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1
المؤلفون: Ben Hock Lim, Wen W. Jiang, Charles A. Flentge, Akhteruzzaman Molla, Hutchinson Douglas K, Darold L. Madigan, Clarence J. Maring, Rolf Wagner, Warren M. Kati, Yaya Liu, John T. Randolph
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:3747-3750
مصطلحات موضوعية: Genotype, High-throughput screening, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Protease Inhibitors, Nucleotide, Binding site, Uracil, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, biology, Aryl, Organic Chemistry, virus diseases, RNA, Dihydrouracil, Molecular biology, digestive system diseases, Kinetics, Amino Acid Substitution, chemistry, biology.protein, Molecular Medicine, Transcription Initiation Site
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2
المؤلفون: Thomas J. Sowin, Minghua Sun, April Kennedy, Steven W. Muchmore, Gary Wang, Vincent S. Stoll, Yu-Gui Y. Gu, Clarence J. Maring, Chen Zhao, Graeme Laver, Kent D. Stewart, Dale J. Kempf, Darold L. Madigan, Jonathan Greer, Yuanwei Chen, Vincent L. Giranda, Hing L. Sham, Warren M. Kati, Ayda Saldivar, Yibo Xu
المصدر: Biochemistry. 42:718-727
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Molecular model, Stereochemistry, Neuraminidase, Cyclopentanes, Crystal structure, Crystallography, X-Ray, Ring (chemistry), Biochemistry, Birds, Structure-Activity Relationship, chemistry.chemical_compound, Zanamivir, medicine, Animals, Combinatorial Chemistry Techniques, Nanotechnology, Amines, Enzyme Inhibitors, Binding Sites, biology, Active site, Esters, Stereoisomerism, chemistry, Influenza A virus, Drug Design, biology.protein, Crystallization, Protein crystallization, Lead compound, medicine.drug
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3
المؤلفون: Chen Zhao, Dale J. Kempf, Hing L. Sham, David A. Betebenner, Thomas Herrin, William Rosenbrook, Kennan C. Marsh, Daniel W. Norbeck, Akhter Molla, Shuqun Lin, Ayda Saldivar, Jacob J. Plattner, Darold L. Madigan, Leping Li, Edith McDonald, Norman E. Wideburg, Suthida Vasavanonda
المصدر: Biochemical and Biophysical Research Communications. 225:436-440
مصطلحات موضوعية: Male, Stereochemistry, medicine.medical_treatment, Molecular Sequence Data, Biophysics, Biological Availability, Biochemistry, Cell Line, Rats, Sprague-Dawley, HIV Protease, HIV-1 protease, medicine, Animals, Humans, Urea, Amino Acid Sequence, Molecular Biology, IC50, Cytopathic effect, Protease, biology, HIV Protease Inhibitors, Cell Biology, Recombinant Proteins, In vitro, Rats, HIV-1, biology.protein
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4
المؤلفون: Darold L. Madigan, Hing L. Sham, A. Chris Krueger, Yibo Xu, Yu Gui Gu
المصدر: Tetrahedron Letters. 43:955-957
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, 1,3-Dipolar cycloaddition, Glycine, Acrolein, Organic chemistry, Stereoselectivity, Proline, Biochemistry, Triethylamine
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5
المؤلفون: H. L. Sham, Kent D. Stewart, Kennan C. Marsh, Chang H. Park, Thomas Herrin, Xiang-Peng Kong, C. Zhao, Dale J. Kempf, David A. Betebenner, J. J. Plattner, Akhter Molla, T. Robins, D. W. Norbeck, Shuqun Lin, Ayda Saldivar, N. Lyons, Darold L. Madigan, W. Jun. Rosenbrook, Edith McDonald, Jon F. Denissen, Norman Wideburg, Suthida Vasavanonda
المصدر: ChemInform. 27
مصطلحات موضوعية: Protease, Chemistry, medicine.medical_treatment, medicine, Human immunodeficiency virus (HIV), General Medicine, medicine.disease_cause, Virology
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6
المؤلفون: Hing L. Sham, Yibo Xu, Darold L. Madigan, Yu Gui Gu, A. Chris Krueger
المصدر: ChemInform. 33
