المؤلفون: Jeanne Mendell, Daniel J. Freeman, Wenqin Feng, Thore Hettmann, Matthias Schneider, Sabine Blum, Jens Ruhe, Johannes Bange, Kenji Nakamaru, Shuquan Chen, Zenta Tsuchihashi, Joachim von Pawel, Catherine Copigneaux, Robert A. Beckman

المصدر: EBioMedicine, Vol 2, Iss 3, Pp 264-271 (2015)

مصطلحات موضوعية: Biomarker, Patritumab, Erlotinib, Non-small cell lung cancer, HER3, Heregulin, Medicine, Medicine (General), R5-920

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396415000481; https://doaj.org/toc/2352-3964

URL الوصول: https://doaj.org/article/7234004e5d4f47c7ab14202b186df656

المؤلفون: Michael J. Boedigheimer, Daniel J. Freeman, Panteha Kiaei, Michael A. Damore, Robert Radinsky

المصدر: Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 2, Pp 125-132 (2013)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1476558613800231; https://doaj.org/toc/1476-5586; https://doaj.org/toc/1522-8002

URL الوصول: https://doaj.org/article/a3e3b8b14754452280b834422ca755f5

المؤلفون: Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::238b4ab5c831dd6063dffdf564c8ad3c
https://doi.org/10.1158/2159-8290.22540037

المؤلفون: Yariv Mazor, Robert W. Wilkinson, Daniel J. Freeman, Ikbel Achour, William Dall'Acqua, Aleksandra D. Toloczko, Thomas V. Murray, Frances Neal, Gareth J. Browne, Godfrey J. Rainey, Michelle Morrow, Asis Palazon, Yanli Wu, James Dodgson, Michael G. Overstreet, Yaya Wang, Kathy Mulgrew, Stacy Kentner, Xiaofang Jin, Arthur Lewis, Kapil Vashisht, Shelby D. Gainer, Deepa S. Subramaniam, Ben Tran, Seock-Ah Im, Bo Wang, Sumati Hasani, Des C. Jones, James Hair, Anna Hansen, Lorraine Irving, Suzanne I. Sitnikova, Chunning Yang, Matthew J. Elder, Simon J. Dovedi

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7eaed273b219faf1bb63ec9cf8694
https://doi.org/10.1158/2159-8290.c.6549263

المؤلفون: Bo Wang, Frances Neal, Arthur Lewis, Kapil Vashisht, Deepa S. Subramaniam, Des C. Jones, Sumati Hasani, Daniel J. Freeman, Chunning Yang, Lorraine Irving, Michael G. Overstreet, Gareth J. Browne, Suzanne I. Sitnikova, James Hair, Robert W. Wilkinson, Yaya Wang, Ben Tran, Ikbel Achour, James Dodgson, Shelby D. Gainer, Xiaofang Jin, Seock-Ah Im, William F Dall'Acqua, Yariv Mazor, Godfrey Rainey, Asis Palazon, Anna Hansen, Yanli Wu, Matthew J. Elder, Stacy Kentner, Aleksandra D. Toloczko, Michelle Morrow, Murray Thomas Vincent, Simon J. Dovedi, Kathy Mulgrew

المصدر: Cancer Discovery. 11:1100-1117

مصطلحات موضوعية: 0301 basic medicine, biology, medicine.drug_class, Chemistry, medicine.medical_treatment, media_common.quotation_subject, Rational design, chemical and pharmacologic phenomena, Immunotherapy, Monoclonal antibody, Blockade, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, In vivo, 030220 oncology & carcinogenesis, medicine, biology.protein, Cancer research, Secretion, Antibody, Internalization, media_common

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::ca36b45e55f3b372d826ed6a15c12039
https://doi.org/10.1158/2159-8290.cd-20-1445

المؤلفون: Simon J, Dovedi, Matthew J, Elder, Chunning, Yang, Suzanne I, Sitnikova, Lorraine, Irving, Anna, Hansen, James, Hair, Des C, Jones, Sumati, Hasani, Bo, Wang, Seock-Ah, Im, Ben, Tran, Deepa S, Subramaniam, Shelby D, Gainer, Kapil, Vashisht, Arthur, Lewis, Xiaofang, Jin, Stacy, Kentner, Kathy, Mulgrew, Yaya, Wang, Michael G, Overstreet, James, Dodgson, Yanli, Wu, Asis, Palazon, Michelle, Morrow, Godfrey J, Rainey, Gareth J, Browne, Frances, Neal, Thomas V, Murray, Aleksandra D, Toloczko, William, Dall'Acqua, Ikbel, Achour, Daniel J, Freeman, Robert W, Wilkinson, Yariv, Mazor

المصدر: Cancer discovery. 11(5)

مصطلحات موضوعية: Male, Stomach Neoplasms, T-Lymphocytes, Programmed Cell Death 1 Receptor, Humans, CTLA-4 Antigen, Immunotherapy, Adenocarcinoma, Middle Aged, Antibodies, Monoclonal, Humanized, Kidney Neoplasms, Adenocarcinoma, Clear Cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::9cee0afaa71445587217670a975d51b1
https://pubmed.ncbi.nlm.nih.gov/33947716

المؤلفون: Daniel J. Freeman, Kevin J. Harrington, James Harper, Jean-Charles Soria, Beth Kelly

