المؤلفون: Jackson JW; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Frederick C Streich Jr; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Pal A; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Coricor G; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Boston C; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Brueckner CT; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Canonico K; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Chapron C; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Cote S; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Dagbay KB; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Danehy FT Jr; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Kavosi M; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Kumar S; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Lin S; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Littlefield C; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Looby K; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Manohar R; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Martin CJ; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Wood M; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA.; ToxStrategies LLC, 23501 Cinco Ranch Boulevard, Katy, TX 77494, USA., Zawadzka A; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Wawersik S; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Nicholls SB; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Datta A; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Buckler A; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Schürpf T; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Carven GJ; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Qatanani M; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA., Fogel AI; Scholar Rock Inc., 301 Binney Street, Cambridge, MA 02142, USA.

المصدر: Science signaling [Sci Signal] 2024 Jul 09; Vol. 17 (844), pp. eadn6052. Date of Electronic Publication: 2024 Jul 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

مواضيع طبية MeSH: Transforming Growth Factor beta1*/metabolism , Fibrosis* , Latent TGF-beta Binding Proteins*/metabolism , Latent TGF-beta Binding Proteins*/antagonists & inhibitors , Extracellular Matrix*/metabolism, Animals ; Humans ; Mice ; Male ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Diseases/drug therapy ; Disease Progression ; Kidney/pathology ; Kidney/metabolism ; Kidney/drug effects ; Mice, Inbred C57BL

المؤلفون: Hollingsworth LR; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.; Program in Biological and Biomedical Sciences, Harvard Medical School, Boston, MA, USA., Sharif H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Griswold AR; Tri-Institutional MD-PhD Program, Weill Cornell Medical College, Rockefeller University and Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences and Memorial Sloan Kettering Cancer Center, New York, NY, USA., Fontana P; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Mintseris J; Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA, USA., Dagbay KB; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA, USA., Gygi SP; Department of Cell Biology, Harvard Medical School, Harvard University, Boston, MA, USA., Bachovchin DA; Pharmacology Program, Weill Cornell Graduate School of Medical Sciences and Memorial Sloan Kettering Cancer Center, New York, NY, USA. bachovcd@mskcc.org.; Chemical Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. bachovcd@mskcc.org., Wu H; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA. wu@crystal.harvard.edu.; Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. wu@crystal.harvard.edu.

المصدر: Nature [Nature] 2021 Apr; Vol. 592 (7856), pp. 778-783. Date of Electronic Publication: 2021 Mar 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/*metabolism , Inflammasomes/*metabolism , NLR Proteins/*metabolism, CARD Signaling Adaptor Proteins ; Catalytic Domain ; Cryoelectron Microscopy ; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/chemistry ; HEK293 Cells ; Humans ; NLR Proteins/chemistry ; Protein Structure, Tertiary

المؤلفون: Dagbay KB; Scholar Rock Inc., Cambridge, Massachusetts 02139., Treece E; Scholar Rock Inc., Cambridge, Massachusetts 02139., Streich FC Jr; Scholar Rock Inc., Cambridge, Massachusetts 02139., Jackson JW; Scholar Rock Inc., Cambridge, Massachusetts 02139., Faucette RR; Scholar Rock Inc., Cambridge, Massachusetts 02139., Nikiforov A; Scholar Rock Inc., Cambridge, Massachusetts 02139., Lin SC; Scholar Rock Inc., Cambridge, Massachusetts 02139., Boston CJ; Scholar Rock Inc., Cambridge, Massachusetts 02139., Nicholls SB; Scholar Rock Inc., Cambridge, Massachusetts 02139., Capili AD; Scholar Rock Inc., Cambridge, Massachusetts 02139., Carven GJ; Scholar Rock Inc., Cambridge, Massachusetts 02139. Electronic address: gcarven@scholarrock.com.

