المؤلفون: Long JY; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Wang ZY; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Zuo MT; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Huang SJ; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Ma X; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Qi XJ; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Huang CY; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China., Liu ZY; College of Veterinary Medicine, Hunan Agricultural University, Changsha, Hunan 410128, China; Hunan Engineering Technology Research Center of Veterinary Drugs, Hunan Agricultural University, Changsha, Hunan 410128, China. Electronic address: liu_zhaoying@hunau.edu.cn.

المصدر: Toxicology letters [Toxicol Lett] 2024 Jun; Vol. 397, pp. 34-41. Date of Electronic Publication: 2024 May 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7709027 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3169 (Electronic) Linking ISSN: 03784274 NLM ISO Abbreviation: Toxicol Lett Subsets: MEDLINE

مواضيع طبية MeSH: Gelsemium*/chemistry , Cytochrome P-450 CYP3A*/metabolism , Indole Alkaloids*/toxicity, Animals ; Tissue Distribution ; Male ; Mice ; Ketoconazole/toxicity ; Ketoconazole/pharmacology ; Cytochrome P-450 CYP3A Inducers/pharmacology ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/drug effects ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Alkaloids

المؤلفون: Chen G; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Sun K; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Michon I; Certara UK Ltd., Simcyp Division, Sheffield, UK., Barter Z; Certara UK Ltd., Simcyp Division, Sheffield, UK., Neuhoff S; Certara UK Ltd., Simcyp Division, Sheffield, UK., Ghosh L; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Ilic K; Takeda Development Center Americas, Inc., Cambridge, MA, USA., Song IH; Takeda Development Center Americas, Inc., Cambridge, MA, USA.

المصدر: Journal of clinical pharmacology [J Clin Pharmacol] 2024 May; Vol. 64 (5), pp. 590-600. Date of Electronic Publication: 2023 Dec 14.

نوع المنشور: Journal Article; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 0366372 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4604 (Electronic) Linking ISSN: 00912700 NLM ISO Abbreviation: J Clin Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Drug Interactions* , Cytochrome P-450 CYP3A Inducers*/pharmacology , Cytochrome P-450 CYP3A Inhibitors*/pharmacology , Cytochrome P-450 CYP3A Inhibitors*/pharmacokinetics , Rifampin*/pharmacology , Rifampin*/pharmacokinetics , Rifampin*/administration & dosage , Models, Biological*, Dichlororibofuranosylbenzimidazole/*analogs & derivatives, Humans ; Male ; Adult ; Benzimidazoles/pharmacokinetics ; Benzimidazoles/administration & dosage ; Benzimidazoles/pharmacology ; Cytochrome P-450 CYP3A/metabolism ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacology ; Female ; Young Adult ; Middle Aged ; Area Under Curve

المؤلفون: Uehara S; Central Institute for Experimental Medicine and Life Science, Kawasaki-ku, Kawasaki 210-0821, Japan., Murayama N; Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan., Higuchi Y; Central Institute for Experimental Medicine and Life Science, Kawasaki-ku, Kawasaki 210-0821, Japan., Shimizu M; Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan., Suemizu H; Central Institute for Experimental Medicine and Life Science, Kawasaki-ku, Kawasaki 210-0821, Japan., Guengerich FP; Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, United States., Yamazaki H; Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan.

المصدر: Chemical research in toxicology [Chem Res Toxicol] 2024 May 20; Vol. 37 (5), pp. 671-674. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 8807448 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5010 (Electronic) Linking ISSN: 0893228X NLM ISO Abbreviation: Chem Res Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Cytochrome P-450 CYP3A*/genetics , Thalidomide*/pharmacology , Thalidomide*/analogs & derivatives , Hepatocytes*/drug effects , Hepatocytes*/metabolism, Humans ; Animals ; Mice ; Liver/drug effects ; Liver/metabolism ; Cell Line ; RNA, Messenger/metabolism ; Enzyme Induction/drug effects ; Male ; Cytochrome P-450 CYP3A Inducers/pharmacology

المؤلفون: Work HM; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.)., Hackett JC; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.)., Lampe JN; Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado, Aurora, Colorado (H.M.W., J.N.L.); and Biomolecular Sciences Institute & Department of Chemistry & Biochemistry, School of Integrated Science & Humanity, College of Arts, Sciences, & Education, Florida International University, Miami, Florida (J.C.H.) jed.lampe@cuanschutz.edu.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 May 16; Vol. 52 (6), pp. 516-525. Date of Electronic Publication: 2024 May 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Antiviral Agents*/pharmacology , Oxidation-Reduction*, Humans ; Female ; Pregnancy ; Dehydroepiandrosterone Sulfate/metabolism ; Hepacivirus/drug effects ; Hepatitis C/drug therapy ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Maternal-Fetal Exchange ; Microsomes, Liver ; Fetus

المؤلفون: Chi Y; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Zhu X; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Chen Y; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Li X; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Jiang Z; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Jian X; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Lian M; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Wu X; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Wang L; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Key Laboratory of New Pharmaceutical Preparations and excipients, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China., Sun M; General Practice Department, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China. Electronic address: 13931123172@163.com., Shi X; Hebei Key Laboratory of Innovative Drug Development and Evaluation, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Demonstration Center for Experimental Pharmacy Education, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China; National Key Laboratory of New Pharmaceutical Preparations and excipients, School of Pharmaceutical Sciences, Hebei Medical University, Shijiazhuang 050017, China. Electronic address: shixiaowei@hebmu.edu.cn.

