المؤلفون: Dell'Aquila AM; Infectious Diseases Discipline, Department of Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil., Reis GNBD; Department of Orthopedics and Traumatology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil., Cuba GT; Infectious Diseases Discipline, Department of Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil., Targa WHC; Institute of Orthopedics and Traumatology, Faculty of Medicine, Universidade de São Paulo, São Paulo 05403-010, Brazil., Bongiovanni JC; Department of Orthopedics and Traumatology, Universidade de Mogi das Cruzes, Mogi das Cruzes 08780-911, Brazil., Durigon TS; Department of Orthopedics and Traumatology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil., Salles MJ; Infectious Diseases Discipline, Department of Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil., Reis FBD; Department of Orthopedics and Traumatology, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP), São Paulo 04023-900, Brazil.

المصدر: Antibiotics (Basel, Switzerland) [Antibiotics (Basel)] 2023 Dec 13; Vol. 12 (12). Date of Electronic Publication: 2023 Dec 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101637404 Publication Model: Electronic Cited Medium: Print ISSN: 2079-6382 (Print) Linking ISSN: 20796382 NLM ISO Abbreviation: Antibiotics (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Reis GNBD; Universidade Federal de São Paulo, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil., Cuba GT; Universidade Federal de São Paulo, Paulista School of Medicine, São Paulo, SP, Brazil., Targa WHC; Universidade de São Paulo, School of Medicine, Institute of Orthopedics and Traumatology, São Paulo, SP, Brazil., Miras PSC; Hospital Municipal Dr. Mário Gatti, Campinas, SP, Brazil., Bongiovanni JC; Universidade de Mogi das Cruzes, Department of Orthopedics and Traumatology, Mogi das Cruzes, SP, Brazil., Salles MJ; Universidade Federal de São Paulo, Paulista School of Medicine, São Paulo, SP, Brazil., Reis FBD; Universidade Federal de São Paulo, Department of Orthopedics and Traumatology, São Paulo, SP, Brazil., Dell'aquila AM; Universidade Federal de São Paulo, Paulista School of Medicine, São Paulo, SP, Brazil.

المصدر: Acta ortopedica brasileira [Acta Ortop Bras] 2023 Feb 20; Vol. 31 (1), pp. e258453. Date of Electronic Publication: 2023 Feb 20 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Atha Comunicação e Editora Country of Publication: Brazil NLM ID: 9804509 Publication Model: eCollection Cited Medium: Print ISSN: 1413-7852 (Print) Linking ISSN: 14137852 NLM ISO Abbreviation: Acta Ortop Bras Subsets: PubMed not MEDLINE

المؤلفون: Cuba GT; Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, SP, Brazil; Universidade de São Paulo (HCFMUSP), Hospital das Clínicas, Faculdade de Medicina, São Paulo, SP, Brazil. Electronic address: gbtrova@gmail.com., Santos PHD; Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, SP, Brazil., Pignatari ACC; Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, SP, Brazil., Nicolau DP; Center of Anti-infective Research and Development, Hartford Hospital, Hartford, CT, United States., Kiffer CRV; Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina, São Paulo, SP, Brazil.

المصدر: The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases [Braz J Infect Dis] 2022 Mar-Apr; Vol. 26 (2), pp. 102355. Date of Electronic Publication: 2022 Apr 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Editora Country of Publication: Brazil NLM ID: 9812937 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4391 (Electronic) Linking ISSN: 14138670 NLM ISO Abbreviation: Braz J Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Amikacin*/pharmacology , Pseudomonas Infections*/drug therapy, Anti-Bacterial Agents/pharmacology ; Carbapenems/pharmacology ; Humans ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa

المؤلفون: Sakata RAP; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil., Cayô da Silva R; Universidade Federal de São Paulo (UNIFESP), Laboratório de Imunologia e Bacteriologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Diadema, SP, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo - SP, Brazil., Gales AC; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo - SP, Brazil., Cuba GT; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil., Pignatari ACC; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo - SP, Brazil., Kiffer CRV; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, SP, Brazil. Electronic address: carlos.rv.kiffer@gmail.com.