المصدر: The Journal of biological chemistry [J Biol Chem] 2020 Apr 17; Vol. 295 (16), pp. 5404-5418. Date of Electronic Publication: 2020 Feb 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Docking Simulation*, Antibodies, Monoclonal/*chemistry , Antibodies, Neutralizing/*chemistry , Myostatin/*chemistry, Antibodies, Monoclonal/immunology ; Antibodies, Neutralizing/immunology ; Binding Sites ; Humans ; Myostatin/antagonists & inhibitors ; Myostatin/immunology ; Protein Binding ; Protein Stability

المؤلفون: Martin CJ; Scholar Rock, Inc., Cambridge, MA 02139, USA., Datta A; Scholar Rock, Inc., Cambridge, MA 02139, USA., Littlefield C; Scholar Rock, Inc., Cambridge, MA 02139, USA., Kalra A; Scholar Rock, Inc., Cambridge, MA 02139, USA., Chapron C; Scholar Rock, Inc., Cambridge, MA 02139, USA., Wawersik S; Scholar Rock, Inc., Cambridge, MA 02139, USA., Dagbay KB; Scholar Rock, Inc., Cambridge, MA 02139, USA., Brueckner CT; Scholar Rock, Inc., Cambridge, MA 02139, USA., Nikiforov A; Scholar Rock, Inc., Cambridge, MA 02139, USA., Danehy FT Jr; Scholar Rock, Inc., Cambridge, MA 02139, USA., Streich FC Jr; Scholar Rock, Inc., Cambridge, MA 02139, USA., Boston C; Scholar Rock, Inc., Cambridge, MA 02139, USA., Simpson A; Scholar Rock, Inc., Cambridge, MA 02139, USA., Jackson JW; Scholar Rock, Inc., Cambridge, MA 02139, USA., Lin S; Scholar Rock, Inc., Cambridge, MA 02139, USA., Danek N; Scholar Rock, Inc., Cambridge, MA 02139, USA., Faucette RR; Scholar Rock, Inc., Cambridge, MA 02139, USA., Raman P; Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA., Capili AD; Scholar Rock, Inc., Cambridge, MA 02139, USA., Buckler A; Scholar Rock, Inc., Cambridge, MA 02139, USA., Carven GJ; Scholar Rock, Inc., Cambridge, MA 02139, USA., Schürpf T; Scholar Rock, Inc., Cambridge, MA 02139, USA. thomas@scholarrock.com.

المصدر: Science translational medicine [Sci Transl Med] 2020 Mar 25; Vol. 12 (536).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy, Transforming Growth Factor beta/*antagonists & inhibitors, Animals ; CD8-Positive T-Lymphocytes ; Cardiotoxicity ; Cell Line, Tumor ; Humans ; Mice ; Rats ; Signal Transduction

المؤلفون: Okerberg ES; ActivX Biosciences, Inc. , La Jolla , California 92037 , United States., Dagbay KB; Department of Chemistry , University of Massachusetts , Amherst , Massachusetts 01002 , United States., Green JL; ActivX Biosciences, Inc. , La Jolla , California 92037 , United States., Soni I; Department of Chemistry , University of Massachusetts , Amherst , Massachusetts 01002 , United States., Aban A; ActivX Biosciences, Inc. , La Jolla , California 92037 , United States., Nomanbhoy TK; ActivX Biosciences, Inc. , La Jolla , California 92037 , United States., Savinov SN; Department of Biochemistry & Molecular Biology , University of Massachusetts , Amherst , Massachusetts 01003 , United States., Hardy JA; Department of Chemistry , University of Massachusetts , Amherst , Massachusetts 01002 , United States.; Models to Medicine Center, Institute of Applied Life Sciences , University of Massachusetts , Amherst , Massachusetts 01003 , United States., Kozarich JW; ActivX Biosciences, Inc. , La Jolla , California 92037 , United States.

المصدر: Biochemistry [Biochemistry] 2019 Dec 31; Vol. 58 (52), pp. 5320-5328. Date of Electronic Publication: 2019 May 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Proteomics*, Adenosine Triphosphate/*metabolism , Caspase 6/*chemistry , Caspase 6/*metabolism , Enzyme Precursors/*chemistry , Enzyme Precursors/*metabolism, Amino Acid Sequence ; Binding Sites ; Humans ; Jurkat Cells ; Models, Molecular ; Protein Conformation

