المؤلفون: Jian-Guang Luo, Tianyu Zhu, Chen Chen, Yi Zhang, Hao Zhang, Dong-Rong Zhu, Xiao-Qin Liu, Ling-Yi Kong, Chao Han, Sifang Wu

المصدر: Acta Pharmaceutica Sinica B, Vol 12, Iss 1, Pp 246-261 (2022)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: PHGDH, phosphoglycerate dehydrogenase, PSAT, phosphoserine aminotransferase, Allosteric regulation, CuAAC, copper-catalyzed alkyne–azide cycloaddition, Regulatory site, ABPP, affinity-based protein profiling, RM1-950, Proteomics, RMSD, root mean square deviation, Serine, CETSA, cellular thermal shift assay, 03 medical and health sciences, 3-PHP, 3-phosphohydroxypyruvate, ROS, reactive oxygen species, 0302 clinical medicine, DARTS, drug affinity responsive target stability, TCEP, tris(2-carboxyethyl) phosphine, GSH, glutathione, TBTA, tris[(1-benzyl-1H-1,2,3-triazol-4-yl)methyl]amine, Phosphoglycerate dehydrogenase, General Pharmacology, Toxicology and Pharmaceutics, Covalent inhibitor, Withanolides, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Chemical proteomics, NADPH, nicotinamide adenine dinucleotide phosphate, Serine synthesis pathway, MD, molecular dynamics, Small molecule, 3-PG, 3-phosphoglycerate, Colon cancer, RMSF, root mean square fluctuations, Enzyme, chemistry, Biochemistry, Oxidative stress, SBD, substrate-binding domain, 030220 oncology & carcinogenesis, Original Article, BLI, biolayer interferometry assay, Therapeutics. Pharmacology, SSP, serine synthesis pathway, Withangulatin A, Cysteine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3543b6d3266f2b136393cdedb4c3da23
http://www.sciencedirect.com/science/article/pii/S2211383521002203

المؤلفون: Hong-Zhuan Chen, Jinmei Jin, Xin Luan, Hong Zhang, Chao Lv, Rui Huang, Yu-Dong Zhou, Hong-Wei Zhang, Ye Wu, Weidong Zhang, Li-Jun Zhang, Sanhong Liu, Dong Lu

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 11, Pp 3481-3492 (2021)

مصطلحات موضوعية: HIF-1α, hypoxia-inducible factor-1α, Hepatocellular carcinoma, β-Catenin, MST, microscale thermophoresis, Regulator, HIF-1α, RM1-950, Carbohydrate metabolism, 03 medical and health sciences, CETSA, cellular thermal shift assay, 0302 clinical medicine, ROS, reactive oxygen species, In vivo, DARTS, drug affinity responsive target stability, BD, bruceine D, medicine, ICAT, inhibitor of β-catenin and T-cell factor, General Pharmacology, Toxicology and Pharmaceutics, Hypoxia, HIF-1β, hypoxia-inducible factor-1β, 030304 developmental biology, 0303 health sciences, Gene knockdown, ICAT, Chemistry, Hypoxia (medical), medicine.disease, Bruceine D, In vitro, Metabolism, Tumor microenvironment, 030220 oncology & carcinogenesis, Catenin, Cyt c, cytochrome c, Cancer research, Original Article, Therapeutics. Pharmacology, medicine.symptom, HCC, hepatocellular carcinoma

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d59238688492b85fe9d982655fde7c
http://europepmc.org/articles/PMC8642446

المؤلفون: Chang Hwa Jung, Hyunjung Lee, Hyo-Deok Seo, Jiyun Ahn, Young In Kim, Tae-Youl Ha, Seung Yeon Ha

