المؤلفون: Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany., Plenker D; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Dammert MA; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Lorenz C; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Brägelmann J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Mildred Scheel School of Oncology, Cologne, University Hospital Cologne, Medical Faculty, Cologne, Germany., Tumbrink HL; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Klein S; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Schmitt A; Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany., Büttner R; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Persigehl T; Department of Radiology, Medical Faculty and University Hospital Cologne, University of Cologne, Cologne, Germany., Shokat KM; Howard Hughes Medical Institute, University of California San Francisco, San Francisco, California.; Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California., Wunderlich FT; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany.; Max Planck Institute for Metabolism Research, Cologne, Germany.; Institute for Genetics, University of Cologne, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), Cologne, Germany.; Center for Endocrinology, Diabetes and Preventive Medicine (CEDP) Cologne, Cologne, Germany., Schram AM; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.; Weill Cornell Medical College, New York, New York., Peifer M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Sos ML; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen), Essen, Germany., Thomas RK; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany.

المصدر: Molecular cancer therapeutics [Mol Cancer Ther] 2022 May 04; Vol. 21 (5), pp. 821-830.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma of Lung* , Lung Neoplasms*, Animals ; Carcinogenesis/genetics ; Humans ; Mice ; Neuregulin-1/genetics ; Oncogenes ; Receptor, ErbB-2/genetics ; Receptor, ErbB-3/genetics

المؤلفون: Brägelmann J; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. johannes.braegelmann@uni-koeln.de.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. johannes.braegelmann@uni-koeln.de.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. johannes.braegelmann@uni-koeln.de.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. johannes.braegelmann@uni-koeln.de., Lorenz C; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Borchmann S; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Else-Kröner-Forschungskolleg Clonal Evolution in Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Nishii K; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Wegner J; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Meder L; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Ostendorp J; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Ast DF; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Heimsoeth A; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Nakasuka T; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Hirabae A; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Okawa S; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan., Dammert MA; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Plenker D; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724, USA.; Lustgarten Foundation Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY, 11724, USA., Klein S; Else-Kröner-Forschungskolleg Clonal Evolution in Cancer, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Lohneis P; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Gu J; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Godfrey LK; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Forster J; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany.; Genome Informatics, Institute of Human Genetics, University Duisburg-Essen, Essen, Germany., Trajkovic-Arsic M; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Zillinger T; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Haarmann M; Mildred Scheel School of Oncology Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Quaas A; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Lennartz S; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Schmiel M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., D'Rozario J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Thomas ES; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Imperial College London, London, UK., Li H; Crown Bioscience, San Diego, CA, USA., Schmitt CA; Department of Hematology, Oncology and Tumor Immunology, Charité - University Medical Center, Virchow Campus, and Molekulares Krebsforschungszentrum, Berlin, Germany.; Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.; Department of Hematology and Oncology, Kepler University Hospital, Johannes Kepler University, Linz, Austria., George J; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department of Head and Neck Surgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Thomas RK; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany., von Karstedt S; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Hartmann G; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Büttner R; Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Ullrich RT; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany., Siveke JT; Institute for Developmental Cancer Therapeutics, West German Cancer Center, University Hospital Essen, Essen, Germany.; Division of Solid Tumor Translational Oncology, German Cancer Consortium (DKTK, partner site Essen) and German Cancer Research Center, DKFZ, Heidelberg, Germany., Ohashi K; Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.; Department of Respiratory Medicine, Okayama University Hospital, Japan, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Schlee M; Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, Germany., Sos ML; Molecular Pathology, Institute of Pathology, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.; Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2021 Sep 17; Vol. 12 (1), pp. 5505. Date of Electronic Publication: 2021 Sep 17.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Immunity, Innate*/drug effects , MAP Kinase Signaling System*/drug effects, DEAD Box Protein 58/*metabolism , Inflammation/*pathology , Neoplasms/*metabolism , Protein Kinase Inhibitors/*pharmacology , Receptors, Immunologic/*metabolism, Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Cell Cycle Checkpoints/drug effects ; Cell Death/drug effects ; Cell Line, Tumor ; Cytokines/metabolism ; ErbB Receptors/metabolism ; Female ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; Immune Evasion/drug effects ; Interferon Regulatory Factor-1/metabolism ; Mice ; Mice, Inbred C57BL ; Neoplasms/pathology ; Oncogenes ; Signal Transduction/drug effects

