المؤلفون: Oren Y; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Cell Biology, Harvard Medical School, Boston, MA, USA., Tsabar M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA., Cuoco MS; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Amir-Zilberstein L; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cabanos HF; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Hütter JC; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hu B; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Thakore PI; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Tabaka M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Fulco CP; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Bristol Myers Squibb, Cambridge, MA, USA., Colgan W; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuevas BM; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hurvitz SA; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Slamon DJ; David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.; Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA., Deik A; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Pierce KA; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Clish C; Metabolomics Platform, Broad Institute, Cambridge, MA, USA., Hata AN; Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.; Departments of Medicine, Harvard Medical School, Boston, MA, USA., Zaganjor E; Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN, USA., Lahav G; Department of Systems Biology, Harvard Medical School, Boston, MA, USA., Politi K; Section of Medical Oncology, Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, New Haven, CT, USA., Brugge JS; Department of Cell Biology, Harvard Medical School, Boston, MA, USA. joan_brugge@hms.harvard.edu.; Ludwig Center at Harvard, Boston, MA, USA. joan_brugge@hms.harvard.edu., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. aviv.regev.sc@gmail.com.; Genentech, South San Francisco, CA, USA. aviv.regev.sc@gmail.com.

المصدر: Nature [Nature] 2021 Aug; Vol. 596 (7873), pp. 576-582. Date of Electronic Publication: 2021 Aug 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Cell Cycle*/drug effects , Cell Lineage*/drug effects, Neoplasm Recurrence, Local/*drug therapy , Neoplasm Recurrence, Local/*pathology , Neoplasms/*drug therapy , Neoplasms/*pathology, Antioxidants/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Clone Cells/drug effects ; Clone Cells/metabolism ; Clone Cells/pathology ; DNA Barcoding, Taxonomic ; Fatty Acids/metabolism ; Gene Expression Regulation, Neoplastic ; Humans ; Lentivirus/genetics ; Neoplasm Recurrence, Local/genetics ; Neoplasms/genetics ; Neoplasms/metabolism ; Oncogene Proteins/antagonists & inhibitors ; Oxidation-Reduction ; Oxidative Stress ; Reactive Oxygen Species/metabolism ; Transcription, Genetic/drug effects