نتائج البحث - "DE, Differentially Expressed"

1

Mechanistic insights into the digestion of complex dietary fibre by the rumen microbiota using combinatorial high-resolution glycomics and transcriptomic analyses

المؤلفون: Ajay Badhan, Kristin E. Low, Darryl R. Jones, Xiaohui Xing, Mohammad Raza Marami Milani, Rodrigo Ortega Polo, Leeann Klassen, Sivasankari Venketachalam, Michael G. Hahn, D. Wade Abbott, Tim A. McAllister

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 20, Iss, Pp 148-164 (2022)

مصطلحات موضوعية: AG, arabinogalactan, Nutrient utilization, GH, glycosyl hydrolase, Rumen microbiome, AB, arabinan, Biophysics, Glycome profiling, Biochemistry, AO, ammonium oxalate, CAZyme, carbohydrate active enzyme, PC, post-chlorite, Structural Biology, PL, polysaccharide lyase, Genetics, XG, xyloglucan, NDF, neutral detergent fibre, HX, heteroxylan, Differential gene expression, BS, barley straw, Dietary polysaccharides, ComputingMethodologies_COMPUTERGRAPHICS, AGP, arabinogalactan protein, CE, carbohydrate esterase, TTIR, total tract indigestible residue, food and beverages, ADF, acid detergent fibre, HG, homogalacturonan, ELISA, enzyme-linked immunosorbent assay, AX, arabinoxylan, DE, differentially expressed, AIR, alcohol insoluble residue, HPAEC-PAD, high performance anion exchange chromatography coupled with pulsed amperometric detection, Computer Science Applications, RG, rhamnogalacturonan, FID, flame ionization detection GC, gas chromatography, MS, mass spectrometry, Glycoside hydrolase, SC, sodium carbonate, CH, chlorite, Transcriptome, TP248.13-248.65, CAZymes, Linkage analysis, mAbs, monoclonal antibodies, Research Article, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f13e6b8708336992febbf16f29ff0d21
https://doi.org/10.1016/j.csbj.2021.12.009

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2

Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic Signatures

المؤلفون: Barbara Joanna Niklinska-Schirtz, Murugadas Anbazhagan, Anil G. Jegga, Vasantha L. Kolachala, Suresh Venkateswaran, Lee A. Denson, Raghavan Chinnadurai, Jason D. Matthews, Subra Kugathasan, Gregory Gibson, David J. Cutler, Anne Dodd, Jarod Prince

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 4, Pp 1267-1280 (2021)

مصطلحات موضوعية: Biopsy, RC799-869, Inflammatory bowel disease, Severity of Illness Index, PDGF, platelet-derived growth factor, Transcriptome, PCR, polymerase chain reaction, Crohn Disease, Gene expression, DEG, differentially expressed gene, PDO, patient-derived organoid, FDR, false discovery rate correction, Gene Regulatory Networks, Intestinal Mucosa, Children, Original Research, Secretome, Crohn's disease, Human Intestinal Organoids, Gastroenterology, Diseases of the digestive system. Gastroenterology, Intestinal epithelium, Phenotype, DE, differentially expressed, VEGF, vascular endothelial growth factor, Organoids, medicine.anatomical_structure, Epigenetics, RIN, RNA integrity number, PBS, phosphate-buffered saline, Biology, In vivo, Ileum, Organoid, medicine, CD, Crohn’s disease, Humans, Metabolomics, Gene, PCA, principal component analysis, Hepatology, Gene Expression Profiling, Inflammatory Bowel Disease, RNA, Computational Biology, FC, fold change, medicine.disease, Intestinal Epithelium, Molecular biology, Epithelium, UC, ulcerative colitis, Gene Expression Regulation, Case-Control Studies, GPCR, G protein–coupled receptor, IBS, inflammatory bowel disease

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a702e5ad7a3308d75a8e643ce59a82d6
http://europepmc.org/articles/PMC8455365

