-
1
المؤلفون: Anthony R. Harris, Susan M. Lotarski, Michael Aaron Brodney, Michael Popiolek, Catherine A. Thorn, Stephen Jenkinson, Che Wah Lee, Jennifer E. Davoren, Stefanus J. Steyn, Lei Zhang, Terrence Peter Kenakin, Betty Pettersen, Sarah Grimwood, Damien Webb, Michelle R. Garnsey, Simeon Ramsey, John T. Lazzaro, Steven Victor O'neil, Lisa Nottebaum, Jean-Philippe Fortin, Jeremy R. Edgerton
المصدر: Journal of Medicinal Chemistry. 60:6649-6663
مصطلحات موضوعية: 0301 basic medicine, Agonist, Allosteric modulator, medicine.drug_class, Chemistry, Allosteric regulation, Muscarinic acetylcholine receptor M1, Pharmacology, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, Convulsion, medicine, Molecular Medicine, Cholinergic, Structure–activity relationship, medicine.symptom, Receptor
-
2
المؤلفون: Damien Webb, Rachel Franks
المصدر: M/C Journal. 22
مصطلحات موضوعية: Geography, Colonialism, Socioeconomics, Metropolitan area, Indigenous
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::11a2e762b9d4dd4fdff42612893a4a41
https://doi.org/10.5204/mcj.1529 -
3
المؤلفون: Christopher Ryan Butler, Qingyi Yang, Michael Popiolek, Natasha M. Kablaoui, Lei Zhang, Sarah Grimwood, John T. Lazzaro, Rouba Kozak, Damien Webb, Rebecca E. O’Connor, Erik Alphie Lachapelle
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Carbamate, 010405 organic chemistry, Chemistry, medicine.medical_treatment, Organic Chemistry, Key features, 01 natural sciences, Biochemistry, 0104 chemical sciences, Structural homology, 010404 medicinal & biomolecular chemistry, Drug Discovery, Muscarinic acetylcholine receptor, medicine, Cholinergic, Interaction mode, Binding site, Neuroscience
-
4Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs
المؤلفون: Kyriacos C. Nicolaou, Holger Karsunky, Sotirios Totokotsopoulos, Damien Webb, Julia Gavrilyuk, Hanan Fernando, Antonia F. Stepan, Athanasios Papakyriakou, Dionisios Vourloumis
المصدر: ChemMedChem. 11:31-37
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Fusion Proteins, bcr-abl, Antineoplastic Agents, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, Cell Line, Tumor, hemic and lymphatic diseases, Drug Discovery, Humans, Structure–activity relationship, Moiety, General Pharmacology, Toxicology and Pharmaceutics, Cytotoxicity, Structural motif, Protein Kinase Inhibitors, Cell Proliferation, Pharmacology, ABL, Dose-Response Relationship, Drug, Molecular Structure, Bicyclic molecule, 010405 organic chemistry, Chemistry, Organic Chemistry, 0104 chemical sciences, Imatinib mesylate, Imatinib Mesylate, Molecular Medicine, Drug Screening Assays, Antitumor
-
5
المؤلفون: Timothy L. Foley, Justin I. Montgomery, Daniel P. Uccello, Anthony R. Harris, Steven Victor O'neil, Bruce N. Rogers, Douglas S. Johnson, Justin R. Piro, Tarek A. Samad, Christopher Ryan Butler, Stephen Noell, Rafael G. Silva, Deane M. Nason, Christopher John Helal, Adam M. Gilbert, Julie Cianfrogna, Laura A. McAllister, Scot Richard Mente, Christopher L. Shaffer, Kari R. Fonseca, Damien Webb, Jayvardhan Pandit, Michael Aaron Brodney
المصدر: Journal of medicinal chemistry. 61(7)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Arachidonic Acids, Pharmacology, 01 natural sciences, Amidohydrolases, Glycerides, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Neuritis, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, Rats, Wistar, Neuroinflammation, Brain Chemistry, Trifluoromethyl, 010405 organic chemistry, Drug discovery, Anti-Inflammatory Agents, Non-Steroidal, Leaving group, Serine hydrolase, Endocannabinoid system, Macaca mulatta, Monoacylglycerol Lipases, 0104 chemical sciences, Rats, Monoacylglycerol lipase, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine, Carbamates, Biomarkers, Endocannabinoids