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, 1,3-Dipolar cycloaddition, Acrolein, Glycine, Stereoselectivity, General Medicine, Proline, Triethylamine, Medicinal chemistry, Pyrrole derivatives
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7
المؤلفون: Akhteruzzaman Molla, Keith F. McDaniel, Dale J. Kempf, Debra Montgomery, Tim Middleton, Teresa I. Ng, Wen W. Jiang, Warren M. Kati, Hongmei Mo, Clarence J. Maring, Hutchinson Douglas K, Darold L. Madigan, A. Chris Krueger, Yaya Liu, Brian E. Green, Sherie Masse
المصدر: Bioorganicmedicinal chemistry letters. 17(8)
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Hepacivirus, Viral Nonstructural Proteins, Benzothiadiazines, Biochemistry, Chemical synthesis, Antiviral Agents, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Drug Discovery, Alkanes, Structure–activity relationship, Molecular Biology, NS5B, Polymerase, chemistry.chemical_classification, Alkane, biology, Organic Chemistry, Sulfonamide, Enzyme, chemistry, Benzothiadiazine, biology.protein, Molecular Medicine, Replicon
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8
المؤلفون: Tim Middleton, Dale J. Kempf, Rong Zhang, Todd W. Rockway, Warren M. Kati, John K. Pratt, Darold L. Madigan, Hongmei Mo, Keith F. McDaniel, Clarence J. Maring, Sherie Masse, Wen W. Jiang, Akhteruzzaman Molla, A. Chris Krueger, Dachun Liu, Yaya Liu, Debra Montgomery
المصدر: Bioorganicmedicinal chemistry letters. 16(13)
مصطلحات موضوعية: Stereochemistry, Hepatitis C virus, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Viral Nonstructural Proteins, medicine.disease_cause, Benzothiadiazines, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, medicine, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, Polymerase, chemistry.chemical_classification, Sulfonamides, biology, Molecular Structure, Chemistry, Organic Chemistry, Enzyme, Enzyme inhibitor, Benzothiadiazine, Lactam, biology.protein, Molecular Medicine
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9
المؤلفون: Akhteruzzaman Molla, Robert J Carrick, Minghua Sun, William E Kohlbrenner, Kent D. Stewart, Krueger Allan C, Chen Zhao, Warren M. Kati, K. C. Marsh, Dale J. Kempf, Kevin R. Steffy, Clarence J. Maring, Anita J Kempf-Grote, Yibo Xu, W. Graeme Laver, Vincent S. Stoll, Darold L. Madigan, Debra Montgomery, Yu-Gui Gu, Hing L. Sham
المصدر: Journal of medicinal chemistry. 48(12)
مصطلحات موضوعية: Models, Molecular, Pyrrolidines, Stereochemistry, Biological Availability, Neuraminidase, Stereoisomerism, Crystallography, X-Ray, Chemical synthesis, Pyrrolidine, Hydrophobic effect, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Animals, Binding Sites, biology, Hydrogen bond, Active site, Rats, Influenza B virus, chemistry, Influenza A virus, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions
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10
المؤلفون: Terrel Robins, Norman E. Wideburg, William Rosenbrook, Ayda Saldivar, Suthida Vasavanonda, Hing L. Sham, Kennan C. Marsh, Kent D. Stewart, Chen Zhao, Jacob J. Plattner, Thomas Herrin, Jon F. Denissen, Nicholas Lyons, Dale J. Kempf, Xiang-P. Kong, David A. Betebenner, Darold L. Madigan, Akhter Molla, Shuqun Lin, Edith McDonald, Chang H. Park, Daniel W. Norbeck
المصدر: Journal of medicinal chemistry. 39(2)
مصطلحات موضوعية: chemistry.chemical_classification, Models, Molecular, Protease, Binding Sites, biology, Molecular model, medicine.medical_treatment, Drug Resistance, Microbial, HIV Protease Inhibitors, In vitro, Virus, Enzyme, chemistry, Biochemistry, HIV Protease, Enzyme inhibitor, In vivo, Drug Discovery, medicine, biology.protein, HIV-1, Molecular Medicine, Gene