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المؤلفون: Vicente E. Torres, Ka Thao, Jessica M. Smith, Peter C. Harris, Madeline R. Martell, Diana Escobar-Zarate, Katharina Hopp, Maria V. Irazabal, Harrison H. Wells, Megan M. Constans, Jennifer Arroyo, Timothy L. Kline, Cynthia J. Sieben
المصدر: Kidney Int
مصطلحات موضوعية: 0301 basic medicine, TRPP Cation Channels, 030232 urology & nephrology, Tolvaptan, Autosomal dominant polycystic kidney disease, Physiology, Renal function, Kidney Volume, Kidney, Kidney cysts, Article, Pathogenesis, Mice, 03 medical and health sciences, 0302 clinical medicine, Animals, Medicine, PKD1, urogenital system, business.industry, Polycystic Kidney, Autosomal Dominant, medicine.disease, Mice, Inbred C57BL, 030104 developmental biology, Nephrology, Mutation, medicine.symptom, business, Genetic Background, Progressive disease, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce66e3ed3b463a4d7d7e627d8ba399e
https://doi.org/10.1016/j .kint.2021.01.028 -
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المؤلفون: Marianna Trakala, Ashleigh Meyer, Darawalee Wangsa, Pei-hsin Hsu, Lauren Zasadil, Angelika Amon, Xiaofeng A. Su, Courtney Sniffen, Glenn A. Paradis, Andrew J. Holland, Thomas Ried, Muskaan Aggarwal, Duanduan Ma, Jian Zhong, Allison Carroll, Jan M. van Deursen, Cynthia J. Sieben
المصدر: Genes & Development
مصطلحات موضوعية: Genetics, 0303 health sciences, Oncogene, Aneuploidy, Chromosome, Karyotype, Locus (genetics), Biology, medicine.disease, medicine.disease_cause, 03 medical and health sciences, Chromosome 15, 0302 clinical medicine, 030220 oncology & carcinogenesis, Chromosome instability, medicine, Carcinogenesis, 030304 developmental biology, Developmental Biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d83b7f0e048c21cc0e3ab9548bed63fd
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المؤلفون: Jan M. van Deursen, Floris Foijer, Cynthia J. Sieben, Ines Sturmlechner, Cheng Zhang, Grace G. Nelson, Karthik B. Jeganathan, Willemijn H. van Deursen, Hu Li, Bjorn Bakker, Darren J. Baker
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Damage and Repair in Cancer Development and Cancer Treatment (DARE), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
المصدر: The Journal of Clinical Investigation, 130(1), 171-188. AMER SOC CLINICAL INVESTIGATION INC
J Clin Investمصطلحات موضوعية: 0301 basic medicine, Pathology, Aging, Lung Neoplasms, Aneuploidy, Dwarfism, PROTEIN, Cell Cycle Proteins, Chromosome Disorders, medicine.disease_cause, Mice, Progeria, 0302 clinical medicine, Clinical investigation, TOOL, Genetics, Mutation, Mosaicism, GENE ONTOLOGY, General Medicine, Phenotype, CANCER, 030220 oncology & carcinogenesis, Corrigendum, CHECKPOINT, Research Article, medicine.medical_specialty, Mitotic index, Mitosis, Protein Serine-Threonine Kinases, Biology, 03 medical and health sciences, Paraffin section, medicine, Animals, AGING-ASSOCIATED PHENOTYPES, Allele, Alleles, BUB1B, TRIP13, Genetic heterogeneity, MUTATIONS, medicine.disease, Mice, Inbred C57BL, SENESCENT CELLS, 030104 developmental biology, ONSET
وصف الملف: application/pdf
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المؤلفون: Masakazu Hamada, Cynthia J. Sieben, Raul O. Fierro Velasco, Nazneen Rahman, Khaled Aziz, David J. Katzmann, Jan M. van Deursen, Karthik B. Jeganathan, Brian A. Davies
المصدر: Journal of Clinical Investigation, 128, 8, pp. 3517-3534
Journal of Clinical Investigation, 128, 3517-3534
The Journal of Clinical Investigationمصطلحات موضوعية: 0301 basic medicine, Centriole, Aneuploidy, Cell Cycle Proteins, Chromosome Disorders, Haploinsufficiency, Biology, medicine.disease_cause, Frameshift mutation, Loss of heterozygosity, Mice, 03 medical and health sciences, Neoplasms, medicine, Animals, Humans, Frameshift Mutation, Centrosome, Mutation, Mosaicism, Tumor Suppressor Proteins, Bone development, Cell Biology, General Medicine, medicine.disease, Chromosomes, Mammalian, Mice, Mutant Strains, 030104 developmental biology, Oncology, Cancer research, Fibroblast Growth Factor 2, Carrier Proteins, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], Multipolar spindles, Research Article, Genetic diseases
وصف الملف: application/pdf
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المصدر: Nature Reviews. Nephrology, 13, 77-89
Nature Reviews. Nephrology, 13, 2, pp. 77-89مصطلحات موضوعية: IGA NEPHROPATHY, 0301 basic medicine, Senescence, Aging, Cell type, GLUCOSE-INDUCED HYPERTROPHY, CYCLE INHIBITOR P16(INK4A), Cell, ACUTE KIDNEY INJURY, SECRETORY PHENOTYPE, ISCHEMIA-REPERFUSION INJURY, Biology, Kidney, medicine.disease_cause, DIABETIC-NEPHROPATHY, 03 medical and health sciences, MESANGIAL CELLS, medicine, Animals, Humans, Cellular Senescence, ACTIVATED PROTEIN-KINASE, Phenotype, TUMOR SUPPRESSION, Cell biology, 030104 developmental biology, medicine.anatomical_structure, Nephrology, Ageing, Immunology, Kidney Diseases, Carcinogenesis, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], Homeostasis