-
6
المؤلفون: Jennifer E, Davoren, Michelle, Garnsey, Betty, Pettersen, Michael A, Brodney, Jeremy R, Edgerton, Jean-Philippe, Fortin, Sarah, Grimwood, Anthony R, Harris, Stephen, Jenkinson, Terry, Kenakin, John T, Lazzaro, Che-Wah, Lee, Susan M, Lotarski, Lisa, Nottebaum, Steven V, O'Neil, Michael, Popiolek, Simeon, Ramsey, Stefanus J, Steyn, Catherine A, Thorn, Lei, Zhang, Damien, Webb
المصدر: Journal of medicinal chemistry. 60(15)
مصطلحات موضوعية: Diarrhea, Male, Lactams, Vomiting, Scopolamine, Isoindoles, Structure-Activity Relationship, Dogs, Allosteric Regulation, Piperidines, Seizures, Thiadiazoles, Animals, Humans, Donepezil, Rats, Wistar, Oxazoles, Sulfonamides, Receptor, Muscarinic M1, Mice, Inbred C57BL, Amphetamine, Drug Design, Indans, Microsomes, Liver, Ataxia, Female
-
7
المؤلفون: Timothy F. Jamison, Andrew S. Kleinke, Damien Webb
المساهمون: Massachusetts Institute of Technology. Department of Chemistry, Jamison, Timothy F, Kleinke, Andrew S., Webb, Damien
المصدر: Prof. Jamison via Erja Kajosalo
مصطلحات موضوعية: Chemistry, Organic Chemistry, Drug Discovery, Polymer chemistry, Ring (chemistry), Biochemistry
وصف الملف: application/pdf
-
8
المؤلفون: Elizabeth Mary Beck, Damien Webb, Antonia F. Stepan
مصطلحات موضوعية: Chemistry, Heteroatom, Molecule, Nanotechnology, Organic molecules
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::68767d310e183696f503f2672dcb5f40
https://doi.org/10.1039/9781782622086-00274 -
9
المؤلفون: Deane M. Nason, Keith Dlugolenski, Chewah Lee, Betty Pettersen, Gregory W. Kauffman, Lei Zhang, Carrie Northcott, Stephen Jenkinson, Yuxia Mao, Jennifer E. Davoren, Susan M. Lotarski, Veronica Reinhart, Damien Webb, Michelle R. Garnsey, Sarah Grimwood, John T. Lazzaro, Michael Aaron Brodney, Jeremy R. Edgerton, Jason Cordes, Stefanus J. Steyn, Romelia Salomon-Ferrer, Steven Victor O'neil, Terrence Peter Kenakin, Lisa Nottebaum, Michael Popiolek, Christopher John Helal, Anthony R. Harris
المصدر: Journal of medicinal chemistry. 59(13)
مصطلحات موضوعية: 0301 basic medicine, Agonist, Male, Models, Molecular, Allosteric modulator, Stereochemistry, medicine.drug_class, Carboxamide, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Mice, Structure-Activity Relationship, 0302 clinical medicine, Muscarinic acetylcholine receptor, Drug Discovery, medicine, Structure–activity relationship, Animals, Picolinic Acids, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Receptor, Muscarinic M1, Rats, Thiazoles, 030104 developmental biology, Pyran, Molecular Medicine, Cholinergic, Female, Pharmacophore, 030217 neurology & neurosurgery
-
10
المؤلفون: Veronica Reinhart, Susan M. Lotarski, Stefanus J. Steyn, Jennifer E. Davoren, Lei Zhang, Erik Alphie Lachapelle, Deane M. Nason, Michael Eric Green, Keith Dlugolenski, Anthony R. Harris, Jiangli Yan, Sarah Grimwood, Michelle R. Garnsey, Chewah Lee, Dennis P. Anderson, John T. Lazzaro, R. Scott Obach, Damien Webb, Lois K. Chenard, Jeremy R. Edgerton, Michael Aaron Brodney, Romelia Salomon-Ferrer, Gregory W. Kauffman, Steven Victor O'neil
المصدر: Bioorganicmedicinal chemistry letters. 26(2)
مصطلحات موضوعية: 0301 basic medicine, Allosteric modulator, Indoles, Stereochemistry, Clinical Biochemistry, Allosteric regulation, Pharmaceutical Science, Biochemistry, Molecular Docking Simulation, 03 medical and health sciences, chemistry.chemical_compound, Mice, Allosteric Regulation, Amide, Drug Discovery, Animals, Humans, Homology modeling, Molecular Biology, Chemistry, Hydrogen bond, Organic Chemistry, Receptor, Muscarinic M1, Hydrogen Bonding, Amides, 030104 developmental biology, Intramolecular force, Drug Design, Molecular Medicine, Pharmacophore
Find this issue from the American Chemical Society