المؤلفون: Richardson TG, Crouch DJM, Power GM, Morales-Berstein F, Hazelwood E, Fang S, Cho Y, Inshaw JRJ, Robertson CC, Sidore C, Cucca F, Rich SS, Todd JA, G Davey Smith

المصدر: Yearbook of Paediatric Endocrinology.

مصطلحات موضوعية: General Economics, Econometrics and Finance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c4d126240488b8ee8bba6c13cd3d76e3
https://doi.org/10.1530/ey.19.10.4

المؤلفون: Mark I. McCarthy, Francesco Cucca, Crouch Djm., Anubha Mahajan, M I Stefana, Inshaw Jrj., John A. Todd, Carlo Sidore

المصدر: Diabetologia

مصطلحات موضوعية: 0301 basic medicine, False discovery rate, Systematic, Male, Genome-wide association study, Genotype, Endocrinology, Diabetes and Metabolism, Short Communication, Disease, Type 2 diabetes, 030105 genetics & heredity, Biology, Polymorphism, Single Nucleotide, Co-localisation, 03 medical and health sciences, Chromosome (genetic algorithm), Internal Medicine, medicine, Genetics, Insulin, Humans, Genetic Predisposition to Disease, Allele, Alleles, Genetic Association Studies, Genetic association, Type 1 diabetes, Statistics, medicine.disease, United Kingdom, 030104 developmental biology, Analyses, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Italy, Etiology, Female

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a271f11840e6c5c876fdb30c0bf9f767
http://europepmc.org/articles/PMC8099827

المؤلفون: Berstein Fm, Carlo Sidore, Stephen S. Rich, Si Fang, Grace M. Power, Catherine C. Robertson, Hazelwood E, Francesco Cucca, Crouch Djm., John A. Todd, Inshaw Jrj., Tom G. Richardson, George Davey Smith, Yoonsu Cho

مصطلحات موضوعية: Pediatrics, medicine.medical_specialty, Type 1 diabetes, business.industry, Overweight, medicine.disease, Childhood obesity, Immune system, Mendelian randomization, medicine, Life course approach, medicine.symptom, business, Asthma, Early onset

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::409a5e2c06ca464803a76745e7ba55a4
https://doi.org/10.1101/2021.04.19.21255222

المؤلفون: Flemming Pociot, Wei Chen, Carlo Sidore, Patrick Concannon, Jie Zhang, Crouch Djm., John A. Todd, Stephen S. Rich, Inshaw, Suna Onengut-Gumuscu, Antony J. Cutler, Francesco Cucca, Catherine C. Robertson

مصطلحات موضوعية: False discovery rate, Genetics, Type 1 diabetes, Polygene, Chromosome regions, medicine, Autoimmune thyroid disease, Biology, medicine.disease, Gene, Genetic analysis, Large sample

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f8f84d31c6926143741ece46fdd4c839
https://doi.org/10.1101/2021.02.05.429962

المؤلفون: Patrick Concannon, Amy S. Shah, Linda S. Wicker, Suna Onengut-Gumuscu, Dana Dabelea, Chen W-M., Robert P. Kimberly, Jasmin Divers, David B. Dunger, Peter K. Gregersen, Jeffrey C. Edberg, Stephen S. Rich, Huan Yang, Santica M. Marcovina, Antony J. Cutler, S L Bridges, Marian Rewers, Carla J. Greenbaum, Flemming Pociot, Jorge R. Oksenberg, Jean M. Lawrence, Inshaw Jrj., D F Santa Cruz, Andrea K. Steck, Panagiotis Deloukas, Mark A. Atkinson, John A. Todd, Emily Farber, Crouch Djm., Jane H. Buckner, Catherine C. Robertson

المصدر: Robertson, C C & Type 1 Diabetes Genetics Consortium 2021, ' Fine-mapping, trans-ancestral and genomic analyses identify causal variants, cells, genes and drug targets for type 1 diabetes ', Nature Genetics, vol. 53, no. 7, pp. 962-971 . https://doi.org/10.1101/2020.06.19.158071, https://doi.org/10.1038/s41588-021-00880-5
Nature genetics

