-
1
المؤلفون: Zhengcai Ju, Lin-shan Jiang, Xunjiang Wang, Wendong Huang, Zhengtao Wang, Siming Sun, Eryun Zhang, Lili Ding, Tong Tian, Qiaoling Yang, Li Yang, Yangmeng Wang, Yingbo Yang
المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 6, Pp 1541-1554 (2021)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: eWAT, epididymal white adipose tissue, Wt, wild-type, Metabolic disorders, Adipose tissue, Ft1, notoginsenoside Ft1, AUC, area under the curve, iWAT, inguinal white adipose tissue, 0302 clinical medicine, HFD, high fat diet, General Pharmacology, Toxicology and Pharmaceutics, Receptor, ANOVA, analysis of variance, 0303 health sciences, Bile acid, Chemistry, TGR5, GLP-1, glucagon-like peptide-1, Tgr5, membrane-bound G protein-coupled receptor, G protein-coupled bile acid receptor, cAMP, adenosine 3′,5′ cyclic monophosphate, medicine.anatomical_structure, FXR, 030220 oncology & carcinogenesis, GTT, glucose tolerance test, Original Article, Agonist, medicine.medical_specialty, medicine.drug_class, Ileum, RM1-950, 03 medical and health sciences, Insulin resistance, Ucp, uncoupling protein, Internal medicine, Fxr, nuclear farnesoid X receptor, medicine, Lipolysis, Obesity, ITT, insulin tolerance test, 030304 developmental biology, KO, knockout, BAs, bile acids, DIO, diet-induced obesity, medicine.disease, Bile acids, FGF, fibroblast growth factor, BAT, brown adipose tissue, Endocrinology, Therapeutics. Pharmacology, GLP-1, Notoginsenoside Ft1
-
2
المؤلفون: Yanhang Liao, Yichun Yang, Zhuolin Guo, Ling-juan Zhang, Yulin Shi
المصدر: JID Innovations, Vol 2, Iss 1, Pp 100064-(2022)
JID Innovationsمصطلحات موضوعية: HFD, high-fat diet, BMI, body mass index, Adipokine, Adipose tissue, Inflammation, White adipose tissue, Review, Dermatology, PA, palmitic acid, Immune system, DC, dendritic cell, SCORAD, SCORing Atopic Dermatitis, TEWL, transepidermal water loss, Psoriasis, AT, adipose tissue, FFA, free fatty acid, Medicine, AMP, antimicrobial peptide, PSO, psoriasis, TLR, toll-like receptor, Th, T helper, Adiponectin, TG, triglyceride, integumentary system, business.industry, dFB, dermal fibroblast, OA, oleic acid, sWAT, subcutaneous white adipose tissue, KC, keratinocyte, WAT, white adipose tissue, Atopic dermatitis, DIO, diet-induced obesity, AD, atopic dermatitis, medicine.disease, BAT, brown adipose tissue, CI, confidence interval, TC, total cholesterol, RL1-803, Immunology, medicine.symptom, dWAT, dermal white adipose tissue, business
-
3
المؤلفون: Hee-Seok Kweon, Si-Hyong Jang, Kae Won Cho, Dahee Choi, Dae Ho Lee, Sang Gyune Kim, Tom Huh, Eunyong Ahn, Eunyoung Moon, Je Kyung Seong, Yongmin Kwon, Young Seok Kim, Seung Hoi Koo, Geum-Sook Hwang, Hye-Sook Han
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 55, Iss, Pp 101402-(2022)مصطلحات موضوعية: Cirrhosis, Lipophagy, mTORC1, HFD, high fat diet, Sirtuin 1, Non-alcoholic Fatty Liver Disease, Nonalcoholic fatty liver disease, Internal medicine, Mice, Knockout, biology, Chemistry, Fatty liver, NAFLD, Non-alcoholic fatty liver disease, CRTC2, CREB regulated transcription co-activator 2, CRTC2, TG, triacylglycerol, Liver, Sirtuin, Lipogenesis, Original Article, miR-34a, Signal Transduction, medicine.medical_specialty, Diet, High-Fat, medicine, Autophagy, Animals, Obesity, mTORC, mammalian target of rapamycin complex, Molecular Biology, SIRT, Sirtuin, NCD, normal chow diet, Cell Biology, DIO, diet-induced obesity, medicine.disease, Lipid Metabolism, RC31-1245, Mice, Inbred C57BL, MicroRNAs, Endocrinology, Diabetes Mellitus, Type 2, biology.protein, Hepatocytes, Ectopic expression, TSC, tuberous sclerosis complex, Transcription Factors
