نتائج البحث - "Cuoco MS"

المؤلفون: Subramanian A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: as3894@cornell.edu., Vernon KA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhou Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA. Electronic address: zhouym35@mail.sysu.edu.cn., Marshall JL; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Alimova M; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arevalo C; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zhang F; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Slyper M; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Montesinos MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen LT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dubinsky D; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Purnell J; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Keller K; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Sturner SH; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Grinkevich E; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ghoshal A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kotek A; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Trivioli G; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Nephrology Department, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK., Richoz N; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK., Humphrey MB; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Darby IG; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Miller SJ; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Xu Y; Institute of Dermatology and Venereology, Dermatology Hospital, Southern Medical University, Guangzhou, China., Weins A; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA., Chloe-Villani A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chang SL; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA, USA; Division of Urology, Brigham and Women's Hospital, Boston, MA, USA., Kretzler M; Internal Medicine, Department of Nephrology, University of Michigan, Ann Arbor, MI, USA., Rosenblatt-Rosen O; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Shaw JL; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Zimmerman KA; Department of Internal Medicine, Division of Nephrology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA., Clatworthy MR; Molecular Immunity Unit, Department of Medicine, University of Cambridge, Cambridge, UK; Cellular Genetics, Wellcome Sanger Institute, Hinxton, UK; NIHR Cambridge Biomedical Research Center, Cambridge, UK; Cambridge Institute of Therapeutic Immunology and Infectious Diseases, Cambridge, UK., Regev A; Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Greka A; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Kidney Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Electronic address: agreka@broadinstitute.org.

المصدر: Cell reports [Cell Rep] 2024 Jun 25; Vol. 43 (6), pp. 114253. Date of Electronic Publication: 2024 May 22.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Immunologic*/metabolism , Receptors, Immunologic*/genetics , Membrane Glycoproteins*/metabolism , Membrane Glycoproteins*/genetics , Macrophages*/metabolism , Obesity*/metabolism , Obesity*/pathology , Obesity*/complications , Diabetic Nephropathies*/metabolism , Diabetic Nephropathies*/pathology , Kidney*/pathology , Kidney*/metabolism , Diet, High-Fat* , Mice, Knockout*, Animals ; Mice ; Humans ; Male ; Mice, Inbred C57BL ; Female

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Long interspersed nuclear elements safeguard neural progenitors from precocious differentiation.

المؤلفون: Toda T; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Laboratory of Neural Epigenomics, Institute of Medical Physics and Micro-tissue Engineering, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany; Nuclear Architecture in Neural Plasticity and Aging Laboratory, German Center for Neurodegenerative Diseases, 01307 Dresden, Germany. Electronic address: tomohisa.toda@fau.de., Bedrosian TA; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA., Schafer ST; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany; TUM Center for Organoid Systems (COS), Munich Institute of Biomedical Engineering, Garching, Germany., Cuoco MS; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Computational Neural DNA Dynamics Lab, Department of Cognitive Science, University of California, San Diego, San Diego, CA, USA; Bioinformatics and Systems Biology Graduate Program, University of California, San Diego, San Diego, CA, USA., Linker SB; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Ghassemzadeh S; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Mitchell L; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Whiteley JT; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Novaresi N; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., McDonald AH; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Gallina IS; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Yoon H; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA., Hester ME; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH 43205, USA., Pena M; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA; Department of Psychiatry and Psychotherapy, School of Medicine and Health, Technical University of Munich, Munich, Germany; TUM Center for Organoid Systems (COS), Munich Institute of Biomedical Engineering, Garching, Germany., Lim C; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Suljic E; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., AlFatah Mansour A; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Boulard M; Epigenetics & Neurobiology Unit, EMBL Rome, European Molecular Biology Laboratory, Via Ramarini 32, 00015 Monterotondo, Italy., Parylak SL; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA., Gage FH; Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gage@salk.edu.