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3

The P2RX7B splice variant modulates osteosarcoma cell behaviour and metastatic properties

المؤلفون: Karan M. Shah, Elena Adinolfi, Elena De Marchi, Archana Singh, Luke Tattersall, Alex Williamson, Jennifer M. Down, William D. Fraser, Alison Gartland, Francesco Di Virgilio, Michelle A. Lawson, Dominique Heymann, Darren Lath, Darrell Green

المساهمون: University of Sheffield [Sheffield], University of East Anglia [Norwich] (UEA), Università degli Studi di Ferrara = University of Ferrara (UniFE), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Norwich University, Heymann, Dominique

المصدر: Journal of Bone Oncology
Journal of Bone Oncology, 2021, 31, pp.100398. ⟨10.1016/j.jbo.2021.100398⟩
Journal of Bone Oncology, Vol 31, Iss, Pp 100398-(2021)

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b702ba5c427745d1727816023f8ed9a8
https://eprints.whiterose.ac.uk/179999/1/1-s2.0-S2212137421000531-main.pdf

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4

Hepatic lysosomal acid lipase overexpression worsens hepatic inflammation in mice fed a Western diet

المؤلفون: Gavin Fredrickson, Fanta Barrow, Michael W. Lopresti, Douglas G. Mashek, Arnav S. Desai, Xavier S. Revelo, Breann Abernathy, Wenqi Cui

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100133-(2021)

مصطلحات موضوعية: Male, RNA-Seq, RNA sequencing, Biochemistry, chemistry.chemical_compound, Mice, iWAT, inguinal white adipose tissue, Endocrinology, Lipid droplet, lipase/hepatic, Nonalcoholic fatty liver disease, CE, cholesteryl ester, Chemistry, Kupffer cell, LAL, lysosomal acid lipase, TEM, transmission electron microscope, Mo/MF, monocyte-derived macrophage, DE, differentially expressed, medicine.anatomical_structure, dietary fat, Cholesteryl ester, lysosomal acid lipase, Female, medicine.symptom, NK, natural killer, Research Article, medicine.medical_specialty, autophagy, LD, lipid droplet, TAG, triacylglycerol, Inflammation, QD415-436, liver, Immune system, Internal medicine, NAFLD, GO, Gene Ontology, medicine, Animals, KC, Kupffer cell, FPC, fructose, palmitate, and cholesterol, Triglyceride, immune infiltration, nutritional and metabolic diseases, Cell Biology, Sterol Esterase, IPA, ingenuity pathway analysis, medicine.disease, cholesterol/cell and tissue, digestive system diseases, Mice, Inbred C57BL, SFA, saturated FA, Disease Models, Animal, Diet, Western, NAFLD, nonalcoholic fatty liver disease, Steatosis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c73a9fbcf47ac6bf68281ac21b125829
https://pubmed.ncbi.nlm.nih.gov/34624333

5

Reverse Phase Protein Array Reveals Correlation of Retinoic Acid Metabolism With Cardiomyopathy in Friedreich's Ataxia

المؤلفون: Lauren A. Hauser, Marek Napierala, Amanda Clark, Jennifer M. Farmer, Kimal Rajapakshe, David A. Lynch, Peining Xu, Clementina Mesaros, Dean P. Edwards, Yu-Yun Chen, Ian A. Blair, Shixia Huang, Cristian Coarfa, Jill S. Napierala

