical and health sciences, Humans, X-ray-crystallography, Binding site, Dihydroorotate dehydrogenase (DHODH) inhibitors, Cell Proliferation, Immunosuppression Therapy, Pharmacology, Binding Sites, 010405 organic chemistry, Drug Discovery3003 Pharmaceutical Science, Organic Chemistry, Molecular, Uridine, 0104 chemical sciences, 030104 developmental biology, chemistry, Drug Design, Azole, Immunosuppression
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7
المؤلفون: Rosmarie Friemann, Marco Piccinini, Giuseppe Saglio, Davide Bonanni, Stefano Sainas, Salam Al-Karadaghi, Parveen Goyal, Marco Lucio Lolli, Mikael Andersson, Marta Giorgis, Alessandro Cignetti, Alex Ducime, Michael Järvå, Elisa Lupino, Valentina Gaidano, Paola Circosta, Cristina Ramondetti, Donatella Boschi, Barbara Buccinnà, Agnese Chiara Pippione, Barbara Rolando
المصدر: Journal of medicinal chemistry. 61(14)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Oxidoreductases Acting on CH-CH Group Donors, Protein Conformation, AUTOIMMUNE-DISEASES, HDHODH INHIBITORS, BREQUINAR SODIUM, CANCER-PATIENTS, DHODH, Dihydroorotate Dehydrogenase, 03 medical and health sciences, Myelogenous, chemistry.chemical_compound, Jurkat Cells, Structure-Activity Relationship, 0302 clinical medicine, Intensive care, Drug Discovery, Structure–activity relationship, Humans, Myeloid Cells, Enzyme Inhibitors, Cytotoxicity, Dihydroorotate Dehydrogenase Inhibitor, Binding Sites, Chemistry, Cell Differentiation, 030104 developmental biology, Biochemistry, 030220 oncology & carcinogenesis, Drug Design, Pyrimidine metabolism, Dihydroorotate dehydrogenase, Molecular Medicine, Pyrazoles, Bioisostere
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8
المؤلفون: Cristina Ramondetti, Barbara Buccinnà, Marco Piccinini, Elisa Lupino
المصدر: Biochemical Pharmacology. 92:235-250
مصطلحات موضوعية: CDK2, p27KIP1, medicine.drug_class, Antineoplastic Agents, Genes, abl, Biochemistry, Piperazines, c-Abl, Tyrosine-kinase inhibitor, Neuroblastoma, Growth factor receptor, Cyclin-dependent kinase, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Humans, Imatinib, pRb, neoplasms, Cell Proliferation, Pharmacology, ABL, Dose-Response Relationship, Drug, biology, Chemistry, Molecular biology, Up-Regulation, Pyrimidines, Imatinib mesylate, Benzamides, Imatinib Mesylate, biology.protein, Cancer research, Tyrosine kinase, Cyclin-Dependent Kinase Inhibitor p27, Platelet-derived growth factor receptor, medicine.drug
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9
المؤلفون: Stefano Sainas, Agnese C. Pippione, Elisa Lupino, Marta Giorgis, Paola Circosta, Valentina Gaidano, Parveen Goyal, Davide Bonanni, Barbara Rolando, Alessandro Cignetti, Alex Ducime, Mikael Andersson, Michael Järvå, Rosmarie Friemann, Marco Piccinini, Cristina Ramondetti, Barbara Buccinnà, Salam Al-Karadaghi, Donatella Boschi, Giuseppe Saglio, Marco L. Lolli
المصدر: Journal of Medicinal Chemistry. 62:1696-1696
مصطلحات موضوعية: Drug Discovery, Molecular Medicine
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10
المؤلفون: Paolo Tosco, Loretta Lazzarato, Alberto Gasco, Clara Cena, Elisa Lupino, Cristina Ramondetti, Elisabetta Marini, Roberta Fruttero, Marco Piccinini
المصدر: ChemMedChem. 6:523-530
مصطلحات موضوعية: Molecular model, Anti-Inflammatory Agents, Biochemistry, Cell Line, chemistry.chemical_compound, Catalytic Domain, inhibitors, Drug Discovery, medicine, Humans, Computer Simulation, Cyclooxygenase Inhibitors, Platelet, General Pharmacology, Toxicology and Pharmaceutics, Site-directed mutagenesis, Pharmacology, chemistry.chemical_classification, Aspirin, biology, NO donors, Organic Chemistry, HEK 293 cells, cyclooxygenases, reaction mechanisms, site-directed mutagenesis, Recombinant Proteins, Enzyme, chemistry, Cyclooxygenase 1, biology.protein, Molecular Medicine, Cyclooxygenase, Salicylic Acid, Platelet Aggregation Inhibitors, Salicylic acid, medicine.drug
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