المصدر: Cell reports [Cell Rep] 2024 Feb 27; Vol. 43 (2), pp. 113774. Date of Electronic Publication: 2024 Feb 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Genomic Instability* , Neural Stem Cells*, Humans ; Animals ; Mice ; Cell Differentiation ; Long Interspersed Nucleotide Elements

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Junior scientists spotlight social bonds in seminars for diversity, equity, and inclusion in STEM.

المؤلفون: Boyle EA; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America., Goldberg G; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America., Schmok JC; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America., Burgado J; Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, San Diego, CA, United States of America., Izidro Layng F; Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, United States of America., Grunwald HA; Department of Genetics, Harvard Medical School, Boston, MA, United States of America., Balotin KM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, United States of America., Cuoco MS; Laboratory of Genetics, The Salk Institute for Biological Studies, San Diego, CA, United States of America., Chang KC; Department of Political Science, University of California San Diego, La Jolla, CA, United States of America., Ecklu-Mensah G; Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America., Arakaki AKS; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America., Ahmed N; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America., Garcia Arceo X; Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, United States of America., Jagannatha P; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America., Pekar J; Department of Biomedical Informatics, University of California San Diego, La Jolla, CA, United States of America., Iyer M; Graduate School of Biomedical Sciences, Sanford Burnham Prebys Medical Discovery Institute, San Diego, CA, United States of America., Yeo GW; Department of Cellular & Molecular Medicine, University of California San Diego, La Jolla, CA, United States of America.; Stem Cell Program, University of California San Diego, La Jolla, CA, United States of America.; Institute for Genomic Medicine, University of California San Diego, La Jolla, CA, United States of America.

مؤلفون مشاركون: DASL Alliance

المصدر: PloS one [PLoS One] 2023 Nov 02; Vol. 18 (11), pp. e0293322. Date of Electronic Publication: 2023 Nov 02 (Print Publication: 2023).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Diversity, Equity, Inclusion* , Ethnicity*, Female ; Humans ; Minority Groups ; Technology

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Cancer aneuploidies are shaped primarily by effects on tumour fitness.

المؤلفون: Shih J; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Tufts University School of Medicine, Boston, MA, USA.; Department of Internal Medicine, Kirk Kerkorian School of Medicine at the University of Nevada, Las Vegas, NV, USA., Sarmashghi S; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Zhakula-Kostadinova N; Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.; Department of Genetics and Development, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Zhang S; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Georgis Y; Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA., Hoyt SH; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Cuoco MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Gao GF; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA., Spurr LF; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Berger AC; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Ha G; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Rendo V; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Shen H; Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA., Meyerson M; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Genetics, Harvard Medical School, Boston, MA, USA., Cherniack AD; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Taylor AM; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA. at3488@cumc.columbia.edu.; Department of Pathology and Cell Biology, Herbert Irving Comprehensive Cancer Center, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA. at3488@cumc.columbia.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. at3488@cumc.columbia.edu., Beroukhim R; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Department of Medicine, Harvard Medical School, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.

المصدر: Nature [Nature] 2023 Jul; Vol. 619 (7971), pp. 793-800. Date of Electronic Publication: 2023 Jun 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Aneuploidy* , Cell Transformation, Neoplastic*/genetics , Neoplasms*/genetics , Neoplasms*/pathology, Humans ; DNA Copy Number Variations/genetics ; Oncogenes/genetics ; Telomere/genetics ; Centromere/genetics ; Cell Lineage ; Chromosomes, Human, Pair 8/genetics ; Genes, Tumor Suppressor

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دورية أكاديمية

Structural and functional properties of mSWI/SNF chromatin remodeling complexes revealed through single-cell perturbation screens.