المصدر: Molecular & Cellular Proteomics : MCP

مصطلحات موضوعية: Male, Proteomics, Retinoic acid, Biochemistry, Analytical Chemistry, chemistry.chemical_compound, reverse phase protein array, Iron-Binding Proteins, Gene expression, RA, retinoic acid, Cells, Cultured, ROL, retinol, 0303 health sciences, frataxin, biology, LDH, lactate dehydrogenase, 030302 biochemistry & molecular biology, PDT, population doubling time, Reverse phase protein lysate microarray, Middle Aged, DE, differentially expressed, Aldehyde Oxidoreductases, H2O2, hydrogen peroxide, CTRL, control, Biomarker (medicine), biomarker, Female, medicine.symptom, Cardiomyopathies, Adult, IRB, Institutional Review Board, Ataxia, Adolescent, retinoid metabolism, ALDH1A3, aldehyde dehydrogenase family 1 member A3, Protein Array Analysis, UAB, University of Alabama at Birmingham, GAA, guanine–adenine–adenine, CHOP, Children's Hospital of Philadelphia, 03 medical and health sciences, Retinoids, Young Adult, FRDA, Friedreich's ataxia, medicine, Humans, RAL, retinal, Molecular Biology, 030304 developmental biology, AOX1, aldehyde oxidase 1, Aged, RPPA, reverse phase protein array, HL, hearing loss, Research, Friedreich's ataxia, FARS, Functional Assessment Rating Scale, FC, fold change, Fibroblasts, Molecular biology, Fold change, CMP, cardiomyopathy, FXN, frataxin, chemistry, ISTD, internal standard, Friedreich Ataxia, BCM, Baylor College of Medicine, Frataxin, biology.protein, integrins, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239d5431dbcbfd7df7c1a470624aee8d
http://europepmc.org/articles/PMC8214145

6

Analysis of genomics and immune infiltration patterns of epithelial-mesenchymal transition related to metastatic breast cancer to bone

المؤلفون: Yong Liu, An Song, Wu Yunxiao, Zhen Huo, Muchuan Wang, Siyuan Yao, Ziquan Li, Xi Zhou, Yipeng Wang, Bo Yang, Shuzhong Liu, Tong Niu, Chengao Gao

المصدر: Translational Oncology, Vol 14, Iss 2, Pp 100993-(2021)
Translational Oncology

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Cell type, ROC curve, receiver operating characteristic curve, Runx2, runt related transcription factor 2, TNM, Tumor, Node, Metastases, Biology, lcsh:RC254-282, TOM, topological overlap measure, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Immune system, KEGG, kyoto encyclopedia of genes and genomes, ME, module eigengene, medicine, Epithelial–mesenchymal transition, Cytokine binding, BMP, Bone morphogenetic protein, Immune infiltration pattern, Differential gene expression, Original Research, GO, gene ontology, IPA, Ingenuity Pathway Analysis, WGCNA, GEO, gene expression omnibus, Bone metastases, PCC, Pearson correlation coefficient, Breast cancer metastases, AUC, Area under curve, Cancer, Bone metastasis, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, DE, differentially expressed, 030104 developmental biology, medicine.anatomical_structure, Oncology, WGCNA, weighted co-expression network analysis, 030220 oncology & carcinogenesis, Mrna, messenger rna, Cancer research, EMT, epithelial-mesenchymal transition, Prognostic model, Memory T cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737cd8522e6f5ae99b1962605d11b80b
http://www.sciencedirect.com/science/article/pii/S193652332030485X

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7

Radiogenomic Analysis of F-18-Fluorodeoxyglucose Positron Emission Tomography and Gene Expression Data Elucidates the Epidemiological Complexity of Colorectal Cancer Landscape

المؤلفون: Alexandros Pintzas, Sven Klippel, Aristotelis Chatziioannou, Dirk Koczan, Caixia Cheng, Christos Sachpekidis, Vasilis Gregoriou, Stefan Willis, Olga Papadodima, Eleftherios Pilalis, Antonia Dimitrakopoulou-Strauss, Efstathios Iason Vlachavas, Leyun Pan

المصدر: Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal, Vol 17, Iss, Pp 177-185 (2019)

