المؤلفون: Du J; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China., Wu C; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China., Zheng WK; School of Basic Medicine, Inner Mongolia Medical University, Hohhot, 010110, China., Cui SN; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China., Li L; Department of endocrinology, Tangdu Hospital, Fourth Military Medical University, Xian, Shaanxi, 710038, China., Liu Z; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China., Gao L; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China. gaoli0529@163.com., Heng CN; Department of endocrinology, Tangdu Hospital, Fourth Military Medical University, Xian, Shaanxi, 710038, China. Lvchenyeye@126.com., Lang HJ; School of Nursing, the Fourth Military Medical University, Xi'an, 710032, China. langhj@fmmu.edu.cn.

المصدر: BMC nursing [BMC Nurs] 2024 Apr 01; Vol. 23 (1), pp. 221. Date of Electronic Publication: 2024 Apr 01.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101088683 Publication Model: Electronic Cited Medium: Print ISSN: 1472-6955 (Print) Linking ISSN: 14726955 NLM ISO Abbreviation: BMC Nurs Subsets: PubMed not MEDLINE

المؤلفون: Zhang JL; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Wang SH; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Cui SN; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zhang J; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Li SZ; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Li L; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Zuo YG; Department of Dermatology, State Key Laboratory of Complex Severe and Rare Diseases, National Clinical Research Center for Dermatologic and Immunologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

المصدر: The Journal of dermatology [J Dermatol] 2023 Nov; Vol. 50 (11), pp. 1433-1441. Date of Electronic Publication: 2023 Jul 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7600545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1346-8138 (Electronic) Linking ISSN: 03852407 NLM ISO Abbreviation: J Dermatol Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19*/complications , COVID-19*/diagnosis , COVID-19*/epidemiology , Pemphigus* , Pemphigoid, Bullous*/epidemiology , Autoimmune Diseases*/epidemiology , Skin Diseases, Vesiculobullous*, Humans ; SARS-CoV-2 ; China/epidemiology ; Myalgia ; Adrenal Cortex Hormones

المؤلفون: Zhao H; Department of Critical Care Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Wang P; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Wang X; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Du W; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Yang HH; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Liu Y; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Cui SN; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.; Department of Anesthesiology, Beijing Cancer Hospital, Peking University School of Oncology, Beijing, China., Huang W; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Peng T; The Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada., Chen J; Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Gao C; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA., Wang Y; Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Sadayappan S; Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Ma C; Department of Critical Care Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China., Fan Y; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH, USA., Wang C; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China., Fan GC; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

المصدر: Cardiovascular research [Cardiovasc Res] 2023 Aug 19; Vol. 119 (10), pp. 1981-1996.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

مواضيع طبية MeSH: Endothelial Cells*/metabolism , Lipopolysaccharides*/pharmacology , Lipopolysaccharides*/metabolism, Humans ; Animals ; Mice ; Signal Transduction ; Inflammation/prevention & control ; Inflammation/metabolism ; Mice, Knockout ; Receptors, LDL/metabolism

المؤلفون: Zhang TQ; Shandong University of Traditional Chinese Medicine Ji'nan 250355, China., Li CC; Linyi Central Hospital Linyi 276400, China., Zhang TF; Shandong University of Traditional Chinese Medicine Ji'nan 250355, China., Wang MY; Guangrao County People's Hospital Dongying 257300, China., Cui SN; Guangzhou University of Chinese Medicine Guangzhou 510006, China., Huo Q; Shandong Affiliated Hospital of University of Traditional Chinese Medicine Ji'nan 250011, China.

