المؤلفون: Leissing TM; Evotec SE, Essener Bogen 7, 22419 Hamburg, Germany., Luh LM; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany., Cromm PM; Research and Development, Pharmaceuticals, Bayer AG, 13353 Berlin, Germany. Electronic address: philipp.cromm@bayer.com.

المصدر: Drug discovery today. Technologies [Drug Discov Today Technol] 2020 Dec; Vol. 37, pp. 73-82. Date of Electronic Publication: 2020 Dec 10.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 101235076 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1740-6749 (Electronic) Linking ISSN: 17406749 NLM ISO Abbreviation: Drug Discov Today Technol Subsets: MEDLINE

مواضيع طبية MeSH: Proteasome Endopeptidase Complex*/metabolism , Ubiquitin-Protein Ligases*/metabolism, Proteolysis ; Ubiquitin ; Ubiquitination

المؤلفون: Luh LM; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany., Scheib U; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany., Juenemann K; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany., Wortmann L; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany., Brands M; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany., Cromm PM; Research and Development, Pharmaceuticals, Bayer AG, 13353, Berlin, Germany.

المصدر: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Sep 01; Vol. 59 (36), pp. 15448-15466. Date of Electronic Publication: 2020 Jul 30.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

مواضيع طبية MeSH: Proteasome Endopeptidase Complex/*metabolism , Proteins/*metabolism, Humans ; Proteolysis

المؤلفون: Cromm PM; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.; Present address: Research and Development, Pharmaceuticals, Bayer AG, Muellerstrasse 178, 13353, Berlin, Germany., Adihou H; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Early CVRM Medicinal Chemistry, R&D BioPharmaceuticals, AstraZeneca, Pepparedsleden 1, 431 83, Mölndal, Sweden., Kapoor S; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Vazquez-Chantada M; Chemistry, Oncology R&D, AstraZeneca, Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK., Davey P; Chemistry, Oncology R&D, AstraZeneca, Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK., Longmire D; Chemistry, Oncology R&D, AstraZeneca, Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK., Hennes E; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Hofer W; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Küchler P; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany., Chiarparin E; Chemistry, Oncology R&D, AstraZeneca, Darwin Building 310, Cambridge Science Park, Milton Road, Cambridge, CB4 0WG, UK., Waldmann H; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany., Grossmann TN; Vrije Universiteit Amsterdam, Department of Chemistry and Pharmaceutical Sciences, De Boelelaan 1083, 1081 HV, Amsterdam, The Netherlands.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2019 Dec 13; Vol. 20 (24), pp. 2987-2990. Date of Electronic Publication: 2019 Nov 19.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Lipid Metabolism*, Adaptor Proteins, Signal Transducing/*metabolism , Peptides/*metabolism , Peptides/*pharmacology, Adaptor Proteins, Signal Transducing/chemistry ; Amino Acid Sequence ; HeLa Cells ; Humans ; Models, Molecular ; Molecular Targeted Therapy ; Peptides/chemistry ; Protein Binding ; Protein Conformation, alpha-Helical

المؤلفون: Cromm PM; Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States., Samarasinghe KTG; Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States., Hines J; Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States., Crews CM; Department of Molecular, Cellular & Developmental Biology , Yale University , New Haven , Connecticut 06511 , United States.; Department of Chemistry , Yale University , New Haven , Connecticut 06511 , United States.; Department of Pharmacology , Yale University , New Haven , Connecticut 06511 , United States.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2018 Dec 12; Vol. 140 (49), pp. 17019-17026. Date of Electronic Publication: 2018 Nov 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzamides/*pharmacology , Focal Adhesion Kinase 1/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Pyrazines/*pharmacology , Sulfonamides/*pharmacology, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Benzamides/chemical synthesis ; Benzamides/chemistry ; Cell Line, Tumor ; Cell Movement/drug effects ; Drug Design ; Focal Adhesion Kinase 1/metabolism ; Humans ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Proteolysis/drug effects ; Pyrazines/chemical synthesis ; Pyrazines/chemistry ; Signal Transduction/drug effects ; Sulfonamides/chemical synthesis ; Sulfonamides/chemistry

المؤلفون: Burslem GM; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA., Ottis P; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA., Jaime-Figueroa S; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA., Morgan A; Arvinas LLC, 5 Science Park, 395 Winchester Avenue, New Haven, CT, 06511, USA., Cromm PM; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA., Toure M; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA., Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University, 219 Prospect Street, New Haven, CT, 06520-8103, USA.; Departments of Chemistry and Pharmacology, Yale University, New Haven, CT, USA.

المصدر: ChemMedChem [ChemMedChem] 2018 Aug 10; Vol. 13 (15), pp. 1508-1512. Date of Electronic Publication: 2018 Jul 04.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem

مواضيع طبية MeSH: Immunologic Factors/*chemical synthesis, Adaptor Proteins, Signal Transducing ; Humans ; Immunologic Factors/chemistry ; Immunologic Factors/pharmacology ; Immunologic Factors/therapeutic use ; Lenalidomide/therapeutic use ; Multiple Myeloma/drug therapy ; Peptide Hydrolases/metabolism ; Structure-Activity Relationship ; Thalidomide/analogs & derivatives ; Thalidomide/therapeutic use ; Ubiquitin-Protein Ligases