مصطلحات موضوعية: False discovery rate, Drug, CD4-Positive T-Lymphocytes, endocrine system diseases, media_common.quotation_subject, Gene Expression, Autoimmunity, Computational biology, Quantitative trait locus, Biology, Genetic analysis, Article, 03 medical and health sciences, Immune system, 0302 clinical medicine, Genetic variation, Drug Discovery, Protein Interaction Mapping, Genetics, medicine, Humans, Genetic Predisposition to Disease, Molecular Targeted Therapy, Allele, Gene, Alleles, 030304 developmental biology, media_common, 0303 health sciences, Type 1 diabetes, Drug discovery, Chromosome Mapping, Genetic Variation, Genomics, medicine.disease, Chromatin, 3. Good health, Diabetes Mellitus, Type 1, General Economics, Econometrics and Finance, 030217 neurology & neurosurgery

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5a3f66533a4cf7a2a983554fd2421f8
https://curis.ku.dk/ws/files/284012839/2020.06.19.158071v1.full.pdf

المؤلفون: Walter F. Bodmer, Crouch Djm.

المصدر: Proc Natl Acad Sci U S A

مصطلحات موضوعية: Multifactorial Inheritance, Multidisciplinary, Models, Genetic, Genetic Variation, Genome-wide association study, Computational biology, Biology, Quantitative trait locus, Heritability, symbols.namesake, Phenotype, Quantitative Trait, Heritable, Perspective, Mendelian inheritance, symbols, Trait, Humans, Identification (biology), Association mapping, Genetic association, Genome-Wide Association Study

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5efcd8754d77e27edc9878e262415c6
https://pubmed.ncbi.nlm.nih.gov/32753378

المؤلفون: Linda S. Wicker, Antony J. Cutler, John A. Todd, Jamie Inshaw, Crouch Djm.

المصدر: Diabetes Care

مصطلحات موضوعية: Adult, Male, Candidate gene, Adolescent, Genotype, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Human leukocyte antigen, 03 medical and health sciences, Islets of Langerhans, Young Adult, 0302 clinical medicine, Immune system, Diabetes mellitus, Insulin-Secreting Cells, Commentaries, Internal Medicine, Medicine, Humans, Genetic Predisposition to Disease, 030212 general & internal medicine, Allele, Age of Onset, Child, Alleles, Autoantibodies, Advanced and Specialized Nursing, Type 1 diabetes, Polymorphism, Genetic, business.industry, Infant, Newborn, Infant, Middle Aged, medicine.disease, IKZF3, Interleukin 10, Diabetes Mellitus, Type 1, Haplotypes, Case-Control Studies, Child, Preschool, Immune System, Immunology, Female, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bced52c281e206632d88faa1cf07dfa3
https://pubmed.ncbi.nlm.nih.gov/31862821

المؤلفون: Atla G; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Bonàs-Guarch S; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain. silvia.bonas@crg.eu.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain. silvia.bonas@crg.eu.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. silvia.bonas@crg.eu., Cuenca-Ardura M; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain., Beucher A; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK., Crouch DJM; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Garcia-Hurtado J; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain., Moran I; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK.; Present Address: Life Sciences Department, Barcelona Supercomputing Center (BSC), 08034, Barcelona, Spain., Irimia M; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain., Prasad RB; Lund University Diabetes Centre, Clinical Research Center, Malmö, Sweden.; Department of Clinical Sciences in Malmö, Lund University, Malmö, Sweden., Gloyn AL; Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.; Department of Pediatrics, Division of Endocrinology, Stanford School of Medicine, Stanford, CA, USA., Marselli L; Department of Clinical and Experimental Medicine, AOUP Cisanello University Hospital, University of Pisa, Pisa, Italy., Suleiman M; Department of Clinical and Experimental Medicine, AOUP Cisanello University Hospital, University of Pisa, Pisa, Italy., Berney T; Cell Isolation and Transplantation Center, University of Geneva, Geneva, Switzerland., de Koning EJP; Department of Medicine, Leiden University Medical Center, Leiden, the Netherlands.; Hubrecht Institute/KNAW, Utrecht, the Netherlands., Kerr-Conte J; University of Lille, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Lille (CHU Lille), Institute Pasteur Lille, U1190 -European Genomic Institute for Diabetes (EGID), F59000, Lille, France., Pattou F; University of Lille, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Lille (CHU Lille), Institute Pasteur Lille, U1190 -European Genomic Institute for Diabetes (EGID), F59000, Lille, France., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Piemonti L; Diabetes Research Institute, IRCCS Ospedale San Raffaele and Università Vita-Salute San Raffaele, Milan, Italy., Ferrer J; Centre for Genomic Regulation, The Barcelona Institute of Science and Technology, Barcelona, Spain. jorge.ferrer@crg.eu.; Centro de Investigación Biomédica en red Diabetes y enfermedades metabólicas asociadas (CIBERDEM), Barcelona, Spain. jorge.ferrer@crg.eu.; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, UK. jorge.ferrer@crg.eu.