المؤلفون: Bebber CM; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Thomas ES; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Imperial College London, London, UK., Stroh J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Chen Z; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Androulidaki A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Schmitt A; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Höhne MN; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany., Stüker L; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., de Pádua Alves C; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Khonsari A; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Dammert MA; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Parmaksiz F; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Tumbrink HL; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Beleggia F; Clinic I for Internal Medicine, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Sos ML; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany., Riemer J; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Department for Chemistry, Institute for Biochemistry, University of Cologne, Cologne, Germany., George J; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Brodesser S; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany.; Institute of Pathology, Medical Faculty, University Hospital of Cologne, Cologne, Germany.; DKFZ, German Cancer Research Center, German Cancer Consortium (DKTK), Heidelberg, Germany., Reinhardt HC; Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK partner site Essen), Essen, Germany., von Karstedt S; Department of Translational Genomics, Medical Faculty, University of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.; Center for Molecular Medicine Cologne, Medical Faculty, University Hospital of Cologne, Cologne, Germany. s.vonkarstedt@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2021 Apr 06; Vol. 12 (1), pp. 2048. Date of Electronic Publication: 2021 Apr 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Ferroptosis*, Neuroendocrine Tumors/*pathology , Small Cell Lung Carcinoma/*pathology, Animals ; Antioxidants/metabolism ; Apoptosis ; Biomarkers, Tumor/metabolism ; Cell Line, Tumor ; Cell Survival ; Humans ; Lipid Metabolism ; Male ; Mice, Nude ; Models, Biological ; Necroptosis ; Phospholipid Hydroperoxide Glutathione Peroxidase/metabolism ; Phospholipids/metabolism ; Prognosis ; Thioredoxins/metabolism ; Mice

المؤلفون: Dammert MA; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany., Olsen RR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Böhm S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Monhasery N; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Whitney CP; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Chalishazar MD; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Guthrie MR; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Klein S; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Ireland AS; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA., Ryan J; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Schmitt A; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Marx A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Ozretić L; Department of Cellular Pathology, Royal Free Hospital, London, NW3 2QG, UK., Castiglione R; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany., Jachimowicz RD; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Wolf E; Theodor Boveri Institute, Biocenter, University of Würzburg, 97074, Würzburg, Germany., Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany., Poirier JT; Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA., Büttner R; Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany., Sen T; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA., Byers LA; Department of Thoracic and Head & Neck Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, 77030, USA., Reinhardt HC; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, 50931, Cologne, Germany., Letai A; Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, 02215, USA., Oliver TG; Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, 84112, USA. trudy.oliver@hci.utah.edu., Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, 50937, Cologne, Germany. martin.sos@uni-koeln.de.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.; Center for Molecular Medicine Cologne, University of Cologne, 50931, Cologne, Germany. martin.sos@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2019 Aug 02; Vol. 10 (1), pp. 3485. Date of Electronic Publication: 2019 Aug 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis/*genetics , Gene Expression Regulation, Neoplastic/*genetics , Lung Neoplasms/*genetics , Proto-Oncogene Proteins c-myc/*metabolism , Small Cell Lung Carcinoma/*genetics, Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; CRISPR-Cas Systems/genetics ; Cell Line, Tumor ; DNA Damage/drug effects ; DNA Damage/genetics ; Disease Models, Animal ; Gene Expression Regulation, Neoplastic/drug effects ; HEK293 Cells ; Humans ; Lung Neoplasms/drug therapy ; Mice ; Molecular Targeted Therapy/methods ; Proto-Oncogene Proteins c-myc/genetics ; RNA, Small Interfering/metabolism ; Small Cell Lung Carcinoma/drug therapy