-
4
المؤلفون: Liming Chen, Junjie Zhu, Lirong Zhang, Xiaochao Ma, Xueyan Shao, Pei Wang, Xiao-bo Zhong, Yifan Bao
المصدر: Acta Pharmaceutica Sinica B, Vol 10, Iss 1, Pp 171-185 (2020)
Acta Pharmaceutica Sinica. Bمصطلحات موضوعية: HFD, high-fat diet, HNF4α, hepatocyte nuclear factor 4 alpha, O-18-LA, offspring from parental mice fed with 18 weeks LFD, BMI, body mass index, Overweight, O-18-HA, offspring from parental mice fed with 18 weeks HFD, 0302 clinical medicine, 4-HA, adult mice fed with 4 weeks HFD, Nuclear receptors, EFV, efavirenz, O-8-LA, offspring from parental mice fed with 8 weeks LFD, SULT1A1, sulfotransferase 1A1, General Pharmacology, Toxicology and Pharmaceutics, 2. Zero hunger, 0303 health sciences, MPA, mobile phase A, PXR, pregnane X receptor, Diet-induced obesity, CYP2E1, cytochrome P450 2E1, 18-HA, adult mice fed with 18 weeks HFD, 7-ER, 7-ethoxyresorufin, 3. Good health, Drug metabolizing enzymes, High-fat diet, 18-LA, adult mice fed with 18 weeks LFD, AhR, aryl hydrocarbon receptor, 030220 oncology & carcinogenesis, 4-LA, adult mice fed with 4 weeks LFD, MDZ, midazolam, DMEs, drug-metabolizing enzymes, medicine.symptom, Drug-metabolizing enzymes, CAR, constitutive androstane receptor, Original article, NAFLD, non-alcoholic fatty liver disease, medicine.medical_specialty, RSF, resorufin, Ontogenic expression, MPB, mobile phase B, O-4-LA, offspring from parental mice fed with 4 weeks LFD, Offspring, PBS, phosphate-buffered saline, 8-HA, adult mice fed with 8 weeks HFD, Gapdh, glyceraldehyde-3-phosphate dehydrogenase, O-8-HA, offspring from parental mice fed with 8 weeks HFD, 03 medical and health sciences, Internal medicine, medicine, 030304 developmental biology, PPARα, peroxisome proliferator-activated receptor alpha, business.industry, lcsh:RM1-950, DIO, diet-induced obesity, RT-qPCR, real-time quantitative PCR, NADPH, nicotinamide adenine dinucleotide phosphate, Severe obesity, medicine.disease, Differential effects, Obesity, LFD, low-fat diet, Endocrinology, lcsh:Therapeutics. Pharmacology, Nuclear receptor, CHZ, chlorzoxazone, UGT1A1, uridine diphosphate glucuronosyltransferase 1A1, O-4-HA, offspring from parental mice fed with 4 weeks HFD, NRs, nuclear receptors, SD, standard deviation, business, 8-LA, adult mice fed with 8 weeks LFD, Ahr aryl hydrocarbon receptor
-
5
المؤلفون: Dan Xu, Jia Nie, Feng Liu, Dandan Jia, Yue Zheng, Xianlin Han, Xueling Liu, Jun Zhang, Xiaoyang Zhang, Jianing Wang, Haoran Sun, Yuguang Shi
المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 763-781 (2019)