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1201-1213 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Male, HFD, high-fat diet, Catechols, Gene Expression, ACC, acetyl-CoA carboxylase, RC799-869, Pathogenesis, Mice, 0302 clinical medicine, Genes, Reporter, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, miRNA, microRNA, Original Research, chemistry.chemical_classification, Chemistry, Fatty liver, Gastroenterology, MicroRNA, 1-Acylglycerol-3-Phosphate O-Acyltransferase, Diseases of the digestive system. Gastroenterology, mRNA, messenger RNA, ChIP, chromatin immunoprecipitation, Hepatocyte nuclear factors, HF, high-fat diet–fed group, UTR, untranslated region, Hepatocyte Nuclear Factor 4, 030211 gastroenterology & hepatology, RNA Interference, Fatty Alcohols, Intracellular, medicine.medical_specialty, TAG, triacylglycerol, DNL, de novo lipogenesis, HNF4α, hepatocyte nuclear factor 4α, 6-G, 6-gingerol, GPAT1, 03 medical and health sciences, Structure-Activity Relationship, cDNA, complementary DNA, GPAT, glycerol-3-phosphate acyltransferase, Internal medicine, NAFLD, microRNA, FFA, free fatty acid, medicine, Animals, Humans, HNF4α, Hepatology, DARTS, drug-affinity–responsive target stability, TLDA, TaqMan low-density arrays, Fatty acid, medicine.disease, Lipid Metabolism, Disease Models, Animal, MicroRNAs, 030104 developmental biology, Endocrinology, Gene Expression Regulation, LysoPA, lysophosphatidic acid, NAFLD, nonalcoholic fatty liver disease, Steatosis, 6-gingerol

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed3294865d4fb01bb2374fab59ed3691
http://www.sciencedirect.com/science/article/pii/S2352345X21001223

المؤلفون: Elva Morretta, Roberta Esposito, Carmen Festa, Raffaele Riccio, Agostino Casapullo, Maria Chiara Monti

المصدر: Marine Drugs, Vol 15, Iss 10, p 312 (2017)

مصطلحات موضوعية: marine bioactive compounds, target identification, affinity chromatography, DARTS (drug affinity responsive target stability), Biology (General), QH301-705.5

وصف الملف: electronic resource

Relation: https://www.mdpi.com/1660-3397/15/10/312; https://doaj.org/toc/1660-3397

URL الوصول: https://doaj.org/article/b7c899504f264dd7991275a5e209086a

المؤلفون: Xunxun, Wu, Lian, Liu, Qiuling, Zheng, Haiping, Hao, Hui, Ye, Ping, Li, Hua, Yang

المصدر: Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: Mitochondrial damage, LDH, lactate dehydrogenase, β-Catenin, Nuclear translocation, Apoptosis, ISO, isoprenaline, OGD, oxygen and glucose deprivation, Myocardial infarction, CETSA, cellular thermal shift assay, PKM2, pyruvate kinase isoform M2, ROS, reactive oxygen species, Heart ischemia, DARTS, drug affinity responsive target stability, TUNEL, deoxynucleotidyl transferase-mediated dUTP nick end-labeling, CK-MB, creatine kinase isoenzyme-MB, Protocatechuic aldehyde, NRVMs, neonatal rat ventricular myocytes, shRNA, short hairpin RNA, Original Article, PCA, protocatechuic aldehyde, TCF4, T-cell factor 4, PKM2, TCF4

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::56972065ff9bfb60fad239d339d0d883
https://pubmed.ncbi.nlm.nih.gov/34900536

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المؤلفون: Chen C; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Zhu T; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Liu X; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Zhu D; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Zhang Y; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Wu S; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Han C; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Zhang H; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Luo J; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Kong L; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 210009, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2022 Jan; Vol. 12 (1), pp. 246-261. Date of Electronic Publication: 2021 Jun 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE

المؤلفون: Wu X; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Liu L; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Zheng Q; College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Hao H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China., Ye H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.; Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing 210009, China., Li P; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China., Yang H; State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Nov; Vol. 11 (11), pp. 3553-3566. Date of Electronic Publication: 2021 Mar 13.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE

المؤلفون: Huang R; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhang L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Jin J; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhou Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; Department of Chemistry and Biochemistry, College of Liberal Arts, University of Mississippi, University, MS 38677-1848, USA., Zhang H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Lv C; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Lu D; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Wu Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhang H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Liu S; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Chen H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Luan X; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China., Zhang W; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.; School of Pharmacy, Second Military Medical University, Shanghai 200433, China.

المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Nov; Vol. 11 (11), pp. 3481-3492. Date of Electronic Publication: 2021 May 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE