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1
المؤلفون: Sébastien Delpeut, Liang Tzung Lin, Richard K. Plemper, Gary Sisson, Christopher D. Richardson, Michael N. Ha, Gilbert G. Privé, Darius Bilimoria, Ryan S. Noyce, Karen M. Black
المصدر: Journal of Virology. 91
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, 030106 microbiology, Immunology, Mutant, Hemagglutinins, Viral, Hemagglutinin (influenza), Antiviral Agents, Membrane Fusion, Microbiology, Measles virus, 03 medical and health sciences, Virology, Chlorocebus aethiops, Animals, Vero Cells, Syncytium, biology, Lipid bilayer fusion, Virus Internalization, biology.organism_classification, Fusion protein, Virus-Cell Interactions, 3. Good health, Oncolytic virus, Heptad repeat, 030104 developmental biology, Insect Science, Benzamides, Mutation, biology.protein, Oligopeptides, Viral Fusion Proteins, Protein Binding
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4bb38a026fdd1b2a1bb0b25e871ca3
https://doi.org/10.1128/jvi.01026-17 -
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المؤلفون: Simon Giroux, Nigel Ewing, Youssef L. Bennani, Francoise Berlioz-Seux, Rebecca S. Shawgo, Anne-Laure Grillot, Nathalie Chauret, Kevin M. Cottrell, Laval C. Chan, Evelyne Dietrich, Francois Denis, Morris Mark A, John Maxwell, Sanjoy Kumar Das, Lucille L’Heureux, Darius Bilimoria, T. Jagadeeswar Reddy, Subajini Selliah, Caroline Cadilhac, Olivier Nicolas, Jinwang Xu, James A. Henderson, Nagraj Mani
المصدر: Bioorganic & Medicinal Chemistry Letters. 25:936-939
مصطلحات موضوعية: Biphenyl, Stereochemistry, Organic Chemistry, Clinical Biochemistry, Imidazoles, virus diseases, Pharmaceutical Science, Viral Nonstructural Proteins, Antiviral Agents, Biochemistry, digestive system diseases, chemistry.chemical_compound, Character (mathematics), chemistry, Genotype 1b, Drug Discovery, Molecular Medicine, NS5A, Molecular Biology, Linker
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المؤلفون: Brian S. Luisi, Philip N. Collier, Pan Li, Lauffer David J, Qing Tang, Carl Poisson, Waal Nathan D, Ganesh Iyer, John J. Court, Sanjoy Kumar Das, Olivier Nicolas, B. Govinda Rao, Rebecca S. Shawgo, Laval C. Chan, Steven M. Ronkin, Nathalie Chauret, Suganthi Nanthakumar, Lucille L’Heureux, Darius Bilimoria, Nagraj Mani, Subajini Selliah, Francois Denis, Kishan Chandupatla, Constantin Yannopoulos, Warren Dorsch, Jeremy Green, Andrzej Ardzinski
المصدر: Journal of medicinal chemistry. 59(13)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, viruses, Hepacivirus, medicine.medical_treatment, 030106 microbiology, Allosteric regulation, Microbial Sensitivity Tests, Thiophenes, Viral Nonstructural Proteins, Virus Replication, Antiviral Agents, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, Allosteric Regulation, Drug Discovery, medicine, Structure–activity relationship, NS5A, NS5B, NS3, Protease, biology, Dose-Response Relationship, Drug, Molecular Structure, Chemistry, Drug discovery, virus diseases, biochemical phenomena, metabolism, and nutrition, biology.organism_classification, Cyclohexanols, digestive system diseases, 030104 developmental biology, Biochemistry, Molecular Medicine
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المؤلفون: Jian Wang, Anne-Laure Grillot, Carl Poisson, Simon Giroux, Nigel Ewing, Youssef L. Bennani, Rebecca S. Shawgo, Ronald Grey, Louis Vaillancourt, Nathalie Chauret, Darius Bilimoria, Olivier Nicolas, Lucille L’Heureux, Subajini Selliah, Kevin M. Cottrell, B. Govinda Rao, Constantin Yannopoulos, Guy Falardeau, Monica Bubenik, Laval C. Chan, James A. Henderson, Sanjoy Kumar Das, Francois Denis, T. Jagadeeswar Reddy, Caroline Cadilhac, Morris Mark A, Oswy Z. Pereira, Evelyne Dietrich, Nagraj Mani, John Maxwell, Francoise Berlioz-Seux, Bingcan Liu
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Benzimidazole, Pyrrolidines, Genotype, Hepatitis C virus, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biology, Viral Nonstructural Proteins, medicine.disease_cause, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Genotype 1b, chemistry, Drug Discovery, medicine, Molecular Medicine, Potency, Benzimidazoles, NS5A, Molecular Biology
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المؤلفون: Anne-Laure Grillot, Nigel Ewing, Youssef L. Bennani, Simon Giroux, Nathalie Chauret, Caroline Cadilhac, Kevin M. Cottrell, Olivier Nicolas, T. Jagadeeswar Reddy, Evelyne Dietrich, Lucille L’Heureux, Francois Denis, Oswy Z. Pereira, Rebecca S. Shawgo, Jinwang Xu, Nagraj Mani, Francoise Berlioz-Seux, Jian Wang, Sanjoy Kumar Das, John Maxwell, Bingcan Liu, James A. Henderson, Louis Vaillancourt, Subajini Selliah, Guy Falardeau, Laval C. Chan, Morris Mark A, Carl Poisson, Darius Bilimoria, Monica Bubenik