المصدر: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2021 Dec; Vol. 46 (24), pp. 6465-6473.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Zhongguo yao xue hui : Zhongguo Zhong yi yan jiu yuan Zhong yao yan jiu suo Country of Publication: China NLM ID: 8913656 Publication Model: Print Cited Medium: Print ISSN: 1001-5302 (Print) Linking ISSN: 10015302 NLM ISO Abbreviation: Zhongguo Zhong Yao Za Zhi Subsets: MEDLINE

مواضيع طبية MeSH: Drugs, Chinese Herbal*/pharmacology , Phosphatidylinositol 3-Kinases*/genetics, Animals ; Molecular Docking Simulation ; Network Pharmacology ; PC12 Cells ; Proto-Oncogene Proteins c-akt/genetics ; Rats ; Saponins ; Signal Transduction ; Triterpenes

المؤلفون: Cui SN; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital and Institute, Beijing, China.; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio., Tan HY; Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Anesthesiology, Peking University Cancer Hospital and Institute, Beijing, China., Fan GC; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.

المصدر: Shock (Augusta, Ga.) [Shock] 2021 Sep 01; Vol. 56 (3), pp. 345-351.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 9421564 Publication Model: Print Cited Medium: Internet ISSN: 1540-0514 (Electronic) Linking ISSN: 10732322 NLM ISO Abbreviation: Shock Subsets: MEDLINE

مواضيع طبية MeSH: SARS-CoV-2*, COVID-19/*immunology , COVID-19/*virology , Neutrophils/*virology, Animals ; Cytokine Release Syndrome ; Cytokines/immunology ; Humans ; Immune System ; Immunity, Innate ; Inflammation ; Intercellular Adhesion Molecule-1/immunology ; Lymphocytes/immunology ; Mice ; Neutrophils/metabolism ; Pathogen-Associated Molecular Pattern Molecules/immunology ; Thrombosis

المؤلفون: Wang X; Department of Hepatobiliary Surgery, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China., Lv YL; Department of Hepatobiliary Surgery, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China., Cui SN; Graduate School, Guizhou Medical University, Guiyang 550001, Guizhou Province, China., Zhu CH; Graduate School, Guizhou Medical University, Guiyang 550001, Guizhou Province, China., Li Y; Graduate School, Guizhou Medical University, Guiyang 550001, Guizhou Province, China., Pan YZ; Department of Hepatobiliary Surgery, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang 550001, Guizhou Province, China. panyaozhen112@163.com.

المصدر: World journal of clinical cases [World J Clin Cases] 2021 Jul 16; Vol. 9 (20), pp. 5695-5700.

نوع المنشور: Case Reports

بيانات الدورية: Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101618806 Publication Model: Print Cited Medium: Print ISSN: 2307-8960 (Print) Linking ISSN: 23078960 NLM ISO Abbreviation: World J Clin Cases Subsets: PubMed not MEDLINE

المؤلفون: Liu Y; School of Life Science, Beijing University of Chinese Medicine, Beijing, China.; Department of Dermatology, Shaanxi Hospital of Chinese Medicine, Xi'an, China., Cui SN; Department of Dermatology, China Academy of Chinese Medical Science, Xiyuan Hospital, Beijing, China., Duan MY; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Dou ZL; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Li YZ; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Liu YX; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Xia Y; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Zhang JW; School of Life Science, Beijing University of Chinese Medicine, Beijing, China., Yan XN; Department of Dermatology, Shaanxi Hospital of Chinese Medicine, Xi'an, China. xny_sxtcm@126.com., Han DR; School of Life Science, Beijing University of Chinese Medicine, Beijing, China. handongr@gmail.com.

المصدر: Virology journal [Virol J] 2021 Jul 02; Vol. 18 (1), pp. 135. Date of Electronic Publication: 2021 Jul 02.

نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis C*/complications , Psoriasis*/complications , Psoriasis*/virology, Computational Biology ; Cross-Sectional Studies ; Humans ; Protein Interaction Maps

المؤلفون: Wang P; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Mu X; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Zhao H; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Department of Critical Care Medicine, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China., Li Y; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Wang L; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China., Wolfe V; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Cui SN; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Department of Anesthesiology, Beijing Cancer Hospital, Peking University School of Oncology, Beijing, China., Wang X; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Peng T; The Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada., Zingarelli B; Division of Critical Care Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Wang C; Department of Critical Care Medicine, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China., Fan GC; Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.