المؤلفون: Eron SJ; Department of Chemistry , University of Massachusetts , 104 LGRT, 710 N. Pleasant St. , Amherst , Massachusetts 01003 , United States., MacPherson DJ; Department of Chemistry , University of Massachusetts , 104 LGRT, 710 N. Pleasant St. , Amherst , Massachusetts 01003 , United States., Dagbay KB; Department of Chemistry , University of Massachusetts , 104 LGRT, 710 N. Pleasant St. , Amherst , Massachusetts 01003 , United States., Hardy JA; Department of Chemistry , University of Massachusetts , 104 LGRT, 710 N. Pleasant St. , Amherst , Massachusetts 01003 , United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2018 May 18; Vol. 13 (5), pp. 1279-1290. Date of Electronic Publication: 2018 Apr 11.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*drug effects , Caspases/*metabolism , Zinc/*metabolism, Humans

المؤلفون: Dagbay KB; Department of Chemistry, University of Massachusetts, Amherst, MA 01002., Hardy JA; Department of Chemistry, University of Massachusetts, Amherst, MA 01002 hardy@chem.umass.edu.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2017 Sep 19; Vol. 114 (38), pp. E7977-E7986. Date of Electronic Publication: 2017 Sep 01.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Dynamics Simulation* , Proteolysis*, Caspase 6/*chemistry, Caspase 6/metabolism ; Deuterium Exchange Measurement ; Humans ; Protein Domains ; Protein Structure, Secondary

المؤلفون: Dagbay KB; Department of Chemistry, University of Massachusetts Amherst , Amherst, Massachusetts 01003, United States., Hill ME; Department of Chemistry, University of Massachusetts Amherst , Amherst, Massachusetts 01003, United States., Barrett E; Department of Chemistry, University of Massachusetts Amherst , Amherst, Massachusetts 01003, United States., Hardy JA; Department of Chemistry, University of Massachusetts Amherst , Amherst, Massachusetts 01003, United States.

المصدر: Biochemistry [Biochemistry] 2017 Aug 29; Vol. 56 (34), pp. 4568-4577. Date of Electronic Publication: 2017 Aug 16.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

مواضيع طبية MeSH: Mutation, Missense*, Caspase 6/*chemistry , Neoplasm Proteins/*chemistry , Neoplasms/*enzymology, Amino Acid Substitution ; Caspase 6/genetics ; Caspase 6/metabolism ; Catalytic Domain ; Humans ; Neoplasm Proteins/metabolism ; Neoplasms/genetics

المؤلفون: Dagbay KB; From the Departments of Chemistry and., Bolik-Coulon N; From the Departments of Chemistry and., Savinov SN; Biochemistry and Molecular Biology, University of Massachusetts, Amherst, Massachusetts 01003., Hardy JA; From the Departments of Chemistry and hardy@chem.umass.edu.

المصدر: The Journal of biological chemistry [J Biol Chem] 2017 Mar 24; Vol. 292 (12), pp. 4885-4897. Date of Electronic Publication: 2017 Feb 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

مواضيع طبية MeSH: Caspase 6/*metabolism, Caspase 6/chemistry ; Caspase 7/chemistry ; Caspase 7/metabolism ; Enzyme Stability ; Humans ; Molecular Dynamics Simulation ; Protein Binding ; Protein Conformation ; Protein Conformation, alpha-Helical ; Protons

المؤلفون: Caparanga AR; School of Chemical Engineering and Chemistry, Mapúa Institute of Technology, Intramuros, Manila 1002, Philippines. arcaparanga@mapua.edu.ph, Basilia BA, Dagbay KB, Salvacion JW

المصدر: Waste management (New York, N.Y.) [Waste Manag] 2009 Sep; Vol. 29 (9), pp. 2425-8. Date of Electronic Publication: 2009 Apr 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Pergamon Press Country of Publication: United States NLM ID: 9884362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2456 (Electronic) Linking ISSN: 0956053X NLM ISO Abbreviation: Waste Manag Subsets: MEDLINE

مواضيع طبية MeSH: Industrial Waste*, Polyethylene Terephthalates/*isolation & purification , Waste Management/*methods, Calorimetry, Differential Scanning ; Carbon Dioxide/analysis ; Hydrolysis ; Octoxynol/chemistry ; Polyethylene Terephthalates/chemistry ; Sodium Hydroxide/chemistry ; Spectroscopy, Fourier Transform Infrared