يعرض 1 - 6 نتائج من 6 نتيجة بحث عن '"Dancheck, K."', وقت الاستعلام: 1.10s تنقيح النتائج
  1. 1
    دورية
    Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

    المؤلفون: Liverton, N. J., Butcher, J. W., Claiborne, C. F., Claremon, D. A., Libby, B. E., Nguyen, K. T., Pitzenberger, S. M., Selnick, H. G., Smith, G. R., Tebben, A., Vacca, J. P., Varga, S. L., Agarwal, L., Dancheck, K., Forsyth, A. J., Fletcher, D. S., Frantz, B., Hanlon, W. A., Harper, C. F., Hofsess, S. J., Kostura, M., Lin, J., Luell, S., O'Neill, E. A., Orevillo, C. J., Pang, M., Parsons, J., Rolando, A., Sahly, Y., Visco, D. M., O'Keefe, S. J.

    المصدر: Journal of Medicinal Chemistry; June 17, 1999, Vol. 42 Issue: 12 p2180-2190, 11p

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  2. 2
    دورية
    Synthesis of a Series of Potent and Orally Bioavailable Thrombin Inhibitors That Utilize 3,3-Disubstituted Propionic Acid Derivatives in the P3 Position

    المؤلفون: Tucker, T. J., Lumma, W. C., Lewis, S. D., Gardell, S. J., Lucas, B. J., Sisko, J. T., Lynch, J. J., Lyle, E. A., Baskin, E. P., Woltmann, R. F., Appleby, S. D., Chen, I-W., Dancheck, K. B., Naylor-Olsen, A. M., Krueger, J. A., Cooper, C. M., Vacca, J. P.

    المصدر: Journal of Medicinal Chemistry; October 24, 1997, Vol. 40 Issue: 22 p3687-3693, 7p

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  3. 3
    دورية
    Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid d-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy

    المؤلفون: Tucker, T. J., Lumma, W. C., Lewis, S. D., Gardell, S. J., Lucas, B. J., Baskin, E. P., Woltmann, R., Lynch, J. J., Lyle, E. A., Appleby, S. D., Chen, I.-W., Dancheck, K. B., Vacca, J. P.

    المصدر: Journal of Medicinal Chemistry; May 23, 1997, Vol. 40 Issue: 11 p1565-1569, 5p

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  4. 4
    دورية
    Design and Synthesis of a Series of Potent and Orally Bioavailable Noncovalent Thrombin Inhibitors That Utilize Nonbasic Groups in the P1 Position

    المؤلفون: Tucker, T. J., Brady, S. F., Lumma, W. C., Lewis, S. D., Gardell, S. J., Naylor-Olsen, A. M., Yan, Y., Sisko, J. T., Stauffer, K. J., Lucas, B. J., Lynch, J. J., Cook, J. J., Stranieri, M. T., Holahan, M. A., Lyle, E. A., Baskin, E. P., Chen, I-W., Dancheck, K. B., Krueger, J. A., Cooper, C. M., Vacca, J. P.

    المصدر: Journal of Medicinal Chemistry; August 13, 1998, Vol. 41 Issue: 17 p3210-3219, 10p

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  5. 5
    دورية
    Discovery of a Novel, Selective, and Orally Bioavailable Class of Thrombin Inhibitors Incorporating Aminopyridyl Moieties at the P1 Position

    المؤلفون: Feng, D.-M., Gardell, S. J., Lewis, S. D., Bock, M. G., Chen, Z., Freidinger, R. M., Naylor-Olsen, A. M., Ramjit, H. G., Woltmann, R., Baskin, E. P., Lynch, J. J., Lucas, R., Shafer, J. A., Dancheck, K. B., Chen, I-W., Mao, S.-S., Krueger, J. A., Hare, T. R., Mulichak, A. M., Vacca, J. P.

    المصدر: Journal of Medicinal Chemistry; November 7, 1997, Vol. 40 Issue: 23 p3726-3733, 8p

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  6. 6
    دورية أكاديمية
    Potent noncovalent thrombin inhibitors that utilize the unique amino acid D-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy.

    المؤلفون: Tucker TJ; Department of Medicinal Chemistry, Merck Research Laboratories, West Point, Pennsylvania 19486, USA., Lumma WC, Lewis SD, Gardell SJ, Lucas BJ, Baskin EP, Woltmann R, Lynch JJ, Lyle EA, Appleby SD, Chen IW, Dancheck KB, Vacca JP

    المصدر: Journal of medicinal chemistry [J Med Chem] 1997 May 23; Vol. 40 (11), pp. 1565-9.

    نوع المنشور: Journal Article

    بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

    مواضيع طبية MeSH: Dipeptides/*chemical synthesis , Fibrinolytic Agents/*chemical synthesis , Phenylalanine/*analogs & derivatives , Thrombin/*antagonists & inhibitors, Animals ; Biological Availability ; Dipeptides/pharmacokinetics ; Dipeptides/therapeutic use ; Dogs ; Fibrinolytic Agents/pharmacokinetics ; Fibrinolytic Agents/therapeutic use ; Lipid Metabolism ; Male ; Molecular Structure ; Partial Thromboplastin Time ; Phenylalanine/chemistry ; Rats ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Thrombosis/drug therapy

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