المؤلفون: Irene Hallyburton, Raffaella Grimaldi, Andrew Woodland, Beatriz Baragaña, Torsten Luksch, Daniel Spinks, Daniel James, Didier Leroy, David Waterson, Alan H. Fairlamb, Paul G. Wyatt, Ian H. Gilbert, Julie A. Frearson

المصدر: Malaria Journal, Vol 16, Iss 1, Pp 1-11 (2017)

مصطلحات موضوعية: Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216

وصف الملف: electronic resource

Relation: http://link.springer.com/article/10.1186/s12936-017-2085-4; https://doaj.org/toc/1475-2875

URL الوصول: https://doaj.org/article/566b9ef7b74a4082b406a4a2a9e0d020

المؤلفون: Michael G. Thomas, Maria L. Marco, John Thomas, Daniel Spinks, Ian H. Gilbert, Laste Stojanovski, Frederick R. C. Simeons, Ola Epemolu, Sujatha Manthri, Claire Naylor, Timothy J. Miles, Manu De Rycker, Suzanne Norval, Susan Wyllie, Stephen Patterson, Jennifer Riley, Maria Osuna-Cabello, Richard J. Wall, Jose M. Fiandor, Paul G. Wyatt, Kevin D. Read, Stephen Thompson

المصدر: Journal of Medicinal Chemistry. 63:9523-9539

مصطلحات موضوعية: 0303 health sciences, Chemistry, Pharmacology, medicine.disease, 01 natural sciences, Parasitic infection, In vitro, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, Visceral leishmaniasis, In vivo, Drug Discovery, Toxicity, medicine, Molecular Medicine, Water chemistry, Structure–activity relationship, Inhibitory concentration 50, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::c2075363d9d5006cac4eca5979afbbe9
https://doi.org/10.1021/acs.jmedchem.0c00705

المؤلفون: Manu De Rycker, John Thomas, Michael G. Thomas, Timothy J. Miles, Paul G. Wyatt, Ignacio Cotillo Torrejon, Kevin D. Read, Jennifer Riley, Daniel Spinks, Ian H. Gilbert

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:3025-3030

مصطلحات موضوعية: 0301 basic medicine, Chagas disease, Trypanosoma cruzi, 030231 tropical medicine, Clinical Biochemistry, Population, Pharmaceutical Science, Disease, Biochemistry, Article, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, medicine, Humans, Chagas Disease, Nifurtimox, education, Molecular Biology, Chronic stage, education.field_of_study, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Metabolic stability, medicine.disease, biology.organism_classification, Pyrimidines, 030104 developmental biology, Benznidazole, Immunology, Molecular Medicine, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e2ae21b584c56a4ef49173602a4cc47
https://doi.org/10.1016/j.bmcl.2018.08.005

المؤلفون: Laste Stojanovski, Tania Bakshi, Iain H. Reid, Maria L. Marco, Stephen Brand, Lars Henrik Sandberg, Sabrinia D. Crouch, Ian H. Gilbert, Lorna MacLean, Jennifer Riley, Christopher J. Nixon, Sharon Robinson, John M. Kelly, Yoko Shishikura, Stephen Thompson, Eun Jung Ko, Kevin D. Read, Daniel Spinks, Jose M. Fiandor, John Thomas, Alan P. Hill, Amanda F. Francisco, Ola Epemolu, Victoria Smith, Chimed Jansen, Paul G. Wyatt, Elisabet Viayna, Sean J. Hindley, Timothy J. Miles, Shiromani Jayawardhana, Frederick R. C. Simeons, Michael G. Thomas, Manu De Rycker, Tim Underwood, Paul Scullion, Maria Osuna-Cabello

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: 0301 basic medicine, Trypanosoma cruzi, hERG, Pharmacology, 01 natural sciences, Article, 03 medical and health sciences, Mice, Structure-Activity Relationship, Chlorocebus aethiops, Drug Discovery, medicine, Potency, Animals, Humans, Chagas Disease, Nifurtimox, Vero Cells, Amination, biology, Intracellular parasite, Triazoles, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, 3. Good health, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, Benznidazole, High-content screening, Vero cell, biology.protein, Molecular Medicine, Female, medicine.drug

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8f828f15d0a52e1f719409da74fd5b
http://europepmc.org/articles/PMC5601362

المؤلفون: David A. Robinson, Suzanne Norval, Irene Hallyburton, Stephen Brand, Ian H. Gilbert, Kevin D. Read, Tracy Bayliss, Michael A. J. Ferguson, Justin R. Harrison, Leah S. Torrie, Daniel Spinks, Laste Stojanovski, Neil R. Norcross, Ruth Brenk, Victoria Smith, Stuart P. McElroy, Julie A. Frearson, Laura A. T. Cleghorn, Alan H. Fairlamb, Paul G. Wyatt

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Databases, Factual, Cell Survival, Trypanosoma brucei brucei, Molecular Conformation, Administration, Oral, Aminopyridines, Pharmacology, Trypanosoma brucei, Crystallography, X-Ray, 01 natural sciences, Article, Cell Line, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Pharmacokinetics, parasitic diseases, Drug Discovery, medicine, Animals, Humans, Structure–activity relationship, African trypanosomiasis, IC50, 030304 developmental biology, Trypanocidal agent, chemistry.chemical_classification, Sulfonamides, 0303 health sciences, biology, 010405 organic chemistry, Drug discovery, medicine.disease, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, 3. Good health, Trypanosomiasis, African, Enzyme, Biochemistry, chemistry, Molecular Medicine, Acyltransferases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7f051b840d7b9653c4810af92787d47
https://doi.org/10.1021/jm201091t

