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1
المؤلفون: John P. Anderson, Dean R. Artis, Hing L. Sham, Roy K. Hom, Michael S. Dappen, Andrei W. Konradi, Simeon Bowers, Hu Pan, Robert A. Galemmo, Marc Adler, Pearl Tanaka, May Lin, Jeanne Baker, Lany Ruslim, Donald J. Fauss, Zhao Ren, Yong L. Zhu, Anh P. Truong, Danny Tam, Marcelle Bergeron, Lee H. Latimer, Paul Beroza, Jacek Jagodzinski, Heather Zhang, Michael P. Bova, George Tonn, Linnea Diep, Ruth Motter, Kent Fitzgerald, Nanhua Yao, Wayman Chan, Jennifer K. Hoffman, R. Jeffrey Neitz, Danielle L. Aubele
المصدر: ChemMedChem. 8:1295-1313
مصطلحات موضوعية: Male, Parkinson's disease, Polo-like kinase, Molecular Dynamics Simulation, Protein Serine-Threonine Kinases, Pharmacology, Biology, Blood–brain barrier, Biochemistry, Rats, Sprague-Dawley, Mice, chemistry.chemical_compound, In vivo, Drug Discovery, medicine, Animals, Humans, Protein Isoforms, Phosphorylation, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Alpha-synuclein, Binding Sites, Kinase, Drug discovery, Organic Chemistry, Brain, medicine.disease, Protein Structure, Tertiary, Rats, HEK293 Cells, medicine.anatomical_structure, chemistry, Blood-Brain Barrier, alpha-Synuclein, Molecular Medicine, Female, Half-Life
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2
المؤلفون: Anna Liao, Gary Probst, Pamela S. Keim, Kang Hu, Roy K. Hom, David A. Quincy, Michael S. Dappen, Grace T. Kwong, Jenifer Smith, Martin L. Neitzel, Ying-zi Xu, Elizabeth F. Brigham, Kevin P. Quinn, Frédérique Bard, Minghua Sun, Jing Wu, John-Michael Sauer, Dora Kholodenko, Hongbin Zhang, William Wallace, Matthew N. Mattson, Patricia Sacayon, Jacek Jagodzinski, Hing L. Sham, Brian T. Peterson, Simeon Bowers, Jennifer Marugg, Guriqbal S. Basi, Lee H. Latimer, Susanna S. Hemphill, Darren B. Dressen, Karina Wong, Kevin Tanaka, Michael P. Bova, Pamela Santiago, Daniel K. Ness, Anh P. Truong, Wes Zmolek, Lany Ruslim, Christopher Willits, Michael K. Lee, Andrei W. Konradi, Xiaocong M. Ye, Lam Nguyen, Chris M. Semko, Ted A. Yednock, Ruth N. Motter, Albert W. Garofalo, Erich Goldbach, Pearl Tanaka, Danielle L. Aubele
المصدر: Journal of Medicinal Chemistry. 56:5261-5274
مصطلحات موضوعية: Trifluoromethyl, biology, Stereochemistry, Quinoline, In vitro, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, biology.protein, medicine, Molecular Medicine, Structure–activity relationship, Chirality (chemistry), Amyloid precursor protein secretase, Semagacestat, medicine.drug
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3
المؤلفون: Kevin P. Quinn, Marc Adler, Gary Probst, Albert W. Garofalo, Anh P. Truong, Danny Tam, Erich Goldbach, Danielle L. Aubele, Maurizio Franzini, David Chian, Grace Kwong, Xiaocong M. Ye, Zhao Ren, Hing L. Sham, Lany Ruslim, Pearl Tanaka, Elizabeth F. Brigham, Ruth Motter
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1974-1977
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Pharmaceutical Science, Mice, Transgenic, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, MAP3K7, Biochemistry, MAP2K7, Mice, Structure-Activity Relationship, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Mice, Knockout, Dose-Response Relationship, Drug, Molecular Structure, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Protein kinase R, nervous system diseases, HEK293 Cells, Mutation, Quinolines, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9
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4
المؤلفون: Anh P. Truong, Shawn Gauby, Pam Santiago, Xiaocong M. Ye, Danielle L. Aubele, Marc Adler, Danny Tam, Albert W. Garofalo, Maurizio Franzini, Hing L. Sham, Erich Goldbach, Gary Probst, Zhao Ren, Kevin P. Quinn
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:1967-1973
مصطلحات موضوعية: Models, Molecular, Clinical Biochemistry, Mutant, Pharmaceutical Science, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Humans, Structure–activity relationship, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Kinase, Organic Chemistry, HEK 293 cells, Wild type, LRRK2, nervous system diseases, Pyridazines, HEK293 Cells, Molecular Medicine, Bioisostere
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5
المؤلفون: Colin Lorentzen, Maurizio Franzini, Anh P. Truong, R. Jeffrey Neitz, Marc Adler, Danielle L. Aubele, Pam Santiago, Hing L. Sham, Albert W. Garofalo, Simeon Bowers, Xiaocong M. Ye, Danny Tam, Kevin P. Quinn, Gary Probst, Zhao Ren, Erich Goldbach
المصدر: Bioorganic & Medicinal Chemistry Letters. 23:71-74