المصدر: Frontiers in immunology [Front Immunol] 2021 Feb 17; Vol. 12, pp. 647070. Date of Electronic Publication: 2021 Feb 17 (Print Publication: 2021).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Growth Differentiation Factor 3/*pharmacology , Liver X Receptors/*immunology , Macrophages/*drug effects , Phagocytosis/*drug effects , Recombinant Proteins/*pharmacology , Sepsis/*prevention & control, Animals ; Benzoates/pharmacology ; Benzylamines/pharmacology ; Cells, Cultured ; Cytokines/immunology ; Cytokines/metabolism ; Gene Expression/drug effects ; Gene Expression/immunology ; Gene Expression Profiling/methods ; Growth Differentiation Factor 3/administration & dosage ; Growth Differentiation Factor 3/genetics ; Liver/drug effects ; Liver/immunology ; Liver/microbiology ; Liver X Receptors/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Phagocytosis/immunology ; RAW 264.7 Cells ; Recombinant Proteins/administration & dosage ; Reverse Transcriptase Polymerase Chain Reaction ; Sepsis/immunology ; Sepsis/microbiology

المؤلفون: Fang XZ; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China; Department of Anesthesiology, Clinical Medical School of Yangzhou University (Subei People's Hospital of Jiangsu Province), Yangzhou, Jiangsu Province, PR China., Ge YL; Department of Anesthesiology, Clinical Medical School of Yangzhou University (Subei People's Hospital of Jiangsu Province), Yangzhou, Jiangsu Province, PR China., Chen ZY; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Shu HQ; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Yang YY; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong Universityof Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Yu Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Zhou XJ; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Chen L; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Cui SN; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Wang YX; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China., Yao SL; Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong Universityof Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Electronic address: ysltian@163.com., Shang Y; Department of Critical Care Medicine, Union Hospital, Tongji Medical College, HuazhongUniversity of Science and Technology, Wuhan, Hubei 430022, China; Institute of Anesthesiology and Critical Care Medicine, Union Hospital, Tongji Medical College,Huazhong University of Science and Technology, Wuhan, Hubei 430022, China. Electronic address: you_shang@yahoo.com.

المصدر: International immunopharmacology [Int Immunopharmacol] 2020 Apr; Vol. 81, pp. 106257. Date of Electronic Publication: 2020 Feb 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100965259 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-1705 (Electronic) Linking ISSN: 15675769 NLM ISO Abbreviation: Int Immunopharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Inflammatory Agents/*therapeutic use , Carrier Proteins/*metabolism , Heterocyclic Compounds, 4 or More Rings/*therapeutic use , Lung/*metabolism , Respiratory Distress Syndrome/*drug therapy , Sulfones/*therapeutic use , Thioredoxins/*metabolism, Animals ; Carrier Proteins/genetics ; Disease Models, Animal ; Gene Expression Regulation ; Humans ; Lipopolysaccharides/immunology ; Lung/pathology ; Male ; Mice ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Peroxidase/metabolism ; RAW 264.7 Cells ; Respiratory Distress Syndrome/immunology ; Signal Transduction ; Thioredoxins/genetics

المؤلفون: Wu J; Division of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. msxiaoyun@139.com., Lu WJ, Shan HZ, Zhang ZW, Cui SN, Chen LZ, Fu YY, Xiao Y

المصدر: European review for medical and pharmacological sciences [Eur Rev Med Pharmacol Sci] 2020 Apr; Vol. 24 (8), pp. 4451-4460.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Verduci Country of Publication: Italy NLM ID: 9717360 Publication Model: Print Cited Medium: Internet ISSN: 2284-0729 (Electronic) Linking ISSN: 11283602 NLM ISO Abbreviation: Eur Rev Med Pharmacol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Lupus Nephritis/*immunology , Proto-Oncogene Proteins c-cbl/*immunology , T-Lymphocytes, Helper-Inducer/*immunology, Adult ; Animals ; Cells, Cultured ; Humans ; Lupus Nephritis/pathology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Mutant Strains ; Proto-Oncogene Proteins c-cbl/deficiency ; Proto-Oncogene Proteins c-cbl/genetics ; T-Lymphocytes, Helper-Inducer/pathology