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المؤلفون: Louisa K. James, Lorna B. Jarvis, Campos L, Krzysztof Polanski, Kerstin B. Meyer, Krishnaa T. Mahbubani, Martin Prete, Zewen K. Tuong, Liz Tuck, Ni Huang, Omer Ali Bayraktar, Eirini S. Fasouli, Edward Needham, Joanne L. Jones, Lira Mamanova, Tong Li, Hamish W King, Sarah Howlett, Dan Rainbow, C Xu, Nathan Richoz, O Suchanek, Hani S Mousa, Rasa Elmentaite, Sophie Pritchard, Kourosh Saeb-Parsy, Tomás Gomes, David K. Menon, Clatworthy, Jong-Eun Park, C Domínguez Conde, Sarah A. Teichmann
مصطلحات موضوعية: Cell type, medicine.anatomical_structure, Immune system, T-cell receptor, Cell, medicine, Somatic hypermutation, Biology, Memory B cell, Receptor, Isotype, Cell biology
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c0f7e714430ed2509b867d2c6918cf02
https://doi.org/10.1101/2021.04.28.441762 -
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المؤلفون: Linda S. Wicker, Elizabeth E. Eynon, Richard A. Flavell, Alexander V. Chervonsky, Dan Rainbow, Masahito Kamanaka, Karin Schuster-Gossler
المصدر: Proceedings of the National Academy of Sciences. 106:11236-11240
مصطلحات موضوعية: Male, Gene isoform, Glycosylation, Blotting, Western, Intracellular Space, Congenic, Nod, Biology, Polymorphism, Single Nucleotide, Cell Line, Mice, chemistry.chemical_compound, Exon, Mice, Inbred NOD, Animals, Gene Knock-In Techniques, Amino Acids, Allele, Gene, Peptide sequence, Alleles, Crosses, Genetic, Embryonic Stem Cells, Mice, Knockout, Genetics, Multidisciplinary, Biological Sciences, Molecular biology, Clone Cells, Diabetes Mellitus, Type 1, chemistry, Interleukin-2, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::528cd368f4cccc750d365e0a6ee88b1a
https://doi.org/10.1073/pnas.0904780106 -
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المؤلفون: John A. Todd, Barry C. Healy, Pau Serra, Dan Rainbow, Laurence B. Peterson, Pere Santamaria, Riitta Veijola, Jane Rogers, Linda S. Wicker, Rose M. Cubbon, Jan Clark, Andrea Gonzalez-Munoz, Show-Ling Chen, Jun Yamanouchi, Sarah Howlett, David V. Serreze, Valerie E S Garner, Paul A. Lyons, Ray Rosa, Anne Marie Cumiskey, Simon G. Gregory, Kara Hunter, Luc J. Smink
المصدر: Nature Genetics. 39:329-337
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Interleukin 2, Transcription, Genetic, Regulatory T cell, medicine.medical_treatment, T cell, Autoimmunity, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, Biology, medicine.disease_cause, T-Lymphocytes, Regulatory, Article, Mice, Mice, Congenic, Immune system, Mice, Inbred NOD, Genetics, medicine, Animals, Homeostasis, IL-2 receptor, Alleles, Autoimmune disease, medicine.disease, Diabetes Mellitus, Type 1, Cytokine, medicine.anatomical_structure, Immunology, Interleukin-2, medicine.drug
