المؤلفون: Larry K. Keefer, Luis G. Rodriguez, Ryan J. Holland, Lucy M. Anderson, Y.-S. Robert Cheng, Joseph E. Saavedra, Anna E. Maciag

المصدر: Redox Biology
Redox Biology, Vol 1, Iss 1, Pp 115-124 (2013)

مصطلحات موضوعية: LC/MS, liquid chromatography/mass spectrometry, Clinical Biochemistry, NAC, N-acetylcysteine, SAPK/JNK, stress activated protein kinase/c-jun N-terminal kinase, DMSO, dimethyl sulfoxide, Biochemistry, ATF, activating transcription factor, Piperazines, chemistry.chemical_compound, GSSG, glutathione disulfide (oxidized GSH), GSH, glutathione, JS-K, O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate, Prodrugs, lcsh:QH301-705.5, Membrane Potential, Mitochondrial, lcsh:R5-920, Leukemia, Glutathione, Reactive Nitrogen Species, Gene Expression Regulation, Neoplastic, lcsh:Medicine (General), Oxidation-Reduction, Intracellular, Research Paper, PARP, poly (ADP-ribose) polymerase, Reducing agent, DCF-DA, 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate, Nitric Oxide, Redox, Nitric oxide, RNS, reactive nitrogen species, ROS, reactive oxygen species, FBS, fetal bovine serum, NSCLC, non-small cell lung cancer, Cell Line, Tumor, Humans, Nitric Oxide Donors, Reactive nitrogen species, IPA, Ingenuity Pathway Analysis, Cell Proliferation, NO, nitric oxide, Cell growth, Organic Chemistry, Acetylcysteine, lcsh:Biology (General), chemistry, Apoptosis, HBSS, Hank's balanced salt solution, DAF-FM, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate, Arylated diazeniumdiolate, Azo Compounds, MAPK, mitogen-activated protein kinase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba49a124fdf9df94aa20894824daedee
http://europepmc.org/articles/PMC3757670

المؤلفون: G. Suárez-Artacho, J. Serrano-Díaz-Canedo, Sheila Pereira, G. Blanco-Fernández, C.A. Padilla, L.M. Marín-Gómez, Raúl González, L. Barrera-Pulido, D. Pacheco, Miguel Ángel Gómez-Bravo, M.A. Torres-Nieto, A. Nogales-Muñoz, Elena Navarro-Villarán, F.J. Padillo, J.M. Álamo-Martínez, A. Gila-Bohórquez, C. Bernal-Bellido, José Antonio Bárcena, A. Sarrias-Giménez, L.B. Soriano-De Castro, A. Rodríguez-Hernández, A. Serrablo-Requejo, Jordi Muntané

المساهمون: [Rodríguez-Hernández,A, Navarro-Villarán,E, Pereira,S, Soriano-De Castro,LB, Sarrias-Giménez,A] Institute of Biomedicine of Seville (IBiS), Hospital Universitario 'Virgen del Rocío'/CSIC/Universidad de Sevilla, Sevilla, Spain. [González,R, Barcena,JA, Padilla,CA] Departament of Biochemistry and Molecular Biology, University of Cordoba, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Barrera-Pulido,L, Álamo-Martínez,JM, Nogales-Muñoz,A, Gila-Bohórquez,A, Serrano-Díaz-Canedo,J, Suárez-Artacho,G, Bernal-Bellido,C, Marín-Gómez,LM, Gómez-Bravo,MA, Padillo,FJ, Muntané,J] Department of General Surgery, Hospital Universitario 'Virgen del Rocío' – 'Virgen Macarena'/Instituto de Biomedicina de Sevilla (IBiS)/CSIC/Universidad de Sevilla, Sevilla, Spain. [Serrablo-Requejo,A] Hepato-Biliary Surgery Unit, Hospital Universitario 'Miguel Servet', Zaragoza, Spain. [Blanco-Fernández,G] Hepato-Biliary-Pancreatic and Liver Transplant Service, Hospital Universitario 'Infanta Cristina', Badajoz, Spain. [Pacheco,D] Department of General Surgery and Department of Pathology, Hospital Universitario 'Rio Hortega', Valladolid, Spain.[Torres-Nieto,MA] Department of Pathology, Hospital Universitario 'Rio Hortega', Valladolid, Spain. [Álamo-Martínez,JM, Muntané,J] CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain., We thank the Instituto de Salud Carlos III (PI13/00021), Spanish Ministry of Economy and Competitiveness (BFU2012-32056), Consejería Economía, Innovación, Ciencia y Empleo, Junta de An- dalucia (BIO-0216 and CTS-6264) and Consejería de Salud (PI13/ 00025) for its financial support. We thank Biomedical Research Network Center for Liver and Digestive Diseases (CIBERehd) founded by Instituto de Salud Carlos III., Universidad de Sevilla. Departamento de Cirugía, Universidad de Sevilla. CTS664: Cirugía Avanzada y Trasplantes. Terapia Celular y Bioingeniería Aplicada a la Cirugía

