-
1
المؤلفون: Jean-Marc Lapierre, Cathy O. Bull, Ronald E. Savage, Sudharshan Eathiraj, David Vensel, Sapna Makhija, Eugene Kelleher, Neil Westlund, Jeff Szwaya, Yanbin Liu, Steffi Koerner, Magdi Moussa, Susan Cornell-Kennon, Akihisa Matsuda, Darin Kizer, Nivedita Namdev, Hui Wu, Shin Iimura, Brian Schwartz, Erika Volckova
المصدر: Journal of Medicinal Chemistry. 59:6455-6469
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Allosteric regulation, Administration, Oral, Aminopyridines, AKT1, Antineoplastic Agents, AKT2, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Allosteric Regulation, Drug Discovery, Animals, Humans, Moiety, Protein Kinase Inhibitors, Protein kinase B, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Imidazoles, Neoplasms, Experimental, Endometrial Neoplasms, 030104 developmental biology, Enzyme, chemistry, 030220 oncology & carcinogenesis, embryonic structures, Molecular Medicine, Phosphorylation, Female, Drug Screening Assays, Antitumor, Carcinoma, Endometrioid, Proto-Oncogene Proteins c-akt
-
2
المؤلفون: Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Karen Bresciano, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Terence Hall, Jason Hill, Eoin Kelleher, Sampada Khanapurkar, Darin Kizer, Steffi Koerner, Jeff Link, Yanbin Liu, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Khanh Nguyen, Robert Nicewonger, Rocio Palma, Jeff Szwaya, Manish Tandon, Uma Uppalapati, David Vensel, Laurie P. Volak, Erika Volckova, Neil Westlund, Hui Wu, Rui-Yang Yang, Thomas C. K. Chan
المصدر: Journal of Medicinal Chemistry. 55:5291-5310
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Pyridines, Administration, Oral, Biological Availability, AKT1, Antineoplastic Agents, Plasma protein binding, Pharmacology, Crystallography, X-Ray, Mice, Structure-Activity Relationship, Adenosine Triphosphate, In vivo, Catalytic Domain, Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, Phosphorylation, Protein kinase B, Adaptor Proteins, Signal Transducing, Cell Proliferation, Effector, Chemistry, Imidazoles, Ribosomal Protein S6 Kinases, 70-kDa, Small molecule, Biochemistry, Microsomes, Liver, Molecular Medicine, Proto-Oncogene Proteins c-akt, Protein Binding
-
3
المؤلفون: Thomas C.K. Chan, Erika Volckova, Rui-Yang Yang, Caiyun Zhong, Mark A. Ashwell, Xiu-Sheng Miao, Darin Kizer, Yunxia Wang, Ronald E. Savage
المصدر: Rapid Communications in Mass Spectrometry. 23:12-22
مصطلحات موضوعية: Cell type, Metabolite, Glucuronidation, Antineoplastic Agents, Glucuronates, Kidney, Mass Spectrometry, Cryopreservation, Analytical Chemistry, Mice, chemistry.chemical_compound, Dogs, Sulfation, Glucosides, Biotransformation, Animals, Humans, Metabolomics, Cytotoxic T cell, Intestinal Mucosa, Lung, Cells, Cultured, Spectroscopy, Sulfates, Chemistry, Hydrolysis, Organic Chemistry, Metabolism, Rats, Biochemistry, Isotope Labeling, Hepatocytes, Chromatography, Liquid, Naphthoquinones
-
4
المؤلفون: Rui-Yang Yang, Syed M. Ali, Manish Tandon, Erika Volckova, Ronald E. Savage, Xiu-Sheng Miao, Hui Wu, Mark A. Ashwell, Thomas C.K. Chan, Darin Kizer
المصدر: Bioorganic & Medicinal Chemistry. 16:5635-5643
مصطلحات موضوعية: Erythrocytes, Magnetic Resonance Spectroscopy, Metabolite, Clinical Biochemistry, Pharmaceutical Science, Oxidative phosphorylation, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Drug Discovery, Humans, Molecular Biology, chemistry.chemical_classification, Molecular Structure, Chemistry, Organic Chemistry, Decarbonylation, Stereoisomerism, Metabolism, In vitro, Quinone, Microsomes, Liver, Molecular Medicine, Lactone, Naphthoquinones
