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المؤلفون: Elisa Ballini, Benjamin D. Bax, Beatrice Oliosi, Claudette Mookherjee, Daniel Marcus Bradley, Stuart P. Ballantine, Nigel E. Austin, Kevin M. Thewlis, Rosemary A. Melarange, Shahnaz P. Yusaf, Gianni Dal Negro, Andrew Jonathan Harris, J. Mosley, Kathrine J. Smith, Laura Aldegheri, Simon E. Ward, B. Clarke, Stephen A Harrison, Mark H Harries, Patrick M. Woollard
المصدر: Journal of medicinal chemistry. 54(1)
مصطلحات موضوعية: Male, Models, Molecular, Indazoles, Patch-Clamp Techniques, Membrane bound, Stereochemistry, Swine, High-throughput screening, Allosteric regulation, Molecular Conformation, AMPA receptor, In Vitro Techniques, Crystallography, X-Ray, Ligands, Rats, Sprague-Dawley, chemistry.chemical_compound, Structure-Activity Relationship, Dogs, Allosteric Regulation, Drug Discovery, Structure–activity relationship, Molecule, Animals, Humans, Receptors, AMPA, Ion channel, Trifluoromethyl, Chemistry, Recombinant Proteins, High-Throughput Screening Assays, Rats, Macaca fascicularis, Solubility, Microsomes, Liver, Molecular Medicine, Swine, Miniature, Calcium, Protein Multimerization
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المؤلفون: Paul W. Smith, Caroline J. Goodacre, Wyman Paul Adrian, Sara A. Coggon, Vong Antonio Kuok Keong, Jeannette M. Watson, William J. Martin, Kirsten L. Searle, Daniel Marcus Bradley, Zining Wu, Peter J. Lovell, Lee A. Dawson, Harrington Frank Peter, David R. Thomas, Roderick A. Porter, Graham Murkitt, Halina T Serafinowska, Sean Thomas Flynn
المصدر: Bioorganicmedicinal chemistry letters. 19(3)
مصطلحات موضوعية: Central Nervous System, Male, medicine.drug_class, Clinical Biochemistry, Pharmaceutical Science, Carboxamide, Gerbil, Biochemistry, Rats, Sprague-Dawley, chemistry.chemical_compound, In vivo, Drug Discovery, Talnetant, medicine, Animals, Amines, Molecular Biology, Cerebral Cortex, Chemistry, Organic Chemistry, Quinoline, Antagonist, Brain, Receptors, Neurokinin-3, Rats, Models, Chemical, Area Under Curve, Lipophilicity, Quinolines, Molecular Medicine, Gerbillinae, Ex vivo, medicine.drug
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