Cellular and Molecular Gastroenterology and Hepatologyمصطلحات موضوعية: RT-PCR, reverse-transcription polymerase chain reaction, Liver Cirrhosis, Male, 0301 basic medicine, HFD, high-fat diet, PG, phosphatidylglycerol, medicine.disease_cause, miR, microRNA, MGAT, monoacylglycerol acyltransferase, chemistry.chemical_compound, 0302 clinical medicine, MAM, mitochondrial-associated membrane, Non-alcoholic Fatty Liver Disease, TBARS, thiobarbituric acid reactive substances, Cardiolipin, Insulin, Original Research, Mice, Knockout, Fatty liver, Gastroenterology, Phosphatidylglycerols, PS, phosphatidylserine, Endoplasmic Reticulum Stress, mRNA, messenger RNA, Mitochondria, Acyltransferase, Mitochondrial Dysfunction, Female, 030211 gastroenterology & hepatology, NASH, nonalcoholic steatohepatitis, Signal Transduction, Mitochondrial DNA, medicine.medical_specialty, CL, cardiolipin, Cardiolipins, PBS, phosphate-buffered saline, MEGDEL, 3-methylglutaconic aciduria with deafness, encephalopathy and Leigh-like, PE, phosphatidylethanolamine, MEGDEL Syndrome, 03 medical and health sciences, ROS, reactive oxygen species, Insulin resistance, LPGAT1, NAFLD, Internal medicine, medicine, Animals, Obesity, lcsh:RC799-869, Phosphatidylglycerol, Hepatology, business.industry, nutritional and metabolic diseases, FCCP, p-trifluoromethoxy carbonyl cyanide phenylhydrazone, Promoter, DIO, diet-induced obesity, medicine.disease, WT, wild-type, digestive system diseases, mtDNA, mitochondrial DNA, Diet, Fatty Liver, Oxidative Stress, 030104 developmental biology, Endocrinology, chemistry, Hepatocytes, LPGAT1, lysophosphatidylglycerol acyltransferase 1, DMEM, Dulbecco’s modified Eagle medium, lcsh:Diseases of the digestive system. Gastroenterology, EGTA, ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid, NAFLD, nonalcoholic fatty liver disease, Insulin Resistance, business, TLCL, tetra linoleoyl cardiolipin, Acyltransferases, Oxidative stress
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358bb0e49578b38ed9658eda93c328c
http://www.sciencedirect.com/science/article/pii/S2352345X19300116 -
6
المؤلفون: Shweta Urva, Julie S. Moyers, Krister Bokvist, Kyle W. Sloop, Jorge Alsina-Fernandez, William C. Roell, Charles Benson, Uma Kuchibhotla, David A. D'Alessio, Corina Loghin, Xuewei Cui, Tamer Coskun, Over Cabrera, Daniel A. Briere, Ruth E. Gimeno, Axel Haupt
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 18, Iss, Pp 3-14 (2018)مصطلحات موضوعية: 0301 basic medicine, ipGTT, Intraperitoneal glucose tolerance test, LY3298176, ADA, Antidrug antibodies, Receptor agonist activity, Pharmacology, 0302 clinical medicine, Glucagon-Like Peptide 1, Medicine, OGTT, Oral glucose tolerance test, Receptor, T2DM, Type 2 diabetes mellitus, CNS, Central nervous system, ECG, Electrocardiogram, SMBG, Self-monitored blood glucose, Glucagon-like peptide-1, SAD, Single-ascending dose, LY, LY3298176, Original Article, medicine.drug, Agonist, POC, Proof-of-concept, lcsh:Internal medicine, Glucose-dependent insulinotropic polypeptide, medicine.drug_class, Incretin, 030209 endocrinology & metabolism, GLP-1 RA, Glucagon-like peptide-1 receptor agonist, Incretins, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Metabolic Diseases, PL, PPlacebo, Diabetes mellitus, Type 2 diabetes mellitus, Humans, DU, Dulaglutide, Obesity, GIP, Glucose-dependent insulinotropic polypeptide, lcsh:RC31-1245, Molecular Biology, MAD, Multiple-ascending dose, Glucagon-like peptide 1 receptor, business.industry, CI, Confidence interval, Cell Biology, medicine.disease, DIO, Diet-induced obesity, 030104 developmental biology, HS, Healthy subjects, Diabetes Mellitus, Type 2, MMRM, Mixed model for repeated measures, Dulaglutide, business, LSM, Least square mean
