نتائج البحث - "Danielle Peeters"

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دورية أكاديمية

Automated quality control tool for high-content imaging data by building 2D prediction intervals on reference biosignatures

المؤلفون: Alemu Takele Assefa, Bie Verbist, Emmanuel Gustin, Danielle Peeters

المصدر: SLAS Discovery, Vol 28, Iss 3, Pp 111-117 (2023)

مصطلحات موضوعية: High-throughput image analysis, Cell painting, Quality control, Biosignature, Medicine (General), R5-920, Biotechnology, TP248.13-248.65

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2472555223000114; https://doaj.org/toc/2472-5552

URL الوصول: https://doaj.org/article/3b1c372133df40018f77f62c05eb9ec2

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Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy

المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2159-2164

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell type, Oral treatment, Clinical Biochemistry, Cancer therapy, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Oral administration, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cancer, Neoplasms, Experimental, medicine.disease, Bioavailability, Fatty Acid Synthase, Type I, Fatty acid synthase, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd313b43d21d3b1660d7723e4aead6d0
https://doi.org/10.1016/j.bmcl.2018.05.014

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Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures

المؤلفون: Danielle Peeters, Sarah Sauviller, Emmanuel Gustin, Peter Vermeulen, Jan Martin Berke, Dirk Wuyts, Frederik Pauwels, Koen Vandyck, Steffen Jaensch, Karen Vergauwen

المصدر: Journal of Virological Methods. 293:114150

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95c0e6c6dae9b7885d2b9f2dff195934
https://doi.org/10.1016/j.jviromet.2021.114150

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4

A small-molecule fusion inhibitor of influenza virus is orally active in mice

المصدر: Science. 363

مصطلحات موضوعية: 0301 basic medicine, Pyridines, Viral protein, Administration, Oral, Tetrazoles, Bronchi, Hemagglutinin Glycoproteins, Influenza Virus, Respiratory Mucosa, medicine.disease_cause, 01 natural sciences, Piperazines, Article, Virus, Madin Darby Canine Kidney Cells, Mice, 03 medical and health sciences, Dogs, Influenza A Virus, H1N1 Subtype, Biomimetic Materials, CR6261, Influenza, Human, medicine, Influenza A virus, Animals, Humans, Cells, Cultured, Viral Fusion Protein Inhibitors, Multidisciplinary, biology, 010405 organic chemistry, Virus Internalization, Antibodies, Neutralizing, Virology, Small molecule, In vitro, 0104 chemical sciences, 030104 developmental biology, Cell culture, biology.protein, Antibody

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cc89b6e36809f142eda1c2131f1632b
https://doi.org/10.1126/science.aar6221

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A Prospective Virtual Screening Study: Enriching Hit Rates and Designing Focus Libraries To Find Inhibitors of PI3Kδ and PI3Kγ

المؤلفون: Daniel DiSepio, Kelly L. Damm-Ganamet, Danielle Peeters, Scott D. Bembenek, Heather M. McAllister, James P. Edwards, Lieve Mangelschots, Taraneh Mirzadegan, Jennifer Venable, Glenda Castro

المصدر: Journal of medicinal chemistry. 59(9)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba06808978408c3c82e2f12502f01e1a
https://pubmed.ncbi.nlm.nih.gov/27043133

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6

430 Design and structure–activity relationships of highly potent and bioavailable imidazolinone FASN KR domain inhibitors

المصدر: European Journal of Cancer. 50:141-142

مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Stereochemistry, Domain (software engineering)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::b2caf22b40b42ea7e9026627bb170080
https://doi.org/10.1016/s0959-8049(14)70556-8

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Abstract 4747: Design and synthesis of a series highly potent and bioavailable FASN KR domain inhibitors for cancer

المصدر: Cancer Research. 74:4747-4747

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, Cell growth, Chemistry, Cancer, Pharmacology, medicine.disease, medicine.disease_cause, Fatty acid synthase, Enzyme, Oncology, Apoptosis, Cancer cell, medicine, biology.protein, Carcinogenesis, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::bbc77f2de582fc793cad2cd350548d6d
https://doi.org/10.1158/1538-7445.am2014-4747

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Abstract 801: Sensitivity of cell lines to Fatty Acid Synthase inhibitors depends on the lipid content in the cellular environment

المصدر: Cancer Research. 74:801-801

مصطلحات موضوعية: Cancer Research, medicine.medical_specialty, biology, Chemistry, Cancer, medicine.disease, Molecular biology, Fatty acid synthase, Endocrinology, Oncology, Growth factor receptor, In vivo, Cell culture, Internal medicine, Cancer cell, LNCaP, medicine, biology.protein, Lipid raft

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1a4a8ba06d36370068648ff2c8bc5179
https://doi.org/10.1158/1538-7445.am2014-801

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Abstract 2535: Structure-activity relationships of novel N-benzoyl arylpiperidine and arylazetidine FASN inhibitors

المؤلفون: Carsten Schubert, Ron Gilissen, Bruce L. Grasberger, Christophe Meyer, Peter J. Connolly, Sabine De Breucker, Luc Van Nuffel, Norbert Esser, James R. Bischoff, Michael H. Parker, Donald William Ludovici, Erwin Fraiponts, Boudewijn Janssens, Danielle Peeters, Karine Smans, Tianbao Lu, Peter Vermeulen, Lieven Meerpoel, Gilles Bignan

المصدر: Cancer Research. 74:2535-2535

مصطلحات موضوعية: chemistry.chemical_classification, Cancer Research, biology, In vitro, Palmitic acid, chemistry.chemical_compound, Fatty acid synthase, Enzyme, Oncology, Biochemistry, Biosynthesis, chemistry, In vivo, Cell culture, biology.protein, IC50

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5984cccf305d5033564ca0577f95f99e
https://doi.org/10.1158/1538-7445.am2014-2535

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Synthesis and biological evaluation of imidazol-2-one and 2-cyanoiminoimidazole derivatives: novel series of PDE4 inhibitors

المصدر: Bioorganicmedicinal chemistry letters. 12(4)

مصطلحات موضوعية: Stereochemistry, Administration, Topical, Clinical Biochemistry, Anti-Inflammatory Agents, Pharmaceutical Science, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, In vivo, Drug Discovery, medicine, Animals, Humans, PDE4 Inhibitors, Enzyme Inhibitors, Ear Diseases, Molecular Biology, Rolipram, chemistry.chemical_classification, Inflammation, biology, Dose-Response Relationship, Drug, Chemistry, Organic Chemistry, Imidazoles, Combinatorial chemistry, In vitro, Cyclic Nucleotide Phosphodiesterases, Type 4, Rats, Disease Models, Animal, Enzyme, Enzyme inhibitor, 3',5'-Cyclic-AMP Phosphodiesterases, biology.protein, Molecular Medicine, Enantiomer, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::370d2b7a16379bfe3918f2b9bb162f31
https://pubmed.ncbi.nlm.nih.gov/11844693

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