يعرض 1 - 10 نتائج من 209 نتيجة بحث عن '"Daniel A Norris"', وقت الاستعلام: 1.30s تنقيح النتائج
  1. 1
    دورية أكاديمية
    Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications

    المؤلفون: Rosie Z Yu, John S Grundy, Scott P Henry, Tae-Won Kim, Daniel A Norris, Jennifer Burkey, Yanfeng Wang, Andrew Vick, Richard S Geary

    المصدر: Molecular Therapy: Nucleic Acids, Vol 4, Iss C (2015)

    مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S2162253116300026; https://doaj.org/toc/2162-2531

    URL الوصول: https://doaj.org/article/246f1041032e42dfa83f03452a855de3

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  2. 2
    دورية أكاديمية
    Development of a population pharmacokinetic model to characterize the pharmacokinetics of intrathecally administered tominersen in cerebrospinal fluid and plasma

    المؤلفون: Yumi Yamamoto, Patricia Sanwald Ducray, Marcus Björnsson, Kevin Smart, Paul Grimsey, Suresh Vatakuti, Agnes Portron, Benoit Massonnet, Daniel A. Norris, Hanna E. Silber Baumann

    المصدر: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 9, Pp 1213-1226 (2023)

    مصطلحات موضوعية: Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: https://doaj.org/toc/2163-8306

    URL الوصول: https://doaj.org/article/3bbd4d99f8d546848ac3c29756f46b8f

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  3. 3
    دورية أكاديمية
    A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

    المؤلفون: Nicholas R Jones, Melissa A Pegues, Mark A McCrory, Walter Singleton, Claudette Bethune, Brenda F Baker, Daniel A Norris, Rosanne M Crooke, Mark J Graham, Alexander J Szalai

    المصدر: Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)

    مصطلحات موضوعية: antisense therapy, CRP, rheumatoid arthritis, Therapeutics. Pharmacology, RM1-950

    وصف الملف: electronic resource

    Relation: http://www.sciencedirect.com/science/article/pii/S216225311630110X; https://doaj.org/toc/2162-2531

    URL الوصول: https://doaj.org/article/392f92544a1e404c948aadef7b9151a7

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  4. 4
    Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease

    المؤلفون: Catherine J. Mummery, Anne Börjesson-Hanson, Daniel J. Blackburn, Everard G. B. Vijverberg, Peter Paul De Deyn, Simon Ducharme, Michael Jonsson, Anja Schneider, Juha O. Rinne, Albert C. Ludolph, Ralf Bodenschatz, Holly Kordasiewicz, Eric E. Swayze, Bethany Fitzsimmons, Laurence Mignon, Katrina M. Moore, Chris Yun, Tiffany Baumann, Dan Li, Daniel A. Norris, Rebecca Crean, Danielle L. Graham, Ellen Huang, Elena Ratti, C. Frank Bennett, Candice Junge, Roger M. Lane

    المساهمون: Neurology, Amsterdam Neuroscience - Neurodegeneration, Molecular Neuroscience and Ageing Research (MOLAR)

    المصدر: Nature medicine 29(6), 1437-1447 (2023). doi:10.1038/s41591-023-02326-3
    Mummery, C J, Börjesson-Hanson, A, Blackburn, D J, Vijverberg, E G B, de Deyn, P P, Ducharme, S, Jonsson, M, Schneider, A, Rinne, J O, Ludolph, A C, Bodenschatz, R, Kordasiewicz, H, Swayze, E E, Fitzsimmons, B, Mignon, L, Moore, K M, Yun, C, Baumann, T, Li, D, Norris, D A, Crean, R, Graham, D L, Huang, E, Ratti, E, Bennett, C F, Junge, C & Lane, R M 2023, ' Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease : a phase 1b, randomized, placebo-controlled trial ', Nature Medicine, vol. 29, no. 6, pp. 1437-1447 . https://doi.org/10.1038/s41591-023-02326-3
    Nature Medicine. Nature Publishing Group
    Nature Medicine, 29, 1437-1447. Nature Publishing Group

    مصطلحات موضوعية: General Medicine, ddc:610, General Biochemistry, Genetics and Molecular Biology

    وصف الملف: application/pdf

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a4826e86379fe0686cd40f5d60108ba
    https://doi.org/10.1038/s41591-023-02326-3

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  5. 5
    Antisense oligonucleotide targeting DMPK in patients with myotonic dystrophy type 1: a multicentre, randomised, dose-escalation, placebo-controlled, phase 1/2a trial

    المؤلفون: Charles A Thornton, Richard Thomas Moxley, Katy Eichinger, Chad Heatwole, Laurence Mignon, W David Arnold, Tetsuo Ashizawa, John W Day, Gersham Dent, Matthew K Tanner, Tina Duong, Ericka P Greene, Laura Herbelin, Nicholas E Johnson, Wendy King, John T Kissel, Doris G Leung, Donovan J Lott, Daniel A Norris, Evan M Pucillo, Wendy Schell, Jeffrey M Statland, Nikia Stinson, Sub H Subramony, Shuting Xia, Kathie M Bishop, C Frank Bennett

    المصدر: The Lancet Neurology. 22:218-228

    مصطلحات موضوعية: Neurology (clinical)

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::06edbb966b88ee3a85a273542b721585
    https://doi.org/10.1016/s1474-4422(23)00001-7