المؤلفون: Otto JE; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Chemical Biology Program, Harvard University, Cambridge, MA, USA., Ursu O; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Wu AP; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA., Winter EB; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ma S; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Qian K; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Michel BC; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Buenrostro JD; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA., Berger B; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA; Department of Mathematics, Massachusetts Institute of Technology, Cambridge, MA, USA., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, UA. Electronic address: aviv.regev.sc@gmail.com., Kadoch C; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA; Broad Institute of MIT and Harvard, Cambridge, MA, USA; Chemical Biology Program, Harvard University, Cambridge, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, UA. Electronic address: cigall_kadoch@dfci.harvard.edu.

المصدر: Molecular cell [Mol Cell] 2023 Apr 20; Vol. 83 (8), pp. 1350-1367.e7. Date of Electronic Publication: 2023 Apr 06.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Chromatin Assembly and Disassembly* , Neoplasms*, Animals ; Humans ; Chromosomal Proteins, Non-Histone/genetics ; Chromosomal Proteins, Non-Histone/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Chromatin/genetics ; Mammals/metabolism

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دورية أكاديمية

Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment.

المؤلفون: Hwang WL; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jagadeesh KA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Guo JA; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; School of Medicine, University of California, San Francisco, San Francisco, CA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Biological and Biomedical Sciences Program, Harvard Medical School, Boston, MA, USA., Hoffman HI; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Harvard-MIT MD/PhD and Health Sciences and Technology Program, Harvard Medical School, Boston, MA, USA., Yadollahpour P; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Reeves JW; NanoString Technologies, Seattle, WA, USA., Mohan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Drokhlyansky E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Van Wittenberghe N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ashenberg O; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Farhi SL; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Schapiro D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Laboratory of Systems Pharmacology, Department of Systems Biology, Harvard Medical School, Boston, MA, USA.; Institute for Computational Biomedicine and Institute of Pathology, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Heidelberg, Germany., Divakar P; NanoString Technologies, Seattle, WA, USA., Miller E; NanoString Technologies, Seattle, WA, USA., Zollinger DR; NanoString Technologies, Seattle, WA, USA., Eng G; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Schenkel JM; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA., Su J; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Shiau C; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yu P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Freed-Pastor WA; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Abbondanza D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mehta A; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gould J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lambden C; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Porter CBM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tsankov A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Dionne D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Waldman J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Cuoco MS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Nguyen L; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Delorey T; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Phillips D; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Barth JL; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Kem M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rodrigues C; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ciprani D; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Roldan J; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zelga P; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jorgji V; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Chen JH; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ely Z; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhao D; New York Medical College, Valhalla, NY, USA., Fuhrman K; NanoString Technologies, Seattle, WA, USA., Fropf R; NanoString Technologies, Seattle, WA, USA., Beechem JM; NanoString Technologies, Seattle, WA, USA., Loeffler JS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ryan DP; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Weekes CD; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ferrone CR; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Qadan M; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Aryee MJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jain RK; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Edwin L. Steele Laboratory for Tumor Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neuberg DS; Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA., Wo JY; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hong TS; Center for Systems Biology and Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Xavier R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Rozenblatt-Rosen O; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Genentech, South San Francisco, CA, USA., Mino-Kenudson M; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Castillo CF; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Liss AS; Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Ting DT; Department of Medical Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. aviv.regev.sc@gmail.com., Regev A; Broad Institute of MIT and Harvard, Cambridge, MA, USA. tjacks@mit.edu.; Genentech, South San Francisco, CA, USA. tjacks@mit.edu.

المصدر: Nature genetics [Nat Genet] 2022 Aug; Vol. 54 (8), pp. 1178-1191. Date of Electronic Publication: 2022 Jul 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology , Carcinoma, Pancreatic Ductal*/therapy , Pancreatic Neoplasms*/drug therapy , Pancreatic Neoplasms*/genetics, Biomarkers, Tumor/genetics ; Gene Expression Profiling ; Humans ; Neoadjuvant Therapy ; Prognosis ; Transcriptome/genetics ; Pancreatic Neoplasms

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