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1
المؤلفون: Manfred Schubert-Zsilavecz, Roberto Carrasco Gomez, Daniel Flesch, Holger Stark, Matthias Gabler, Ramona Steri, Andreas Lill, Gisbert Schneider, Daniel Merk
المصدر: Bioorganic & Medicinal Chemistry. 23:3490-3498
مصطلحات موضوعية: Agonist, Cell Survival, medicine.drug_class, Clinical Biochemistry, Regulator, Gene Expression, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Crystallography, X-Ray, Ligands, Transfection, Biochemistry, Protein Structure, Secondary, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Humans, Moiety, Isoxazole, Molecular Biology, Transcription factor, Chemistry, Ligand, Hydrolysis, Organic Chemistry, Hep G2 Cells, Isoxazoles, Protein Structure, Tertiary, Molecular Docking Simulation, Nuclear receptor, Molecular Medicine, Farnesoid X receptor, HeLa Cells, Plasmids
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2
المؤلفون: Annika Klara Giegerich, Andreas von Knethen, Mario Wurglics, Lisa K. Sha, Manfred Schubert-Zsilavecz, Bernhard Brüne, Tilo Knape, Nerea Ferreirós, Daniel Flesch, Laura Kuchler, Tobias Schmid, Sandra Labocha, Michael J. Parnham, Eugen Proschak
المصدر: European Journal of Pharmacology. 755:16-26
مصطلحات موضوعية: Transcriptional Activation, Cell Survival, Pharmacology, Jurkat cells, Cell Line, Rosiglitazone, Transactivation, medicine, Humans, Cytotoxic T cell, Anilides, Luciferases, Receptor, Cytotoxicity, Chemistry, HEK 293 cells, Molecular Docking Simulation, PPAR gamma, Nuclear receptor, Biochemistry, Cinnamates, Quinolines, Thiazolidinediones, medicine.drug
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3
المؤلفون: Sascha Weggen, Ramona Steri, Isabella Ogorek, Sven Popella, Oliver Werz, Gerd Dannhardt, Manfred Schubert-Zsilavecz, Julia Ness, Martina Hieke, Friederike Dehm, Daniel Flesch, Christina Lamers
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:841-846
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Inflammation, Disease, Pharmacology, Inhibitory postsynaptic potential, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Alzheimer Disease, Drug Discovery, medicine, Humans, Lipoxygenase Inhibitors, γ secretase, Caproates, Molecular Biology, Hexanoic acid, chemistry.chemical_classification, Arachidonate 5-Lipoxygenase, biology, Organic Chemistry, PPAR gamma, chemistry, Arachidonate 5-lipoxygenase, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, medicine.symptom, Derivative (chemistry)
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4
المؤلفون: Markus Hartmann, Daniel Flesch, Astrid Kaiser, Pascal Heitel, Jan S. Kramer, Hartmut Lüddens, Sun-Yee Cheung, Manfred Schubert-Zsilavecz, Mario Wurglics, Jan Heering, Daniel Merk, Ewgenij Proschak, Jurema Schmidt, Matthias Gabler, Kerstin Lüddens-Dämgen, Mara Lindner, Christina Lamers
المساهمون: Publica
المصدر: Journal of medicinal chemistry. 60(16)
مصطلحات موضوعية: 0301 basic medicine, Male, medicine.drug_class, Pyridines, Peroxisome proliferator-activated receptor, Receptors, Cytoplasmic and Nuclear, ATP-binding cassette transporter, Cholesterol 7 alpha-hydroxylase, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, Structure-Activity Relationship, Drug Stability, Drug Discovery, medicine, Glucose homeostasis, Animals, Humans, PPAR alpha, Receptor, Cholesterol 7-alpha-Hydroxylase, ATP Binding Cassette Transporter, Subfamily B, Member 11, chemistry.chemical_classification, Bile acid, 010405 organic chemistry, Chemistry, HEK 293 cells, Imidazoles, Membrane Transport Proteins, Hep G2 Cells, 0104 chemical sciences, Molecular Docking Simulation, Zolpidem, 030104 developmental biology, HEK293 Cells, Biochemistry, Molecular Medicine, Farnesoid X receptor, ATP-Binding Cassette Transporters, Sterol Regulatory Element Binding Protein 1, HeLa Cells