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  6. 6
    A physiologically-based pharmacokinetic model to describe antisense oligonucleotide distribution after intrathecal administration

    المؤلفون: Yanfeng Wang, Michael Monine, Daniel A. Norris, Ivan Nestorov

    المصدر: Journal of Pharmacokinetics and Pharmacodynamics. 48:639-654

    مصطلحات موضوعية: Central Nervous System, Primates, Central nervous system, Pharmacology, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Cerebrospinal fluid, medicine, Animals, Humans, Distribution (pharmacology), Injections, Spinal, business.industry, Biological Transport, Spinal muscular atrophy, Oligonucleotides, Antisense, medicine.disease, Spinal cord, Spinal column, medicine.anatomical_structure, Blood-Brain Barrier, 030220 oncology & carcinogenesis, Systemic administration, Nusinersen, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81036a69e7e0e6db771c4647d2f09fb
    https://doi.org/10.1007/s10928-021-09761-0

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  7. 7
    Immunogenicity Assessment of Inotersen, a 2′-O-(2-Methoxyethyl) Antisense Oligonucleotide in Animals and Humans: Effect on Pharmacokinetics, Pharmacodynamics, and Safety

    المؤلفون: Yanfeng Wang, Padma Narayanan, Daniel A. Norris, Richard S. Geary, Scott P. Henry, Tae-Won Kim, Brett P. Monia, Rosie Z. Yu

    المصدر: Nucleic Acid Therapeutics. 30:265-275

    مصطلحات موضوعية: medicine.medical_specialty, Hematology, biology, business.industry, Immunogenicity, Cmax, Pharmacology, Biochemistry, Titer, Transthyretin, Pharmacokinetics, Internal medicine, Pharmacodynamics, Drug Discovery, Toxicity, Genetics, medicine, biology.protein, Molecular Medicine, business, Molecular Biology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::9bdd6fde5c778b60361c6e8fcb009283
    https://doi.org/10.1089/nat.2020.0867

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  8. 8
    Results of the first‐in‐human, randomized, double‐blind, placebo‐controlled phase 1b study of lumbar intrathecal bolus administrations of antisense oligonucleotide (ISIS 814907; BIIB080) targeting tau mRNA in patients with mild Alzheimer’s disease

    المؤلفون: Catherine J Mummery, Candice Junge, Holly B Kordasiewicz, Laurence Mignon, Katrina M Moore, Chris Yun, Tiffany L Baumann, Dan Li, Daniel A Norris, Rebecca Crean, Danielle Graham, Ellen Huang, Elena Ratti, Roger M Lane

    المصدر: Alzheimer's & Dementia. 17

    مصطلحات موضوعية: Psychiatry and Mental health, Cellular and Molecular Neuroscience, Developmental Neuroscience, Epidemiology, Health Policy, Neurology (clinical), Geriatrics and Gerontology

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::36e8adff8866a7530fffbf1a0ca81ae9
    https://doi.org/10.1002/alz.051871

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  9. 9
    Bioanalysis considerations on the pharmacokinetic evaluation of antisense therapeutics

    المؤلفون: Yanfeng Wang, Daniel A. Norris, Rosie Z. Yu, Noah Post, Sarah Greenlee

    المصدر: Bioanalysis. 11:1909-1912

    مصطلحات موضوعية: Bioanalysis, Chemistry, Oligonucleotide, Clinical Biochemistry, General Medicine, Oligonucleotides, Antisense, Pharmacology, Analytical Chemistry, Medical Laboratory Technology, Pharmacokinetics, Liquid chromatography–mass spectrometry, Humans, Tissue Distribution, Tissue distribution, General Pharmacology, Toxicology and Pharmaceutics

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183b7e8183addbc9348a7bf9523388fa
    https://doi.org/10.4155/bio-2019-0194

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  10. 10
    Age-dependent SMN expression in disease-relevant tissue and implications for SMA treatment

    المؤلفون: Sergey Paushkin, Charlotte J. Sumner, Frank Rigo, Ian Waters, Pamela J. Snyder, Thomas W. Prior, Shannon J. Taylor, Constantin d’Ydewalle, Christine L. Hatem, Nikhil Gupte, Thomas O. Crawford, Daniel A. Norris, John B. Matson, Amal Dakka, Kathryn J. Swoboda, C. Frank Bennett, Phillip G. Zaworski, Nikolai Naryshkin, Vijayalakshmi Gabbeta, Stephanie Klein, Daniel M. Ramos, David Valdivia

    المصدر: Journal of Clinical Investigation. 129:4817-4831

    مصطلحات موضوعية: Male, 0301 basic medicine, Aging, medicine.medical_specialty, Neuromuscular disease, Cell Survival, animal diseases, Oligodeoxyribonucleotides, Antisense, Muscular Atrophy, Spinal, 03 medical and health sciences, Exon, 0302 clinical medicine, Atrophy, Internal medicine, Humans, Medicine, Motor Neurons, Messenger RNA, business.industry, Neurodegeneration, General Medicine, Motor neuron, medicine.disease, SMA, Spinal cord, nervous system diseases, Survival of Motor Neuron 2 Protein, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, nervous system, Spinal Cord, 030220 oncology & carcinogenesis, Female, Autopsy, Clinical Medicine, business

    URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b3e5c1e2561445e157362017e51ffe6
    https://doi.org/10.1172/jci124120

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