المؤلفون: Fassunke J; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Müller F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany., Michels S; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany., Dammert MA; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Schmitt A; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Joseph Stelzmann Str. 26, 50931, Cologne, Germany., Plenker D; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Lategahn J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany., Heydt C; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Tumbrink HL; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Alber Y; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany., Klein S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Else Kröner Forschungskolleg Clonal Evolution in Cancer, University Hospital Cologne, Weyertal 115b, 50931, Cologne, Germany., Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Dahmen I; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Fischer RN; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany., Scheffler M; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany., Ihle MA; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Priesner V; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany., Scheel AH; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Wagener S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Kron A; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany., Frank K; Section Pneumology, Clinic III of Internal Medicine, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Garbert K; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany., Persigehl T; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Püsken M; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Haneder S; Institute of Diagnostic and Interventional Radiology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Schaaf B; Hospital Dortmund gGmbH, Muensterstrasse 240, 44145, Dortmund, Germany., Rodermann E; Onkologie Rhein-Sieg, Schloßstraße 18, 53840, Troisdorf, Germany., Engel-Riedel W; Department of Pneumology, Lung Hospital Cologne Merheim, City of Cologne Municipal Hospitals, Cologne, Germany., Felip E; Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain., Smit EF; Thoracic Oncology Service, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands., Merkelbach-Bruse S; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany., Reinhardt HC; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany.; Department I of Internal Medicine, University Hospital of Cologne, Weyertal 115b, 50931, Cologne, Germany.; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Joseph Stelzmann Str. 26, 50931, Cologne, Germany., Kast SM; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany., Wolf J; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany. juergen.wolf@uk-koeln.de., Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227, Dortmund, Germany. daniel.rauh@tu-dortmund.de., Büttner R; Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. reinhard.buettner@uk-koeln.de.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany. reinhard.buettner@uk-koeln.de.; Lung Cancer Group Cologne and Network Genomic Medicine (Lung Cancer), Department I of Internal Medicine, Center for Integrated Oncology Cologne-Bonn, University Hospital Cologne, Kerpener Str. 62, 50931, Cologne, Germany. reinhard.buettner@uk-koeln.de., Sos ML; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. martin.sos@uni-koeln.de.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, Weyertal 115b, 50931, Cologne, Germany. martin.sos@uni-koeln.de.; Center for Molecular Medicine Cologne, University of Cologne, Robert-Koch-Str. 21, 50931, Cologne, Germany. martin.sos@uni-koeln.de.

المصدر: Nature communications [Nat Commun] 2018 Nov 07; Vol. 9 (1), pp. 4655. Date of Electronic Publication: 2018 Nov 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Drug Resistance, Neoplasm/*drug effects , ErbB Receptors/*antagonists & inhibitors , Piperazines/*pharmacology , Protein Kinase Inhibitors/*pharmacology, Acrylamides ; Aniline Compounds ; Animals ; Cell Line, Tumor ; Disease Progression ; ErbB Receptors/chemistry ; ErbB Receptors/metabolism ; Female ; Humans ; Kinetics ; Mice ; Mice, Nude ; Mutation/genetics ; NIH 3T3 Cells ; Piperazines/chemistry ; Protein Binding/drug effects ; Protein Conformation ; Protein Kinase Inhibitors/chemistry

المؤلفون: Brägelmann J; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Dammert MA; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Dietlein F; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, Gottfried-Hagen-Str. 20, 51105 Cologne, Germany., Choidas A; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Böhm S; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Richters A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Basu D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Tischler V; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Lorenz C; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Habenberger P; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Fang Z; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Ortiz-Cuaran S; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Leenders F; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Eickhoff J; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Koch U; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Getlik M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Termathe M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Sallouh M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Greff Z; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Varga Z; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Balke-Want H; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., French CA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA., Peifer M; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany., Reinhardt HC; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany., Örfi L; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary; Department of Pharmaceutical Chemistry, Semmelweis University, Hőgyes E. U.9, Budapest, Hungary., Kéri G; Vichem Chemie Research Ltd., Herman Ottó u. 15, Budapest, Hungary., Ansén S; Department I of Internal Medicine and Center for Integrated Oncology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Heukamp LC; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Büttner R; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany., Rauh D; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44221 Dortmund, Germany., Klebl BM; Lead Discovery Center (LDC) GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany., Thomas RK; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Institute of Pathology, Medical Faculty, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. Electronic address: roman.thomas@uni-koeln.de., Sos ML; Molecular Pathology, Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937 Cologne, Germany; Department of Translational Genomics, Medical Faculty, University of Cologne, Weyertal 115b, 50931 Cologne, Germany; Center for Molecular Medicine Cologne, University of Cologne, 50931 Cologne, Germany. Electronic address: martin.sos@uni-koeln.de.