مصطلحات موضوعية: Multivariate analysis, Colorectal cancer, Radiogenomics, PET, Positron Emission Tomography, FDG, F-18-Fluorodeoxyglucose, Biochemistry, 0302 clinical medicine, Structural Biology, TCGA-COAD, The Cancer Genome Atlas-Colon Adenocarcinoma, GEO, Gene Expression Omnibus, CD44, CD44 Molecule (Indian Blood Group), 0303 health sciences, Translational bioinformatics, medicine.diagnostic_test, Lasso, least absolute shrinkage and selection operator, KIT, Proto-Oncogene Receptor Tyrosine Kinase, Computer Science Applications, Positron emission tomography, 030220 oncology & carcinogenesis, Biotechnology, Research Article, 18F-FDG PET, GSTP1, Glutathione S-Transferase Pi 1, lcsh:Biotechnology, Biophysics, Computational biology, Biology, FD, Fractal Dimension, 03 medical and health sciences, lcsh:TP248.13-248.65, Genetics, medicine, SUV, Standardized Uptake Value, CRC, Colorectal cancer, AUC, Area Under the Curve, PCs, Principal Components, 030304 developmental biology, ROC, Receiver-operator Characteristic curve, GDC, Genomics Data Commons, Microarray analysis techniques, Genetic heterogeneity, ACADM, Acyl-Coenzyme A Dehydrogenase, Dimensionality reduction, Microarray analysis, TCGA, medicine.disease, DE, Differentially Expressed, CCT7, Chaperonin Containing TCP1 Subunit 7, MFA, Multiple Factor Analysis

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23e2c956748941640069306f295781c0
http://europepmc.org/articles/PMC6374701

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8

A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells

المؤلفون: Gerald Klanert, Neža Novak, Heena Dhiman, Evgenija Serafimova, Valerie Schmieder, Helene Faustrup Kildegaard, Ly Ngoc Nguyen, Martina Baumann, Nicole Borth

المصدر: Schmieder, V, Novak, N, Dhiman, H, Nguyen, L N, Serafimova, E, Klanert, G, Baumann, M, Kildegaard, H F & Borth, N 2021, ' A pooled CRISPR/AsCpf1 screen using paired gRNAs to induce genomic deletions in Chinese hamster ovary cells ', Biotechnology Reports, vol. 31, e00649 . https://doi.org/10.1016/j.btre.2021.e00649
Biotechnology Reports, Vol 31, Iss, Pp e00649-(2021)
Biotechnology Reports

مصطلحات موضوعية: pgRNA, paired gRNA, Genetic screen, Applied Microbiology and Biotechnology, Genome, CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats, GS, glutamine synthetase, UP-TSS, upstream transcription start site, lncRNA, long non-coding RNA, CPM, counts per million reads mapped, Qp, specific productivity, CRISPR, Cas9, CRISPR-associated protein 9, Chinese hamster ovary cell, oligo, oligonucleotide, gRNA, guide RNA, DE, differentially expressed, Genomic deletion, Chinese hamster ovary cells, Research Article, Biotechnology, dCas9, deactivated Cas9, FDR, false discovery rate, In silico, DOWN-TTS, downstream transcription termination site, NTC, no template control, Computational biology, Biology, CHO, Chinese hamster ovary, Frameshift mutation, AsCpf1, Cpf1 from Acidaminococcus sp BV3L6, VCD, viable cell density, PAM, protospacer adjacent motif, genomic deletion, Gene, DR, differentially represented, Whole genome sequencing, EV, empty vector, PCA, principal component analysis, ncGene, non-coding gene, sgRNA, single guide RNA, NGS, next generation sequencing, paired gRNAs, Cpf1, CRISPR-associated protein in Prevotella and Francisella, RMCE, recombinase-mediated cassette exchange, FACS, fluorescence activated cell sorting, FC, fold change, CRISPR/AsCpf1, TMM, trimmed mean of M values, µ, growth rate, EpoFc, Erythropoietin Fc fusion protein, TP248.13-248.65, Paired gRNAs