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المؤلفون: John A. Todd, Kara Hunter, Anne Marie Cumiskey, Giselle Chamberlain, Jan Clark, Laurence B. Peterson, Amanda Kingsnorth, Jane Rogers, Luc J. Smink, Joanna M. M. Howson, Linda S. Wicker, Simon G. Gregory, Ray Rosa, Andrea Gonzalez-Munoz, Dan Rainbow, Paul A. Lyons, Paul G. Tiffen, Sarah Howlett
المصدر: The Journal of Immunology. 173:164-173
مصطلحات موضوعية: Antigens, Differentiation, T-Lymphocyte, Candidate gene, Molecular Sequence Data, Immunology, Congenic, Single-nucleotide polymorphism, Biology, Inducible T-Cell Co-Stimulator Protein, Mice, Exon, Antigens, CD, Mice, Inbred NOD, Genetic variation, Animals, Humans, Immunology and Allergy, SNP, Coding region, CTLA-4 Antigen, Amino Acid Sequence, RNA, Messenger, Cation Transport Proteins, Gene, Genetics, Chromosome Mapping, Antigens, Differentiation, Diabetes Mellitus, Type 1, Gene Expression Regulation, Chromosomes, Human, Pair 2
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82faab91679b81bd48477b6a306b13e0
https://doi.org/10.4049/jimmunol.173.1.164 -
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المؤلفون: Neil Walker, Constantin Ionescu-Tirgoviste, Kathleen M Gillespie, Cristian Guja, David A. Savage, Jane Rogers, Eva Tuomilehto-Wolf, Christopher Patterson, Dag E. Undlien, Laurence B. Peterson, H Ueda, Michael L. Metzker, Francesco Cucca, Jaakko Tuomilehto, C Bordin, R Nithiyananthan, Hywel Snook, Amit Allahabadia, Simon G. Gregory, Helen E. Rance, Jayne A. Franklyn, John A. Todd, A C Lam, F Payne, John S. Hulme, Laura Esposito, Polly J. Bingley, Anne Smith, Giselle Chamberlain, Dennis Carson, Gough Scl., Kjersti S. Rønningen, Deborah J. Smyth, G Di Genova, Barry C. Healy, Alexander P. Maxwell, Joanne M. Heward, Sarah Nutland, Howson Jmm., Christopher E. Lowe, Twells Rcj., Hunter Kmd., Sarah Howlett, Heather J. Cordell, Ingrid Dahlman, J F Hess, David Clayton, Linda S. Wicker, Mathias H. Herr, Vincent H. Everett, Costantino Motzo, Dan Rainbow, Luc J. Smink
المصدر: Ueda, H, Howson, J M M, Esposito, L, Heward, J, Snook, H, Chamberlain, G, Rainbow, D B, Hunter, K M D, Smith, A N, Di Genova, G, Herr, M H, Dahlman, I, Payne, F, Smyth, D, Lowe, C, Twells, R C J, Howlett, S, Healy, B, Nutland, S, Rance, H E, Everett, V, Smink, L J, Lam, A C, Cordell, H J, Walker, N M, Bordin, C, Hulme, J, Motzo, C, Cucca, F, Hess, J F, Metzker, M L, Rogers, J, Gregory, S, Allahabadia, A, Nithiyananthan, R, Tuomilehto-Wolf, E, Tuomilehto, J, Bingley, P, Gillespie, K M, Undlien, D E, Ronningen, K S, Guja, C, Ionescu-Tirgoviste, C, Savage, D, Maxwell, A, Carson, D, Patterson, C, Franklyn, J A, Clayton, D G, Peterson, L B, Wicker, L S, Todd, J A & Gough, S C L 2003, ' Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease ' Nature, vol. 423 (6939), no. 6939, pp. 506-511 .