المصدر: Cell reports [Cell Rep] 2017 Sep 19; Vol. 20 (12), pp. 2833-2845.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy*, Neoplasms/*enzymology , Neoplasms/*pathology , Protein Kinase Inhibitors/*pharmacology, Cell Cycle Proteins ; Cell Line, Tumor ; Cyclin T/metabolism ; Cyclin-Dependent Kinase 9/antagonists & inhibitors ; Cyclin-Dependent Kinase 9/metabolism ; HEK293 Cells ; High-Throughput Screening Assays ; Humans ; Neoplasms/genetics ; Nuclear Proteins/antagonists & inhibitors ; Nuclear Proteins/metabolism ; Protein Kinase Inhibitors/chemistry ; RNA Polymerase II/metabolism ; Transcription Elongation, Genetic/drug effects ; Transcription Factors/antagonists & inhibitors ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects

المؤلفون: Plenker D; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Riedel M; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Brägelmann J; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Dammert MA; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Chauhan R; Structural Biology Laboratory, Francis Crick Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Knowles PP; Structural Biology Laboratory, Francis Crick Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK., Lorenz C; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Keul M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Bührmann M; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Pagel O; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany., Tischler V; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Scheel AH; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany., Schütte D; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Song Y; Crown BioScience, Inc., 3375 Scott Blvd, Suite 108, Santa Clara, CA 95054, USA., Stark J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Mrugalla F; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Alber Y; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Richters A; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Engel J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Leenders F; NEO New Oncology GmbH, 51105 Cologne, Germany., Heuckmann JM; NEO New Oncology GmbH, 51105 Cologne, Germany., Wolf J; Department of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital Cologne, Cologne, 50931 Cologne, Germany., Diebold J; Cancer Center, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland., Pall G; Department of Internal Medicine 5, University Hospital Innsbruck, Haematology/Oncology, Anichstraße 35, 6020 Innsbruck, Austria., Peifer M; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany., Aerts M; VIB-UGent Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium.; Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium., Gevaert K; VIB-UGent Center for Medical Biotechnology, VIB, B-9000 Ghent, Belgium.; Department of Biochemistry, Ghent University, B-9000 Ghent, Belgium., Zahedi RP; Leibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany., Buettner R; Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany., Shokat KM; Department of Cellular and Molecular Pharmacology, Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA., McDonald NQ; Structural Biology Laboratory, Francis Crick Institute, 44 Lincoln's Inn Fields, London WC2A 3LY, UK.; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, Malet Street, London WC1E 7HX, UK., Kast SM; Faculty of Chemistry and Chemical Biology, TU Dortmund University, 44227 Dortmund, Germany., Gautschi O; Cancer Center, Lucerne Cantonal Hospital, 6000 Lucerne, Switzerland., Thomas RK; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.; Department of Internal Medicine, Center for Integrated Oncology Köln Bonn, University Hospital Cologne, Cologne, 50931 Cologne, Germany.; German Cancer Consortium (DKTK), partner site Heidelberg, and German Cancer Research Center (DKFZ), Heidelberg, Germany., Sos ML; Molecular Pathology, Institute of Pathology, Center of Integrated Oncology, University Hospital Cologne, 50937 Cologne, Germany. martin.sos@uni-koeln.de.; Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.