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5
المؤلفون: Daniel Flesch, Gisbert Schneider, Matthias Gabler, Christina Lamers, Oliver Werz, Roberto Carrasco Gomez, Daniel Merk, Manfred Schubert-Zsilavecz, Thomas Hanke, Astrid Kaiser
المصدر: Bioorganic & Medicinal Chemistry. 22:2447-2460
مصطلحات موضوعية: medicine.drug_class, Clinical Biochemistry, Receptors, Cytoplasmic and Nuclear, Pharmaceutical Science, Ligands, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Anthranilic acid, Glucose homeostasis, ortho-Aminobenzoates, Receptor, Molecular Biology, Virtual screening, Binding Sites, Bile acid, Organic Chemistry, Protein Structure, Tertiary, Molecular Docking Simulation, chemistry, Nuclear receptor, Docking (molecular), Molecular Medicine, Farnesoid X receptor, Protein Binding
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6
المصدر: Expert Opinion on Therapeutic Patents. 23:233-267
مصطلحات موضوعية: Prostaglandin E2 receptor, medicine.medical_treatment, Inflammation, Pharmacology, Dinoprostone, Patents as Topic, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Receptors, Prostaglandin E, Structure–activity relationship, Prostaglandin E2, Prostaglandin receptor, Receptor, Molecular Structure, business.industry, Prostanoid, General Medicine, Receptors, Prostaglandin E, EP2 Subtype, Receptors, Prostaglandin E, EP1 Subtype, chemistry, Drug Design, Receptors, Prostaglandin E, EP3 Subtype, lipids (amino acids, peptides, and proteins), medicine.symptom, business, Receptors, Prostaglandin E, EP4 Subtype, Signal Transduction, medicine.drug, Prostaglandin E
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7
المصدر: Expert Opinion on Therapeutic Patents. 23:47-77
مصطلحات موضوعية: Drug, media_common.quotation_subject, Receptors, Prostaglandin, Inflammation, Biology, Pharmacology, Patents as Topic, chemistry.chemical_compound, Drug Discovery, medicine, Animals, Humans, Molecular Targeted Therapy, Prostaglandin receptor, Receptor, media_common, Prostanoid, General Medicine, chemistry, Drug Design, Expert opinion, Prostaglandins, Patent activity, lipids (amino acids, peptides, and proteins), medicine.symptom, Ep receptor
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8
المؤلفون: Matthias Gabler, Daniel Flesch, Manfred Schubert-Zsilavecz, Astrid Kaiser, Daniel Merk, Christina Lamers
المصدر: Future medicinal chemistry. 8(2)
مصطلحات موضوعية: 0301 basic medicine, Transcriptional Activation, Cell signaling, medicine.drug_class, Receptors, Cytoplasmic and Nuclear, Biology, Receptors, G-Protein-Coupled, Bile Acids and Salts, 03 medical and health sciences, Structure-Activity Relationship, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Humans, Receptor, Pharmacology, chemistry.chemical_classification, Bile acid, Fatty acid, Benzoic Acid, G protein-coupled bile acid receptor, 030104 developmental biology, chemistry, Biochemistry, Nuclear receptor, 030220 oncology & carcinogenesis, Pirinixic Acid, Molecular Medicine, Farnesoid X receptor, HeLa Cells, Protein Binding
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9
المؤلفون: Christina Lamers, Daniel Merk, Ewgenij Proschak, Julia Weber, Daniel Flesch, Manfred Schubert-Zsilavecz, Matthias Gabler
المصدر: Bioorganicmedicinal chemistry. 23(3)
مصطلحات موضوعية: Clinical Biochemistry, Peroxisome Proliferator-Activated Receptors, Pharmaceutical Science, Peroxisome proliferator-activated receptor, Receptors, Cytoplasmic and Nuclear, Ligands, Biochemistry, Partial agonist, PPAR agonist, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Chlorocebus aethiops, Anthranilic acid, Animals, ortho-Aminobenzoates, Receptor, Molecular Biology, chemistry.chemical_classification, Chemistry, Organic Chemistry, Lipid metabolism, Lipid Metabolism, Nuclear receptor, COS Cells, Molecular Medicine, Farnesoid X receptor