-
7
المؤلفون: Xiangli Han, Qi Wang, Huanhuan Wang, Wenwen Zeng, Ying Cao
المصدر: Molecular Metabolism, Vol 14, Iss, Pp 71-81 (2018)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, lcsh:Internal medicine, Pathology, medicine.medical_specialty, Fluorescence-lifetime imaging microscopy, Adipose Tissue, White, Cold-induced beiging, Adipose tissue, Sympathetic arborizations, Plasticity, Biology, Mice, 03 medical and health sciences, Immunolabeling, Imaging, Three-Dimensional, WAT, white adipose tissues, 0302 clinical medicine, iDISCO, immunolabeling-enabled three-dimensional imaging of solvent-cleared organs, medicine, Animals, Obesity, lcsh:RC31-1245, Molecular Biology, Process (anatomy), Cold-Shock Response, Adipose tissues, DIO, diet-induced obesity, Cell Biology, Adipose Tissue, Beige, Capillaries, Mice, Inbred C57BL, Vascular plasticity, BAT, brown adipose tissues, 030104 developmental biology, Microscopy, Fluorescence, 030220 oncology & carcinogenesis, Catecholamine, Immunohistochemistry, Original Article, 3D volume fluorescence-imaging, Homeostasis, Body Temperature Regulation, medicine.drug
-
8
المؤلفون: Daniel J. Horan, Hyun Cheol Roh, Aaron C. Ericsson, Surabhi D. Abhyankar, Natalie D. Stull, Xiaocheng C. Dong, Alexander G. Robling, Hongxia Ren, Robert N. Bone, Austin M. Reilly, Shijun Yan, Jason M. Conley, Carmella Evans-Molina, Menghao Huang
المصدر: The Journal of Biological Chemistry
مصطلحات موضوعية: insulin receptor (INSR), HFD, high-fat diet, OGTT, oral glucose tolerance test, medicine.medical_treatment, Glucose uptake, ROI, region of interest, Type 2 diabetes, Biochemistry, type 2 diabetes (T2DM), Insr, insulin receptor, Mice, insulin resistance, Hyperinsulinemia, Insulin, glucose transporter type 4 (GLUT4), Mice, Knockout, Glucose Transporter Type 4, diabetes, biology, GLUT4, glucose transporter type 4, GIRKO, GLUT4 promoter-driven insulin receptor knockout, FFPE, formalin-fixed paraffin-embedded, IPGTT, intraperitoneal glucose tolerance test, LPS, lipopolysaccharide, MIRKO, muscle-Insr-KO, Research Article, medicine.medical_specialty, glucose metabolism, T2D, type 2 diabetes, Diet, High-Fat, GSIS, glucose-stimulated insulin secretion, Insulin resistance, Diabetes mellitus, Internal medicine, Glucose Intolerance, medicine, Animals, Molecular Biology, micro-CT, micro-computed tomography, NCD, normal chow diet, business.industry, VLDL, very-low-density lipoprotein, nutritional and metabolic diseases, DIO, diet-induced obesity, Cell Biology, medicine.disease, Mice, Inbred C57BL, FIRKO, fat-Insr-KO, Insulin receptor, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, biology.protein, diet, business, metabolism, GLUT4
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a1f584191ae8f0764e128eed5d78d0
https://doi.org/10.1016/j.jbc.2021.101431 -
9
المؤلفون: Philip Pickford, Guy A. Rutter, Alejandra Tomas, Stephen R. Bloom, James Minnion, Ben Jones, Katja Schoeneberg, Stavroula Bitsi, Jan Ungewiss, Maria Lucey