المصدر: Nature reviews. Drug discovery. 18(9)

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, Population, 03 medical and health sciences, 0302 clinical medicine, Immune system, Drug Delivery Systems, Cancer immunotherapy, Antigen, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Drug Discovery, Medicine, Humans, education, Pharmacology, Oncolytic Virotherapy, education.field_of_study, business.industry, Cancer, General Medicine, Immunotherapy, medicine.disease, Immune checkpoint, Oncolytic virus, 030104 developmental biology, 030220 oncology & carcinogenesis, Cancer research, Drug Screening Assays, Antitumor, business, Biomarkers

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86a06d85eb0e330b5eba3a5cb8421745
https://pubmed.ncbi.nlm.nih.gov/31292532

المؤلفون: Kenji Nakamaru, Daniel J. Freeman, Catherine Copigneaux, Jens Ruhe, Johannes Bange, Thore Hettmann, Jeanne Mendell, Joachim von Pawel, Sabine Blum, Matthias Schneider, Zenta Tsuchihashi, Robert A. Beckman, Wenqin Feng, Shuquan Chen

المصدر: EBioMedicine, Vol 2, Iss 3, Pp 264-271 (2015)
EBioMedicine

مصطلحات موضوعية: Male, Oncology, Lung Neoplasms, Receptor, ErbB-3, lcsh:Medicine, Translational Research, Biomedical, Non-small cell lung cancer, Carcinoma, Non-Small-Cell Lung, Antineoplastic Combined Chemotherapy Protocols, Prospective Studies, Prospective cohort study, Aged, 80 and over, lcsh:R5-920, Heregulin, Antibodies, Monoclonal, General Medicine, Middle Aged, ErbB Receptors, Treatment Outcome, Erlotinib, Biomarker (medicine), Original Article, Female, lcsh:Medicine (General), medicine.drug, Adult, Patritumab, medicine.medical_specialty, medicine.drug_class, Neuregulin-1, Antibodies, Monoclonal, Humanized, Monoclonal antibody, Disease-Free Survival, General Biochemistry, Genetics and Molecular Biology, Erlotinib Hydrochloride, Double-Blind Method, HER3, Internal medicine, Biomarkers, Tumor, medicine, Humans, Lung cancer, Aged, Retrospective Studies, Predictive biomarker, business.industry, lcsh:R, Retrospective cohort study, Biomarker, medicine.disease, Antibodies, Neutralizing, Immunology, Commentary, business, Broadly Neutralizing Antibodies

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4788bf0216a6cbe316403902a891f1db
https://doi.org/10.1016/j.ebiom.2015.02.005

المؤلفون: Yunxin Bo, Tisha San Miguel, Nobuko Nishimura, Jian Jiang, Douglas A. Whittington, Paul E. Hughes, Sean Caenepeel, Mark H. Norman, John D. McCarter, Erin L. Mullady, Daniel J. Freeman, Kevin Yang, Ryan Wurz, Longbin Liu, Raju Subramanian, Kristin L. Andrews, Ling Wang, Liping H. Pettus, Nancy Zhang

المصدر: Bioorganic & Medicinal Chemistry Letters. 22:5714-5720

مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Crystallography, X-Ray, Biochemistry, Mice, Phosphatidylinositol 3-Kinases, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Neoplasms, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Sulfonamides, Binding Sites, Phosphoinositide 3-kinase, biology, Triazines, Akt/PKB signaling pathway, Chemistry, TOR Serine-Threonine Kinases, Cellular Assay, Organic Chemistry, Rats, Molecular Docking Simulation, biology.protein, Molecular Medicine, Female, Proto-Oncogene Proteins c-akt, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62866028e9510797810acdca23680ada
https://doi.org/10.1016/j.bmcl.2012.06.078

المؤلفون: Bradley J. Herberich, Tian Wu, Paul E. Hughes, Claire L. M. Jackson, Nobuko Nishimura, Nancy Zhang, Ryan Wurz, Douglas A. Whittington, Shon Booker, Sean Caenepeel, Tisha San Miguel, Jian Jiang, Anthony B. Reed, Adrian L. Smith, Seifu Tadesse, Brian A. Lanman, Andrew Tasker, Erin L. Mullady, John D. McCarter, Fang-Tsao Hong, Liping H. Pettus, Divesh Aidasani, Victor J. Cee, Ling Wang, Bin Wu, Mark H. Norman, Daniel J. Freeman, Kevin Yang, Longbin Liu, Leeanne Zalameda, Yunxin Y. Bo, Xiaochun Zhu, Kristin L. Andrews, Markian Stec, Nuria A. Tamayo, Raju Subramanian, Noel D'angelo

المصدر: Journal of Medicinal Chemistry. 55:7796-7816

مصطلحات موضوعية: Models, Molecular, Phosphoinositide 3-kinase, biology, Triazines, Chemistry, Cell growth, Pharmacology, Crystallography, X-Ray, medicine.disease, chemistry.chemical_compound, In vivo, Glioma, Drug Discovery, Second messenger system, medicine, biology.protein, Molecular Medicine, Phosphorylation, Phosphatidylinositol, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7379e5002efb24d810fb0e1f33a3641
https://doi.org/10.1021/jm300846z