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6دورية أكاديمية
المؤلفون: Darren J. Baker, Bennett G. Childs, Matej Durik, Melinde E. Wijers, Cynthia J. Sieben, Jian Zhong, Rachel A. Saltness, Karthik B. Jeganathan, Grace Casaclang Verzosa, Abdulmohammad Pezeshki
المصدر: Nature, Nature. 530(7589):184-189
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المصدر: Trends in Cell Biology, 28, 9, pp. 723-737
Trends in Cell Biology, 28, 723-737مصطلحات موضوعية: 0301 basic medicine, Senescence, Aging, SECRETORY PHENOTYPE, Antineoplastic Agents, DNA-DAMAGE RESPONSE, Biology, Models, Biological, Article, OVARIAN-CANCER, 03 medical and health sciences, Immune system, Breast cancer, TISSUE-MICROENVIRONMENT, Neoplasms, ONCOGENE-INDUCED SENESCENCE, medicine, Animals, Humans, BREAST-CANCER, Neoplastic transformation, IN-VIVO, TUMOR-GROWTH, CELLULAR SENESCENCE, Cancer, RAS-INDUCED SENESCENCE, Cell Biology, medicine.disease, 030104 developmental biology, Apoptosis, Immune System, Cancer cell, Cancer research, Ovarian cancer, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]
وصف الملف: application/pdf
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المؤلفون: Hyun Ja Nam, Yusuke Kojima, Reeja S. Maskey, Thomas C. Smyrk, Annyoceli Santiago, Yuka Machida, Scott H. Kaufmann, Cynthia J. Sieben, Myoung Shin Kim, Yuichi J. Machida, Karen S. Flatten, Jan M. van Deursen, Darren J. Baker, Kevin L. Peterson
المصدر: Nucleic Acids Research, 45, 8, pp. 4564-4576
Nucleic Acids Research, 45, 4564-4576
Nucleic Acids Researchمصطلحات موضوعية: Male, 0301 basic medicine, Genome instability, Carcinoma, Hepatocellular, Carcinogenesis, Chromosomal Proteins, Non-Histone, DNA damage, Gene Expression, Genome Integrity, Repair and Replication, Biology, medicine.disease_cause, DNA Adducts, Mice, 03 medical and health sciences, chemistry.chemical_compound, Progeria, Germline mutation, Genetics, medicine, Animals, Humans, Mice, Knockout, Topoisomerase, Liver Neoplasms, Syndrome, Aneuploidy, medicine.disease, Phenotype, Molecular biology, DNA-Binding Proteins, Disease Models, Animal, 030104 developmental biology, DNA Topoisomerases, Type I, Liver, chemistry, Proteolysis, Cancer research, biology.protein, Female, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19], DNA
وصف الملف: application/pdf
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c28aa5b4b0a228b7586252dcd78dd2e
https://doi.org/10.1093/nar/gkx107 -
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المؤلفون: Peter C. Harris, Ping Zhu, Cynthia J. Sieben, Xueying Lin, Xiaolei Xu
مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, Embryo, Nonmammalian, TRPP Cation Channels, ATG5, Autosomal dominant polycystic kidney disease, urologic and male genital diseases, Kidney, Autophagy-Related Protein 5, Mice, 03 medical and health sciences, Internal medicine, Genetics, medicine, Autophagy, Animals, Humans, Molecular Biology, Mechanistic target of rapamycin, Cells, Cultured, Zebrafish, Genetics (clinical), PI3K/AKT/mTOR pathway, Mice, Knockout, Sirolimus, Cystic kidney, Polycystic Kidney Diseases, PKD1, biology, urogenital system, TOR Serine-Threonine Kinases, RPTOR, Epithelial Cells, General Medicine, Articles, medicine.disease, Polycystic Kidney, Autosomal Dominant, female genital diseases and pregnancy complications, Disease Models, Animal, Carbamazepine, 030104 developmental biology, Endocrinology, biology.protein, Cancer research
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f21967055ebfdfbd537d3c0894d8555
https://europepmc.org/articles/PMC6251521/ -
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المؤلفون: Cynthia J. Sieben, Khashayarsha Khazaie, Abdulmohammad Pezeshki, Jian Zhong, Rachel A. Saltness, Matej Durik, Karthik B. Jeganathan, Melinde Wijers, Darren J. Baker, Bennett G. Childs, Jan M. van Deursen, Grace C Verzosa, Jordan D. Miller
المصدر: Nature, 530, 184-9
Nature, 530, 7589, pp. 184-9مصطلحات موضوعية: Male, 0301 basic medicine, Aging, Time Factors, Lipodystrophy, Transgene, Longevity, Physiology, Apoptosis, Cell Separation, Biology, Kidney, medicine.disease_cause, Mice, 03 medical and health sciences, Adipocytes, medicine, Animals, Senolytic, Cellular Senescence, Cyclin-Dependent Kinase Inhibitor p16, Multidisciplinary, Myocardium, Stem Cells, Epithelial Cells, Phenotype, 3. Good health, Cell biology, Cell Transformation, Neoplastic, 030104 developmental biology, medicine.anatomical_structure, Health, Organ Specificity, Ageing, Female, Carcinogenesis, Wound healing, Nanomedicine Radboud Institute for Molecular Life Sciences [Radboudumc 19]
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