-
5
المؤلفون: Hui Wu, Darin Kizer, Ronald E. Savage, Erika Volckova, Xiu-Sheng Miao, Rui-Yang Yang, Mark A. Ashwell, Caiyun Zhong, Thomas C.K. Chan, Xiaoying He, Jeffrey G. Supko, Pengfei Song
المصدر: Drug Metabolism and Disposition. 36:641-648
مصطلحات موضوعية: Pharmacology, Chromatography, Metabolite, Pharmaceutical Science, Haplorhini, Metabolism, Plasma protein binding, Gas Chromatography-Mass Spectrometry, In vitro, Pyrone, Rats, Mice, Metabolic pathway, chemistry.chemical_compound, Dogs, Species Specificity, chemistry, Biochemistry, Pyran, Animals, Humans, Naphthoquinones, Protein Binding, Whole blood
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62245b50c3a4ff50e367a6b94662646
https://doi.org/10.1124/dmd.107.018572 -
6
المؤلفون: Syed M. Ali, Chris Brassard, Audra Dalton, Darin Kizer, Jean-Marc Lapierre, Yanbin Liu, Magdi Moussa, Rocio Palma, Manish Tandon, David Vensel, Erika Volckova, Jianqiang Wang, Neil Westlund, Hui Wu, Rui-Yang Yang, Craig Bates, Mayank Bhavsar, Cathy Bull, Sudharshan Eathiraj, Robert Nicewonger, Ron Savage, Carol Waghorne, Jennifer Castro, Enkeleda Nakuci, Chang-Rung Chen, Dennis S. France, Thomas C.K. Chan, Mark A. Ashwell
المصدر: Cancer Research. 72:3905-3905
مصطلحات موضوعية: Cancer Research, Kinase, In silico, Cancer, Pharmacology, Biology, medicine.disease, In vitro, Oncology, Biochemistry, In vivo, Fibroblast growth factor receptor, medicine, Structure–activity relationship, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f3f2f570d6e9677ed33340d22c18292f
https://doi.org/10.1158/1538-7445.am2012-3905 -
7
المؤلفون: Thomas C.K. Chan, Mark A. Ashwell, Jean-Marc Lapierre, Christopher Brassard, Cathy Bull, Susan Cornell-Kennon, Sudharshan Eathiraj, Dennis S. France, Jason Hill, Steffi Koerner, Eoin Kelleher, Darin Kizer, Yanbin Liu, Jeff Link, Sapna Makhija, Magdi Moussa, Nivedita Namdev, Robert Nicewonger, Uma Uppalapati, Rocio Palma, Jeff Szwaya, Manish Tandon, David Vensel, Laurie Volak, Erika Volckova, Neil Westland, Hui Wu, Rui-Yang Yang
المصدر: Cancer Research. 72:LB-1
مصطلحات موضوعية: Cancer Research, Effector, Chemistry, AKT1, Cancer, Pharmacology, medicine.disease, Small molecule, In vitro, Oncology, In vivo, medicine, Protein kinase B, Intracellular
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::34014a12fe34271da22ab4f26b260726
https://doi.org/10.1158/1538-7445.am2012-lb-1 -
8
المؤلفون: Chang-Rung Chen, Syed Ali, Rocio Palma, Sudharshan Eathiraj, Craig Bates, Mayank Bhavsar, Chris Brassard, Jennifer O. Brown, Cathy Bull, Li Huang, Darin Kizer, Yanbin Liu, Denise McSweeney, Magdi Moussa, Enkeleda Nakuci, Manish Tandon, Dave Vensel, Erika Volckova, Jianqiang Wang, Neil Westlund, Hui Wu, Rui-Yang Yang, Dennis S. France, Mark A. Ashwell, Thomas C.K Chan
المصدر: Molecular Cancer Therapeutics. 8:A139-A139
مصطلحات موضوعية: Cancer Research, Drug discovery, Kinase, Pharmacology, Biology, chemistry.chemical_compound, Insulin receptor, Oncology, chemistry, In vivo, Fibroblast growth factor receptor, Cancer research, biology.protein, Kinome, Growth inhibition, Tyrosine kinase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::af8e142c6f693f42ce27b7f0ae548025
https://doi.org/10.1158/1535-7163.targ-09-a139
Find this issue from the American Chemical Society