المصدر: Journal of global antimicrobial resistance [J Glob Antimicrob Resist] 2022 Mar; Vol. 28, pp. 115-119. Date of Electronic Publication: 2021 Dec 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Published by Elsevier Ltd. on behalf of International Society of Chemotherapy for Infection and Cancer Country of Publication: Netherlands NLM ID: 101622459 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-7173 (Electronic) Linking ISSN: 22137165 NLM ISO Abbreviation: J Glob Antimicrob Resist Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Infective Agents*/pharmacology , Bacterial Infections*/drug therapy, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Drug Resistance, Bacterial ; Gram-Negative Bacteria ; Humans ; Meropenem/pharmacology ; Microbial Sensitivity Tests

المؤلفون: Lasko MJ; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA., Cuba GT; Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil., Kiffer CRV; Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina-EPM, Universidade Federal de São Paulo-UNIFESP, São Paulo, SP, Brazil., Nicolau DP; Center for Anti-Infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, 06102, USA. david.nicolau@hhchealth.org.; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA. david.nicolau@hhchealth.org.

المصدر: Archives of microbiology [Arch Microbiol] 2021 Dec 22; Vol. 204 (1), pp. 55. Date of Electronic Publication: 2021 Dec 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE

مواضيع طبية MeSH: Carbapenems* , Pseudomonas aeruginosa*/genetics, Anti-Bacterial Agents ; Bacterial Proteins/genetics ; Edetic Acid/pharmacology ; Microbial Sensitivity Tests ; beta-Lactamases/genetics

المؤلفون: Rocha-Santos G; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil., Cuba GT; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil. Electronic address: gbtrova@gmail.com., Cayô R; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório de Imunologia e Bacteriologia (LIB), Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas (DCB), Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF), Diadema, Brazil., Streling AP; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil., Nodari CS; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil., Gales AC; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil., Pignatari ACC; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil; Universidade Federal de São Paulo (UNIFESP), Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil., Nicolau DP; Center for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA., Kiffer CRV; Universidade Federal de São Paulo (UNIFESP), Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina (EPM), São Paulo, Brazil.

المصدر: Diagnostic microbiology and infectious disease [Diagn Microbiol Infect Dis] 2021 Jun; Vol. 100 (2), pp. 115343. Date of Electronic Publication: 2021 Feb 10.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Biomedical Country of Publication: United States NLM ID: 8305899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0070 (Electronic) Linking ISSN: 07328893 NLM ISO Abbreviation: Diagn Microbiol Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*administration & dosage , Anti-Bacterial Agents/*pharmacology , Pseudomonas aeruginosa/*drug effects , beta-Lactamases/*metabolism, Aztreonam/administration & dosage ; Aztreonam/pharmacology ; Cephalosporins/pharmacology ; Clavulanic Acids/administration & dosage ; Clavulanic Acids/pharmacology ; Drug Synergism ; Gene Expression Regulation, Bacterial/drug effects ; Gene Expression Regulation, Enzymologic/drug effects ; Microbial Sensitivity Tests ; Tazobactam/pharmacology ; Ticarcillin/administration & dosage ; Ticarcillin/pharmacology ; beta-Lactamases/genetics

المؤلفون: Cuba GT; Universidade Federal de São Paulo, UNIFESP, Laboratório Especial de Microbiologia Clınica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, EPM, Brazil; Infectious Diseases Division, University of São Paulo, São Paulo, Brazil. Electronic address: gbtrova@gmail.com., Ramos JF; Infectious Diseases Division, University of São Paulo, São Paulo, Brazil., Veiga Kiffer CR; Universidade Federal de São Paulo, UNIFESP, Laboratório Especial de Microbiologia Clınica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina, EPM, Brazil.

المصدر: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2021 Mar; Vol. 27 (3), pp. 497-498. Date of Electronic Publication: 2020 Aug 06.

نوع المنشور: Letter; Comment

بيانات الدورية: Publisher: Elsevier Country of Publication: England NLM ID: 9516420 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-0691 (Electronic) Linking ISSN: 1198743X NLM ISO Abbreviation: Clin Microbiol Infect Subsets: MEDLINE

مواضيع طبية MeSH: Acinetobacter Infections*/drug therapy , Colistin*, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Humans ; Meropenem/pharmacology

المؤلفون: Cuba GT; Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Rocha-Santos G; Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Cayô R; Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.; Universidade Federal de São Paulo - UNIFESP, Laboratório de Imunologia e Bacteriologia - LIB, Setor de Biologia Molecular, Microbiologia e Imunologia, Departamento de Ciências Biológicas - DCB, Instituto de Ciências Ambientais, Químicas e Farmacêuticas - ICAQF, Diadema - SP, Brazil., Streling AP; Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Nodari CS; Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Gales AC; Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.; Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Pignatari ACC; Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.; Universidade Federal de São Paulo - UNIFESP, Laboratório Alerta, Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil., Nicolau DP; Center for Anti-infective Research and Development, Hartford Hospital, Hartford, CT, USA.; Division of Infectious Diseases, Hartford Hospital, Hartford, CT, USA., Kiffer CRV; Universidade Federal de São Paulo - UNIFESP, Laboratório Especial de Microbiologia Clínica (LEMC), Division of Infectious Diseases, Department of Internal Medicine, Escola Paulista de Medicina - EPM, São Paulo - SP, Brazil.