المساهمون: Medical Research Council (MRC), The Academy of Medical Sciences, Society for Endocrinology, European Foundation for the Study of Diabetes
المصدر: Molecular Metabolism
Molecular Metabolism, Vol 37, Iss, Pp 100991-(2020)مصطلحات موضوعية: 0301 basic medicine, Male, Acylation, GLP-1RA, glucagon-like peptide-1 receptor agonist, Pharmacology, 0601 Biochemistry and Cell Biology, law.invention, Mice, 0302 clinical medicine, n.c., not calculable, law, Glucagon-Like Peptide 1, Receptors, Glucagon, Receptor, TR-FRET, time-resolved Förster resonance energy transfer, Trafficking, Chemistry, Type 2 diabetes, Ligand (biochemistry), Glucagon-like peptide-1, 3. Good health, cAMP, cyclic adenosine monophosphate, FITC, fluorescein isothiocyanate, Signal Transduction, lcsh:Internal medicine, PBS, phosphate-buffered saline, 030209 endocrinology & metabolism, T2D, type 2 diabetes, AUC, area under curve, Brief Communication, SEM, standard error of the mean, Glucagon-Like Peptide-1 Receptor, 03 medical and health sciences, Pharmacokinetics, Confocal microscopy, In vivo, Potency, Animals, Humans, HTRF, homogenous time-resolved fluorescence, lcsh:RC31-1245, HBSS, Hank's buffered salt solution, Molecular Biology, Biased signalling, Dose-Response Relationship, Drug, Exendin-4, Cell Biology, DIO, diet-induced obesity, LC/MSMS, liquid chromatography/tandem mass spectrometry, 0606 Physiology, Peptide Fragments, 030104 developmental biology, Glucose, HEK293 Cells, Exenatide, Blood sugar regulation, BSA, bovine serum albumin, Peptides
-
10
المؤلفون: Jean M. Whaley, Yin Liang, Ken Boayke, Anthony J. Kihm, Thomas Kirchner, Philip Cooper, Eilyn R. Lacy, Robert Perkinson, Russell B. Lingham, Anne M. Cieniewicz, Steve Jarantow, Rupesh Nanjunda, Jason Aligo, Mark L. Chiu, Simon A. Hinke, Katharine D'Aquino, Dana L. Johnson
المصدر: Molecular Metabolism, Vol 10, Iss, Pp 87-99 (2018)
Molecular Metabolismمصطلحات موضوعية: 0301 basic medicine, Blood Glucose, Male, T2D, Type 2 Diabetes Mellitus, medicine.medical_treatment, Glucose uptake, OGTT, oral glucose tolerance test, Pharmacology, Impaired glucose tolerance, Mice, HFD, high fat diet, Insulin, Receptor, Fab, antigen binding antibody fragment, biology, Chemistry, Diabetes, Antibodies, Monoclonal, 3T3 Cells, ELISA, enzyme-linked immunosorbent assay, Liver, IR, insulin receptor, Original Article, KRPH, Kreb's ringer phosphate HEPES buffer, Allosteric Site, Signal Transduction, Agonist, Monoclonal antibody, lcsh:Internal medicine, medicine.drug_class, MMTT, mixed meal tolerance test, SPR, surface plasmon resonance, STZ, streptozotocin, 03 medical and health sciences, Insulin resistance, Allosteric Regulation, PBS, phosphate buffered saline, Diabetes mellitus, Cell Line, Tumor, medicine, Animals, Humans, Hypoglycemic Agents, Positive allosteric modulator, mAb, monoclonal antibody, Muscle, Skeletal, lcsh:RC31-1245, Molecular Biology, Cell Biology, DIO, diet-induced obesity, medicine.disease, ECD, extracellular domain, Receptor, Insulin, Mice, Inbred C57BL, Insulin receptor, 030104 developmental biology, Akt, protein kinase B, biology.protein, BSA, bovine serum albumin, Abs, antibodies
Full Text via ClinicalKey