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Ledipasvir, Daclatasvir, viruses, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, chemistry.chemical_compound, Structure-Activity Relationship, Amide, Drug Discovery, medicine, Structure–activity relationship, NS5A, Molecular Biology, Organic Chemistry, virus diseases, biochemical phenomena, metabolism, and nutrition, Combinatorial chemistry, digestive system diseases, Ombitasvir, chemistry, Molecular Medicine, Pharmacophore, medicine.drug
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المؤلفون: John Maxwell, Francois Denis, Kevin M. Cottrell, Francoise Berlioz-Seux, Subajini Selliah, Rebecca S. Shawgo, Nigel Ewing, Youssef L. Bennani, Morris Mark A, Anne-Laure Grillot, Laval C. Chan, Simon Giroux, Darius Bilimoria, Nagraj Mani, Caroline Cadilhac, T. Jagadeeswar Reddy, James A. Henderson, Olivier Nicolas, Sanjoy Kumar Das, Nathalie Chauret, Jinwang Xu, Lucille L’Heureux, Evelyne Dietrich
المصدر: Bioorganicmedicinal chemistry letters. 25(4)
مصطلحات موضوعية: Genotype, Clinical Biochemistry, Non symmetric, Pharmaceutical Science, Hepacivirus, Pharmacology, Viral Nonstructural Proteins, Biochemistry, Antiviral Agents, Genotype 1b, Drug Discovery, Potency, Animals, Humans, NS5A, Molecular Biology, Chemistry, Organic Chemistry, Imidazoles, virus diseases, Aromaticity, digestive system diseases, Rats, Molecular Medicine, Linker
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المؤلفون: Nathalie Chauret, Francoise Berlioz-Seux, Anne-Laure Grillot, Nigel Ewing, Sanjoy Kumar Das, Jinwang Xu, Oliver Nicolas, James A. Henderson, Youssef L. Bennani, Darius Bilimoria, Simon Giroux, Francois Denis, John Maxwell, Caroline Cadilhac, Morris Mark A, Mark N. Namchuk, Nagraj Mani, Laval C. Chan, Lucille L’Heureux, Subajini Selliah, T. Jagadeeswar Reddy, Rebecca S. Shawgo, Kevin M. Cottrell
مصطلحات موضوعية: Stereochemistry, business.industry, Organic Chemistry, HCV genotypes, Sonogashira coupling, Bioinformatics, Biochemistry, Genotype 1b, Drug Discovery, Potency, Common key, Medicine, Replicon, business, NS5A, Linker
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6659bdfa639f80381f726c3da883bd65
https://europepmc.org/articles/PMC4027595/ -
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المؤلفون: Melanie Proulx, Constantin G. Yannopoulos, Nathalie Turcotte, Richard Bethell, Carl Poisson, Martine Hamel, Arshad Siddiqui, Nghe Nguyen-Ba, Lucille L'Heureux, M. Hicham Alaoui-Ismaili, Wuyi Wang, Darius Bilimoria, Alexandre Drouin, T. Jagadeeswar Reddy, Laval Chan, Sanjoy Kumar Das, Oswy Z. Pereira
المصدر: Journal of Medicinal Chemistry. 46:1283-1285
مصطلحات موضوعية: Phenylalanine, viruses, Hepacivirus, Hepatitis C virus, RNA-dependent RNA polymerase, Viral Nonstructural Proteins, medicine.disease_cause, Antiviral Agents, Virus, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Enzyme Inhibitors, NS5B, chemistry.chemical_classification, biology, Chemistry, virus diseases, RNA-Dependent RNA Polymerase, biology.organism_classification, Nucleotidyltransferase, digestive system diseases, Enzyme, Viral replication, Biochemistry, Molecular Medicine
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المؤلفون: Laval Chan, Darius Bilimoria, Sanjoy K. Das, Christopher R. Corbeil, Constantin G. Yannopoulos, Pablo Englebienne, Nicolas Moitessier, Lucille L’Heureux
المصدر: ChemInform. 39
مصطلحات موضوعية: Virtual screening, biology, Docking (molecular), Chemistry, biology.protein, General Medicine, Combinatorial chemistry, Polymerase, Macromolecule
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المؤلفون: Christopher R. Corbeil, Laval Chan, Sanjoy K. Das, Constantin G. Yannopoulos, Darius Bilimoria, Lucille L’Heureux, Pablo Englebienne, Nicolas Moitessier
المصدر: Journal of chemical information and modeling. 48(4)
مصطلحات موضوعية: Virtual screening, biology, Chemistry, General Chemical Engineering, Hepatitis C virus, Drug Evaluation, Preclinical, General Chemistry, Computational biology, Hepacivirus, Library and Information Sciences, medicine.disease_cause, Ligands, RNA-Dependent RNA Polymerase, Molecular biology, Ns5b polymerase, Computer Science Applications, Docking (molecular), medicine, biology.protein, Pharmacophore, Enzyme Inhibitors, Polymerase, Macromolecule