المصدر: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Jul 01; Vol. 75 (7), pp. 1874-1878.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Fosfomycin*/pharmacology , Pseudomonas Infections*/drug therapy, Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Aztreonam/pharmacology ; Cephalosporins/pharmacology ; Humans ; Microbial Sensitivity Tests ; Pseudomonas aeruginosa ; Tazobactam/pharmacology

المؤلفون: da Costa TM; Laboratório de Infecção Hospitalar, Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - bloco I, Sala I2-010, Cidade Universitária Rio de Janeiro, Rio de Janeiro, Brazil. thainamc@uol.com.br., Cuba GT; Laboratório Especial de Microbiologia Clínica, Disciplina de Infectologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Leandro Dupret, São Paulo, SP, 188, Brazil. gbtrova@gmail.com., Morgado PGM; Laboratório de Infecção Hospitalar, Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - bloco I, Sala I2-010, Cidade Universitária Rio de Janeiro, Rio de Janeiro, Brazil., Nicolau DP; Center for Anti-infective Research and Development, Hartford Hospital, 80 Seymour Street, Hartford, CT, USA., Nouér SA; Hospital Universitário Clementino Fraga FilhoFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Rua Rodolpho Paulo Rocco, 255, Rio de Janeiro, RJ, Brazil., Dos Santos KRN; Laboratório de Infecção Hospitalar, Departamento de Microbiologia Médica, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Av. Carlos Chagas Filho, 373 - bloco I, Sala I2-010, Cidade Universitária Rio de Janeiro, Rio de Janeiro, Brazil., Kiffer CRV; Laboratório Especial de Microbiologia Clínica, Disciplina de Infectologia, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), Rua Leandro Dupret, São Paulo, SP, 188, Brazil.

المصدر: BMC infectious diseases [BMC Infect Dis] 2020 Jan 23; Vol. 20 (1), pp. 74. Date of Electronic Publication: 2020 Jan 23.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968551 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2334 (Electronic) Linking ISSN: 14712334 NLM ISO Abbreviation: BMC Infect Dis Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Bacteremia/*drug therapy , Staphylococcal Infections/*drug therapy , Staphylococcus aureus/*drug effects , Vancomycin/*pharmacology, Anti-Bacterial Agents/pharmacokinetics ; Bacteremia/microbiology ; Brazil ; Cephalosporins/pharmacokinetics ; Cephalosporins/pharmacology ; Daptomycin/pharmacokinetics ; Daptomycin/pharmacology ; Humans ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Microbial Sensitivity Tests ; Monte Carlo Method ; Retrospective Studies ; Staphylococcal Infections/microbiology ; Vancomycin/pharmacokinetics ; Ceftaroline

المؤلفون: Antonio MB; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de Sao Paulo., Cuba GT; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de Sao Paulo.; Laboratório Especial de Microbiologia Clínica, Universidade Federal de Sao Paulo, Escola Paulista de Medicina., Vasconcelos RP; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de Sao Paulo., Alves APPS, da Silva BO, Avelino-Silva VI; Department of Infectious and Parasitic Diseases, Faculdade de Medicina da Universidade de Sao Paulo.; Hospital Sirio-Libanes, Sao Paulo, Brazil.

المصدر: AIDS (London, England) [AIDS] 2019 Jan 27; Vol. 33 (1), pp. 77-81.

نوع المنشور: Comparative Study; Journal Article

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: England NLM ID: 8710219 Publication Model: Print Cited Medium: Internet ISSN: 1473-5571 (Electronic) Linking ISSN: 02699370 NLM ISO Abbreviation: AIDS Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*therapeutic use , Doxycycline/*therapeutic use , HIV Infections/*complications , Penicillin G Benzathine/*therapeutic use , Syphilis/*drug therapy, Adult ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Seroconversion ; Treatment Outcome