المصدر: Repositorio Institucional de la Consejería de Sanidad de la Comunidad de Madrid
Consejería de Sanidad de la Comunidad de Madrid
Redox Biology
idUS. Depósito de Investigación de la Universidad de Sevilla
instname

مصطلحات موضوعية: Hepatoblastoma, Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Complex and Mixed::Hepatoblastoma [Medical Subject Headings], Neoplasias Hepáticas, Receptor expression, Clinical Biochemistry, Apoptosis, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3 [Medical Subject Headings], Chemicals and Drugs::Organic Chemicals::Urea::Phenylurea Compounds [Medical Subject Headings], Biochemistry, TNF-R1, tumor necrosis factor receptor type I, Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans [Medical Subject Headings], Diseases::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Glandular and Epithelial::Carcinoma::Adenocarcinoma::Carcinoma, Hepatocellular [Medical Subject Headings], Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Initiator::Caspase 8 [Medical Subject Headings], FADD, Receptor, NOS, nitric oxide synthase, Caspase 8, Cell Death, Caspase 3, Caspasa 8, Chemicals and Drugs::Inorganic Chemicals::Free Radicals::Nitric Oxide [Medical Subject Headings], Hep G2 Cells, CSNO, S-nitroso-l-cysteine, Sorafenib, Caspase 9, Cell biology, Gene Expression Regulation, Neoplastic, Receptors, Tumor Necrosis Factor, Type I, H2O2, hydrogen peroxide, Anatomy::Cells::Cells, Cultured::Tumor Cells, Cultured::Cell Line, Tumor::Hep G2 Cells [Medical Subject Headings], Signal transduction, Chemicals and Drugs::Heterocyclic Compounds::Acids, Heterocyclic::Nicotinic Acids::Niacinamide [Medical Subject Headings], medicine.drug, Research Paper, Signal Transduction, Niacinamide, Programmed cell death, Nitric Oxide Synthase Type III, TRAIL-R1, tumor necrosis factor-related apoptosis-inducing ligand type I, Muerte Celular, Diseases::Digestive System Diseases::Digestive System Neoplasms::Liver Neoplasms [Medical Subject Headings], Antineoplastic Agents, Biology, Nitric Oxide, NO, medicine, Death-receptors, Humans, Caspasa 3, Nitric Oxide Donors, Cysteine, Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Nitric Oxide Donors [Medical Subject Headings], Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Death Domain [Medical Subject Headings], FADD, Fas-associated death domain, NO, nitric oxide, S-Nitrosothiols, Óxido Nítrico, NONOate, 1,1-diethyl-2-hydroxy-2-nitroso-hydrazine sodium, Phenylurea Compounds, Organic Chemistry, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death [Medical Subject Headings], digestive system diseases, S-nitrosylation, Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis [Medical Subject Headings], Receptors, TNF-Related Apoptosis-Inducing Ligand, Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxidoreductases Acting on CH-NH2 Group Donors::Amino Acid Oxidoreductases::Nitric Oxide Synthase::Nitric Oxide Synthase Type III [Medical Subject Headings], biology.protein, Cancer research, DAF-FM, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetate, O2·−, superoxide anion, Phenomena and Processes::Genetic Phenomena::Genetic Processes::DNA Damage::DNA Fragmentation [Medical Subject Headings], Compuestos de Fenilurea

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b6e36ed61083a2525dbb900b9fc31
https://hdl.handle.net/10668/2005

المؤلفون: Maciag AE; Basic Science Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, USA., Holland RJ, Robert Cheng YS, Rodriguez LG, Saavedra JE, Anderson LM, Keefer LK

المصدر: Redox biology [Redox Biol] 2013 Feb 01; Vol. 1, pp. 115-24. Date of Electronic Publication: 2013 Feb 01 (Print Publication: 2013).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier, B.V Country of Publication: Netherlands NLM ID: 101605639 Publication Model: eCollection Cited Medium: Internet ISSN: 2213-2317 (Electronic) Linking ISSN: 22132317 NLM ISO Abbreviation: Redox Biol Subsets: MEDLINE

مواضيع طبية MeSH: Azo Compounds/*pharmacology , Leukemia/*metabolism , Nitric Oxide Donors/*pharmacology , Piperazines/*pharmacology , Prodrugs/*chemical synthesis, Acetylcysteine/pharmacology ; Azo Compounds/chemical synthesis ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation, Neoplastic/drug effects ; Glutathione/metabolism ; Humans ; Leukemia/pathology ; Membrane Potential, Mitochondrial/drug effects ; Nitric Oxide/metabolism ; Nitric Oxide Donors/chemical synthesis ; Oxidation-Reduction/drug effects ; Piperazines/chemical synthesis ; Prodrugs/pharmacology ; Reactive Nitrogen Species/metabolism