مصطلحات موضوعية: Immunoconjugates, Genotype, T-Lymphocytes, T cell, Population, chemical and pharmacologic phenomena, Biology, Polymorphism, Single Nucleotide, Autoimmune Diseases, Abatacept, PTPN22, Mice, 03 medical and health sciences, 0302 clinical medicine, Hypothyroidism, Gene mapping, Antigens, CD, medicine, Animals, Humans, Protein Isoforms, CTLA-4 Antigen, Genetic Predisposition to Disease, Allele, General, education, Gene, 030304 developmental biology, Regulator gene, Genetics, Autoimmune disease, 0303 health sciences, education.field_of_study, Multidisciplinary, Base Sequence, medicine.disease, Antigens, Differentiation, Graves Disease, 3. Good health, Alternative Splicing, Disease Models, Animal, Diabetes Mellitus, Type 1, medicine.anatomical_structure, Immunology, 030215 immunology
وصف الملف: application/pdf
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المؤلفون: Joanna M. M. Howson, Linda S. Wicker, Laurence B. Peterson, Luc J. Smink, Andrea Gonzalez-Munoz, Anne Marie Cumiskey, Barry C. Healy, Dan Rainbow, Simon G. Gregory, Valerie E S Garner, Amanda Kingsnorth, Carlos Penha-Gonçalves, Giselle Chamberlain, Carolyn Moule, Jan Clark, Kara Hunter, John A. Todd, Heather I. Fraser, Sarah Howlett, Paul A. Lyons, Jane Rogers, Paul G. Tiffen
المصدر: Genetics of Autoimmunity: Novartis Foundation Symposium 267
مصطلحات موضوعية: Genetics, Type 1 diabetes, Immune system, medicine, Human genome, Disease, Biology, Central tolerance, medicine.disease, medicine.disease_cause, Gene, Phenotype, Autoimmunity
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::719698aa009317fa454863c0a1810228
https://doi.org/10.1002/047002139x.ch6 -
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المؤلفون: Arlene S Sharpe, Vijay K. Kuchroo, Jacqueline M. Slavik, Dan Rainbow, Lalitha Vijayakrishnan, Laurence B. Peterson, Zsolt Illes, Linda S. Wicker
مصطلحات موضوعية: Autoimmune disease, Transgene, T cell, chemical and pharmacologic phenomena, Nod, Biology, medicine.disease, Cell biology, medicine.anatomical_structure, Antigen, medicine, Cytotoxic T cell, NOD mice, Binding domain
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::37af2140b8689b1e1a5eaba7b3cdb89a
https://doi.org/10.1002/047002139x.ch13 -
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المؤلفون: John A. Todd, Dan Rainbow, Linda S. Wicker, Sarah Howlett, Laura Esposito, Laurence B. Peterson, Kara Hunter
المصدر: Biochemical Society transactions. 36(Pt 3)
مصطلحات موضوعية: Genetics, Type 1 diabetes, Genetic Variation, Biology, medicine.disease, Biochemistry, Article, Immune tolerance, Mice, Diabetes Mellitus, Type 1, Species Specificity, Mice, Inbred NOD, Immunology, Genetic variation, Gene expression, medicine, Animals, Humans, Interleukin-2, Genetic Predisposition to Disease, Allele, Gene, TCF7L2, Alleles, NOD mice
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34feb8b0599af9a5dc8394e3d087b2cc
https://pubmed.ncbi.nlm.nih.gov/18481948 -
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المؤلفون: Laurence B. Peterson, William M. Ridgway, Dan Rainbow, Linda S. Wicker, John A. Todd, Barry C. Healy, Oliver S. Burren
المصدر: Immunopathogenesis of Type 1 Diabetes Mellitus ISBN: 9780123743268
مصطلحات موضوعية: Genetics, Candidate gene, education.field_of_study, Population, Congenic, Genome-wide association study, Human genome, Biology, Allele, education, Gene, Genetic association
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المؤلفون: Kara Hunter, Vincent Plagnol, Laurence B. Peterson, Linda S. Wicker, John A. Todd, Dan Rainbow
المصدر: Journal of immunology (Baltimore, Md. : 1950). 179(12)
مصطلحات موضوعية: Immunology, Gene Dosage, chemical and pharmacologic phenomena, Locus (genetics), Single-nucleotide polymorphism, Biology, Chromosomes, PTPN22, Exon, Mice, Mice, Congenic, Antigens, CD, Immunology and Allergy, Animals, Humans, CTLA-4 Antigen, Genetic Predisposition to Disease, Allele, Gene, Cation Transport Proteins, Alleles, Genetics, Chromosome Mapping, C957T, Molecular biology, Null allele, Antigens, Differentiation, Diabetes Mellitus, Type 1
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3476057fd629266bbde880159b0b1465
https://pubmed.ncbi.nlm.nih.gov/18056379