مصطلحات موضوعية: Clinical Biochemistry, Pharmaceutical Science, Protein Serine-Threonine Kinases, Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Transfection, Heterocyclic Compounds, 2-Ring, Biochemistry, MAP2K7, Mice, TANK-binding kinase 1, Drug Discovery, Animals, Humans, c-Raf, Kinase activity, Protein Kinase Inhibitors, Molecular Biology, Binding Sites, biology, Cyclin-dependent kinase 4, Chemistry, Organic Chemistry, Cyclin-dependent kinase 2, Amides, Protein kinase R, Protein Structure, Tertiary, nervous system diseases, Molecular Docking Simulation, HEK293 Cells, Mutation, biology.protein, Molecular Medicine, Cyclin-dependent kinase 9, Protein Binding
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6
المؤلفون: Chris M. Semko, Danielle L. Aubele, Guriqbal S. Basi, Wes Zmolek, Gary Probst, Matthew N. Mattson, Elizabeth F. Brigham, Erich Goldbach, Karina Wong, William A Wallace, John-Michael Sauer, Hing L. Sham, Lan K. Nguyen, Michael P. Bova, Andrei W. Konradi, Albert W. Garofalo, Susanna S. Hemphill, Darren B. Dressen, Kevin P. Quinn, Minghua Sun, Anh P. Truong, Simeon Bowers
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:5791-5794
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Mice, Inbred Strains, Biochemistry, Amyloid beta-Protein Precursor, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Peptide synthesis, Animals, Structure–activity relationship, γ secretase, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Sulfonamides, Amyloid beta-Peptides, Bicyclic molecule, Chemistry, Organic Chemistry, Combinatorial chemistry, Sulfonamide, Design synthesis, Drug Design, Molecular Medicine, Amyloid Precursor Protein Secretases, Selectivity, Heterocyclic Compounds, 3-Ring
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7
المؤلفون: John-Michael Sauer, Michael P. Bova, Michael A. Pleiss, Danielle L. Aubele, Elizabeth F. Brigham, Kevin P. Quinn, Balazs G. Szoke, Jennifer Marugg, Wes Zmolek, Andrei W. Konradi, Erich Goldbach, William A Wallace, Guriqbal S. Basi, Martin L. Neitzel, Jacek Jagodzinski, Susanna S. Hemphill
المصدر: Bioorganic & Medicinal Chemistry Letters. 21:3715-3720
مصطلحات موضوعية: Clinical Biochemistry, Notch signaling pathway, Pharmaceutical Science, Biochemistry, Inhibitory Concentration 50, Mice, Alzheimer Disease, Drug Discovery, medicine, Amyloid precursor protein, Animals, Caprolactam, Potency, Infusions, Parenteral, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Amyloid beta-Peptides, Molecular Structure, biology, Organic Chemistry, Sulfonamide (medicine), Biological activity, medicine.disease, Peptide Fragments, Enzyme Activation, Enzyme, chemistry, biology.protein, Molecular Medicine, Amyloid Precursor Protein Secretases, Signal transduction, Alzheimer's disease, medicine.drug
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8
المؤلفون: Xiaocong M, Ye, Andrei W, Konradi, Jenifer, Smith, Danielle L, Aubele, Albert W, Garofalo, Jennifer, Marugg, Marty L, Neitzel, Chris M, Semko, Hing L, Sham, Minghua, Sun, Anh P, Truong, Jing, Wu, Hongbin, Zhang, Erich, Goldbach, John-Michael, Sauer, Elizabeth F, Brigham, Michael, Bova, Guriqbal S, Basi
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:3502-3506
مصطلحات موضوعية: Sulfonamides, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Biochemistry, Drug Stability, Piperidines, Drug Discovery, Microsomes, Liver, Animals, Molecular Medicine, Protease Inhibitors, Amyloid Precursor Protein Secretases, Molecular Biology
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9
المؤلفون: Danielle L. Aubele, Paul E. Floreancig, V. Satish Kumar, Shuangyi Wan
المصدر: Tetrahedron: Asymmetry. 16:3570-3578
مصطلحات موضوعية: Reaction conditions, Chemistry, Organic Chemistry, Oxocarbenium, Rational design, food and beverages, Epoxide, Catalysis, Inorganic Chemistry, chemistry.chemical_compound, Cascade, Electrophile, Organic chemistry, Physical and Theoretical Chemistry
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10
المؤلفون: Paul E. Floreancig, Danielle L. Aubele, Shuangyi Wan
المصدر: Angewandte Chemie International Edition. 44:3485-3488
مصطلحات موضوعية: Molecular Structure, Chemistry, Stereochemistry, Enantioselective synthesis, Dactylolide, Total synthesis, Antineoplastic Agents, Stereoisomerism, General Medicine, General Chemistry, Alkenes, Prins reaction, Carbocation, Bridged Bicyclo Compounds, Heterocyclic, Catalysis, Lactones, Cyclization, Organic chemistry, Molecule, Peterson olefination
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