المصدر: Science translational medicine [Sci Transl Med] 2017 Jun 14; Vol. 9 (394).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Adenocarcinoma/*metabolism , Gene Rearrangement/*genetics , Lung Neoplasms/*metabolism , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins c-ret/*genetics, Adenocarcinoma of Lung ; Animals ; Cell Line, Tumor ; Cytoskeletal Proteins/genetics ; Drug Resistance, Neoplasm/genetics ; Gene Rearrangement/drug effects ; Heterocyclic Compounds, 4 or More Rings/pharmacology ; Humans ; Imidazoles/pharmacology ; Mice ; Mutation ; NIH 3T3 Cells ; Pyridazines/pharmacology

المؤلفون: Zhao Z; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Dammert MA; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Hoppe S; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Bierhoff H; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany., Grummt I; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, D-69120 Heidelberg, Germany i.grummt@dkfz.de.

المصدر: Nucleic acids research [Nucleic Acids Res] 2016 Sep 30; Vol. 44 (17), pp. 8144-52. Date of Electronic Publication: 2016 Jun 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

مواضيع طبية MeSH: Heat-Shock Response/*genetics , Nucleosomes/*metabolism , Pol1 Transcription Initiation Complex Proteins/*metabolism , RNA, Long Noncoding/*metabolism , RNA, Ribosomal/*biosynthesis, Animals ; Casein Kinase II/metabolism ; Chromatin Assembly and Disassembly ; HEK293 Cells ; Histone-Lysine N-Methyltransferase ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; NIH 3T3 Cells ; Phosphorylation ; Promoter Regions, Genetic ; Transcription, Genetic

المؤلفون: Zhao Z; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany., Dammert MA; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany., Grummt I; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany., Bierhoff H; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Electronic address: holger.bierhoff@uni-jena.de.

المصدر: Cell reports [Cell Rep] 2016 Mar 01; Vol. 14 (8), pp. 1876-82. Date of Electronic Publication: 2016 Feb 18.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Genes, rRNA* , Osmotic Pressure*, Endosomal Sorting Complexes Required for Transport/*genetics , Histone-Lysine N-Methyltransferase/*genetics , Nucleosomes/*chemistry , RNA, Long Noncoding/*genetics , Ubiquitin-Protein Ligases/*genetics, Animals ; Chromatin Assembly and Disassembly ; Endosomal Sorting Complexes Required for Transport/metabolism ; Gene Expression Regulation ; HEK293 Cells ; Histone-Lysine N-Methyltransferase/metabolism ; Histones/genetics ; Histones/metabolism ; Humans ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/genetics ; Mi-2 Nucleosome Remodeling and Deacetylase Complex/metabolism ; Mice ; NIH 3T3 Cells ; Nedd4 Ubiquitin Protein Ligases ; Nucleosomes/metabolism ; Nucleosomes/ultrastructure ; Osmolar Concentration ; Proteasome Endopeptidase Complex/metabolism ; Proteolysis ; RNA, Long Noncoding/metabolism ; Signal Transduction ; Transcription, Genetic ; Ubiquitin-Protein Ligases/metabolism ; Ubiquitination

المؤلفون: Bierhoff H; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Dammert MA; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Brocks D; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany., Dambacher S; Adolf Butenandt Institute and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität, 80336 Munich, Germany., Schotta G; Adolf Butenandt Institute and Center for Integrated Protein Science Munich, Ludwig-Maximilians-Universität, 80336 Munich, Germany., Grummt I; Division of Molecular Biology of the Cell II, German Cancer Research Center, DKFZ-ZMBH Alliance, 69120 Heidelberg, Germany. Electronic address: i.grummt@dkfz.de.

المصدر: Molecular cell [Mol Cell] 2014 May 22; Vol. 54 (4), pp. 675-82. Date of Electronic Publication: 2014 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

مواضيع طبية MeSH: Gene Silencing* , Genes, rRNA*, Chromatin/*metabolism , Histone-Lysine N-Methyltransferase/*metabolism , Histones/*metabolism , Lysine/*metabolism , RNA, Long Noncoding/*metabolism, Animals ; Cell Proliferation ; Chromatin/genetics ; Gene Expression Regulation ; Genes, Intracisternal A-Particle ; Genetic Loci ; Histone-Lysine N-Methyltransferase/genetics ; Histones/chemistry ; Histones/genetics ; Methylation ; Mice ; NIH 3T3 Cells ; RNA, Long Noncoding/genetics ; Telomere/genetics