المؤلفون: Alan H. Fairlamb, Victoria Smith, Daniel Spinks, Julie A. Frearson, Ruth Brenk, Suzanne Norval, Andrew Woodland, Paul G. Wyatt, Iain T. Collie, Ian H. Gilbert, Laura A. T. Cleghorn, Kevin D. Read, N. Yi Mok, Irene Hallyburton

المصدر: Chemmedchem

مصطلحات موضوعية: Models, Molecular, Narcotic antagonists, human African trypanosomiasis, Narcotic Antagonists, Trypanosoma brucei brucei, Antiprotozoal Agents, Trypanosoma brucei, Pharmacology, Biochemistry, Structure-Activity Relationship, Pharmacokinetics, Opioid Agonist, medicinal chemistry, parasitic diseases, Drug Discovery, Humans, Structure–activity relationship, General Pharmacology, Toxicology and Pharmaceutics, EC50, Full Paper, biology, Organic Chemistry, 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer, U50488, biology.organism_classification, Trypanosomiasis, African, Receptors, Opioid, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae13d4a2d2cb7098bf2bf745fcdba3d
https://doi.org/10.1002/cmdc.201100278

المؤلفون: David A. Robinson, Alan H. Fairlamb, Ian H. Gilbert, Iain T. Collie, Han B. Ong, Julie A. Frearson, Chidochangu P. Mpamhanga, Paul G. Wyatt, Ruth Brenk, Kevin D. Read, Daniel Spinks, Emma Shanks

المصدر: Chemmedchem

مصطلحات موضوعية: Models, Molecular, pteridine reductase, Stereochemistry, Drug Evaluation, Preclinical, Trypanosoma brucei, 010402 general chemistry, 01 natural sciences, Biochemistry, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Dihydrobiopterin, Drug Discovery, Dihydrofolate reductase, Animals, Structure–activity relationship, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Virtual screening, Full Paper, biology, Drug discovery, Organic Chemistry, biology.organism_classification, 3. Good health, 0104 chemical sciences, Pteridine reductase, Enzyme, chemistry, Drug Design, biology.protein, structure-based drug design, Molecular Medicine, Oxidoreductases, antiprotozoal agents

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e4c491acee852439be6822f1a2c4436
https://doi.org/10.1002/cmdc.201000450

المؤلفون: Paul G. Wyatt, Alan H. Fairlamb, Julie A. Frearson, Sandra L. Oza, Stephen Thompson, Daniel Spinks, Susan Wyllie, Justin R. Harrison, Leah S. Torrie, Ian H. Gilbert

المصدر: Journal of Biological Chemistry. 284:36137-36145

مصطلحات موضوعية: 0303 health sciences, biology, 030306 microbiology, High-throughput screening, Trypanothione, Cell Biology, Glutathione, Trypanosoma brucei, Pharmacology, biology.organism_classification, Biochemistry, 3. Good health, Spermidine, 03 medical and health sciences, chemistry.chemical_compound, Enzyme activator, chemistry, Biosynthesis, Drug development, Molecular Biology, 030304 developmental biology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::36c78e133cf4f22c0fa9463171f02a96
https://doi.org/10.1074/jbc.m109.045336

المؤلفون: David A. Robinson, William N. Hunter, Emma Shanks, Alan H. Fairlamb, Ian H. Gilbert, Daniel Spinks, Iain T. Collie, Chidochangu P. Mpamhanga, Lindsay B. Tulloch, Paul G. Wyatt, Julie A. Frearson, Ruth Brenk

المصدر: Journal of Medicinal Chemistry

مصطلحات موضوعية: Models, Molecular, Stereochemistry, Trypanosoma brucei brucei, Drug Evaluation, Preclinical, Molecular Conformation, 01 natural sciences, Article, Substrate Specificity, 03 medical and health sciences, Oxidoreductase, Drug Discovery, Animals, Humans, Computer Simulation, Benzothiazoles, Enzyme Inhibitors, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Virtual screening, biology, 010405 organic chemistry, Drug discovery, Biological activity, 3. Good health, 0104 chemical sciences, Pteridine reductase, Enzyme, Protein–ligand docking, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Benzimidazoles, Oxidoreductases

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255720e57c1d46d64c446b46a179286a
http://europepmc.org/articles/PMC2966039

المؤلفون: S. L. Shepheard, Peter H. Hutson, Desmond O'Connor, Linda J. Bristow, Peter Blurton, G.P. Cook, Graham D Bentley, Rose Marwood, Stephen Robert Fletcher, Angus Murray Macleod, José L. Castro, Frank Burkamp, Robert Clarkson, Matthew T. Tudge, Daniel Spinks, Monique Bodil Van Niel, Smita Patel, Kerry L. Chapman, Susan K. F. Cheng

المصدر: Journal of Medicinal Chemistry. 45:492-503

مصطلحات موضوعية: Male, ERG1 Potassium Channel, Potassium Channels, medicine.drug_class, Stereochemistry, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Carboxamide, Ether, In Vitro Techniques, Chemical synthesis, Cell Line, Sulfone, Rats, Sprague-Dawley, Electrocardiography, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Transcriptional Regulator ERG, Pharmacokinetics, In vivo, Cricetinae, Nitriles, Drug Discovery, medicine, Animals, Humans, Receptor, Serotonin, 5-HT2A, Spiro Compounds, Sulfones, Cation Transport Proteins, Chemistry, Ferrets, Brain, Ether-A-Go-Go Potassium Channels, Rats, Serotonin Receptor Agonists, Bioavailability, DNA-Binding Proteins, Potassium Channels, Voltage-Gated, Receptors, Serotonin, Benzamides, Microsomes, Liver, Trans-Activators, Molecular Medicine, Serotonin Antagonists, Piperidine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1afa4fc4cadf21e96b0a58afc824c74f
https://doi.org/10.1021/jm011030v