المصدر: International journal of biological macromolecules [Int J Biol Macromol] 2024 May; Vol. 268 (Pt 2), pp. 131502. Date of Electronic Publication: 2024 Apr 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Microsomes, Liver*/metabolism , Microsomes, Liver*/drug effects , Dioxolanes*/pharmacology , Dioxolanes*/chemistry , Activation, Metabolic*, Animals ; Humans ; Rats ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Cytochrome P-450 Enzyme System/metabolism ; Male ; Piperidones ; Benzodioxoles

المؤلفون: Yin W; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Dong C; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Stevenson A; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Lloyd V; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Petrillo M; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Baratta M; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Hui T; Takeda Development Center Americas, Inc., Cambridge, Massachusetts., Han S; Takeda Development Center Americas, Inc., Cambridge, Massachusetts.

المصدر: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Feb 14; Vol. 52 (3), pp. 180-187. Date of Electronic Publication: 2024 Feb 14.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: United States NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Rifampin*/adverse effects , Piperidines* , Pyridines*, Adult ; Humans ; Male ; Cytochrome P-450 CYP3A Inducers/adverse effects ; Cytochrome P-450 CYP3A Inducers/pharmacokinetics ; Itraconazole/adverse effects ; UDP-Glucuronosyltransferase 1A9 ; Healthy Volunteers ; Mefenamic Acid ; Drug Interactions ; Cytochrome P-450 CYP3A Inhibitors/adverse effects ; Area Under Curve

المؤلفون: Al Zaria MH; Department of Pharmacy Services, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA. malzaria@bwh.harvard.edu., Buckley LF; Department of Pharmacy Services, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA., Dell'orfano H; Department of Pharmacy Services, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA., Manzo P; Department of Pharmacy Services, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA., Fanikos J; Department of Pharmacy Services, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.

المصدر: Journal of thrombosis and thrombolysis [J Thromb Thrombolysis] 2024 Apr; Vol. 57 (4), pp. 598-602. Date of Electronic Publication: 2024 Mar 30.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Kluwer Academic Publishers Country of Publication: Netherlands NLM ID: 9502018 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-742X (Electronic) Linking ISSN: 09295305 NLM ISO Abbreviation: J Thromb Thrombolysis Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A* , Hemorrhage*/drug therapy, Humans ; Drug Interactions ; Cytochrome P-450 CYP3A Inhibitors ; Anticoagulants/therapeutic use ; Administration, Oral

المؤلفون: Bowman C; Genentech, Inc., South San Francisco, California, USA., Dolton M; Genentech, Inc., South San Francisco, California, USA., Ma F; Genentech, Inc., South San Francisco, California, USA., Cheeti S; Genentech, Inc., South San Francisco, California, USA., Kuruvilla D; Genentech, Inc., South San Francisco, California, USA., Sane R; Genentech, Inc., South San Francisco, California, USA., Kassir N; Genentech, Inc., South San Francisco, California, USA., Chen Y; Genentech, Inc., South San Francisco, California, USA.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Apr; Vol. 13 (4), pp. 660-672. Date of Electronic Publication: 2024 Mar 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Cytochrome P-450 CYP3A*/metabolism , Pyrimidines* , Pyrazoles*, Humans ; Drug Interactions ; Pyridines ; Membrane Transport Proteins ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Models, Biological

المؤلفون: Lewis GJ; Drug Metabolism and Pharmacokinetics, In Vitro In Vivo Translation, Research, GlaxoSmithKline, Stevenage, UK., Ahire D; Department of Pharmaceutical Sciences, Washington State University, Spokane, Washington, USA., Taskar KS; Drug Metabolism and Pharmacokinetics, In Vitro In Vivo Translation, Research, GlaxoSmithKline, Stevenage, UK.

المصدر: CPT: pharmacometrics & systems pharmacology [CPT Pharmacometrics Syst Pharmacol] 2024 Apr; Vol. 13 (4), pp. 563-575. Date of Electronic Publication: 2024 Jan 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 101580011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2163-8306 (Electronic) Linking ISSN: 21638306 NLM ISO Abbreviation: CPT Pharmacometrics Syst Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Progestins* , Cytochrome P-450 CYP3A*, Humans ; Female ; Contraceptives, Oral ; Drug Interactions ; Ethinyl Estradiol ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Models, Biological

المؤلفون: Wang C; Department of Pharmacy Center, Shandong Public Health Clinical Center, Jinan, China., Zhou N; Department of Office, Jiyang People's Hospital of Jinan, Jinan, China., Li M; Department of Pharmacy, Shanghe T.C.M Hospital, Jinan, China., Chen H; Department of Pharmacy, Qilu Hospital of Shandong University, Jinan, China.

المصدر: Xenobiotica; the fate of foreign compounds in biological systems [Xenobiotica] 2024 Apr; Vol. 54 (4), pp. 195-200. Date of Electronic Publication: 2024 Mar 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Informa Healthcare Country of Publication: England NLM ID: 1306665 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5928 (Electronic) Linking ISSN: 00498254 NLM ISO Abbreviation: Xenobiotica Subsets: MEDLINE

مواضيع طبية MeSH: Microsomes, Liver*/metabolism , Microsomes, Liver*/drug effects , Cytochrome P-450 CYP3A*/metabolism, Humans ; Cytochrome P-450 CYP2C9/metabolism ; Cytochrome P-450 CYP3A Inhibitors/pharmacology ; Cytochrome P-450 CYP2D6/metabolism ; Cytochrome P-450 Enzyme Inhibitors/pharmacology