المؤلفون: Durek T; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Cromm PM; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia.; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85747 Garching , Germany., White AM; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Schroeder CI; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Kaas Q; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Weidmann J; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Ahmad Fuaad A; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Cheneval O; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Harvey PJ; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Daly NL; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia., Zhou Y; Department of Chemistry and Biochemistry , University of Arizona , Tucson , Arizona 85721 , United States., Dellsén A; Mechanistic Biology & Profiling, Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Österlund T; Discovery Biology, Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden.; Drug Safety and Metabolism, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Larsson N; Discovery Biology, Discovery Sciences, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Knerr L; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Bauer U; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Kessler H; Institute for Advanced Study and Center of Integrated Protein Science, Department Chemie , Technische Universität München , Lichtenbergstrasse 4 , 85747 Garching , Germany., Cai M; Department of Chemistry and Biochemistry , University of Arizona , Tucson , Arizona 85721 , United States., Hruby VJ; Department of Chemistry and Biochemistry , University of Arizona , Tucson , Arizona 85721 , United States., Plowright AT; Medicinal Chemistry, Cardiovascular and Metabolic Diseases, IMED Biotech Unit , AstraZeneca , Gothenburg 43183 Sweden., Craik DJ; Institute for Molecular Bioscience , The University of Queensland , Brisbane , QLD 4072 , Australia.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3674-3684. Date of Electronic Publication: 2018 Apr 11.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Peptides, Cyclic/*pharmacology , Receptor, Melanocortin, Type 1/*agonists , Receptor, Melanocortin, Type 3/*agonists, Drug Design ; HEK293 Cells ; Helianthus/chemistry ; Humans ; Methylation ; Molecular Structure ; Peptides, Cyclic/chemical synthesis ; Peptides, Cyclic/chemistry ; Structure-Activity Relationship

المؤلفون: Ottis P; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States., Toure M; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States., Cromm PM; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States., Ko E; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States., Gustafson JL; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States., Crews CM; Department of Molecular, Cellular and Developmental Biology, Yale University , New Haven, Connecticut, United States.; Department of Chemistry, Yale University , New Haven, Connecticut, United States.; Department of Pharmacology, Yale University , New Haven, Connecticut, United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Oct 20; Vol. 12 (10), pp. 2570-2578. Date of Electronic Publication: 2017 Sep 05.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Ubiquitin-Protein Ligases/*metabolism, Cell Line ; Cloning, Molecular ; Humans ; Models, Molecular ; Molecular Structure ; Protein Conformation ; Proteolysis ; Ubiquitin-Protein Ligases/genetics ; Ubiquitination/drug effects

المؤلفون: Cromm PM; Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT 06511, USA. Electronic address: philipp.cromm@yale.edu., Crews CM; Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, CT 06511, USA; Department of Chemistry, Yale University, New Haven, CT 06511, USA; Department of Pharmacology, Yale University, New Haven, CT 06511, USA. Electronic address: craig.crews@yale.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2017 Sep 21; Vol. 24 (9), pp. 1181-1190. Date of Electronic Publication: 2017 Jun 22.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Proteins/*metabolism , Proteolysis/*drug effects , Small Molecule Libraries/*pharmacology, Animals ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Receptors, Estrogen/antagonists & inhibitors ; Receptors, Estrogen/metabolism ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/metabolism ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination/drug effects

المؤلفون: Cromm PM; Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, Connecticut 06511, United States., Crews CM; Department of Molecular, Cellular & Developmental Biology, Yale University, New Haven, Connecticut 06511, United States.; Department of Chemistry, Yale University, New Haven, Connecticut 06511, United States.; Department of Pharmacology, Yale University, New Haven, Connecticut 06511, United States.

المصدر: ACS central science [ACS Cent Sci] 2017 Aug 23; Vol. 3 (8), pp. 830-838. Date of Electronic Publication: 2017 Aug 07.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE

المؤلفون: Cromm PM; Department of Chemical Biology, Max-Planck-Institute of Molecular Physiology, Otto-Hahn-Strasse 11, 44227, Dortmund, Germany.; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany., Wallraven K; VU University Amsterdam, Department of Chemistry and Pharmaceutical Sciences, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands., Glas A; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.; Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, 44227, Dortmund, Germany., Bier D; Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, 44227, Dortmund, Germany.; University of Eindhoven, Department of Biomedical Engineering, Institute of Complex Molecular Systems, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.; Department of Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45141, Essen, Germany., Fürstner A; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany.; Max-Planck-Institut für Kohlenforschung, Kaiser-Wilhelm-Platz 1, 45470, Mülheim/Ruhr, Germany., Ottmann C; University of Eindhoven, Department of Biomedical Engineering, Institute of Complex Molecular Systems, Den Dolech 2, 5612 AZ, Eindhoven, The Netherlands.; Department of Chemistry, University of Duisburg-Essen, Universitätsstrasse 7, 45141, Essen, Germany., Grossmann TN; Technische Universität Dortmund, Fakultät für Chemie und Chemische Biologie, Otto-Hahn-Strasse 6, 44227, Dortmund, Germany. t.n.grossmann@vu.nl.; VU University Amsterdam, Department of Chemistry and Pharmaceutical Sciences, De Boelelaan 1108, 1081 HZ, Amsterdam, The Netherlands. t.n.grossmann@vu.nl.; Chemical Genomics Centre of the Max Planck Society, Otto-Hahn-Strasse 15, 44227, Dortmund, Germany. t.n.grossmann@vu.nl.

المصدر: Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Oct 17; Vol. 17 (20), pp. 1915-1919. Date of Electronic Publication: 2016 Sep 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

مواضيع طبية MeSH: Alkynes/*chemistry , Peptides/*chemistry, 14-3-3 Proteins/chemistry ; Cyclization ; Models, Molecular ; Molecular Structure ; Small Molecule Libraries/chemical synthesis ; Small Molecule Libraries/chemistry