مؤلفون مشاركون: T2DSystems Consortium

المصدر: Genome biology [Genome Biol] 2022 Sep 15; Vol. 23 (1), pp. 196. Date of Electronic Publication: 2022 Sep 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 1*/genetics , Diabetes Mellitus, Type 1*/metabolism , Diabetes Mellitus, Type 2*/genetics , Islets of Langerhans*/metabolism , RNA, Long Noncoding*/metabolism, Exodeoxyribonucleases/genetics ; Exodeoxyribonucleases/metabolism ; Humans ; Proinsulin/genetics ; Proinsulin/metabolism ; Protein Isoforms/genetics ; RNA Splicing

المؤلفون: Robertson CC; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, USA., Inshaw JRJ; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Onengut-Gumuscu S; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Chen WM; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Santa Cruz DF; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Yang H; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Cutler AJ; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Crouch DJM; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Farber E; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA., Bridges SL Jr; Division of Rheumatology, Department of Medicine, Hospital for Special Surgery, New York, NY, USA.; Division of Rheumatology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Edberg JC; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Kimberly RP; Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA., Buckner JH; Center for Translational Immunology, Benaroya Research Institute, Seattle, WA, USA., Deloukas P; Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.; Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD), King Abdulaziz University, Jeddah, Saudi Arabia., Divers J; Division of Health Services Research, Department of Foundations of Medicine, New York University Long Island School of Medicine, Mineola, NY, USA., Dabelea D; Colorado School of Public Health and Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Lawrence JM; Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA., Marcovina S; Northwest Lipid Metabolism and Diabetes Research Laboratories, University of Washington, Seattle, WA, USA.; Medpace Reference Laboratories, Cincinnati, OH, USA., Shah AS; Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, OH, USA., Greenbaum CJ; Center for Interventional Immunology, Benaroya Research Institute, Seattle, WA, USA.; Diabetes Program, Benaroya Research Institute, Seattle, WA, USA., Atkinson MA; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA., Gregersen PK; Robert S. Boas Center for Genomics and Human Genetics, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, NY, USA., Oksenberg JR; Department of Neurology and Weill Institute for Neurosciences, University of California at San Francisco, San Francisco, CA, USA., Pociot F; Department of Pediatrics, Herlev University Hospital, Copenhagen, Denmark.; Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark., Rewers MJ; Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Steck AK; Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Dunger DB; Department of Paediatrics, University of Cambridge, Cambridge, UK.; Wellcome Trust Medical Research Council Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Wicker LS; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK., Concannon P; Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.; Genetics Institute, University of Florida, Gainesville, FL, USA., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. jatodd@well.ox.ac.uk., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.

مؤلفون مشاركون: Type 1 Diabetes Genetics Consortium

المصدر: Nature genetics [Nat Genet] 2021 Jul; Vol. 53 (7), pp. 962-971. Date of Electronic Publication: 2021 Jun 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Alleles* , Chromosome Mapping* , Genetic Predisposition to Disease* , Genetic Variation* , Genomics*/methods, Diabetes Mellitus, Type 1/*genetics, Autoimmunity/genetics ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Diabetes Mellitus, Type 1/drug therapy ; Diabetes Mellitus, Type 1/metabolism ; Drug Discovery ; Gene Expression ; Humans ; Molecular Targeted Therapy ; Protein Interaction Mapping

المؤلفون: Inshaw JRJ; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. jinshaw@well.ox.ac.uk., Sidore C; Institute for Research in Genetics and Biomedicine (IRGB), Cagliari, Sardinia, Italy., Cucca F; Institute for Research in Genetics and Biomedicine (IRGB), Cagliari, Sardinia, Italy., Stefana MI; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Crouch DJM; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK., McCarthy MI; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Mahajan A; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Genentech, South San Francisco, CA, USA., Todd JA; JDRF/Wellcome Diabetes and Inflammation Laboratory, Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK. jatodd@well.ox.ac.uk.

المصدر: Diabetologia [Diabetologia] 2021 Jun; Vol. 64 (6), pp. 1342-1347. Date of Electronic Publication: 2021 Apr 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Predisposition to Disease* , Polymorphism, Single Nucleotide*, Diabetes Mellitus, Type 1/*genetics , Diabetes Mellitus, Type 2/*genetics, Alleles ; Female ; Genetic Association Studies ; Genotype ; Humans ; Italy ; Male ; United Kingdom